Stoichiometric selection of tight-binding inhibitors by wild-type mutant forms of malarial (Plasmodium falciparum) dihydrofolate reductase

Analytical Chemistry

Volumn 77, Issue 5, 2005, Pages 1222-1227

  Kamchonwongpaisan, Sumalee ^a   Vanichtanankul, Jarunee ^a   Tarnchompoo, Bongkoch ^a   Yuvaniyama, Jirundon ^b   Taweechai, Supannee ^a   Yuthavong, Yongyuth ^a  

^a NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY   (Thailand)

^b Mahidol University   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING AFFINITY; BOUND INHIBITORS; CHEMICAL LIBRARIES; STOICHIOMETRIC SELECTION;

BINDING ENERGY; DISEASE CONTROL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; STOICHIOMETRY; ULTRAFILTRATION;

ENZYME INHIBITION;

ANTIMALARIAL AGENT; DIHYDROFOLATE REDUCTASE; MUTANT PROTEIN; PYRIMETHAMINE;

ARTICLE; BINDING AFFINITY; COMBINATORIAL CHEMISTRY; DRUG PROTEIN BINDING; DRUG SCREENING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PLASMODIUM FALCIPARUM; STOICHIOMETRY; WILD TYPE;

ALGORITHMS; ANIMALS; CHLOROGUANIDE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMBINATORIAL CHEMISTRY TECHNIQUES; FOLIC ACID ANTAGONISTS; HUMANS; KINETICS; MASS SPECTROMETRY; MOLECULAR STRUCTURE; MUTATION; PLASMODIUM FALCIPARUM; PROGUANIL; PROTEIN BINDING; PYRIMETHAMINE; RECOMBINANT PROTEINS; REPRODUCIBILITY OF RESULTS; TETRAHYDROFOLATE DEHYDROGENASE; TRIAZINES; TRIMETHOPRIM;

EID: 14744274646     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac0487597     Document Type: Article

References (16)

1. Snow, R. W.; Craig, M.; Deichmann, U.; Marsh, K. Bull. World Health Organization 1999, 77, 624-640.
2. Breman, J. Am. J. Trop. Med. Hyg. 2001, 64 (Suppl. 1-2), 1-11.
3. Hyde, J. E. Microbes Infect. 2002, 4, 165-174.
4. Yuthavong, Y. Microbes Infect. 2002, 4, 175-182.
5. Sirawaraporn, W.; Sathikul, T.; Sirawaraporn, R.; Yuthavong, Y.; Santi, D. V. Proc. Natl. Acad. Sci. U.S.A. 1997, 94, 1124-1129.
6. Yuthavong, Y.; Vilaivan, T.; Charoensethakul, N.; Kamchonwongpaisan, S.; Sirawaraporn, W.; Quarrell, R.; Lowe, G. J. Med. Chem. 2000, 43, 2738-2744.
7. Tarnchompoo, B.; Sirichaiwat, C.; Phupong, W.; Intaraudom, C.; Sirawaraporn, W.; Kamchonwongpaisan, S.; Vanichtanankul, J.; Thebtaranonth, Y.; Yuthavong, Y. J. Med. Chem. 2002, 45, 1244-1252.
8. Kamchonwongpaisan, S.; Quarrell, R.; Charoensetakul, N.; Ponsinet, R.; Vilaivan, T.; Vanichtanankul, J.; Tarnchompoo, B.; Sirawaraporn, W.; Lowe, G.; Yuthavong, Y. J. Med. Chem. 2004, 47, 673-680.
9. Lee, H.-K.; Chui, W.-K. Bioorg. Med. Chem. 1999, 7, 1255-1262.
10. Vilaivan, T.; Saesaengseerung, N.; Jarprung, D.; Kamchonwongpaisan, S.; Sirawaraporn, W.; Yuthavong, Y. Bioorg. Med. Chem. 2003, 11, 217-224.
11. Nikolic, D.; van Breemen, R. B. Comb. Chem. High Throughput Screen 1998, 1, 47-55.
12. van Breemen, R. B.; Huang, C.-R.; Nikolic, D.; Woodbury, C. P.; Zhao, Y.-Z.; Venton, D. L. Anal. Chem. 1997, 69, 2159-2164.
13. Zhoa, Y.-Z.; van Breemen, R. B.; Nikolic, D.; Huang, C.-R.; Woodbury, C. P.; Schilling, A.; Venton, D. L. J. Med. Chem. 1997, 40, 4006-4012.
14. Wattanarangsan, J.; Chusacultanachai, S.; Yuvaniyama, J.; Kamchonwongpaisan, S.; Yuthavong, Y. Mol. Biochem. Parasitol. 2003, 126, 97-102.
15. McKie, J. H.; Douglas, K. T.; Chan, C.; Roser, S. A.; Yates, R.; Read, M.; Hyde, J. E.; Dascombe, M. J.; Yuthavong, Y.; Sirawaraporn, W. J. Med. Chem. 1998, 41, 1367-1370.
16. Bradford, M. M. Anal. Biochem. 1976, 72, 248-254.