-
1
-
-
0021182202
-
Pressure-dependent membrane depolarization in cat middle cerebral artery
-
Harder DR: Pressure-dependent membrane depolarization in cat middle cerebral artery. Circ Res (1984) 55(2):197-202.
-
(1984)
Circ Res
, vol.55
, Issue.2
, pp. 197-202
-
-
Harder, D.R.1
-
2
-
-
0036080081
-
P-450 metabolites of arachidonic acid in the control of cardiovascular function
-
Roman RJ: P-450 metabolites of arachidonic acid in the control of cardiovascular function. Physiol Rev (2002) 82(1):131-185.
-
(2002)
Physiol Rev
, vol.82
, Issue.1
, pp. 131-185
-
-
Roman, R.J.1
-
3
-
-
0036912721
-
Nitric oxide as a unique signaling molecule in the vascular system: A historical overview
-
Ignarro LJ: Nitric oxide as a unique signaling molecule in the vascular system: A historical overview. J Physiol Pharmacol (2002) 53(4Pt1):503-514.
-
(2002)
J Physiol Pharmacol
, vol.53
, Issue.4 PT1
, pp. 503-514
-
-
Ignarro, L.J.1
-
4
-
-
0033652990
-
Abnormalities of endothelial function in the pathogenesis of stroke: The importance of endothelin
-
Volpe M, Cosentino F: Abnormalities of endothelial function in the pathogenesis of stroke: The importance of endothelin. J Cardiovasc Pharmacol (2000) 35(4 Suppl 2):S45-S48.
-
(2000)
J Cardiovasc Pharmacol
, vol.35
, Issue.4 SUPPL. 2
-
-
Volpe, M.1
Cosentino, F.2
-
5
-
-
0036140090
-
Endothelin-1 and endothelin receptor antagonists as potential cardiovascular therapeutic agents
-
Ergul A: Endothelin-1 and endothelin receptor antagonists as potential cardiovascular therapeutic agents. Pharmacotherapy (2002) 22(1):54-65.
-
(2002)
Pharmacotherapy
, vol.22
, Issue.1
, pp. 54-65
-
-
Ergul, A.1
-
7
-
-
0034617142
-
Production of 20-HETE and its role in autoregulation of cerebral blood flow
-
Gebremedhin D, Lange AR, Lowry TF, Taheri MR, Birks EK, Hudetz AG, Narayanan J, Falck JR, Okamoto H, Roman RJ, Nithipatikom K et al: Production of 20-HETE and its role in autoregulation of cerebral blood flow. Circ Res (2000) 87(1):60-65.
-
(2000)
Circ Res
, vol.87
, Issue.1
, pp. 60-65
-
-
Gebremedhin, D.1
Lange, A.R.2
Lowry, T.F.3
Taheri, M.R.4
Birks, E.K.5
Hudetz, A.G.6
Narayanan, J.7
Falck, J.R.8
Okamoto, H.9
Roman, R.J.10
Nithipatikom, K.11
-
8
-
-
0033993749
-
Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase
-
Capdevila JH, Falck JR, Harris RC: Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase. J Lipid Res (2000) 41(2):163-181.
-
(2000)
J Lipid Res
, vol.41
, Issue.2
, pp. 163-181
-
-
Capdevila, J.H.1
Falck, J.R.2
Harris, R.C.3
-
9
-
-
0030774838
-
20- Hydroxyeicosatetraenoic acid-induced vasoconstriction and inhibition of potassium current in cerebral vascular smooth muscle is dependent on activation of protein kinase C
-
Lange A, Gebremedhin D, Narayanan J, Harder D: 20- Hydroxyeicosatetraenoic acid-induced vasoconstriction and inhibition of potassium current in cerebral vascular smooth muscle is dependent on activation of protein kinase C. J Biol Chem (1997) 272(43):27345-27352.
