Glutamate receptors and circuits in the vertebrate retina

Progress in Retinal and Eye Research

Volumn 18, Issue 6, 1999, Pages 765-810

  Thoreson, Wallace B ^a   Witkovsky, Paul ^b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b NEW YORK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPA RECEPTOR; CALCIUM CHANNEL; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR AGONIST; GLUTAMATE RECEPTOR ANTAGONIST; GLUTAMIC ACID; IONOTROPIC RECEPTOR; KAINIC ACID RECEPTOR; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROTRANSMITTER;

BRAIN REGION; GLIA CELL; MUELLER CELL; NERVE ENDING; NEUROTRANSMISSION; NEUROTRANSMITTER RELEASE; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; RETINA; RETINA AMACRINE CELL; RETINA BIPOLAR GANGLION CELL; RETINA HORIZONTAL NERVE CELL; RETINA NERVE CELL; REVIEW; VERTEBRATE;

ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; FORECASTING; GLUTAMIC ACID; NEUROTRANSMITTER AGENTS; RECEPTORS, GLUTAMATE; RECEPTORS, METABOTROPIC GLUTAMATE; RETINA; VERTEBRATES;

EID: 0032865768     PISSN: 13509462     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1350-9462(98)00031-7     Document Type: Review

References (388)

1. Aizenman E., Frosch M.P., Lipton S.A. Responses mediated by excitatory amino acid receptors in solitary retinal ganglion cells from rat. J. Physiol. (Lond.). 396:1988;75-91.
2. Akazawa C., Ohishi H., Nakajima Y., Okamoto N., Shigemoto R., Nakanishi S., Mizuno N. Expression of mRNAs of L-AP4-sensitive metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7) in the rat retina. Neurosci. Lett. 171:1994;52-54.
3. Akopian A., Witkovsky P. Modulation of transient outward potassium current by GTP, calcium and glutamate in horizontal cells of the Xenopus retina. J. Neurophysiol. 71:1994;1661-1671.
4. Akopian A., Witkovsky P. Activation of metabotropic glutamate receptors decreases a high-threshold calcium current in spiking neurons of the Xenopus retina. Vis. Neurosci. 13:1996;549-557.
5. Akopian A., Witkovsky P. D2 dopamine receptor-mediated inhibition of a hyperpolarization activated current in rod photoreceptors. J. Neurophysiol. 76:1996;1828-1835.
6. Altschuler R.A., Mosinger J.L., Harmison G.G., Parakkal M.H., Wenthold R.J. Aspartate aminotransferase-like immunoreactivity in guinea pig photoreceptors. Nature. 298:1982;657-659.
7. Amato A., Barbour B., Szatkowski M., Attwell D. Counter-transport of potassium by the glutamate uptake carrier in glial cells isolated from the tiger salamander retina. J. Physiol. (Lond.). 479:1994;371-380.
8. Ariel M., Lasater E.M., Mangel S.C., Dowling J.E. On the sensitivity of H1 horizontal cells of the carp retina to glutamate, aspartate and their agonists. Brain Res. 295:1984;179-183.
9. Arkin M.S., Miller R.F. Subtle actions of 2-amino-4-phosphonobutyrate (APB) on the OFF pathway in the mudpuppy retina. Brain Res. 426:1987;142-148.
10. Arriza J.L., Eliasof S., Kavanaugh M.P., Amara S.G. EAAT5, a retinal glutamate transporter coupled to a chloride conductance. Proc. Natl. Acad. Sci. USA. 95:1997;4155-4160.
11. Ascher P., Nowak L. Electrophysiological studies of NMDA receptors. Trends Neurosci. 10:1987;284-288.
12. Attwell D., Mobbs P., Tessier-Lavigne M., Wilson M. Neurotransmitter-induced currents in retinal bipolar cells of the axolotl, Ambystoma mexicanum. J. Physiol. (Lond.). 387:1987;125-161.
13. Augustine G.J., Charlton M.P., Smith S.J. Calcium entry and transmitter release at voltage-clamped nerve terminals of squid. J. Physiol. (Lond). 367:1985;163-181.
14. Ayoub G.S., Copenhagen D.R. Application of a fluorometric method to measure glutamate release from single retinal photoreceptors. J. Neurosci. Meth. 37:1991;7-14.
15. Ayoub G.S., Matthews G. Substance P modulates calcium current in retinal bipolar neurons. Vis. Neurosci. 8:1992;539-544.
16. Ayoub G.S., Korenbrot J.I., Copenhagen D.R. Release of endogenous glutamate from isolated cone photoreceptors of the lizard. Neurosci. Res. Suppl. 10:1989;S47-S56.
17. Bader C.R., Bertrand D., Schwartz E.A. Voltage-activated and calcium-activated currents studied in solitary rod inner segments from the salamander retina. J. Physiol. (Lond.). 331:1982;253-284.
18. Barbour B., Brew H., Attwell D. Electrogenic glutamate uptake in glial cells is activated by intracellular potassium. Nature. 335:1988;433-435.
19. Barbour B., Szatkowski M., Ingledew N., Attwell D. Arachidonic acid induces a prolonged inhibition of glutamate uptake into glial cells. Nature. 342:1989;918-920.
20. Barbour B., Brew H., Attwell D. Electrogenic uptake of glutamate and aspartate into glial cells isolated from the salamander (Ambystoma) retina. J. Physiol. (Lond.). 436:1991;169-193.
21. Barbour B., Magnus C., Szatkowski M., Gray P.T., Attwell D. Changes in NAD(P)H fluorescence and membrane current produced by glutamate uptake into salamander Müller cells. J. Physiol. (Lond.). 466:1993;573-597.
22. Barnes S., Hille B. Ionic channels of the inner segment of tiger salamander cone photoreceptors. J. Gen. Physiol. 94:1989;719-743.
23. Barnes S., Merchant V., Mahmud F. Modulation of transmission gain by protons at the photoreceptor output synapse. Proc. Natl. Acad. Sci. USA. 90:1993;10081-10085.
24. Betz W.J., Mao F., Smith C.S. Imaging exocytosis and endocytosis. Curr. Opin. Neurobiol. 6:1996;365-371.
25. Billups B., Attwell D. Modulation of non-vesicular glutamate release by pH. Nature. 379:1996;171-174.
26. Billups B., Rossi D., Attwell D. Anion conductance behavior of the glutamate uptake carrier in salamander retinal glial cells. J. Neurosci. 16:1996;6722-6731.
27. Bisti S., Gargini C., Chalupa L.M. Blockade of glutamate-mediated activity in the developing retina perturbs the functional segregation of ON and OFF pathways. J. Neurosci. 18:1998;5019-5025.
28. 2+- and stimulus duration-dependent switch for hippocampal gene expression. Cell. 87:1996;1203-1214.
29. Boos R., Muller F., Wässle H. Actions of excitatory amino acids on brisk ganglion cells in the cat retina. J. Neurophysiol. 64:1990;1368-1379.
30. Boos R., Schneider H., Wässle H. Voltage- and transmitter-gated currents of AII-amacrine cells in a slice preparation of the rat retina. J. Neurosci. 13:1993;2874-2888.
31. Boss V., Nutt K.M., Conn P.J. L-cysteine sulfinic acid as an endogenous agonist of a novel metabotropic receptor coupled to stimulation of phospholipase D activity. Mol. Pharmacol. 45:1994;1177-1182.
32. Bouvier M., Szatkowski M., Amato A., Attwell D. The glial cell glutamate uptake carrier countertransports pH-changing anions. Nature. 360:1992;471-474.
33. Brandon C., Lam D.M.-K. L-Glutamic acid: a neurotransmitter candidate for cone photoreceptors in human and rat retinas. Proc. Natl. Acad. Sci. USA. 80:1983;5117-5121.
34. Brandstätter J.H., Hartveit E., Sassoe-Pognetto M., Wässle H. Expression of NMDA and high-affinity kainate receptor subunit mRNA's in the adult rat retina. Eur. J. Neurosci. 6:1994;1100-1112.
35. Brandstätter J.H., Koulen P., Kuhn R., van der Putten H., Wässle H. Compartmental localization of a metabotropic glutamate receptor (mGluR7): two different active sites at a retinal synapse. J. Neurosci. 16:1996;4749-4756.
36. Brandstätter J.H., Koulen P., Wässle H. Selective synaptic distribution of kainate receptor subunits in the two plexiform layers of the rat retina. J. Neurosci. 17:1997;9298-9307.
37. Brandstätter J.H., Koulen P., Kuhn R., Wässle H. The metabotropic glutamate receptor, mGluR8, in the rat retina: localization and possible function. Invest. Ophthalmol. Vis. Sci. Suppl. 39:1998;S412.
38. Brandstatter J.H., Koulen P., Wassle H. Diversity of glutamate receptors in the mammalian retina. Vision Res. 38:1998;1385-1397.
39. Brew H., Attwell D. Electrogenic glutamate uptake is a major current carrier in the membrane of axolotl retinal glial cells. Nature. 327:1987;707-709.
40. Brown E.M., Gamba G., Riccardi D., Lombardi M., Butters R., Kifor O., Sun A., Hediger M.A., Lytton J., Hebert S.C. Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid. Nature. 366:1993;575-580.
41. Burnashev N., Monyer H., Seeburg P.H., Sakmann B. Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunit. Neuron. 8:1992;189-198.
