TGF-β-mediated activation of RhoA signalling is required for efficient V12HaRas and V600EBRAF transformation

Oncogene

Volumn 28, Issue 7, 2009, Pages 983-993

  Fleming, Y M ^a   Ferguson, G J ^a   Spender, L C ^a   Larsson, J ^b   Karlsson, S ^b   Ozanne, B W ^a   Grosse, R ^c   Inman, G J ^a  

^a BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Raf; Ras; RhoA; TGF ; Transformation

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; 4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; ACTIN; B RAF KINASE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TUMOR PROMOTER; TUMOR SUPPRESSOR PROTEIN;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; ARTICLE; AUTOCRINE EFFECT; CELL IMMORTALIZATION; CELL PROLIFERATION; CELL STRAIN 3T3; CELL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; MALIGNANT TRANSFORMATION; NONHUMAN; ONCOGENE H RAS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ACTINS; ANIMALS; BENZAMIDES; BLOTTING, WESTERN; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; CYTOSKELETON; DIOXOLES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBROBLASTS; FLUORESCENT ANTIBODY TECHNIQUE; GENES, RAS; GUANOSINE TRIPHOSPHATE; HUMANS; MICE; NIH 3T3 CELLS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS B-RAF; RATS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA;

RODENTIA;

EID: 60549095395     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2008.449     Document Type: Article

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