-
(1997)
J Biol Chem
, vol.272
, Issue.43
, pp. 27345-27352
-
-
Lange, A.1
Gebremedhin, D.2
Narayanan, J.3
Harder, D.4
-
11
-
-
0029930387
-
Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes
-
Alkayed NJ, Narayanan J, Gebremedhin D, Medhora M, Roman RJ, Harder DR: Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes. Stroke (1996) 27(5):971-979.
-
(1996)
Stroke
, vol.27
, Issue.5
, pp. 971-979
-
-
Alkayed, N.J.1
Narayanan, J.2
Gebremedhin, D.3
Medhora, M.4
Roman, R.J.5
Harder, D.R.6
-
12
-
-
0036462415
-
Astrocytes function in matching blood flow to metabolic activity
-
Harder DR, Zhang C, Gebremedhin D: Astrocytes function in matching blood flow to metabolic activity. News Physiol Sci (2002) 17:27-31.
-
(2002)
News Physiol Sci
, vol.17
, pp. 27-31
-
-
Harder, D.R.1
Zhang, C.2
Gebremedhin, D.3
-
13
-
-
0026758963
-
Mechanism of action of cerebral epoxyeicosatrienoic acids on cerebral arterial smooth muscle
-
Gebremedhin D, Ma YH, Falck JR, Roman RJ, VanRollins M, Harder DR: Mechanism of action of cerebral epoxyeicosatrienoic acids on cerebral arterial smooth muscle. Am J Physiol (1992) 263(2Pt 2):H519-H525.
-
(1992)
Am J Physiol
, vol.263
, Issue.2 PART 2
-
-
Gebremedhin, D.1
Ma, Y.H.2
Falck, J.R.3
Roman, R.J.4
VanRollins, M.5
Harder, D.R.6
-
14
-
-
0030051805
-
Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors
-
Campbell WB, Gebremedhin D, Pratt PF, Harder DR: Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. Circ Res (1996) 78(3):415-423.
-
(1996)
Circ Res
, vol.78
, Issue.3
, pp. 415-423
-
-
Campbell, W.B.1
Gebremedhin, D.2
Pratt, P.F.3
Harder, D.R.4
-
15
-
-
10744221010
-
Effects of a 20-HETE antagonist and agonists on cerebral vascular tone
-
in press
-
Ming Y, Cambj-Sapunar L, Kehl F, Maier KG, Takeuchi K, Miyata N, Ishimoto T, Reddy LM, Falck JR, Gebremedhin D, Roman RJ: Effects of a 20-HETE antagonist and agonists on cerebral vascular tone. Eur J Pharmacol (2004): in press.
-
(2004)
Eur J Pharmacol
-
-
Ming, Y.1
Cambj-Sapunar, L.2
Kehl, F.3
Maier, K.G.4
Takeuchi, K.5
Miyata, N.6
Ishimoto, T.7
Reddy, L.M.8
Falck, J.R.9
Gebremedhin, D.10
Roman, R.J.11
-
16
-
-
0034764957
-
HET0016, a potent and selective inhibitor of 20-HETE synthesizing enzyme
-
Miyata N, Taniguchi K, Seki T, Ishimoto T, Sato-Watanabe M, Yasuda Y, Doi M, Kametani S, Tomishima Y, Ueki T, Sato M, Kameo K: HET0016, a potent and selective inhibitor of 20-HETE synthesizing enzyme. Br J Pharmacol (2001) 133(3):325-329.
-
(2001)
Br J Pharmacol
, vol.133
, Issue.3
, pp. 325-329
-
-
Miyata, N.1
Taniguchi, K.2
Seki, T.3
Ishimoto, T.4
Sato-Watanabe, M.5
Yasuda, Y.6
Doi, M.7
Kametani, S.8
Tomishima, Y.9
Ueki, T.10
Sato, M.11
Kameo, K.12
-
17
-
-
0031963859
-
Functional hyperemia in the brain: Hypothesis for astrocyte-derived vasodilator metabolites
-
Harder DR, Alkayed NJ, Lange AR, Gebremedhin D, Roman RJ: Functional hyperemia in the brain: Hypothesis for astrocyte-derived vasodilator metabolites. Stroke (1998) 29(1):229-234.