42. Cahill G.M., Besharse J.C. Light-sensitive melatonin synthesis by Xenopus photoreceptors after destruction of the inner retina. Vis. Neurosci. 8:1992;487-490.
43. Chiba C., Saito T. APB (2-amino-4-phosphonobutyric acid) activates a chloride conductance in ganglion cells isolated from newt retina. NeuroReport. 5:1994;489-492.
44. Choe H.-G., Louie K., Basinger S.F. Effects of excitatory amino acids on phosphoinositide metabolism in frog retina. Vision Res. 36:1996;1873-1881.
45. Choi D.W., Rothman S.M. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. Ann. Rev. Neurosci. 13:1990;171-182.
46. Christensen, B. N., Shingai, R. and Hals, G. (1985) Excitatory effects of L-glutamate and some analogs on isolated horizontal cells from the catfish retina. In: Contemporary Sensory Neurobiology, pp. 33-45, Alan R. Liss, New York.
47. Clark B., Mobbs P. Transmitter-operated channels in rabbit retinal astrocytes studied in situ by whole-cell patch clamping. J. Neurosci. 12:1992;664-673.
48. Cohen E.D., Miller R.F. The role of NMDA and non-NMDA excitatory amino acid receptors in the functional organization of primate retinal ganglion cells. Vis. Neurosci. 11:1994;317-332.
49. Cohen E.D., Miller R.F. Quinoxalines block the mechanism of directional selectivity in ganglion cells of the rabbit retina. Proc. Natl. Acad. Sci. USA. 92:1995;1127-1131.
50. Cohen E.D., Zhou Z.J., Fain G.L. Ligand-gated currents of alpha and beta ganglion cells in the cat retinal slice. J. Neurophysiol. 72:1994;1260-1269.
51. Coleman P.A., Massey S.C., Miller R.F. Kynurenic acid distinguishes kainate and quisqualate receptors in the vertebrate retina. Brain Res. 381:1986;172-175.
52. Coleman P.A., Miller R.F. Do N-methyl-D-aspartate receptors mediate synaptic responses in the mudpuppy retina? J. Neurosci. 8:1988;4728-4733.
53. Colquhoun D., Jonas P., Sakmann B. Action of brief pulses of glutamate on Ampa/kainate receptors in patches from different neurones of rat hippocampal slices. J. Physiol. (Lond.). 458:1992;261-287.
54. Conn P.J., Pin J.P. Pharmacology and functions of metabotropic glutamate receptors. Annu. Rev. Pharmacol. Toxicol. 37:1997;205-237.
55. Copenhagen D.R., Jahr C.E. Release of endogenous excitatory amino acids from turtle photoreceptors. Nature. 341:1989;536-539.
56. Corey D.P., Dubinsky J.M., Schwartz E.A. The calcium current in inner segments of rods from the salamander (Ambystoma tigrinum) retina. J. Physiol. (Lond.). 354:1984;557-575.
57. Danbolt N.C. The high affinity uptake system for excitatory amino acids in the brain. Prog. Neurobiol. 4:1994;377-396.
58. Davanger S., Torp R., Ottersen O.P. Co-localization of glutamate and homocysteic acid immunoreactivities in human photoreceptor terminals. Neurosci. 63:1994;123-133.
59. de la Villa P., Kurahashi T., Kaneko A. L-glutamate-induced responses and cGMP-activated channels in three subtypes of retinal bipolar cells dissociated from the cat. J. Neurosci. 15:1995;3571-3582.
60. de Mello M.C., Klein W.L., deMello F.G. L-glutamate evoked release of GABA from cultured avian retina cells does not require glutamate receptor activation. Brain Res. 443:1988;166-172.
61. Derouiche A. Possible role of the Müller cell in uptake and metabolism of glutamate in the mammalian outer retina. Vision Res. 36:1996;3875-3878.
62. Derouiche A., Rauen T. Coincidence of L-glutamate/L-aspartate transporter (GLAST) and glutamine synthetase (GS) immunoreactions in retinal glia: evidence for coupling of GLAST and GS in transmitter clearance. J. Neurosci. Res. 42:1995;131-143.
63. DeVries S.H., Schwartz E.A. Modulation of an electrical synapse between solitary pairs of catfish horizontal cells by dopamine and second messengers. J. Physiol. (Lond.). 414:1989;351-375.
64. Diamond J.S., Copenhagen D.R. The contribution of NMDA and non-NMDA receptors to the light-evoked input-output characteristics of retinal ganglion cells. Neuron. 11:1993;725-738.
65. Diamond J.S., Copenhagen D.R. The relationship between light-evoked synaptic excitation and spiking behaviour of salamander retinal ganglion cells. J. Physiol. (Lond.). 487:1995;711-725.
66. Dixon D.B., Copenhagen D.R. Suppression of a calcium current by CNQX and kynurenate. Neurosci. Lett. 147:1992;147-150.
67. Dixon D.B., Copenhagen D.R. Two types of glutamate receptors differentially excite amacrine cells in the tiger salamander retina. J. Physiol. (Lond.). 449:1992;589-606.
68. Dixon D.B., Copenhagen D.R. Metabotropic glutamate receptor-mediated suppression of an inward rectifier current is linked via a cGMP cascade. J. Neurosci. 17:1997;8945-8954.
69. Dixon D.B., Takahashi K.-I., Copenhagen D.R. L-glutamate suppresses HVA calcium current in catfish horizontal cells by raising intracellular proton concentration. Neuron. 11:1993;267-277.
70. Dolan R.P., Schiller P.H. Effects of ON channel blockade with 2-amino-4-phosphonobutyrate (APB) on brightness and contrast perception in monkeys. Vis. Neurosci. 11:1994;23-32.
71. Dong C.J., McReynolds J.S. The relationship between light, dopamine release, and horizontal cell coupling in the mudpuppy retina. J. Physiol. (Lond.). 440:1991;291-309.
72. Dong C.J., Werblin F.S. Inwardly rectifying potassium conductance can accelerate the hyperpolarizing response in retinal horizontal cells. J. Neurophysiol. 74:1995;2258-2265.
73. Dowling, J. E. (1987) The Retina. An approachable part of the brain. Belknap Press, Cambridge, MA.
74. Dowling J.E., Lasater E.M., van Buskirk R., Watling K.J. Pharmacological properties of isolated fish horizontal cells. Vision Res. 23:1983;421-432.
75. 2+ channels in mammalian central neurons. Trends. Neurosci. 18:1995;89-98.
76. Duvoisin R.M., Zhang C., Hamassaki-Britto D.E., Britto L.R. G. Changes in expression of glutamate receptor subunits following photoreceptor degeneration in the rd mouse retina. Neurosci. Lett. 183:1995;83-86.
77. Duvoisin R.M., Zhang C., Ramonell K. A novel metabotropic glutamate receptor expressed in the retina and olfactory bulb. J. Neurosci. 15:1995;3075-3083.
78. Ehinger B., Ottersen O.P., Storm-Mathisen J., Dowling J.E. Bipolar cells in the turtle retina are strongly immunoreactive for glutamate. Proc. Natl. Acad. Sci. USA. 85:1988;8321-8325.
79. Eliasof S., Jahr C.E. The retinal glial cell glutamate transporter is coupled to an anionic conductance. Proc. Natl. Acad. Sci. USA. 93:1996;4153-4158.
80. Eliasof S., Jahr C.E. Rapid AMPA receptor desensitization in catfish cone horizontal cells. Vis. Neurosci. 14:1997;13-18.
81. Eliasof S., Werblin F. Characterization of the glutamate transporter in retinal cones of the tiger salamander. J. Neurosci. 13:1993;402-411.
82. Eliasof S., Arriza J.L., Leighton B.H., Amara S.G., Kavanaugh M.P. Localization and function of five glutamate transporters cloned from the salamander retina. Vision Res. 38:1998;1443-1454.
83. Eliasof S., Arriza J.L., Leighton B.H., Kavanaugh M.P., Amara S.G. Excitatory amino acid transporters of the salamander retina: identification, localization and function. J. Neurosci. 18:1998;698-712.
84. Engbretson G.A., Anderson K.J., Wu J.-Y. GABA as a potential transmitter in lizard photoreceptors: immunocytochemical and biochemical evidence. J. Comp. Neurol. 278:1988;461-471.
85. Engisch K.L., Nowycky M.C. Calcium dependence of large dense-cored vesicle exocytosis evoked by calcium influx in bovine adrenal chromaffin cells. J. Neurosci. 16:1996;1359-1369.
86. C receptors to rod and cone bipolar cells in a rat retinal slice preparation. J. Neurophysiol. 79:1998;1384-1395.
87. Euler T., Schneider H., Wässle H. Glutamate responses of bipolar cells in a slice preparation of the rat retina. J. Neurosci. 16:1996;2934-2944.
88. C receptors in rat retinal bipolar cells by protein kinase C. J. Physiol. (Lond.). 481:1994;325-330.
89. Fosse V.M., Kolstad J., Fonnum F. A bioluminescence method for the measurement of L-glutamate: applications to the study of changes in the release of L-glutamate from lateral geniculate nucleus and superior colliculus after visual cortex ablation in rats. J. Neurochem. 47:1986;340-349.
90. Fox A.P., Nowycky M.C., Tsien R.W. Kinetic and pharmacological properties distinguishing three types of Ca currents in chick sensory neurons. J. Physiol. (Lond.). 394:1987;149-172.
91. +-ATPase. Invest. Ophthalmol. Vis. Sci. Suppl. 39:1998;S9.
