메뉴 건너뛰기




Volumn 10, Issue 20, 2004, Pages 7022-7030

Troglitazone acts on cellular pH and DNA synthesis through a peroxisome proliferator-activated receptor γ-independent mechanism in breast cancer-derived cell lines

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; AMMONIUM CHLORIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA INHIBITOR; PROTEIN INHIBITOR; SODIUM PROTON EXCHANGE PROTEIN 1; TROGLITAZONE; UNCLASSIFIED DRUG;

EID: 6044243631     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-04-0879     Document Type: Article
Times cited : (62)

References (47)
  • 1
    • 0026795032 scopus 로고
    • Regulation of intracellular pH in tumor cell lines: Influence of microenvironmental conditions
    • Boyer MJ, Tannock IF. Regulation of intracellular pH in tumor cell lines: influence of microenvironmental conditions. Cancer Res 1992;52:4441-7.
    • (1992) Cancer Res , vol.52 , pp. 4441-4447
    • Boyer, M.J.1    Tannock, I.F.2
  • 2
    • 0032080644 scopus 로고    scopus 로고
    • Heterogeneity of intracellular pH and of mechanisms that regulate intracellular pH in populations of cultured cells
    • Lee AH, Tannock IF. Heterogeneity of intracellular pH and of mechanisms that regulate intracellular pH in populations of cultured cells. Cancer Res 1998;58:1901-8.
    • (1998) Cancer Res , vol.58 , pp. 1901-1908
    • Lee, A.H.1    Tannock, I.F.2
  • 3
    • 0030698096 scopus 로고    scopus 로고
    • Role of intracellular pH in proliferation, transformation, and apoptosis
    • Shrode LD, Tapper H, Grinstein S. Role of intracellular pH in proliferation, transformation, and apoptosis. J Bioenerg Biomembr 1997;29:393-9.
    • (1997) J Bioenerg Biomembr , vol.29 , pp. 393-399
    • Shrode, L.D.1    Tapper, H.2    Grinstein, S.3
  • 5
    • 0033746761 scopus 로고    scopus 로고
    • + exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes
    • + exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes. FASEB J 2000;14:2185-97.
    • (2000) FASEB J , vol.14 , pp. 2185-2197
    • Reshkin, S.J.1    Bellizzi, A.2    Caldeira, S.3
  • 6
    • 0024213268 scopus 로고
    • Glucose uptake, lactate release, ketone body turnover, metabolic micromilieu, and pH distributions in human breast cancer xenografts in nude rats
    • Kallinowski F, Vaupel P, Runkel S, et al. Glucose uptake, lactate release, ketone body turnover, metabolic micromilieu, and pH distributions in human breast cancer xenografts in nude rats. Cancer Res 1988;48:7264-72.
    • (1988) Cancer Res , vol.48 , pp. 7264-7272
    • Kallinowski, F.1    Vaupel, P.2    Runkel, S.3
  • 7
    • 0024408986 scopus 로고
    • Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review
    • Vaupel P, Kallinowski F, Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 1989;49:6449-65.
    • (1989) Cancer Res , vol.49 , pp. 6449-6465
    • Vaupel, P.1    Kallinowski, F.2    Okunieff, P.3
  • 8
    • 0037093411 scopus 로고    scopus 로고
    • Contribution by different fuels and metabolic pathways to the total ATP turnover of proliferating MCF-7 breast cancer cells
    • Guppy M, Leedman P, Zu X, Russell V. Contribution by different fuels and metabolic pathways to the total ATP turnover of proliferating MCF-7 breast cancer cells. Biochem J 2002;364:309-15.
    • (2002) Biochem J , vol.364 , pp. 309-315
    • Guppy, M.1    Leedman, P.2    Zu, X.3    Russell, V.4
  • 10
    • 0042242676 scopus 로고    scopus 로고
    • The glycolytic phenotype in carcinogenesis and tumor invasion: Insights through mathematical models
    • Gatenby RA, Gawlinski ET. The glycolytic phenotype in carcinogenesis and tumor invasion: insights through mathematical models. Cancer Res 2003;63:3847-54.
