Atorvastatin promotes presenilin-1 expression and Notch1 activity and increases neural progenitor cell proliferation after stroke

Stroke

Volumn 39, Issue 1, 2008, Pages 220-226

  Chen, Jieli ^a   Zacharek, Alex ^a   Li, Ang ^a   Cui, Xu ^a   Roberts, Cynthia ^a   Lu, Mei ^b   Chopp, Michael ^a,c  

^a HENRY FORD HOSPITAL   (United States)

^b HENRY FORD HEALTH SCIENCES CENTER   (United States)

^c OAKLAND UNIVERSITY   (United States)

Author keywords

Neural stem progenitor cells; Notch1; Presenilin1; Stroke

Indexed keywords

ATORVASTATIN; NOTCH1 RECEPTOR; PRESENILIN 1; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR HES 1; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; HEPTANOIC ACID DERIVATIVE; HES1 PROTEIN, RAT; HOMEODOMAIN PROTEIN; HYPOCHOLESTEROLEMIC AGENT; NOTCH1 PROTEIN, RAT; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; CELL PROLIFERATION; CELL RENEWAL; CONTROLLED STUDY; DRUG MECHANISM; GENE EXPRESSION; IN VITRO STUDY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STROKE; SUBVENTRICULAR ZONE; UPREGULATION; WESTERN BLOTTING; ANIMAL; CYTOLOGY; DISEASE MODEL; DRUG EFFECT; METABOLISM; MIDDLE CEREBRAL ARTERY; NERVE CELL; PATHOLOGY; PHYSIOLOGY; STEM CELL; WISTAR RAT;

ANIMALS; ANTICHOLESTEREMIC AGENTS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; HEPTANOIC ACIDS; HOMEODOMAIN PROTEINS; MALE; MIDDLE CEREBRAL ARTERY; NEURONS; PRESENILIN-1; PYRROLES; RATS; RATS, WISTAR; RECEPTOR, NOTCH1; SIGNAL TRANSDUCTION; STEM CELLS; STROKE;

EID: 38149064671     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.107.490946     Document Type: Article

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