Ammonium and glutamate released by neurons are signals regulating the nutritive function of a glial cell

Journal of Neuroscience

Volumn 17, Issue 7, 1997, Pages 2383-2390

  Tsacopoulos, Marcos ^a   Poitry Yamate, Carol L ^a   Poitry, Serge ^a  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

fluorescence imaging; glutamate transport; NADH; NH4+ transport; pH; retina

Indexed keywords

6 PHOSPHOFRUCTOKINASE; ALANINE; AMMONIA; GLUTAMATE DEHYDROGENASE; GLUTAMIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

AEROBIC METABOLISM; ANIMAL CELL; ARTICLE; BRAIN METABOLISM; ENERGY METABOLISM; GLIA CELL; GLYCOLYSIS; METABOLIC REGULATION; NERVE CELL; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; REGULATORY MECHANISM;

EID: 0030909997     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-07-02383.1997     Document Type: Article

References (25)

1. Albrecht J, Bender AS, Norenberg MD (1994) Ammonia stimulates the release of taurine from cultured astrocytes. Brain Res 660:288-292.
2. +) antiport. J Biol Chem 269:21962-21971.
3. Barbour B, Magnus C, Szatkowski M, Gray PTA, Attwell D (1993) Changes in NAD(P)H fluorescence and membrane current produced by glutamate uptake into salamander Müller cells. J Physiol (Lond) 466:573-597.
4. Baumann O, Takeyasu K (1993) Polarized distribution of Na, K-ATPase in honeybee photoreceptors is maintained by interaction with glial cells. J Cell Sci 105:287-301.
5. Bouvier M, Szatkowski M, Amato A, Attwell D (1992) The glial cell glutamate uptake carrier countertransports pH-changing anions. Nature 360:471-474.
6. Brew H, Attwell D (1987) Electrogenic glutamate uptake is a major current carrier in the membrane of axolotl retinal glial cells. Nature 327:707-709.
7. Cardinaud B, Coles JA, Perrottet P, Spencer AJ, Osborne MP, Tsacopoulos M (1994) The composition of the interstitial fluid in the retina of the honeybee drone: implications for the supply of substrates of energy metabolism from blood to neurons. Proc R Soc Lond [Biol] 257:49-58.
8. Christensen HN (1990) Role of amino acid transport and countertransport in nutrition and metabolism. Physiol Rev 70:43-77.
9. Coles JA (1989) Functions of glial cells in the retina of the honeybee drone. Glia 2:1-9.
10. +. J Physiol (Lond) 495:305-318.
11. Coles JA, Thwaites DT, Marcaggi P, Deitmer JW (1996b) Ammonium causes acidification of glial cells isolated from drone retina. J Physiol (Lond) 491:147P.
12. Cooper AJL, Plum F (1987) Biochemistry and physiology of brain ammonia. Physiol Rev 67:440-519.
13. + movement nor by cAMP. J Gen Physiol 98:497-515.
14. Fahien LA, Lin-Yu J-H, Smith SE, Happy JM (1971) Interactions between glutamate dehydrogenase, transaminases, and keto acids. J Biol Chem 246:7241-7249.
15. Hawkins RA, Miller AL, Nielsen RC, Veech RL (1973) The acute action of ammonia on rat brain metabolism in vivo. Biochem J 134:1001-1008.
16. Innocent C (1995) Immobilisation de biomolécules dans des polypyrroles fonctionnalisés: application à l'électroanalyse. PhD dissertation, Université Joseph Fourier, Grenoble, France.
17. Kanai Y, Hediger MA (1992) Primary structure and functional characterization of a high-affinity glutamate transporter. Nature 360:467-471.
18. Kikeri D, Sun A, Zeidel ML, Hebert SC (1989) Cell membranes impermeable to NH3. Nature 339:478-480.
19. --cotransporter. J Membr Biol 94:279-284.
20. Larrabee MG (1983) Lactate uptake and release in the presence of glucose by sympathetic ganglia of chicken embryos and by neuronal and nonneuronal cultures prepared from these ganglia. J Neurochem 40:1237-1250.
21. Veuthey A-L, Tsacopoulos M, Millan-de-Ruiz L, Perrottet P (1994) Cellular and subcellular localization of hexokinase, glutamate dehydrogenase, and alanine aminotransferase in the honeybee drone retina. J Neurochem 62:1939-1946.
22. Walz B (1988) Brain but not retinal glial cells have carbonic anhydrase activity in the honeybee drone. Neurosci Lett 85:47-50.
23. Waniewski RA (1992) Physiological levels of ammonia regulate glutamine synthesis from extracellular glutamate in astrocyte cultures. J Neurochem 58:167-174.
24. 15N]glutamate by cultured astrocytes. Biochem J 234:185-192.
25. Yudkoff M, Nissim I, Hertz L, Pleasure D, Erecinska M (1992) Nitrogen metabolism: neuronal-astroglial relationships. Prog Brain Res 94:213-224.