    • (2003) Cancer Res , vol.63 , pp. 3847-3854
    • Gatenby, R.A.1    Gawlinski, E.T.2
  • 11
    • 0033609365 scopus 로고    scopus 로고
    • An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: Implications for clonal selection during colorectal carcinogenesis
    • Williams AC, Collard TJ, Paraskeva C. An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: implications for clonal selection during colorectal carcinogenesis. Oncogene 1999;18:3199-204.
    • (1999) Oncogene , vol.18 , pp. 3199-3204
    • Williams, A.C.1    Collard, T.J.2    Paraskeva, C.3
  • 12
    • 0022179004 scopus 로고
    • Cytoplasmic pH, a key determinant of growth factor-induced DNA synthesis in quiescent fibroblasts
    • Pouyssegur J, Franchi A, L'Allemain G, Paris S. Cytoplasmic pH, a key determinant of growth factor-induced DNA synthesis in quiescent fibroblasts. FEBS Lett 1985;190:115-9.
    • (1985) FEBS Lett , vol.190 , pp. 115-119
    • Pouyssegur, J.1    Franchi, A.2    L'Allemain, G.3    Paris, S.4
  • 13
    • 0037375523 scopus 로고    scopus 로고
    • Control of hepatocyte DNA synthesis by intracellular pH and its role in the action of tumor promoters
    • Lee CH, Cragoe EJ, Edwards AM. Control of hepatocyte DNA synthesis by intracellular pH and its role in the action of tumor promoters. J Cell Physiol 2003;195:61-9.
    • (2003) J Cell Physiol , vol.195 , pp. 61-69
    • Lee, C.H.1    Cragoe, E.J.2    Edwards, A.M.3
  • 15
    • 0034058373 scopus 로고    scopus 로고
    • + exchange, motility, and invasion induced by serum deprivation
    • + exchange, motility, and invasion induced by serum deprivation. J Biol Chem 2000;275:5361-9.
    • (2000) J Biol Chem , vol.275 , pp. 5361-5369
    • Reshkin, S.J.1    Bellizzi, A.2    Albarani, V.3
  • 16
    • 0024379967 scopus 로고
    • Acid pH in tumors and its potential for therapeutic exploitation
    • Tannock IF, Rotin D. Acid pH in tumors and its potential for therapeutic exploitation. Cancer Res 1989;49:4373-84.
    • (1989) Cancer Res , vol.49 , pp. 4373-4384
    • Tannock, I.F.1    Rotin, D.2
  • 17
    • 0030013044 scopus 로고    scopus 로고
    • The chronic administration of drugs that inhibit the regulation of intracellular pH: In vitro and anti-tumour effects
    • Yamagata M, Tannock IF. The chronic administration of drugs that inhibit the regulation of intracellular pH: in vitro and anti-tumour effects. Br J Cancer 1996;73:1328-34.
    • (1996) Br J Cancer , vol.73 , pp. 1328-1334
    • Yamagata, M.1    Tannock, I.F.2
  • 19
    • 0030612740 scopus 로고    scopus 로고
    • PPARγ induces cell cycle withdrawal: Inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A
    • Altiok S, Xu M, Spiegelman BM. PPARγ induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A. Genes Dev 1997;11:1987-98.
    • (1997) Genes Dev , vol.11 , pp. 1987-1998
    • Altiok, S.1    Xu, M.2    Spiegelman, B.M.3
  • 20
    • 0034114625 scopus 로고    scopus 로고
    • Differential activation of peroxisome proliferator-activated receptor-γ by troglitazone and rosiglitazone
    • Camp HS, Li O, Wise SC, et al. Differential activation of peroxisome proliferator-activated receptor-γ by troglitazone and rosiglitazone. Diabetes 2000;49:539-47.
    • (2000) Diabetes , vol.49 , pp. 539-547
    • Camp, H.S.1    Li, O.2    Wise, S.C.3
  • 21
    • 0035018327 scopus 로고    scopus 로고
    • Troglitazone, but not rosiglitazone, inhibits Na/H exchange activity and proliferation of macrovascular endothelial cells
    • de Dios ST, Hannan KM, Dilley RJ, Hill MA, Little PJ. Troglitazone, but not rosiglitazone, inhibits Na/H exchange activity and proliferation of macrovascular endothelial cells. J Diabetes Compl 2001;15:120-7.
