Inhibition of superoxide anion and elastase release in human neutrophils by 3′-isopropoxychalcone via a cAMP-dependent pathway

British Journal of Pharmacology

Volumn 148, Issue 1, 2006, Pages 78-87

  Hwang, Tsong Long ^a   Yeh, Shang Hsin ^a   Leu, Yann Lii ^a   Chern, Ching Yuh ^b   Hsu, Hui Chi ^a  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b NATIONAL CHIAYI UNIVERSITY   (Taiwan)

Author keywords

cAMP; Chalcone; Elastase; Human neutrophil; Phosphodiesterase; Superoxide

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; 3' ISOPROPOXYCHALCONE; ADENOSINE; ADENOSINE A2A RECEPTOR; ADENOSINE A2A RECEPTOR ANTAGONIST; ADENOSINE DEAMINASE; ADENOSINE DEAMINASE INHIBITOR; ADENYLATE CYCLASE; ANTIINFLAMMATORY AGENT; CALCIUM ION; CHALCONE DERIVATIVE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; CYCLIC GMP; ELASTASE; FORMYLMETHIONYLLEUCYLPHENYLALANINE; GUANYLATE CYCLASE; H2O7D; KT 5720; LACTATE DEHYDROGENASE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PHOSPHODIESTERASE; PROSTAGLANDIN E1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; ROLIPRAM; SCAVENGER; SUPEROXIDE; UNCLASSIFIED DRUG;

ADULT; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CONTROLLED STUDY; DEGRANULATION; DRUG SYNTHESIS; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; MALE; NEUTROPHIL; PRIORITY JOURNAL; RESPIRATORY BURST;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ADENYLATE CYCLASE; ADULT; ANTI-INFLAMMATORY AGENTS; CALCIUM; CELL DEGRANULATION; CHALCONES; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; ISOQUINOLINES; LEUKOCYTE ELASTASE; MALE; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHILS; PHOSPHODIESTERASE INHIBITORS; PROTEIN KINASE INHIBITORS; RESPIRATORY BURST; SULFONAMIDES; SUPEROXIDES;

EID: 33646424741     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706712     Document Type: Article

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