15-Deoxy-Δ12,14-prostaglandin J2 induces mitochondrial-dependent apoptosis through inhibition of PKA/NF-κB in renal proximal epithelial cells

Toxicology

Volumn 258, Issue 1, 2009, Pages 17-24

  Lee, Dong Ryeol ^a   Kwon, Chae Hwa ^a   Park, Ji Yeon ^a   Kim, Yong Keun ^a   Woo, Jae Suk ^a  

^a Pusan National University School of Medicine   (South Korea)

Author keywords

Apoptosis; Bax; Cytochrome c release; Mitochondrial membrane potential; NF B; PKA; Renal proximal epithelial cells

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; CASPASE 3; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYTOCHROME C; FORSKOLIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN BAX; TRANSCRIPTION FACTOR RELA;

ANIMAL CELL; APOPTOSIS; ARTICLE; ATTENUATION; CELL DEATH; CONTROLLED STUDY; DRUG INHIBITION; ENZYME ACTIVATION; ENZYME INHIBITION; EPITHELIUM CELL; GENE; GENETIC TRANSFECTION; KIDNEY EPITHELIUM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CASPASES; CELL SURVIVAL; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYTOCHROMES C; EPITHELIAL CELLS; GENES, REPORTER; IMMUNOHISTOCHEMISTRY; KIDNEY TUBULES, PROXIMAL; LUCIFERASES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NF-KAPPA B; OPOSSUMS; PROSTAGLANDIN D2;

EID: 60249095867     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2009.01.001     Document Type: Article

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