-
(1998)
Stroke
, vol.29
, Issue.1
, pp. 229-234
-
-
Harder, D.R.1
Alkayed, N.J.2
Lange, A.R.3
Gebremedhin, D.4
Roman, R.J.5
-
18
-
-
0033695239
-
P-450 epoxygenase and NO synthase inhibitors reduce cerebral blood flow response to N-methyl-D-aspartate
-
Bhardwaj A, Northington FJ, Carhuapoma JR, Falck JR, Harder DR, Traystman RJ, Koehler RC: P-450 epoxygenase and NO synthase inhibitors reduce cerebral blood flow response to N-methyl-D-aspartate. Am J Physiol Heart Circ Physiol (2000) 279(4):H1616-H1624.
-
(2000)
Am J Physiol Heart Circ Physiol
, vol.279
, Issue.4
-
-
Bhardwaj, A.1
Northington, F.J.2
Carhuapoma, J.R.3
Falck, J.R.4
Harder, D.R.5
Traystman, R.J.6
Koehler, R.C.7
-
19
-
-
0037123936
-
14,15-Epoxyeicosa-5(Z)-enoic acid: A selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-dependent hyperpolarization and relaxation in coronary arteries
-
Gauthier KM, Deeter C, Krishna UM, Reddy YK, Bondlela M, Falck JR, Campbell WB: 14,15-Epoxyeicosa-5(Z)-enoic acid: A selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-dependent hyperpolarization and relaxation in coronary arteries. Circ Res (2002) 90(9):1028-1036.
-
(2002)
Circ Res
, vol.90
, Issue.9
, pp. 1028-1036
-
-
Gauthier, K.M.1
Deeter, C.2
Krishna, U.M.3
Reddy, Y.K.4
Bondlela, M.5
Falck, J.R.6
Campbell, W.B.7
-
20
-
-
0141962643
-
14,15-Epoxyeicosa- 5(Z)-enoic-mSI: A 14,15- and 5,6-EET antagonist in bovine coronary arteries
-
Gauthier KM, Jagadeesh SG, Falck JR, Campbell WB: 14,15-Epoxyeicosa- 5(Z)-enoic-mSI: A 14,15- and 5,6-EET antagonist in bovine coronary arteries. Hypertension (2003) 42(4):555-561.
-
(2003)
Hypertension
, vol.42
, Issue.4
, pp. 555-561
-
-
Gauthier, K.M.1
Jagadeesh, S.G.2
Falck, J.R.3
Campbell, W.B.4
-
21
-
-
0033619262
-
Cytochrome P450 2C is an EDHF synthase in coronary arteries
-
Fisslthaler B, Popp R, Kiss L, Potente M, Harder DR, Fleming I, Busse R: Cytochrome P450 2C is an EDHF synthase in coronary arteries. Nature (1999) 401 (6752):493-497.
-
(1999)
Nature
, vol.401
, Issue.6752
, pp. 493-497
-
-
Fisslthaler, B.1
Popp, R.2
Kiss, L.3
Potente, M.4
Harder, D.R.5
Fleming, I.6
Busse, R.7
-
22
-
-
0035910620
-
Endothelium-derived hyperpolarizing factor synthase (Cytochrome P450 2C9) is a functionally significant source of reactive oxygen species in coronary arteries
-
Fleming I, Michaelis UR, Bredenkotter D, Fisslthaler B, Dehghani F, Brandes RP, Busse R: Endothelium-derived hyperpolarizing factor synthase (Cytochrome P450 2C9) is a functionally significant source of reactive oxygen species in coronary arteries. Circ Res (2001) 88(1):44-51.
