Characterization of the oligomeric states of insulin in self-assembly and amyloid fibril formation by mass spectrometry

Biophysical Journal

Volumn 79, Issue 2, 2000, Pages 1053-1065

  Nettleton, Ewan J ^a   Tito, Paula ^a   Sunde, Margaret ^b   Bouchard, Mario ^a   Dobson, Christopher M ^a   Robinson, Carol V ^a,c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; INSULIN;

ANALYTIC METHOD; ARTICLE; ELECTRON MICROSCOPY; FIBER; FOURIER ANALYSIS; INSULIN SYNTHESIS; MASS SPECTROMETRY; OLIGOMERIZATION; PROTEIN AGGREGATION; PROTEIN SECONDARY STRUCTURE;

EID: 0033869084     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(00)76359-4     Document Type: Article

References (6)

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2. Bai, Y., J. S. Milne, L. Mayne, and S. W. Englander. 1993. Primary structure effects on peptide group hydrogen exchange. Proteins Struct. Funct., Genet. 17:75-86.
3. Benson, M. D. 1989. Familial amyloidotic polyneuropathy. Trends Biochem. Sci. 12:88-92.
4. Booth, D., M. Sunde, V. