Heme oxygenase-1: The "emerging molecule" has arrived

American Journal of Respiratory Cell and Molecular Biology

Volumn 27, Issue 1, 2002, Pages 8-16

  Morse, Danielle ^a   Choi, Augustine M K ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEME OXYGENASE; HEME OXYGENASE 1; HMOX1 PROTEIN, HUMAN; MEMBRANE PROTEIN; NITRIC OXIDE;

ANIMAL; APOPTOSIS; CARDIOVASCULAR DISEASE; ENZYME INDUCTION; HUMAN; LUNG DISEASE; METABOLISM; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CARDIOVASCULAR DISEASES; ENZYME INDUCTION; HEME OXYGENASE (DECYCLIZING); HEME OXYGENASE-1; HUMANS; LUNG DISEASES; MEMBRANE PROTEINS; NITRIC OXIDE; SIGNAL TRANSDUCTION;

EID: 0035983247     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.27.1.4862     Document Type: Review

References (158)

1. Degradation of haemoglobin and hemin to biliverdin by a new cell-free system obtained from the hemophagous organ of dog placenta
2. The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase
3. Microsomal heme oxygenase: Characterization of the enzyme
4. Characterization of two constitutive forms of rat liver microsomal heme oxygenase
5. Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite
6. Induction of heme oxygenase as a defense against oxidative stress
7. Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency
8. Heme oxygenase 1 is required for mammalian iron reutilization
9. The antioxidant defense protein ferritin is a novel and specific target for pentaerithrityl tetranitrate in endothelial cells
10. The antioxidant effect of free bilirubin on cumene-hydroperoxide treated human leukocytes
11. Heme oxygenase: Colors of defense against cellular stress
12. Heme oxygenase-1: Function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury
13. The heme oxygenase system: A regulator of second messenger gases
14. Induction of heme oxygenase-1 gene expression by lipopolysaccharide is mediated by AP-1 activation
15. Expression of heme oxygenase-1 in the lung in chronic hypoxia
16. Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia
17. Overexpression of heme oxygenase-1 expression in human pulmonary epithelial cells results in cell growth arrest and increased resistance to hyperoxia
18. Both near ultraviolet radiation and the oxidizing agent hydrogen peroxide induce a 32-kDa stress protein in normal human skin fibroblasts
19. Endogenous glutathione levels modulate both constitutive and UVA radiation/hydrogen peroxide inducible expression of the human heme oxygenase gene
20. Rapid induction of heme oxygenase 1 mRNA and protein by hyperthermia in rat brain: Heme oxygenase 2 is not a heat shock protein
21. Differential regulation of cardiac heme oxygenase-1 and vascular endothelial growth factor mRNA expressions by hemin, heavy metals, heat shock and anoxia
22. Induction of ferritin and heme oxygenase-1 by endotoxin in the lung
23. Cytokine induction of haem oxygenase mRNA in mouse liver: Interleukin 1 transcriptionally activates the haem oxygenase gene
24. Linoleyl hydroperoxide transcriptionally upregulates heme oxygenase-1 gene expression in human renal epithelial and aortic endothelial cells
25. Iron regulates hyperoxia-dependent human heme oxygenase-1 gene expression in pulmonary endothelial cells
26. Nitric oxide induces heme oxygenase-1 gene expression and carbon monoxide production in vascular smooth muscle cells
27. Coordinated expression and mechanisms of induction of HSP32 (heme oxygenase-1) mRNA by hyperthermia in rat organs
28. Regulation of human heme oxygenase-1 gene expression under thermal stress
29. Identification of binding sites for transcription factors NF-kappa B and AP-2 in the promoter region of the human heme oxygenase-1 gene
30. Identification of a cis-acting element that is responsible for cadmium-mediated induction of the human heme oxygenase gene
31. The saga of leucine zippers continues in response to oxidative stress
32. Isolation and characterization of the mouse heme oxygenase-1 gene: Distal 5′ sequences are required for induction by heme and heavy metals
33. Identification of a second 5′ distal region that functions as a basal and inducer-dependent transcriptional enhancer of the mouse heme oxygenase-1 gene