    • (2001) J Diabetes Compl , vol.15 , pp. 120-127
    • De Dios, S.T.1    Hannan, K.M.2    Dilley, R.J.3    Hill, M.A.4    Little, P.J.5
  • 22
    • 0034033786 scopus 로고    scopus 로고
    • Thiazolidinedione compounds ameliorate glomerular dysfunction independent of their insulin-sensitizing action in diabetic rats
    • Isshiki K, Haneda M, Koya D, et al. Thiazolidinedione compounds ameliorate glomerular dysfunction independent of their insulin-sensitizing action in diabetic rats. Diabetes 2000;49:1022-32.
    • (2000) Diabetes , vol.49 , pp. 1022-1032
    • Isshiki, K.1    Haneda, M.2    Koya, D.3
  • 23
    • 0033920602 scopus 로고    scopus 로고
    • Ligands for the peroxisome proliferator-activated receptor-γ and the retinoid X receptor-α exert synergistic antiproliferative effects on human coronary artery smooth muscle cells
    • Benson S, Padmanabhan S, Kurtz TW, Pershadsingh HA. Ligands for the peroxisome proliferator-activated receptor-γ and the retinoid X receptor-α exert synergistic antiproliferative effects on human coronary artery smooth muscle cells. Mol Cell Biol Res Commun 2000;3:159-64.
    • (2000) Mol Cell Biol Res Commun , vol.3 , pp. 159-164
    • Benson, S.1    Padmanabhan, S.2    Kurtz, T.W.3    Pershadsingh, H.A.4
  • 24
    • 0346668393 scopus 로고    scopus 로고
    • A non-thiazolidinedione partial peroxisome proliferator-activated receptor γ ligand inhibits vascular smooth muscle cell growth
    • Bruemmer D, Berger JP, Liu J, et al. A non-thiazolidinedione partial peroxisome proliferator-activated receptor γ ligand inhibits vascular smooth muscle cell growth. Eur J Pharmacol 2003;466:225-34.
    • (2003) Eur J Pharmacol , vol.466 , pp. 225-234
    • Bruemmer, D.1    Berger, J.P.2    Liu, J.3
  • 25
    • 0038130698 scopus 로고    scopus 로고
    • PPARγ ligand attenuates PDGF induced mesangial cell proliferation: Role of MAP kinase
    • Ghosh SS, Gehr TWB, Ghosh S, et al. PPARγ ligand attenuates PDGF induced mesangial cell proliferation: role of MAP kinase. Kidney Int 2003;64:52-62.
    • (2003) Kidney Int , vol.64 , pp. 52-62
    • Ghosh, S.S.1    Gehr, T.W.B.2    Ghosh, S.3
  • 26
    • 0343683281 scopus 로고    scopus 로고
    • Mechanisms of action of troglitazone in the prevention of high glucose-induced migration and proliferation of cultured coronary smooth muscle cells
    • Yasunari K, Kohno M, Kano H, et al. Mechanisms of action of troglitazone in the prevention of high glucose-induced migration and proliferation of cultured coronary smooth muscle cells. Circ Res 1997;81:953-62.
    • (1997) Circ Res , vol.81 , pp. 953-962
    • Yasunari, K.1    Kohno, M.2    Kano, H.3
  • 27
    • 0034889267 scopus 로고    scopus 로고
    • Magnitude of peroxisome proliferator-activated receptor-γ activation is associated with important and seemingly opposite biological responses in breast cancer cells
    • Clay CE, Namen AM, Atsumi G, et al. Magnitude of peroxisome proliferator-activated receptor-γ activation is associated with important and seemingly opposite biological responses in breast cancer cells. J Investig Med 2001;49:413-20.
    • (2001) J Investig Med , vol.49 , pp. 413-420
    • Clay, C.E.1    Namen, A.M.2    Atsumi, G.3
  • 28
    • 0031993322 scopus 로고    scopus 로고
    • Terminal differentiation of human breast cancer through PPAR gamma
    • Mueller E, Sarraf P, Tontonoz P, et al. Terminal differentiation of human breast cancer through PPAR gamma. Mol Cell 1998;1:465-70.