-
(2001)
Circ Res
, vol.88
, Issue.1
, pp. 44-51
-
-
Fleming, I.1
Michaelis, U.R.2
Bredenkotter, D.3
Fisslthaler, B.4
Dehghani, F.5
Brandes, R.P.6
Busse, R.7
-
23
-
-
0031021585
-
An active site substitution, F87V, converts cytochrome P450 BM-3 into a regio- and stereoselective (14S,15R)-arachidonic acid epoxygenase
-
Graham-Lorence S, Truan G, Peterson JA, Falck JR, Wei S, Helvig C, Capdevila JH: An active site substitution, F87V, converts cytochrome P450 BM-3 into a regio- and stereoselective (14S,15R)-arachidonic acid epoxygenase. J Biol Chem (1997) 272(2):1127-1135.
-
(1997)
J Biol Chem
, vol.272
, Issue.2
, pp. 1127-1135
-
-
Graham-Lorence, S.1
Truan, G.2
Peterson, J.A.3
Falck, J.R.4
Wei, S.5
Helvig, C.6
Capdevila, J.H.7
-
24
-
-
0030966110
-
Gene transfer to cerebral blood vessels after subarachnoid hemorrhage
-
Muhonen MG, Ooboshi H, Welsh MJ, Davidson BL, Heistad DD: Gene transfer to cerebral blood vessels after subarachnoid hemorrhage. Stroke (1997) 28(4):822-828.
-
(1997)
Stroke
, vol.28
, Issue.4
, pp. 822-828
-
-
Muhonen, M.G.1
Ooboshi, H.2
Welsh, M.J.3
Davidson, B.L.4
Heistad, D.D.5
-
25
-
-
0012589042
-
Expression of recombinant cytochrome P450 epoxygenase in rat brain
-
Vanhoutte PM Ed, Taylor & Francis, London, UK
-
Medhora MM, Okamoto H, Narayanan J, Zhang C, Niu X, Taheri MR, Kraemer R, Capdevila J, Harder D: Expression of recombinant cytochrome P450 epoxygenase in rat brain. In: EDHF. Vanhoutte PM (Ed), Taylor & Francis, London, UK (2001):228-238.
-
(2001)
EDHF
, pp. 228-238
-
-
Medhora, M.M.1
Okamoto, H.2
Narayanan, J.3
Zhang, C.4
Niu, X.5
Taheri, M.R.6
Kraemer, R.7
Capdevila, J.8
Harder, D.9
-
26
-
-
0034109792
-
Cerebral microvascular endothelial cell tube formation: Role of astrocytic epoxyeicosatrienoic acid release
-
Munzenmaier DH, Harder DR: Cerebral microvascular endothelial cell tube formation: Role of astrocytic epoxyeicosatrienoic acid release. Am J Physiol Heart Circ Physiol (2000) 278(4):H1163-H1167.
-
(2000)
Am J Physiol Heart Circ Physiol
, vol.278
, Issue.4
-
-
Munzenmaier, D.H.1
Harder, D.R.2
-
27
-
-
0036901546
-
Cerebral capillary endothelial cell mitogenesis and morphogenesis induced by astrocytic epoxyeicosatrienoic acid
-
Zhang C, Harder DR: Cerebral capillary endothelial cell mitogenesis and morphogenesis induced by astrocytic epoxyeicosatrienoic acid. Stroke (2002) 33(12):2957-2964.
-
(2002)
Stroke
, vol.33
, Issue.12
, pp. 2957-2964
-
-
Zhang, C.1
Harder, D.R.2
-
28
-
-
0036277938
-
Neuroprotection and P450 2C11 upregulation after experimental transient ischemic attack
-
Alkayed NJ, Goyagi T, Joh HD, Klaus J, Harder DR, Traystman RJ, Hurn PD: Neuroprotection and P450 2C11 upregulation after experimental transient ischemic attack. Stroke (2002) 33(6):1677-1684.