34. Transcriptional activation of the HO-1 gene by lipopolysaccharide is mediated by 5′ distal enhancers: Role of reactive oxygen intermediates and AP-1
35. Distal AP-1 binding sites mediate basal level enhancement and TPA induction by heavy metals
36. The proximal promoter region of the human heme oxygenase gene contains elements involved in stimulation of transcriptional activity by a variety of agents including oxidants
37. Regulation of heme oxygenase-1 expression in vivo and in vitro in hyperoxic lung injury
38. AP-1 and STAT mediate hyperoxia-induced gene transcription of heme oxygenase-1
39. Differential activation pattern of redox-sensitive transcription factors and stress-inducible dilator systems heme oxygenase-1 and inducible nitric oxide synthase in hemorrhagic and endotoxic shock
40. Transcriptional regulation of heme oxygenase by HIF-1α in renal medullary interstitial cells
41. The signaling pathways of interleukin-6 and gamma interferon converge by the activation of different transcription factors which bind to common responsive DNA elements
42. Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene
43. Mechanism of heme oxygenase-1 gene activation by cadmium in MCF-7 mammary epithelial cells: Role of p38 kinase and Nrf2 transcription factor
44. Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein
45. Protein serine/threonine kinases of the MAPK cascade
46. Multiple intracellular MAP kinase signaling cascades
47. Protein kinase cascades activated by stress and inflammatory cytokines
48. Involvement of the tyrosine phosphorylation pathway in induction of human heme oxygenase-1 by hemin, sodium arsenite and cadmium chloride
49. Molecular cloning, characterization, and expression of the chicken heme oxygenase-1 gene in transfected primary cultures of chick embryo liver cells
50. Heme oxygenase: Recent advances in understanding its regulation and role
51. Mechanism of sodium arsenite-mediated induction of heme oxygenase-1 in hepatoma cells: Role of mitogen activated protein kinases
52. Carbon monoxide generated by heme oxygenase-1 suppresses endothelial cell apoptosis
53. Differential modulation by exogenous carbon monoxide of TNF-α-stimulated mitogen activated protein kinase signaling in rat pulmonary artery endothelial cells
54. Haem oxygenase-1 prevents cell death by regulating cellular iron
55. Neurons overexpressing heme oxygenase-1 resist oxidative stress-mediated cell death
56. Heme oxygenase-1 gene ablation or expression modulates cisplatin-induced renal tubular apoptosis
57. Heme oxygenase-1 inhibits TNF-α-induced apoptosis in cultured fibroblasts
58. Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury
59. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
60. Localization of nitric oxide synthase indicating a neural role for nitric oxide
61. Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide
62. L-argininine reduces endothelial inflammation and myocardial stunning during ischemia/reperfusion
63. Purification of soluble guanylyl cyclase from bovine lung by a new immunoaffinity chromatographic method
64. Modulation of cyclic guanosine monophosphate levels in cultured aortic smooth muscle cells by carbon monoxide
65. Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase
66. Heme stoichiometry of heterodimeric soluble guanylate cyclase
67. Soluble guanylate cyclase from bovine lung: Activation with nitric oxide and carbon monoxide and spectral characterization of the ferrous states
68. Carbon monoxide relaxes ilial smooth muscle through activation of guanylate cyclase
69. Carbon monoxide: An endogenous modulator of the nitric oxide-cyclic GMP signaling system
70. The heme oxygenase pathway and its interaction with nitric oxide in the control of cellular homeostasis
71. Regulation of heme oxygenase-1 gene expression in vascular smooth muscle cells by nitric oxide
72. Nitric oxide-inducible expression of heme oxygenase-1 in human cells
73. NO-mediated activation of heme oxygenase: Endogenous cytoprotection against oxidative stress to endothelium
74. Heme oxygenase inhibitor zinc protoporphyrin-IX causes activation of nitric-oxide synthase in the rabbit internal anal sphincter
75. Nitric oxide synthase inhibition by haem oxygenase decreases macrophage nitric oxide dependent cytotoxicity: A negative feedback mechanism for the regulation of nitric oxide production