    • (1998) Mol Cell , vol.1 , pp. 465-470
    • Mueller, E.1    Sarraf, P.2    Tontonoz, P.3
  • 29
    • 0035052916 scopus 로고    scopus 로고
    • Inhibition of cellular proliferation through IκB kinase-independent and peroxisome proliferator-activated receptor γ-dependent repression of cyclin D1
    • Wang C, Fu M, D'Amico M, et al. Inhibition of cellular proliferation through IκB kinase-independent and peroxisome proliferator-activated receptor γ-dependent repression of cyclin D1. Mol Cell Biol 2001;21:3057-70.
    • (2001) Mol Cell Biol , vol.21 , pp. 3057-3070
    • Wang, C.1    Fu, M.2    D'Amico, M.3
  • 31
    • 0036469001 scopus 로고    scopus 로고
    • Troglitazone suppresses cell growth of KU812 cells independently of PPARγ
    • Abe A, Kiriyama Y, Hirano M, et al. Troglitazone suppresses cell growth of KU812 cells independently of PPARγ. Eur J Pharmacol 2002;436:7-13.
    • (2002) Eur J Pharmacol , vol.436 , pp. 7-13
    • Abe, A.1    Kiriyama, Y.2    Hirano, M.3
  • 32
    • 0037457286 scopus 로고    scopus 로고
    • 1 cell cycle arrest and apoptosis in human and rat hepatoma cell lines
    • 1 cell cycle arrest and apoptosis in human and rat hepatoma cell lines. Toxic Lett 2003;139:67-75.
    • (2003) Toxic Lett , vol.139 , pp. 67-75
    • Bae, M.1    Rhee, H.2    Song, B.J.3
  • 33
    • 0037458680 scopus 로고    scopus 로고
    • Expression of NAG-1, a TGF-beta superfamily member, by troglitazone requires the early growth response gene Egr-1
    • Baek SJ, Wilson LC, Hsi LC, Eling TE. Expression of NAG-1, a TGF-beta superfamily member, by troglitazone requires the early growth response gene Egr-1. J Biol Chem 2003;278:5845-53.
    • (2003) J Biol Chem , vol.278 , pp. 5845-5853
    • Baek, S.J.1    Wilson, L.C.2    Hsi, L.C.3    Eling, T.E.4
  • 34
    • 0035881317 scopus 로고    scopus 로고
    • Anticancer effects of thiazolidinediones are independent of peroxisome proliferator-activated receptor γ and mediated by inhibition of translation initiation
    • Palakurthi S, Aktas H, Huseyin A, et al. Anticancer effects of thiazolidinediones are independent of peroxisome proliferator-activated receptor γ and mediated by inhibition of translation initiation. Cancer Res 2001;61:6213-18.
    • (2001) Cancer Res , vol.61 , pp. 6213-6218
    • Palakurthi, S.1    Aktas, H.2    Huseyin, A.3
  • 35
    • 0036784671 scopus 로고    scopus 로고
    • Glitazones regulate glutamine metabolism by inducing a cellular acidosis in MDCK cells
    • Coates G, Nissim I, Battarbee H, Welbourne T. Glitazones regulate glutamine metabolism by inducing a cellular acidosis in MDCK cells. Am J Physiol 2002;283:E729-37.
    • (2002) Am J Physiol , vol.283
    • Coates, G.1    Nissim, I.2    Battarbee, H.3    Welbourne, T.4
  • 36
    • 0036084383 scopus 로고    scopus 로고
    • Troglitazone induces a cellular acidosis by inhibiting acid extrusion in cultured rat mesangial cells
    • Welbourne T, Su G, Coates G, et al. Troglitazone induces a cellular acidosis by inhibiting acid extrusion in cultured rat mesangial cells. Am J Physiol 2002;282:R1600-7.
    • (2002) Am J Physiol , vol.282
    • Welbourne, T.1    Su, G.2    Coates, G.3
  • 37
    • 0347990538 scopus 로고    scopus 로고
    • Troglitazone acts by PPARγ and PPAR-γ-independent pathways on LLC-PK1-F+ acid-base metabolism
    • Welbourne T, Friday E, Fowler R, Turturro F, Nissim I. Troglitazone acts by PPARγ and PPAR-γ-independent pathways on LLC-PK1-F+ acid-base metabolism. Am J Physiol Renal Physiol 2004;286:F100-10.
