Troglitazone induces a cellular acidosis by inhibiting acid extrusion in cultured rat mesangial cells

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 282, Issue 6 51-6, 2002, Pages

  Welbourne, Tomas ^a   Su, Gan ^a   Coates, Greg ^a   Routh, Robert ^a   McCarthy, Kevin ^a   Battarbee, Harold ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

2 7 bis(2 carboxyethyl) 5,6 carboxyfluorescein; Bicarbonate activated acid extrusion; Glutamine metabolism; Lactic acid; Sodium hydrogen exchange

Indexed keywords

ALANINE; AMMONIA; FLUORESCEIN DERIVATIVE; GLUTAMINE; LACTIC ACID; TROGLITAZONE;

ACIDOSIS; AMINO ACID METABOLISM; ANIMAL CELL; ARTICLE; CELL CULTURE; CELL PH; CONTROLLED STUDY; DRUG MECHANISM; MESANGIUM CELL; NONHUMAN; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; RAT; TRANSAMINATION;

EID: 0036084383     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00506.2001     Document Type: Article

References (34)

1. Trade-offs in the adaptation to acidosis
2. + exchange in experimental porcine cryptoridiosis
3. + exchanger in renal microvillus membrane vesicles
4. Intracellular pH regulation in epithelial cells
5. -
6. Intracellular-pH dependence of Na-H exchange and acid loading in quiescent and arginine vasopressin inactivated mesangial cells
7. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
8. Metabolic regulation via intracellular pH
9. Thiazolidinediones: A new class of antidiabetic drugs
10. Troglitazone, but not rosiglitazone, inhibits Na/H exchange activity and proliferation of macrovascular endothelial cells
11. Peroxisome proliferator-activated receptors: Insight into multiple cellular functions
12. Acute non-insulin-like stimulation of rat muscle glucose metabolism by troglitazone in vitro
13. Renal fibrosis in diabetic and aortic-constricted hypertensive rats
14. Effects of angiotensin II and vasopressin on intracellular pH of glomerular mesangial cells
15. + exchanger
16. Thiazolidinedione compounds ameliorate glomerular dysfunction independent of their insulin-sensitizing action in diabetic rats
17. + exchanger in luminal membrane vesicles isolated from cortical tubules
18. Evidence indicating that pig renal phosphate glutaminase has a functional predominant external localization in the inner mitochondrial membrane
19. Peroxisome proliferator-activated receptor-γ troglitazone protects against nondiabetic glomerulosclerosis in rats
20. Transamination pathways influencing L-glutamine and L-glutamate oxidation by rat enterocyte mitochondria and subcellular localization of L-alanine aminotransferase and L-aspartate aminotransferase
21. Troglitazone halts diabetic glomerulosclerosis by blockade of mesangial expansion
22. The pathways of glutamate and glutamine oxidation by tumor cell mitochondria
23. + cells to metabolic acidosis
24. Intracellular ion activities and membrane transport in parietal cells measured with fluorescent dyes
25. Evidence that glutamine, and not sugar, is the major energy source for cultured HeLa cells
26. + exchange in porcine jejunal enterocytes
27. Properties and submitochondrial localization of pig and rat renal phosphate-activated glutaminase
28. Direct action of troglitazone on mesangial cell behavior: Troglitazone suppresses the secretion of type 1 collagen by mesangial cells in vitro
29. Troglitazone inhibits glutamine metabolism in rat mesangial cells
30. Transport of metabolic substrates in renal mitochondria
31. Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ
32. Renal glutamine metabolism and hydrogen ion homeostasis
33. The glutamine/glutamate couplet and cellular function
34. Intracellular acidosis activates c-Src