92. Francesconi A., Duvoisin R.M. Role of the second and third intracellular loops of metabotropic glutamate receptors in mediating dual signal transduction activation. J. Biol. Chem. 273:1998;5615-5624.
93. Frings S., Seifert R., Godde M., Kaupp U.B. Profoundly different calcium permeation and blockage determine the specific function of distinct cyclic nucleotide-gated channels. Neuron. 15:1995;169-179.
94. Furukawa T., Hanawa I. Effects of some common cations on electroretinogram of the toad. Japan. J. Physiol. 5:1955;289-300.
95. Gaal L., Roska B., Picaud S.A., Wu S.M., Marc R., Werblin F.S. Postsynaptic response kinetics are controlled by a transporter at cone photoreceptors. J. Neurophysiol. 79:1998;190-196.
96. Garaschuk O., Yaari Y., Konnerth A. Release and sequestration of calcium by ryanodine-sensitive stores in rat hippocampal neurones. J. Physiol. (Lond.). 502:1997;13-30.
97. Gebhard R. Histochemical demonstration of glutamate dehydrogenase and phosphate-activated glutaminase activities in semithin sections of the rat retina. Histochem. 97:1992;101-103.
98. Ghosh P.K., Baskaran N., van den Pol A.N. Developmentally regulated gene expression of all eight metabotropic glutamate receptors in hypothalamic suprachiasmatic and arcuate nuclei - a PCR analysis. Dev. Brain Res. 102:1997;1-12.
99. Gilbertson T.A., Scobey R., Wilson M. Permeation of calcium ions through non-NMDA glutamate channels in retinal bipolar cells. Science. 251:1991;1613-1615.
100. 2+ influx and efflux. Neuron. 13:1994;1109-1117.
101. 2+ loads from retinal amacrine cells in culture. J. Neurosci. 15:1995;3612-3621.
102. Gottesman J., Miller R.F. Pharmacological properties of N-methyl-D-aspartate receptors on ganglion cells of an amphibian retina. J. Neurophysiol. 68:1992;596-604.
103. Grant G.B., Dowling J.E. A glutamate-activated chloride current in cone-driven ON bipolar cells of the white perch retina. J. Neurosci. 15:1995;3852-3862.
104. Grant G.B., Dowling J.E. ON bipolar cell responses in the teleost retina are generated by two distinct mechanisms. J. Neurophysiol. 76:1996;3842-3849.
105. Grant G.B., Werblin F.S. A glutamate-elicited chloride current with transporter-like properties in rod photoreceptors of the tiger salamander. Vis. Neurosci. 13:1996;135-144.
106. Greenstreet E.H., Djamgoz M.B. Triphasic chromaticity-type horizontal cells selectively contact short wavelength-sensitive cone photoreceptors in the retina of a cyprinid fish, Rutilus rutilus. Proc. Roy. Soc. Lond. 256:1994;227-230.
107. Hals G., Christensen B.N., O'Dell T., Christensen M., Shingai R. Voltage-clamp analysis of currents produced by glutamate and some glutamate analogues on horizontal cells isolated from the catfish retina. J. Neurophysiol. 56:1986;19-31.
108. Hamassaki-Britto D.E., Hermans-Borgmeyer I., Heinemann S., Hughes T.E. Expression of glutamate receptor genes in the mammalian retina: the localization of GluR1 through GluR7 mRNAs. J. Neurosci. 13:1993;1888-1898.
109. Harada T., Harada C., Watanabe M., Inoue Y., Sakagawa T., Nakayama N., Sasaki S., Okuyama S., Watase K., Wada K., Tanaka K. Functions of the two glutamate transporters GLAST and GLT-1 in the retina. Proc. Natl. Acad. Sci. USA. 95:1998;4663-4666.
110. Hare W.A., Owen W.G. Effects of 2-amino-4-phosphonobutyric acid on cells in the distal layers of the tiger salamander's retina. J. Physiol. (Lond.). 445:1992;741-757.
111. Hartveit E. Membrane currents evoked by ionotropic glutamate receptor agonists in rod bipolar cells in the rat retinal slice preparation. J. Neurophysiol. 76:1996;401-422.
112. Hartveit E., Veruki M.L. AII amacrine cells express functional NMDA receptors. NeuroReport. 8:1997;1219-1223.
113. Hartveit E., Brandstätter J.H., Enz R., Wässle H. Expression of the mRNA of seven metabotropic glutamate receptors (mGluR1 to 7) in the rat retina. An in situ hybridization study on tissue sections and isolated cells. Eur. J. Neurosci. 7:1995;1472-1483.
114. Hartveit E., Brandstätter J.H., Sassoe-Pognetto M., Laurie D.J., Seeburg P.H., Wässle H. Localization and developmental expression of the NMDA receptor subunit NR2A in the mammalian retina. J. Comp. Neurol. 348:1994;570-582.
115. Haugeto O., Ullensvang K., Levy L.M., Chaudhry F.A., Honore T., Nielsen M., Lehre K.P., Danbolt N.C. Brain glutamate transporter proteins form homomultimers. J. Biol. Chem. 271:1996;27715-27722.
116. Hayashi Y., Momiyama A., Takahashi T., Ohishi H., Ogawa-Meguro R., Shigemoto R., Mizuno N., Nakanishi S. Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb. Nature. 366:1993;687-690.
117. He S., Masland R.H. Retinal direction selectivity after targeted laser ablation of starburst amacrine cells. Nature. 389:1997;378-382.
118. Heidelberger R., Matthews G. Inhibition of calcium influx and calcium current by γ-aminobutyric acid in single synaptic terminals. Proc. Natl. Acad. Sci. USA. 88:1991;7135-7139.
119. 2+ responses in synaptic terminals of retinal bipolar neurons. NeuroReport. 5:1994;729-732.
120. Heidelberger R., Matthews G. Calcium influx and calcium current in single synaptic terminals of goldfish retinal bipolar neurons. J. Physiol. (Lond.). 447:1992;235-256.
121. Heidelberger R., Heinemann C., Neher E., Matthews G. Calcium dependence of the rate of exocytosis in a synaptic terminal. Nature. 371:1994;513-515.
122. 2+. Biophys. J. 67:1994;2546-2557.
123. Hensley S.H., Yang X.-L., Wu S.M. Identification of glutamate receptor subtypes mediating inputs to bipolar cells and ganglion cells in the tiger salamander retina. J. Neurophysiol. 69:1993;2099-2107.
124. Hille, B. (1992) Ionic Channels of Excitable Cells. Sinauer Assoc. Inc., Sunderland, MA.
125. Hirano A.A., MacLeish P.R. Glutamate and 2-amino-4-phosphonobutyrate evoke an increase in potassium conductance in retinal bipolar cells. Proc. Natl. Acad. Sci. USA. 88:1991;805-809.
126. Holler T., Cappel E., Klein J., Loffelholz K. Glutamate activates phospholipase D in hippocampal slices of newborn and adult rats. J. Neurochem. 61:1993;1569-1572.
127. Hollman M., Heinemann S. Cloned glutamate receptors. Annu. Rev. Neurosci. 17:1994;31-108.
128. Huba R., Hofmann H.D. Transmitter-gated currents of GABAergic amacrine-like cells in chick retinal cultures. Vis. Neurosci. 6:1991;303-314.
129. Hughes T.E. Are there ionotropic glutamate receptors on the rod bipolar cell of the mouse retina? Vis. Neurosci. 14:1997;103-109.
130. Hughes T.E., Hermans-Borgmeyer I., Heinemann S. Differential expression of glutamate receptor genes (GluR1-5) in the rat retina. Vis. Neurosci. 8:1992;49-55.
131. Ikeda H., Dawes E., Hankins M. Spontaneous firing level distinguishes the effects of NMDA and non-NMDA receptor antagonists on the ganglion cells in the cat retina. Eur. J. Pharmacol. 210:1992;53-59.
132. Ishida A.T. Responses of solitary retinal horizontal cells to L-glutamate and kainic acid are antagonized by D-aspartate. Brain Res. 298:1984;25-32.
133. Ishida A.T., Fain G.L. D-aspartate potentiates the effects of L-glutamate on horizontal cells in goldfish retina. Proc. Natl. Acad. Sci. USA. 78:1981;5890-5894.
134. Ishida A.T., Neyton J. Quisqualate and L-glutamate inhibit retinal horizontal-cell responses to kainate. Proc. Natl. Acad. Sci. USA. 82:1985;1837-1841.
135. Ishida A.T., Kaneko A., Tachibana M. Responses of solitary retinal horizontal cells from Carassius auratus to L-glutamate and related amino acids. J. Physiol. (Lond.). 348:1984;255-270.
136. Jahr C.E., Stevens C.F. Voltage dependence of NMDA-activated macroscopic conductances predicted by single-channel kinetics. J. Neurosci. 10:1990;3178-3182.
137. Janssen-Bienhold U., Wenzel A., Hannken T., Weiler R. Involvement of metabotropic and ionotropic glutamate receptors in inositol polyphosphate formation in carp retinal slices. Eur. J. Neurosci. 6:1994;1897-1902.
138. Jensen R.J. Effects of group II metabotropic glutamate receptor ligands on directional selectivity in rabbit retinal ganglion cells. Invest. Ophthalmol. Vis. Sci. Suppl. 39:1998;S985.
139. Johnson J.W., Ascher P. Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature. 325:1987;529-531.
140. Jojich L., Pourcho R.G. Glutamate immunoreactivity in the cat retina: a quantitative study. Vis. Neurosci. 13:1996;117-133.