    • (2004) Am J Physiol Renal Physiol , vol.286
    • Welbourne, T.1    Friday, E.2    Fowler, R.3    Turturro, F.4    Nissim, I.5
  • 38
    • 0036083043 scopus 로고    scopus 로고
    • Troglitazone inhibits glutamine metabolism in rat mesangial cells
    • Routh R, McCarthy K, Welbourne T. Troglitazone inhibits glutamine metabolism in rat mesangial cells. Am J Physiol 2002;282:E231-8.
    • (2002) Am J Physiol , vol.282
    • Routh, R.1    McCarthy, K.2    Welbourne, T.3
  • 39
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-54.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 40
    • 0035966105 scopus 로고    scopus 로고
    • 2 and thiazolidinediones activate the MEK/ERK pathway through phosphatidylinositol 3-kinase in vascular smooth muscle cells
    • 2 and thiazolidinediones activate the MEK/ERK pathway through phosphatidylinositol 3-kinase in vascular smooth muscle cells. J Biol Chem 2001;276:48950-5.
    • (2001) J Biol Chem , vol.276 , pp. 48950-48955
    • Takeda, K.1    Ichiki, T.2    Tokunou, T.3    Iino, N.4    Takeshita, A.5
  • 41
    • 0031945458 scopus 로고    scopus 로고
    • Cell cycle regulation and apoptosis
    • King KL, Cidlowski JA. Cell cycle regulation and apoptosis. Annu Rev Physiol 1998;60:601-17.
    • (1998) Annu Rev Physiol , vol.60 , pp. 601-617
    • King, K.L.1    Cidlowski, J.A.2
  • 42
    • 0033776271 scopus 로고    scopus 로고
    • Changes in intramitochondrial and cytosolic pH: Early events that modulate caspase activation during apoptosis
    • Matsuyama S, Llopis J, Deveraux QL, Tsien RY, Reed JC. Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis. Nat Cell Biol 2000;2:318-25.
    • (2000) Nat Cell Biol , vol.2 , pp. 318-325
    • Matsuyama, S.1    Llopis, J.2    Deveraux, Q.L.3    Tsien, R.Y.4    Reed, J.C.5
  • 44
    • 0023186613 scopus 로고
    • Induction of v-mos and activated Ha-ras oncogene expression in quiescent NIH3T3 cells cause intracellular alkalinisation and cell-cycle progression
    • Doppler WR, Jaggi R, Groner B. Induction of v-mos and activated Ha-ras oncogene expression in quiescent NIH3T3 cells cause intracellular alkalinisation and cell-cycle progression. Gene (Amst) 1987;54:14715-3.
    • (1987) Gene (Amst) , vol.54 , pp. 14715-14713
    • Doppler, W.R.1    Jaggi, R.2    Groner, B.3
  • 45
    • 0028095118 scopus 로고
    • 3 exchange in NIH-3T3 fibroblasts
    • 3 exchange in NIH-3T3 fibroblasts. J Biol Chem 1994;269:4116-24.
    • (1994) J Biol Chem , vol.269 , pp. 4116-4124
    • Kaplan, D.L.1    Boron, W.F.2
  • 46
    • 0036594889 scopus 로고    scopus 로고
    • Regulation of intracellular pH in human melanoma: Potential therapeutic implications
    • Wahl ML, Owen JA, Burd R, et al. Regulation of intracellular pH in human melanoma: potential therapeutic implications. Mol Cancer Ther 2002;1:617-28.
    • (2002) Mol Cancer Ther , vol.1 , pp. 617-628
    • Wahl, M.L.1    Owen, J.A.2    Burd, R.3
  • 47
    • 0032843099 scopus 로고    scopus 로고
    • A cell cycle-dependent mechanism of renal tubule epithelial cell hypertrophy
    • Preisig P. A cell cycle-dependent mechanism of renal tubule epithelial cell hypertrophy. Kidney Int 1999;56:1193-8.
    • (1999) Kidney Int , vol.56 , pp. 1193-1198
    • Preisig, P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.