-
(2002)
Stroke
, vol.33
, Issue.6
, pp. 1677-1684
-
-
Alkayed, N.J.1
Goyagi, T.2
Joh, H.D.3
Klaus, J.4
Harder, D.R.5
Traystman, R.J.6
Hurn, P.D.7
-
29
-
-
0035844126
-
αs mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids
-
αs mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids. J Biol Chem (2001) 276(19):15983-15989.
-
(2001)
J Biol Chem
, vol.276
, Issue.19
, pp. 15983-15989
-
-
Node, K.1
Ruan, X.L.2
Dai, J.3
Yang, S.X.4
Graham, L.5
Zeldin, D.C.6
Liao, J.K.7
-
30
-
-
0033588034
-
Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids
-
Node K, Huo Y, Ruan X, Yang B, Spiecker M, Ley K, Zeldin DC, Liao JK: Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids. Science (1999) 285(5431):1276-1279.
-
(1999)
Science
, vol.285
, Issue.5431
, pp. 1276-1279
-
-
Node, K.1
Huo, Y.2
Ruan, X.3
Yang, B.4
Spiecker, M.5
Ley, K.6
Zeldin, D.C.7
Liao, J.K.8
-
31
-
-
0034923447
-
Overexpression of cytochrome P450 CYP2J2 protects against hypoxia-reoxygenation injury in cultured bovine aortic endothelial cells
-
Yang B, Graham L, Dikalov S, Mason RP, Falck JR, Liao JK, Zeldin DC: Overexpression of cytochrome P450 CYP2J2 protects against hypoxia-reoxygenation injury in cultured bovine aortic endothelial cells. Mol Pharmacol (2001) 60(2):310-320.
-
(2001)
Mol Pharmacol
, vol.60
, Issue.2
, pp. 310-320
-
-
Yang, B.1
Graham, L.2
Dikalov, S.3
Mason, R.P.4
Falck, J.R.5
Liao, J.K.6
Zeldin, D.C.7
-
32
-
-
0022982159
-
Inhibition of cyclooxygenase activity and platelet aggregation by epoxyeicosatrienoic acids. Influence of stereochemistry
-
Fitzpatrick FA, Ennis MD, Baze ME, Wynalda MA, McGee JE, Liggett WF: Inhibition of cyclooxygenase activity and platelet aggregation by epoxyeicosatrienoic acids. Influence of stereochemistry. J Biol Chem (1986) 261(32):15334-15338.
-
(1986)
J Biol Chem
, vol.261
, Issue.32
, pp. 15334-15338
-
-
Fitzpatrick, F.A.1
Ennis, M.D.2
Baze, M.E.3
Wynalda, M.A.4
McGee, J.E.5
Liggett, W.F.6
-
33
-
-
0036384287
-
Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain
-
Bylund J, Zhang C, Harder DR: Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain. Biochem Biophys Res Commun (2002) 296(3):677-684.
-
(2002)
Biochem Biophys Res Commun
, vol.296
, Issue.3
, pp. 677-684
-
-
Bylund, J.1
Zhang, C.2
Harder, D.R.3
-
34
-
-
0028087299
-
Effects of 17-octadecynoic acid, a suicide-substrate inhibitor of cytochrome P450 fatty acid ω-hydroxylase, on renal function in rats
-
Zou AP, Ma YH, Sui ZH, Ortiz de Montellano PR, Clark JE, Masters BS, Roman RJ: Effects of 17-octadecynoic acid, a suicide-substrate inhibitor of cytochrome P450 fatty acid ω-hydroxylase, on renal function in rats. J Pharmacol Exp Ther (1994) 268(1):474-481.
-
(1994)
J Pharmacol Exp Ther
, vol.268
, Issue.1
, pp. 474-481
-
-
Zou, A.P.1
Ma, Y.H.2
Sui, Z.H.3
Ortiz de Montellano, P.R.4
Clark, J.E.5
Masters, B.S.6
Roman, R.J.7
|