76. Cloned, expressed rat cerebellar NOS containing stoichiometric amounts of heme which binds CO
77. Nitric oxide synthase is a cytochrome P-450 type hemoprotein
78. Biochemistry of nitric oxide and its redox-activated forms
79. Nitric oxide: A cytotoxic activated macrophage effector molecule
80. The reactions of sheep haemoglobin with nitric oxide
81. Regulation of heme oxygenase-1 expression in vivo and in vitro in hyperoxic lung injury
82. Protective effects of transient HO-1 overexpression on susceptibility to oxygen toxicity in lung cells
83. Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung injury
84. Carbon monoxide provides protection against hyperoxic lung injury
85. Inhaled carbon monoxide and hyperoxic lung injury in rats
86. Carbon monoxide has antiinflammatory effects involving the mitogen-activated protein kinase pathway
87. Transfer of heme oxygenase 1 cDNA by a replication-deficient adenovirus enhances interleukin 10 production from alveolar macruphages that attenuates lipopolysaccharide-induced acute lung injury in mice
88. Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma
89. Eosinophilic inflammation in asthma
90. Increased carbon monoxide in exhaled air of asthmatic patients
91. Raised levels of exhaled carbon monoxide are associated with an increased expression of heme oxygenase-1 in airway macrophages in asthma: A new marker of oxidative stress
92. Heme oxygenase-1 (HO-1) protein induction in a mouse model of asthma
93. Carbon monoxide attenuates aeroallergen-induced inflammation in mice
94. Increased expression of heme oxygenase (HO)-1 in alveolar spaces and HO-2 in alveolar walls of smokers
95. Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema
96. Prevention of hypoxia-induced pulmonary hypertension by enhancement of endogenous heme oxygenase-1 in the rat
97. Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia
98. Adenovirus-mediated transfer of heme oxygenase-1 cDNA attenuates severe lung injury induced by the influenza virus in mice
99. Response of rat coronary circulation to carbon monoxide and nitrogen hypoxia
100. Studies on the mechanism of carbon monoxide-induced vasodilation in the isolated perfused rat heart
101. Effect of heme arginate administration on blood pressure in spontaneously hypertensive rats
102. A heme oxygenase product, presumably carbon-monoxide, mediates a vasodepressor function in rats
103. Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP
104. Endothelial cell expression of vaso-constrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxide
105. Carbon monoxide is a major contributor to the regulation of vascular tone in aortas expressing high levels of haeme oxygenase-1
106. Carbon monoxide: An endogenous modulator of sinusoidal tone in the perfused rat liver
107. Heme oxygenase-1 protects against vascular constriction and proliferation
108. Mechanisms by which oxygen regulates gene expression and cell-cell interaction in the vasculature
109. Carbon monoxide and nitric oxide suppress the hypoxic induction of vascular endothelial growth factor gene via the 5′ enhancer
110. Induction of kidney heme oxygenase-1 (HSP32) mRNA and protein by ischemia/reperfusion: Possible role of heme as both promoter of tissue damage and regulator of HSP32
111. Nitric oxide: A retrograde messenger for carbon monoxide signalling in ischemic heart
112. Hemodynamic forces induce the expression of heme oxygenase in cultured vascular smooth muscle cells
113. Induction of heme oxygenase-1 suppresses venular leukocyte adhesion elicited by oxidative stress: Role of bilirubin generated by the enzyme
114. Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice
115. Heme oxygenase-1 derived bilirubin ameliorates postischemic myocardial dysfunction
116. The levels of bilirubin may be related to an inflammatory condition in patients with coronary heart disease
117. Gilbert syndrome and ischemic heart disease: A protective effect of elevated bilirubin levels
118. Total serum bilirubin and risk of cardiovascular disease in the Framingham Offspring study
119. Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by dercpression of fibrinolysis
120. Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants
121. Protective roles of endogenous carbon monoxide in neointimal development elicited by arterial injury
122. Balloon injury does not induce heme oxygenase-1 expression, but administration of hemin inhibits neointimal formation in balloon-injured rat carotid artery
123. Adenovirus-mediated heme oxygenase-1 gene delivery inhibits injury-induced vascular neointima formation
124. Heme oxygenase-1 gene promoter microsatellite polymorphism is associated with restenosis after percutaneous transluminal angioplasty
125. Increased carbon monoxide in exhaled air of asthmatic patients
126. Elevated levels of exhaled carbon monoxide are associated with an incresased expression of heme oxygenase-1 in airway macrophages in asthma: A new marker of chronic inflammation
127. Exhaled ethane is elevated in cystic fibrosis and correlates with carbon monoxide levels and airway obstruction
128. Exhaled carbon monoxide levels elevated in diabetes and correlated with glucose concentration in blood: A new test for monitoring the disease?
129. Increased carbon monoxide in exhaled air of critically ill patients
130. Exhaled carbon monoxide levels during treatment of acute asthma
131. Increase in exhaled carbon monoxide during exacerbations of cystic fibrosis
132. Carbon monoxide-releasing molecules: Characterization of biochemical and vascular activities
133. Heme oxygenase-carbon monoxide signaling pathway in atherosclerosis: Anti-atherogenic actions of bilirubin and carbon monoxide?
134. Tubular injury as a cardinal pathologic feature in human heme oxygenase-1 deficiency
135. Induction of heme oxygenase is a rapid, protective response in rhabdomyolysis in the rat
136. Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease
137. Induction of heme oxygenase-1 (HO-1) in the contused spinal cord of the rat
138. Expression of antioxidant protective proteins in the rat retina during prenatal and postnatal development
139. Heme oxygenase-1 and heat shock protein 70 induction in glia and neurons throughout rat brain after experimental intracerebral hemorrhage
140. Carbon monoxide regulates cerebral blood flow in epileptic seizures but not in hypercapnia
141. Carbon monoxide: A putative neural messenger
142. Expression of stress proteins heme oxygenase-1 and -2 in acute pancreatitis and pancreatic islet betaTC3 and acinar AR42J cells
143. Heme oxygenase immunoreactive neurons in the rat intestine and their relationship to nitrergic neurons
144. The heme oxygenase-carbon monoxide system: A regulator of hepatobiliary function
145. Carbon monoxide from heme catabolism protects against hepatobiliary dysfunction in endotoxin-treated rat liver
146. Differential expression pattern of heme oxygenase-1/heat shock protein 32 and nitric oxide synthase-II and their impact on liver injury in a rat model of hemorrhage and resuscitation
147. Elevated levels of heme oxygenase activity and mRNA in peripheral blood adherent cells of acquired immunodeficiency syndrome patients
148. Mechanism of hemoglobin-induced protection against endotoxemia in rats: A ferritin-independent pathway
149. Heme oxygenase-dependent carbon monoxide production is a hepatic adaptive response to sepsis
150. Carbon monoxide enhances human neutrophil migration in a cyclic GMP-dependent way
151. The role of carbon monoxide in the regulation of neuroendocrine function
152. Nitric oxide and carbon monoxide have a stimulatory role in the hypothalamic-pituitary-adrenal response to physico-emotional stressors in rats
153. Occurrence and putative hormone regulatory function of a constitutive heme oxygenase in rat pancreatic islets
154. End-tidal carbon monoxide measurements in women with pregnancy-induced hypertension and preeclampsia
155. Hemeoxygenase-1 inhibits human myometrial contractility via carbon monoxide and is upregulated by progesterone during pregnancy
156. Hemeoxygenase expression in human placenta and placental bed implies a role in regulation of trophoblast invasion and placental function
157. Heme oxygenase-1 is required for mammarian iron reutilization
158. Cholinergic nerves in human corpus cavernosum and spongiosum contain nitric oxide synthase and heme oxygenase