141. Kalloniatis M., Fletcher E.L. Immunocytochemical localization of the amino acid neurotransmitters in the chicken retina. J. Comp. Neurol. 336:1993;174-193.
142. Kalloniatis M., Marc R.E., Murry R.F. Amino acid signatures in the primate retina. J. Neurosci. 16:1996;6807-6829.
143. Kaneko A., Tachibana M. Effects of L-glutamate on the anomalous rectifier potassium current in horizontal cells of Carassius auratus retina. J. Physiol. (Lond.). 358:1985;169-182.
144. Kaneko, A. and Tachibana, M. (1986) Effects of gamma-aminobutyric acid on isolated cone photoreceptors of the turtle retina. J. Physiol. (Lond.) 373, 443-461.
145. Kaneko A., Pinto L.H., Tachibana M. Transient calcium current of retinal bipolar cells of the mouse. J. Physiol. (Lond.). 410:1989;613-629.
146. Kato S., Ishita S., Sugawara K., Mawatari K. Cystine/glutamate antiporter expression in retinal Müller cells: implications for DL-α-aminoadipate toxicity. Neurosci. 57:1993;473-482.
147. Kaupmann K., Huggel K., Heid J., Flor P.J., Bischoff S., Mickel S.J., McMaster G., Angst C., Bittiger H., Froestl W., Bettler B. Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. Nature. 386:1997;239-246.
148. Keirstead S.A., Miller R.F. Metabotropic glutamate receptor agonists evoke calcium waves in isolated Müller cells. Glia. 21:1997;194-203.
149. Keller B.U., Hollmann M., Heinemann S., Konnerth A. Calcium influx through subunits GluR1/GluR3 of kainate/AMPA receptor channels is regulated by cAMP dependent protein kinase. Eur. Mol. Biol. Org. J. 11:1992;891-896.
150. Kikkawa S., Nakagawa M., Iwasa T., Kaneko A., Tsuda M. GTP-binding protein couples with metabotropic glutamate receptor in bovine retinal ON-bipolar cell. Biochem. Biophys. Res. Comm. 195:1993;374-379.
151. Kim H.G., Miller R.F. Rods and cones activate different excitatory amino acid receptors on the mudpuppy retinal horizontal cell. Brain Res. 538:1991;141-146.
152. Kim H.G., Miller R.F. Properties of synaptic transmission from photoreceptors to bipolar cells in the mudpuppy retina. J. Neurophysiol. 69:1993;352-360.
153. Kittila C.A., Massey S.C. Pharmacology of directionally selective ganglion cells in the rabbit retina. J. Neurophysiol. 77:1997;675-689.
154. Knapp A.G., Dowling J.E. Dopamine enhances excitatory amino acid-gated conductances in cultured retinal horizontal cells. Nature. 325:1987;437-439.
155. Knapp A.G., Schmidt K.F., Dowling J.E. Dopamine modulates the kinetics of ion channels gated by excitatory amino acids in retinal horizontal cells. Proc. Natl. Acad. Sci. USA. 87:1990;767-771.
156. 2+ regulation in the presynaptic terminals of goldfish retinal bipolar cells. J. Physiol. (Lond.) 483, 79-94.
157. 2+ transients in the presynaptic terminals of goldfish retinal bipolar cells. J. Physiol. (Lond.). 482:1996;7-13.
158. Kolb H. Amacrine cells of the mammalian retina: neurocircuitry and functional roles. Eye. 11:1997;904-923.
159. Kolb, H. and Nelson, R. (1995) The organization of photoreceptor to bipolar synapses in the outer plexiform layer. In Neurobiology and Clinical Aspects of the Outer Retina, (ed. M. B. A. Djamgoz, S. N. Archer and S. Vallerga), pp. 273-296. Chapman and Hall, London.
160. Kondo H., Toyoda J.I. Dual effect of glutamate and aspartate on the on-center bipolar cell in the carp retina. Brain Res. 199:1980;240-243.
161. Koulen P., Malitschek B., Kihn R., Wässle H., Brandstätter J.H. Group II and group III metabotropic glutamate receptors in the rat retina: distributions and developmental expression patterns. Eur. J. Neurosci. 8:1996;2177-2187.
162. Koulen P., Kuhn R., Wässle H., Brandstätter J.H. Group I metabotropic glutamate receptors mGluR1a and mGluR5a: localization in both synaptic layers of the rat retina. J. Neurosci. 17:1997;2200-2211.
163. Koutalos Y., Yau K.-W. Regulation of sensitivity in vertebrate rod photoreceptors by calcium. Trends Neurosci. 19:1996;73-81.
164. Krizaj, D. and Copenhagen, D. R. (1988) Compartmentaliza-tion of calcium extrusion mechanisms in the outer and inner segments of photoreceptors. Neuron 21, 249-256.
165. Krizaj D., Akopian A., Witkovsky P. The effects of L-glutamate, AMPA, quisqualate, and kainate on retinal horizontal cells depend on adaptational state: implications for rod-cone interactions. J. Neurosci. 14:1994;5661-5671.
166. Krizaj, D., Schmitz, Y., Bao, J. X., Witkovsky, P. and Copenhagen, D. R. (1998) The action of caffeine on transmitter release from vertebrate rods. Soc. Neurosci. Abstr. 24, 1027.
167. Kruse M., Schmidt K.-F. Studies on the dopamine-dependent modulation of amino acid-gated currents in cone horizontal cells of the perch (Perca fluviatilis). Vision Res. 33:1993;2031-2042.
168. Kurenny D.E., Moroz L.L., Turner R.W., Sharkey K.A., Barnes S. Modulation of ion channels in rod photoreceptors by nitric oxide. Neuron. 13:1994;315-324.
169. Ladanyi M., Beaudet A. In vivo labeling of (3H)D-aspartate uptake sites in monkey retina. Cell Tissue Res. 243:1986;59-63.
170. Lagnado L., Gomis A., Job C. Continuous vesicle cycling in the synaptic terminal of retinal bipolar cells. Neuron. 17:1996;957-967.
171. Larsson H.P., Picaud S.A., Werblin F.S., Lecar H. Noise analysis of the glutamate-activated current in photoreceptors. Biophys. J. 70:1996;733-742.
172. Lasater E.M., Dowling J.E. Carp horizontal cells in culture respond selectively to L-glutamate and its agonists. Proc. Natl. Acad. Sci. USA. 79:1982;936-940.
173. Lasater E.M., Witkovsky P. The calcium current of turtle photoreceptor axon terminals. Neurosci. Res. Suppl. 15:1991;S165-S173.
174. Lasater E.M., Dowling J.E., Ripps H. Pharmacological properties of isolated horizontal and bipolar cells from the skate retina. J. Neurosci. 4:1984;1966-1975.
175. Laube B., Hirai H., Sturgess M., Betz H., Kuhse J. Molecular determinants of agonist discrimination by NMDA receptors subunits: analysis of the glutamate binding site on the NR2B subunit. Neuron. 18:1997;493-503.
176. Laurie D.J., Schoeffter P., Wiederhold K.H., Sommer B. Cloning, distribution and functional expression of the human mGlu6 metabotropic glutamate receptor. Neuropharmacol. 36:1997;145-152.
177. Lehre K.P., Davanger S., Danbolt N.C. Localization of the glutamate transporter protein GLAST in rat retina. Brain Res. 744:1997;129-137.
178. 2+ signals. J. Neurophysiol. 72:1994;2503-2516.
179. Lerma J. Kainate reveals its targets. Neuron. 19:1997;1155-1158.
180. Lester H.A., Cao Y., Mager S. Listening to neurotransmitter transporters. Neuron. 17:1996;807-810.
181. Liets L.C., Chalupa L.M. The metabotropic glutamate agonist 2-amino-4-phosphonobutyric acid (APB) does not activate currents in postnatal retinal ganglion cells. NeuroReport. 7:1996;2873-2877.
182. Liman E.R., Knapp A.G., Dowling J.E. Enhancement of kainate-gated currents in retinal horizontal cells by cyclic AMP-dependent protein kinase. Brain Res. 481:1989;399-402.
183. 2+ in isolated catfish cone horizontal cells measured under voltage- and concentration-clamp conditions. J. Neurosci. 12:1992;2156-2164.
184. Linn D.M., Blazynski C., Redburn D.A., Massey S.C. Acetylcholine release from the rabbit retina mediated by kainate receptors. J. Neurosci. 11:1991;111-122.
185. Llinas R., Sugimori M., Silver R.B. The concept of calcium concentration microdomains in synaptic transmission. Neuropharmacol. 34:1995;1443-1453.
186. Lo W., Molloy R., Hughes T.E. Ionotropic glutamate receptors in the retina: moving from molecules to circuits. Vision Res. 38:1998;1399-1410.
187. Lukasiewicz P.D., McReynolds J.S. Synaptic transmission at N-methyl-D-aspartate receptors in the proximal retina of the mudpuppy. J. Physiol. (Lond.). 367:1985;99-115.
188. Lukasiewicz P.D., Lawrence J.E., Valentino T.L. Desensitizing glutamate receptors shape excitatory synaptic inputs to tiger salamander retinal ganglion cells. J. Neurosci. 15:1995;6189-6199.
189. Lukasiewicz P.D., Wilson J.A., Lawrence J.E. AMPA-preferring receptors mediate excitatory synaptic inputs to retinal ganglion cells. J. Neurophysiol. 77:1997;57-64.
190. Maguire G., Maple B., Lukasiewicz P., Werblin F. γ-Aminobutyrate type B receptor modulation of L-type calcium channel current at bipolar cell terminals in the retina of the tiger salamander. Proc. Natl. Acad. Sci. USA. 86:1989;10144-10147.
191. Maguire G., Werblin F. Dopamine enhances a glutamate-gated ionic current in OFF bipolar cells of the tiger salamander retina. J. Neurosci. 14:1994;6094-6101.
192. Mammen A.L., Kameyama K., Roche K.W., Huganir R.L. Phosphorylation of the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subnit by calcium/calmodulin-dependent kinase II. J. Biol. Chem. 272:1997;32528-32533.
193. Mangel S.C., Ariel M., Dowling J.E. D-aspartate potentiates the effects of both L-aspartate and L-glutamate on carp horizontal cells. Neurosci. 32:1989;19-26.
194. Marc R.E., Lam D.M.-K. Uptake of aspartic and glutamic acid by goldfish photoreceptors. Proc. Natl. Acad. Sci. USA. 78:1981;7185-7189.
195. Marc R.E., Liu W.-L. S., Kalloniatis M., Raiguel S.F., van Haesendonck E. Patterns of glutamate immunoreactivity in the goldfish retina. J. Neurosci. 10:1990;4006-4034.
196. Marc R.E., Murry R.F., Basinger S.F. Pattern recognition of amino acid signatures in retinal neurons. J. Neurosci. 15:1995;5106-5129.
197. Maricq A.V., Korenbrot J.I. Calcium and calcium-dependent chloride currents generate action potentials in solitary cone photoreceptors. Neuron. 1:1988;503-515.
198. Martin P.R., Grünert U. Spatial density and immunoreactivity of bipolar cells in the Macaque monkey retina. J. Comp. Neurol. 323:1992;269-287.
199. Massey S.C. Cell types using glutamate as a neurotransmitter in the vertebrate retina. Prog. Ret. Res. 9:1990;399-425.
200. Massey, S. C. and Maguire, G. (1995) The role of glutamate in retinal circuitry. In: Excitatory Amino Acids and Synaptic Transmission, (ed. H. Wheal and A. Thomson), 2nd edn, pp. 201-221. Academic Press, New York.
201. Massey S.C., Miller R.F. Glutamate receptors of ganglion cells in the rabbit retina: evidence for glutamate as a bipolar cell transmitter. J. Physiol. (Lond.). 405:1988;635-655.
202. Massey S.C., Miller R.F. N-Methyl-D-aspartate receptors of ganglion cells in rabbit retina. J. Neurophysiol. 63:1990;16-30.
203. Masu M., Iwakabe H., Tagawa Y., Miyoshi T., Yamashita M., Fukuda Y., Sasaki H., Hiroi K., Nakamura Y., Shigemoto R., Takada M., Nakamura K., Nakao K., Katsuki M., Nakanishi S. Specific deficit of the ON response in visual transmission by targeted disruption of the mGluR6 gene. Cell. 80:1995;757-765.
204. Matsui K., Hosoi N., Tachibana M. Excitatory synaptic transmission in the inner retina: paired recordings of bipolar cells and neurons of the ganglion cell layer. J. Neurosci. 18:1998;4500-4510.
205. Matthews G. Neurotransmitter release. Annu. Rev. Neurosci. 19:1996;219-233.
206. McMahon D.G., Ponomareva L.V. Nitric oxide and cGMP modulate retinal glutamate receptors. J. Neurophysiol. 76:1996;2307-2315.
207. Mennerick S., Matthews G. Ultrafast exocytosis elicited by calcium current in synaptic terminals of retinal bipolar neurons. Neuron. 17:1996;1241-1249.
208. Michaelis E.K. Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging. Prog. Neurobiol. 54:1998;369-415.
209. Miller R.F., Slaughter M.M. Excitatory amino acid receptors of the retina: diversity of subtypes and conductance mechanisms. Trends Neurosci. 9:1986;211-218.
210. Mintz I.M., Sabatini B.L., Regehr W.G. Calcium control of transmitter release at a cerebellar synapse. Neuron. 15:1995;675-688.
211. Mittman S., Taylor W.R., Copenhagen D.R. Concomitant activation of two types of glutamate receptor mediates excitation of salamander retinal ganglion cells. J. Physiol. (Lond.). 428:1990;175-197.
212. Morgans C.W., El Far O., Berntson A., Wässle H., Taylor W.R. Calcium extrusion from mammalian photoreceptor terminals. J. Neurosci. 18:1998;2467-2474.
213. Muller F., Wässle H., Voigt T. Pharmacological modulation of the rod pathway in the cat retina. J. Neurophysiol. 59:1988;1657-1672.
214. Muller F., Greferath U., Wässle H., Wisden W., Seeburg P. Glutamate receptor expression in the rat retina. Neurosci. Lett. 138:1992;179-182.
215. Murakami M., Takahashi K.-I. Calcium action potential and its use for measurement of reversal potentials of horizontal cell responses in carp retina. J. Physiol. (Lond.). 386:1987;165-180.
216. Naito S., Ueda T. Characterization of glutamate uptake into synaptic vesicles. J. Neurochem. 44:1985;99-109.
217. Nakajima Y., Iwakabe H., Akazawa C., Nawa H., Shigemoto R., Mizuno N., Nakanishi S. Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate. J. Biol. Chem. 268:1993;11368-11373.
218. Nawy S., Copenhagen D.R. Multiple classes of glutamate receptor on depolarizing bipolar cells in retina. Nature. 325:1987;56-58.
219. Nawy S., Copenhagen D.R. Intracellular cesium separates two glutamate conductances in retinal bipolar cells of goldfish. Vision Res. 30:1990;967-972.
220. Nawy S., Jahr C.E. Suppression by glutamate of cGMP-activated conductance in retina bipolar cells. Nature. 346:1990;269-271.
221. Nawy S., Jahr C.E. cGMP-gated conductance in retinal bipolar cells is suppressed by the photoreceptor transmitter. Neuron. 7:1991;677-683.
222. Nawy S., Sie A., Copenhagen D.R. The glutamate analog 2-amino-4-phosphonobutyrate antagonizes synaptic transmission from cones to horizontal cells in the goldfish retina. Proc. Natl. Acad. Sci. USA. 86:1989;1726-1730.
223. Newman E., Reichenbach A. The Müller cell: a functional element of the retina. Trends Neurosci. 19:1996;307-311.
224. Newman E.A., Zahs K.R. Modulation of neuronal activity by glial cells in the retina. J. Neurosci. 18:1998;4022-4028.
225. Nishimura Y., Schwartz M.L., Rakic P. GABA and GAD immunoreactivity of photoreceptor terminals in primate retina. Nature. 320:1986;753-756.
226. - fluorescent probe. Soc. Neurosci. Abstr. 21:1995;389.
227. Nomura A., Shigemoto R., Nakamura Y., Okamoto N., Mizuno N., Nakanishi S. Developmentally regulated postsynaptic localization of a metabotropic glutamate receptor in rat rod bipolar cells. Cell. 77:1994;361-369.
228. O'Dell T.J. Pharmacological characterization of voltage-clamped catfish rod horizontal cell responses to kainic acid. Brain Res. 477:1989;118-125.
229. O'Dell T.J., Christensen B.N. N-methyl-D-aspartate receptors coexist with kainate and quisqualate receptors on single isolated catfish horizontal cells. Brain Res. 381:1986;359-362.
230. O'Dell T.J., Christensen B.N. Horizontal cells isolated from catfish retina contain two types of excitatory amino acid receptors. J. Neurophysiol. 61:1989;1097-1109.
231. O'Dell T.J., Christensen B.N. A voltage-clamp study of isolated stingray horizontal cell non-NMDA excitatory amino acid receptors. J. Neurophysiol. 61:1989;162-172.
232. O'Hara P.J., Sheppard P.O., Thogersen H., Venezia D., Haldeman B.A., McGrane V., Houamed K.M., Thomsen C., Gilbert T.L., Mulvihill E.R. The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins. Neuron. 11:1993;41-52.
233. Ohishi H., Shigemoto R., Nakanishi S., Mizuno N. Distribution of the mRNA for a metabotropic glutamate receptor (mGluR3) in the rat brain: an in situ hybridization study. J. Comp. Neurol. 335:1993;252-266.
234. Okamoto N., Hori S., Akazawa C., Hayashi Y., Shigemoto R., Mizuno N., Nakanishi S. Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction. J. Biol. Chem. 269:1994;1231-1236.
235. Otori Y., Wei J.-Y., Barnstable C.J. Neurotoxic effects of low doses of glutamate on purified rat retinal ganglion cells. Invest. Ophthalmol. Vis. Sci. 39:1998;972-981.
236. Partin K.M., Patneau D.K., Winters C.A., Mayer M.L., Buonanno A. Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin A. Neuron. 11:1993;1069-1082.
237. Partin K.M., Fleck M.W., Mayer M.L. AMPA receptor flip/flop mutants affecting deactivation, desensitization, and modulation by cyclothiazide, aniracetam, and thiocyanate. J. Neurosci. 16:1996;6634-6647.
238. Peng Y.-W., Sharp A.H., Snyder S.H., Yau K.-W. Localization of the inositol 1,4,5-trisphosphate receptor in synaptic terminals in the vertebrate retina. Neuron. 6:1991;525-531.
