Carboxylated, heteroaryl-substituted chalcones as inhibitors of vascular cell adhesion molecule-1 expression for use in chronic inflammatory diseases

Journal of Medicinal Chemistry

Volumn 50, Issue 6, 2007, Pages 1304-1315

  Meng, Charles Q ^a   Ni, Liming ^a   Worsencroft, Kimberly J ^a   Ye, Zhihong ^a   Weingarten, M David ^a   Simpson, Jacob E ^a   Skudlarek, Jason W ^a   Marino, Elaine M ^a   Suen, Ki Ling ^a   Kunsch, Charles ^a   Souder, Amy ^a   Howard, Randy B ^a   Sundell, Cynthia L ^a   Wasserman, Martin A ^a   Sikorski, James A ^a  

^a AtheroGenics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [[5 (1H INDOL 2 YL) 2,4 DIMETHOXYPHENYL]ACRYLOYL]BENZOIC ACID; ANTIINFLAMMATORY AGENT; BENZOIC ACID DERIVATIVE; CHALCONE DERIVATIVE; CREMOPHOR; DEXAMETHASONE; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ALLERGY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; CARBOXYLATION; CHEMICAL MODIFICATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG ACTIVITY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG POTENCY; DRUG SOLUBILITY; DRUG STRUCTURE; HUMAN; HUMAN CELL; INFLAMMATORY DISEASE; LIPOPHILICITY; MALE; MOUSE; NONHUMAN; PHARMACOPHORE; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AORTA; ASTHMA; BENZOIC ACIDS; CELLS, CULTURED; CHALCONES; CHRONIC DISEASE; DEPRESSION, CHEMICAL; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HUMANS; INDOLES; INFLAMMATION; MALE; MICE; MICE, INBRED BALB C; PULMONARY ARTERY; STEREOISOMERISM; VASCULAR CELL ADHESION MOLECULE-1;

EID: 33947665959     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0614230     Document Type: Article

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