Troglitazone inhibits glutamine metabolism in rat mesangial cells

American Journal of Physiology - Endocrinology and Metabolism

Volumn 282, Issue 1 45-1, 2002, Pages

  Matzinger, Oscar ^a   Schneiter, Philippe ^a   Tappy, Luc ^a,b  

^a University of Lausanne Medical Center   (Switzerland)

^b Institut de Physiologie   (Switzerland)

Author keywords

Alanine aminotransferase; Intracellular pH; Matrix proteins; Peroxisome proliferator activated receptor

Indexed keywords

ALANINE AMINOTRANSFERASE; AMMONIA; COLLAGEN; GLUTAMINE; GLYCOSAMINOGLYCAN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TROGLITAZONE;

AMINO ACID METABOLISM; AMINO ACID TRANSPORT; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DEAMINATION; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; DRUG EFFICACY; MALE; MESANGIUM CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; RAT; REACTION ANALYSIS;

EID: 0036083043     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.2002.282.1.e231     Document Type: Article

References (34)

1. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
2. Differential activation of peroxisome proliferator-activated receptor-γ by troglitazone and rosiglitazone
3. The effects of 6-diazo-5-oxo-L-norleucine, a glutamine analog, on the structure of the major cartilage proteoglycan synthesized by cultured chondrocytes
4. Effects of oral antihyperglycemic agents on extracellular matrix synthesis by mesangial cells
5. Thiazolidinediones: A new class of antidiabetic drugs
6. Peroxisome proliferator-activated receptors: Insight into multiple cellular functions
7. Acute non-insulin-like stimulation of rat muscle glucose metabolism by troglitazone in vitro
8. Overexpression of glucose transporters in rat mesangial cells cultured in a normal glucose milieu mimics the diabetic phenotype
9. Effect of glutamine on protein synthesis in isolated intestinal epithelial cells
10. Thiazolidinedione compounds ameliorate glomerular dysfunction independent of their insulin-sensitizing action in diabetic rats
11. Glomerular cells in culture
12. Peroxisome proliferator-activated receptor-γ troglitazone protects against nondiabetic glomerulosclerosis in rats
13. Transamination pathways influencing L-glutamine and L-glutamate oxidation by rat enterocyte mitochondria and subcellular localization of L-alanine aminotransferase and L-aspartate aminotransferase
14. Troglitazone halts diabetic glomerulosclerosis by blockade of mesangial expansion
15. Fibroblast growth factor-binding protein is a novel partner for perlecan protein core
16. Culture of normal human leukocytes
17. The pathways of glutamate and glutamine oxidation by tumor cell mitochondria
18. 1 cells
19. Induction by peroxisome proliferators and triiodothyronine of serine:pyruvate/alanine:glyoxylate aminotransferase of rat liver
20. Involvement of glutamic acid and glutamine in protein synthesis and maturation
21. 2 by the intact functioning kidney of the dog
22. Evidence that glutamine, and not sugar, is the major energy source for cultured HeLa cells
23. Regulation of connective tissue growth factor activity in cultured rat mesangial cells and its expression in experimental diabetic glomerulosclerosis
24. Direct action of troglitazone on mesangial cell behavior: Troglitazone suppresses the secretion of type 1 collagen by mesangial cells in vitro
25. Glutamate dehydrogenase: UV assay
26. Role of the hexosamine biosynthetic pathway in diabetic nephropathy
27. Transport of metabolic substrates in renal mitochondria
28. Role of glutamine in glycosaminoglycan synthesis in vitro by chondrocytes
29. Coordinated regulation of glutamine: Fructose-6-phosphate amidotransferase activity by insulin, glucose, and glutamine
30. + cells
31. The glutamine/glutamate couplet and cellular function
32. Serum glutamic-pyruvic transaminase in cardiac and hepatic disease
33. Flux of the L-serine metabolism in rabbit, human and dog livers. Substantial contribution of both the mitochondrial and peroxisomal serine:pyruvate/alanine:glyoxylate aminotransferase
34. Reciprocal regulation of glucose and glutamine utilization by cultured human diploid fibroblasts