239. Peng Y.-W., Blackstone C.D., Huganir R.L., Yau K.-W. Distribution of glutamate receptor subtypes in the vertebrate retina. Neurosci. 66:1995;483-497.
240. Perlman I., Knapp A.G., Dowling J.E. Responses of isolated white perch horizontal cells to changes in the concentration of photoreceptor transmitter agonists. Brain Res. 487:1989;16-25.
241. Peterson N.L., Thoreson W.B., Johnson R.L., Koerner J.F., Miller R.F. Characterization of retinal and hippocampal L-AP4 receptors using conformationally constrained AP4 analogues. Brain Res. 568:1991;15-23.
242. Pfeiffer-Linn C.L., Gafka A.C. Electrophysiological characterization of metabotropic glutamate receptors on catfish horizontal cells. Soc. Neurosci. Abstr. 23:1997;1184.
243. Picaud S., Larsson H.P., Grant G.B., Lecar H., Werblin F.S. Glutamate-gated chloride channel with glutamate-transporter-like properties in cone photoreceptors of the tiger salamander. J. Neurophysiol. 74:1995;1760-1771.
244. Picaud S., Larsson H.P., Wellis D.P., Lecar H., Werblin F.S. Cone photoreceptors respond to their own glutamate release in the tiger salamander. Proc. Natl. Acad. Sci. USA. 92:1995;9417-9421.
245. Piccolino M., Byzov A.I., Kurennyi D.E., Pignatelli A., Sappia F., Wilkinson M., Barnes S. Low-calcium-induced enhancement of chemical synaptic transmission from photoreceptors to horizontal cells in the vertebrate retina. Proc. Natl. Acad. Sci. USA. 93:1996;2302-2306.
246. Pin J.-P., Duvoisin R. The metabotropic glutamate receptors: structure and functions. Neuropharmacol. 34:1995;1-26.
247. Pow D.V., Robinson S.R. Glutamate in some retinal neurons is derived solely from glia. Neurosci. 60:1994;355-366.
248. Protti D.A., Llano I. Calcium currents and calcium signaling in rod bipolar cells of rat retinal slices. J. Neurosci. 18:1998;3715-3724.
249. Puro D.G., Yuan J.P., Sucher N.J. Activation of NMDA receptor-channels in human retinal Müller glial cells inhibits inward-rectifying potassium currents. Vis. Neurosci. 13:1996;319-326.
250. Qin P., Pourcho R.G. Distribution of AMPA-selective glutamate receptor subunits in the cat retina. Brain Res. 710:1996;303-307.
251. Raman I.M., Trussell L.O. The kinetics of the response to glutamate and kainate in neurons of the avian cochlear nucleus. Neuron. 9:1992;173-186.
252. Rauen T., Kanner B.I. Localization of the glutamate transporter GLT-1 in rat and macaque monkey retinae. Neurosci. Lett. 169:1994;137-140.
253. Rauen T., Rothstein J.D., Wässle H. Differential expression of three glutamate transporter subtypes in the rat retina. Cell Tiss. Res. 286:1996;325-336.
254. Raviola E., Gilula N.B. Intramembrane organization of specialized contacts in the outer plexiform layer of the retina: a freeze-fracture study in monkeys and rabbits. J. Cell Biol. 65:1975;192-222.
255. Rieke F., Schwartz E.A. A cGMP-gated current can control exocytosis at cone synapses. Neuron. 13:1994;863-873.
256. Rieke F., Schwartz E.A. Asynchronous transmitter release: control of exocytosis and endocytosis at the salamander rod synapse. J. Physiol. (Lond.). 493:1996;1-8.
257. Riepe R.E., Norenberg M.D. Müller cell localization of glutamine synthetase in rat retina. Nature. 268:1977;654-655.
258. Roche K.W., O'Brien R.J., Mammen A.L., Bernhardt J., Huganir R.L. Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit. Neuron. 16:1996;1179-1188.
259. Rodriguez-Moreno A., Lerma J. Kainate receptor modulation of GABA release involves a metabotropic function. Neuron. 20:1998;1211-1218.
260. Romano C., Price M.T., Olney J.W. Delayed excitotoxic neurodegeneration induced by excitatory amino acid agonists in isolated retina. J. Neurochem. 65:1995;59-67.
261. Romano C., Yang W.L., O'Malley K.L. Metabotropic glutamate receptor 5 is a disulfide-linked dimer. J. Biol. Chem. 271:1996;28612-28616.
262. Rörig B., Grantyn R. Glutamatergic and GABAergic synaptic currents in ganglion cells from isolated retinae of pigmented rats during postnatal development. Dev. Brain Res. 74:1993;98-110.
263. Rosenmund C., Stern-Bach Y., Stevens C.F. The tetrameric structure of a glutamate receptor channel. Science. 280:1998;1596-1599.
264. Ross C.D., Bowers M., Godfrey D.A. Distribution of glutaminase activity in retinal layers of rat and guinea pig. Brain Res. 401:1987;168-172.
265. Rothe T., Bigl V., Grantyn R. Potentiating and depressant effects of metabotropic glutamate receptor agonists on high-voltage-activated calcium currents in cultured retinal ganglion neurons from postnatal mice. Pflug. Arch. 426:1994;161-170.
266. Ryba N.J., Tirindelli R. A new multigene family of putative pheromone receptors. Neuron. 19:1997;371-379.
267. Sah P., Hestrin S., Nicoll R.A. Tonic activation of NMDA receptors by ambient glutamate enhances excitability of neurons. Science. 246:1989;815-818.
268. Saito T., Kujiraoka T. Physiological and morphological identification of two types of On-center bipolar cells in the carp retina. J. Comp. Neurol. 205:1982;161-170.
269. Saito T., Kondo H., Toyoda J.I. Rod and cone signals in the on-center bipolar cell: their different ionic mechanisms. Vision Res. 18:1978;591-595.
270. Saito T., Kondo H., Toyoda J.I. Ionic mechanisms of two types of on-center bipolar cells in the carp retina. I. The responses to central illumination. J. Gen. Physiol. 73:1979;73-90.
271. + current at presynaptic terminals of goldfish retinal bipolar cells. Neurosci. Res. 27:1997;219-228.
272. Sarantis M., Attwell D. Glutamate uptake in mammalian retinal glia is voltage- and potassium-dependent. Brain Res. 516:1990;322-325.
273. Sarantis M., Mobbs P. The spatial relationship between Müller cell processes and the photoreceptor output synapse. Brain Res. 584:1992;299-304.
274. Sarantis M., Everett K., Attwell D. A presynaptic action of glutamate at the cone output synapse. Nature. 332:1988;451-453.
275. Sarthy P.V., Hendrickson A.E., Wu J.Y. L-glutamate: a neurotransmitter candidate for cone photoreceptors in the monkey retina. J. Neurosci. 6:1986;637-643.
276. Sasaki T., Kaneko A. L-glutamate-induced responses in OFF-type bipolar cells of the cat retina. Vision Res. 36:1996;787-795.
277. Satoh, H., Aoki, K., Watanabe, S.-I. and Kaneko, A. (1998) L-type calcium channels in the axon terminal of mouse bipolar cells. NeuroReport 9, 2161-2165.
278. Savchenko A., Barnes S., Kramer R.H. Cyclic-nucleotide-gated channels mediate synaptic feedback by nitric oxide. Nature. 390:1997;694-698.
279. Scatton B. The NMDA receptor complex. Fundam. Clin. Pharmacol. 7:1993;389-400.
280. Scheetz A.J., Constantine-Paton M. Modulation of NMDA receptor function: implications for vertebrate neural development. FASEB J. 8:1994;745-752.
281. Schiller P.H., Sandell J.H., Maunsell J.H. R. Functions of the ON and OFF channels of the visual system. Nature. 322:1986;824-825.
282. Schmidt K.-F., Kruse M., Hatt H. Dopamine alters glutamate receptor desensitization in retinal horizontal cells of the perch (Perca fluviatilis). Proc. Natl. Acad. Sci. USA. 91:1994;8288-8291.
283. Schmitz Y., Witkovsky P. Glutamate release by the intact light-responsive photoreceptor layer of the Xenopus retina. J. Neurosci. Meth. 68:1996;55-60.
284. Schmitz Y., Witkovsky P. Dependence of photoreceptor glutamate release on a dihydropyridine-sensitive calcium channel. Neurosci. 78:1997;1209-1216.
285. Schultz K., Stell W.K. Immunocytochemical localization of the high-affinity glutamate transporter, EAAC1, in the retina of representative vertebrate species. Neurosci. Lett. 211:1996;191-194.
286. Schultz K., Goldman D.J., Ohtsuka T., Hirano J., Barton L., Stell W.K. Identification and localization of an immunoreactive AMPA-type glutamate receptor subunit (GluR4) with respect to identified photoreceptor synapses in the outer plexiform layer of goldfish retina. J. Neurocytol. 26:1997;651-666.
287. Schütte M., Schlemermeyer E. Depolarization elicits, while hyperpolarization blocks uptake of endogenous glutamate by retinal horizontal cells of the turtle. Cell Tissue Res. 274:1993;553-558.
288. + current of Müller glial cells. Neuron. 10:1993;1141-1149.
289. Schwartz E.A., Tachibana M. Electrophysiology of glutamate and sodium co-transport in a glial cell of the salamander retina. J. Physiol. (Lond.). 426:1990;43-80.
290. Seeburg P.H. The TIPS/TINS lecture: the molecular biology of mammalian glutamate receptor channels. Trends Pharm. Sci. 14:1993;297-303.
291. Shen W., Slaughter M.M. Metabotropic and ionotropic glutamate receptors regulate calcium channel currents in salamander retinal ganglion cells. J. Physiol. (Lond.). 510:1998;815-828.
292. Sherry D.M., Yazulla S. Goldfish bipolar cells and axon terminal patterns: a golgi study. J. Comp. Neurol. 329:1993;188-200.
293. Shiells R. Glutamate receptors for signal amplification. Current Biol. 4:1994;917-918.
294. Shiells R.A., Falk G. Joro spider venom: glutamate agonist and antagonist on the rod retina of the dogfish. Neurosci. Lett. 77:1987;221-225.
295. Shiells R.A., Falk G. Glutamate receptors of rod bipolar cells are linked to a cyclic GMP cascade via a G-protein. Proc. R. Soc. Lond. B 242:1990;91-94.
296. Shiells R.A., Falk G. The glutamate-receptor linked cGMP cascade of retinal on-bipolar cells is pertussis and cholera toxin-sensitive. Proc. R. Soc. Lond. B. 247:1992;17-20.
297. Shiells R.A., Falk G. Properties of the cGMP-activated channel of retinal on-bipolar cells. Proc. R. Soc. Lond. B. 247:1992;21-25.
298. Shiells, R. and Falk, G. (1992c) Retinal on-bipolar cells contain a nitric oxide-sensitive guanylate cyclase. Neuroreport 3, 345-348.
299. Shiells R.A., Falk G., Naghshineh S. Action of glutamate and aspartate analogues on rod horizontal and bipolar cells. Nature. 294:1981;592-594.
300. Shiells R.A., Falk G., Naghshineh S. Ionotophoretic study of the action of excitatory amino acids on rod horizontal cells of the dogfish retina. Proc. R. Soc. Lond. B 227:1986;121-135.
301. Shigemoto R., Nakanishi S., Mizuno N. Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: an in situ hybridization study in adult and developing rat. J. Comp. Neurol. 322:1992;121-135.
302. +-ATPase activity via a selective effect on the α3 isozyme. Proc. Natl. Acad. Sci. USA. 93:1996;8034-8039.
303. Slaughter M.M., Miller R.F. 2-amino-4-phosphonobutyric acid: a new pharmacological tool for retina research. Science. 211:1981;182-185.
304. Slaughter M.M., Miller R.F. Bipolar cells in the mudpuppy retina use an excitatory amino acid neurotransmitter. Nature. 303:1983;537-538.
305. Slaughter M.M., Miller R.F. An excitatory amino acid antagonist blocks cone input to sign-conserving second-order retinal neurons. Science. 219:1983;1230-1232.
306. Slaughter M.M., Miller R.F. The role of excitatory amino acid transmitters in the mudpuppy retina: an analysis with kainic acid and N-methyl aspartate. J. Neurosci. 3:1983;1701-1711.
307. Slaughter M.M., Miller R.F. Identification of a distinct synaptic glutamate receptor on horizontal cells in mudpuppy retina. Nature. 314:1985;96-97.
308. Somlyo, A. P. and Walz, B. (1985) Elemental distribution in Rana pipiens retinal rods: quantitative electron probe analysis. J. Physiol. (Lond.) 358, 183-195.
309. Sommer B., Keinanen K., Verdoorn T.A., Wisden W., Burnashev N., Herb A., Kohler M., Takagi T., Sakmann B., Seeburg P.H. Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS. Science. 249:1990;1580-1585.
310. Somohano F., Lopez-Colome A.M. Characteristics of excitatory amino acid uptake in cultures from neurons and glia from the retina. J. Neurosci. Res. 28:1991;556-562.
311. Spiridon M., Kamm D., Billups B., Mobbs P., Attwell D. Modulation by zinc of the glutamate transporters in glial cells and cones isolated from the tiger salamander retina. J. Physiol. (Lond.). 506:1998;373-376.
312. Stell W.K., Ishida A.T., Lightfoot D.O. Structural basis for on- and off-center responses in retinal bipolar cells. Science. 198:1977;1269-1271.
313. Stella S.L. Jr., Thoreson W.B. Differential modulation of rod and cone calcium currents by cAMP and a D2 dopamine receptor agonist. Invest. Ophthalmol. Vis. Sci. Suppl. 39:1998;S983.
314. Strettoi E., Masland R.H. The number of unidentified amacrine cells in the mammalian retina. Proc. Natl. Acad. Sci. USA. 93:1996;14906-14911.
315. Sucher N.J., Lipton S.A., Dreyer E.B. Molecular basis of glutamate toxicity in retinal ganglion cells. Vision Res. 37:1997;3483-3493.
316. Sugihara H., Inoue T., Nakanishi S., Fukuda Y. A late ON response remains in visual response of the mGluR6-deficient mouse. Neurosci. Lett. 233:1997;137-140.
317. Szatkowski M., Barbour B., Attwell D. Non-vesicular release of glutamate from glial cells by reversed electrogenic glutamate uptake. Nature. 348:1990;443-446.
318. Szatkowski M., Barbour B., Attwell D. The potassium-dependence of excitatory amino acid transport: resolution of a paradox. Brain Res. 555:1991;343-345.
319. Tachibana M. Permeability changes induced by L-glutamate in solitary retinal horizontal cells isolated from Carassius auratus. J. Physiol. (Lond.). 358:1985;153-167.
320. Tachibana M., Kaneko A. Gamma-amino butyric acid acts at axon terminals of turtle photoreceptors: difference in sensitivity among cell types. Proc. Natl. Acad. Sci. USA. 81:1984;7961-7964.
321. Tachibana M., Kaneko A. L-glutamate-induced depolarization in solitary photoreceptors: a process that may contribute to the interaction between photoreceptors in situ. Proc. Natl. Acad. Sci. USA. 85:1988;5315-5319.
322. Tachibana M., Okada T. Release of endogenous excitatory amino acids from ON-type bipolar cells isolated from the goldfish retina. J. Neurosci. 11:1991;2199-2208.
323. Tachibana M., Okada T., Arimura T., Kobayashi K., Piccolino M. Dihydropyridine-sensitive calcium current mediates neurotransmitter release from bipolar cells of the goldfish retina. J. Neurosci. 13:1993;2898-2909.
324. Takahashi K.-I., Copenhagen D.R. APB suppresses synaptic input to retinal horizontal cells in fish: a direct action on horizontal cells modulated by intracellular pH. J. Neurophysiol. 67:1992;1633-1642.
325. Takahashi K.-I., Murakami M. Subtype of excitatory amino acid receptor in cone horizontal cells of the carp retina as specified by reversal potential measurement technique. Neurosci. Res. 5:1988;453-464.
326. 2+ channels mediate glutamatergic synaptic responses to activation of single Thy-1-immunolabeled rat retinal ganglion neurons. J. Neurosci. 15:1995;2240-2254.
327. Taschenberger H., Engert F., Grantyn R. Synaptic current kinetics in a solely AMPA-receptor-operated glutamatergic synapse formed by rat retinal ganglion neurons. J. Neurophysiol. 74:1995;1123-1136.
328. Taylor W.R., Chen E., Copenhagen D.R. Characterization of spontaneous excitatory synaptic currents in salamander retinal ganglion cells. J. Physiol. (Lond.). 486:1995;207-221.
329. Tehrani A., Guenther E. Gene expression patterns of metabotropic glutamate receptors in ganglion cells of the rat retina. Invest. Ophthalmol. Vis. Sci. Suppl. 39:1998;S508.
330. Thomsen C. The L-AP4 receptor. Gen. Pharmacol. 29:1997;151-158.
331. Thoreson W.B., Burkhardt D.A. Ionic influences on the prolonged depolarization of turtle cones in situ. J. Neurophysiol. 65:1991;96-110.
332. Thoreson W.B., Miller R.F. Membrane currents evoked by excitatory amino acid agonists in ON bipolar cells of the mudpuppy retina. J. Neurophysiol. 70:1993;1326-1338.
333. Thoreson W.B., Miller R.F. Actions of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) in retinal ON bipolar cells indicate that it is an agonist at L-AP4 receptors. J. Gen. Physiol. 103:1994;1019-1034.
334. Thoreson W.B., Miller R.F. Removal of extracellular chloride suppresses glutamate release from photoreceptor terminals in the mudpuppy retina. J. Gen. Physiol. 107:1996;631-642.
335. Thoreson W.B., Ulphani J.S. Pharmacology of selective and non-selective metabotropic glutamate receptor agonists at L-AP4 receptors in retinal ON bipolar cells. Brain Res. 676:1995;93-102.
336. Thoreson W.B., Velte T.J., Miller R.F. Actions of phenylglycine derivatives at L-AP4 receptors in retinal ON bipolar cells. Neuropharmacol. 34:1995;27-34.
337. Thoreson W.B., Gottesman J., Jane D.E., Tse H.-W., Watkins J.C., Miller R.F. Two phenylglycine derivatives antagonize responses to L-AP4 in ON bipolar cells of the amphibian retina. Neuropharmacol. 36:1997;13-20.
338. Thoreson W.B., Nitzan R., Miller R.F. Reducing extracellular chloride suppresses dihydropyridine-sensitive calcium currents and synaptic transmission in amphibian photoreceptors. J. Neurophysiol. 77:1997;2175-2190.
339. Tian N., Slaughter M.M. Pharmacological similarity between the retinal APB receptor and the family of metabotropic glutamate receptors. J. Neurophysiol. 71:1994;2258-2268.
340. Tian N., Slaughter M.M. Functional properties of a metabotropic glutamate receptor at dendritic synapses of ON bipolar cells in the amphibian retina. Vis. Neurosci. 12:1995;755-765.
341. Tunnicliff G. Glutamate uptake by chick retina. Biochem. J. 150:1975;297-299.
342. Ueda Y., Iwakabe H., Masu M., Suzuki M., Nakanishi S. The mGluR6 5′ upstream transgene sequence directs a cell-specific and developmentally regulated expression in retinal rod and ON-type cone bipolar cells. J. Neurosci. 17:1997;3014-3023.
343. Valentino T.L., Lukasiewicz P.D., Romano C. Immunocytochemical localization of polyamines in the tiger salamander retina. Brain Res. 713:1996;278-285.
344. Vandenbranden C.A. V., Verweij J., Kamermans M., Muller L.J., Ruijter J.M., Vrensen G.F. J. M., Spekreijse H. Clearance of neurotransmitter from the cone synaptic cleft in goldfish retina. Vision Res. 36:1996;3859-3874.
345. Vardi N., Morigiwa K. ON cone bipolar cells in rat express the metabotropic receptor mGluR6. Vis. Neurosci. 14:1997;789-794.
346. Vardi N., Morigiwa K., Wang T.-L., Shi Y.-J., Sterling P. Neurochemistry of the mammalian cone 'synaptic complex'. Vision Res. 38:1998;1359-1369.
347. Vardi, N., Matesic, D. F., Manning, D. R., Liebman, P. A. and Sterling, P. (1993) Identification of a G-protein in depolarizing rod bipolar cells. Vis. Neurosci. 10, 473-478.
348. von Gersdorff H., Matthews G. Dynamics of synaptic vesicle fusion and membrane retrieval in synaptic terminals. Nature. 367:1994;735-739.
349. von Gersdorff H., Matthews G. Depletion and replenishment of vesicle pools at a ribbon-type synaptic terminal. J. Neurosci. 17:1997;1919-1927.
350. von Gersdorff H., Vardi E., Matthews G., Sterling P. Evidence that vesicles on the synaptic ribbon of retinal bipolar neurons can be rapidly released. Neuron. 16:1996;1221-1227.
351. Wakakura M., Yamamoto N. Cytosolic calcium transient increase through the AMPA/kainate receptor in cultured Müller cells. Vision Res. 34:1994;1105-1109.
352. Walters R.J., Kramer R.H., Nawy S. Regulation of cGMP-dependent current in On bipolar cells by calcium/calmodulin-dependent kinase. Vis. Neurosci. 15:1998;257-261.
353. i-protein in cortical neurons. Nature. 389:1997;502-504.
354. Wässle H., Grünert U., Cook N.J., Molday R.S. The cGMP-gated channel of rod outer segments is not localized in bipolar cells of the mammalian retina. Neurosci. Lett. 134:1992;199-202.
355. Watanabe M., Mishina M., Inoue Y. Differential distributions of the NMDA receptor channel subunit mRNAs in the mouse retina. Brain Res. 634:1994;328-332.
356. Watkins, J. C. (1978) Excitatory amino acids. In: Kainic Acid as a Tool in Neurobiology, (ed. E. G. McGeer, J. W. Olney and P. L. McGeer), pp. 37-69. Raven Press, NY.
357. Watkins J.C., Olverman H.J. Agonists and antagonists for excitatory amino acid receptors. Trends Neurosci. 10:1987;265-271.
358. Weiler R., Schultz K. Ionotropic non-N-methyl-D-aspartate agonists induce retraction of dendritic spinules from retinal horizontal cells. Proc. Natl Acad. Sci. USA. 90:1993;6533-6537.
359. c receptors mediating inhibition of calcium entry into and transmitter release from bipolar cell terminals in tiger salamander retina. J. Neurosci. 15:1995;4748-4761.
360. Wenzel A., Benke D., Mohler H., Fritschy J.-M. N-methyl-D-aspartate receptors containing the NR2D subunit in the retina are selectively expressed in rod bipolar cells. Neurosci. 78:1997;1105-1112.
361. White R.D., Neal M.J. The uptake of L-glutamate by the retina. Brain Res. 111:1976;79-93.
362. Wilkinson M.F., Barnes S. The dihydropyridine-sensitive calcium channel subtype in cone photoreceptors. J. Gen. Physiol. 107:1996;621-630.
363. Wilson, M. (1994) Glutamate-gated channels in the outer retina. In: Handbook of Membrane Channels, (ed. C. Peracchia), pp. 287-302. Academic Press, New York.
364. Witkovsky P., Powell C.C. Synapse formation and modification between distal retinal neurons in larval and juvenile Xenopus. Proc. R. Soc. Lond. B 211:1981;373-389.
365. Witkovsky P., Gabriel R., Krizaj D., Akopian A. Feedback from luminosity horizontal cells mediates depolarizing responses of chromaticity horizontal cells in the Xenopus retina. Proc. Natl. Acad. Sci. USA. 92:1995;3556-3560.
366. Witkovsky P., Schmitz Y., Akopian A., Krizaj D., Tranchina D. Gain of rod to horizontal cell synaptic transfer: relation to glutamate release and a dihydropyridine-sensitive calcium current. J. Neurosci. 17:1997;7297-7306.
367. Wu S.M. Synaptic transmission in the outer retina. Annu. Rev. Physiol. 56:1994;141-168.
368. Wu S.M., Maple B.R. Amino acid neurotransmitters in the retina: a functional overview. Vision Res. 38:1998;1371-1384.
369. Wu S.M., Qiao X., Noebels J.L., Yang X.L. Localization and modulatory actions of zinc in vertebrate retina. Vision Res. 33:1993;2611-2616.
370. Yagi T., MacLeish P.R. Ionic conductances of monkey solitary cone inner segments. J. Neurophysiol. 71:1994;656-665.
371. Yamada M., Djamgoz M.B. A., Low J.C., Furukawa T., Yasui S. Conductance-decreasing synaptic mechanisms mediating cone input to H1 horizontal cells in carp retina. Neurosci. Res. Suppl. 15:1991;S51-S65.
372. Yamada M., Low J.C., Djamgoz M.B. A. Chromaticity of synaptic inputs to H1 horizontal cells in carp retina: analysis by voltage-clamp and spectral adaptation. Exp. Brain Res. 89:1992;465-472.
373. Yamashita M., Wässle H. Responses of rod bipolar cells isolated from the rat retina to the gluamate agonist 2-amino-4-phosphonobutyric acid (APB). J. Neurosci. 11:1991;2372-2382.
374. Yamashita M., Huba R., Hofmann H.D. Early in vitro development of voltage- and transmitter-gated currents in GABAergic amacrine cells. Brain Res. Dev. Brain Res. 82:1994;95-102.
375. Yang X.-L., Wu S.M. Effects of CNQX, APB, PDA and kynurenate on horizontal cells of the tiger salamander retina. Vis. Neurosci. 3:1989;207-212.
376. Yang X.-L., Wu S.M. Coexistence and function of glutamate receptor subtypes in the horizontal cells of the tiger salamander retina. Vis. Neurosci. 7:1991;377-382.
377. Yang J.-H., Wu S.M. Characterization of glutamate transporter function in the tiger salamander retina. Vision Res. 37:1997;827-838.
378. Yasui S., Yamada M., Djamgoz M.B. A. Dopamine and 2-amino-4-phosphonobutyrate differentially modify spectral responses of H1 horizontal cells in carp retina. Exp. Brain Res. 83:1990;79-84.
379. Yazejian B., Fain G.L. Excitatory amino acid receptors on isolated retinal ganglion cells from the goldfish. J. Neurophysiol. 67:1992;94-107.
380. Yu W., Miller R.F. NBQX, an improved non-NMDA antagonist studied in retinal ganglion cells. Brain Res. 692:1995;190-194.
381. Yu W., Miller R.F. The mechanism by which NBQX enhances NMDA currents in retinal ganglion cells. Brain Res. 709:1996;184-196.
382. Zerangue N., Kavanaugh M.P. Flux coupling in a neuronal glutamate transporter. Nature. 383:1996;634-637.
383. 2+ permeability in single rat retinal ganglion cells. Neurosci. 67, 177-188.
384. Zhang C., Hamassaki-Britto D.E., Britto L.R. G., Duvoisin R.M. Expression of glutamate receptor subunit genes during development of the mouse retina. NeuroReport. 8:1996;335-340.
385. Zhou Z.J., Fain G.L. Neurotransmitter receptors of starburst amacrine cells in rabbit retinal slices. J. Neurosci. 15:1995;5334-5345.
386. Zhou Z.J., Fain G.L., Dowling J.E. The excitatory and inhibitory amino acid receptors on horizontal cells isolated from the white perch retina. J. Neurophysiol. 70:1993;8-19.
387. Zhou Z.J., Marshak D.W., Fain G.L. Amino acid receptors of midget and parasol ganglion cells in primate retina. Proc. Natl. Acad. Sci. USA. 91:1994;4907-4911.
388. Zufall F., Shepherd G.M., Barnstable C.J. Cyclic nucleotide gated channels as regulators of CNS development and plasticity. Curr. Opin. Neurobiol. 7:1997;404-412.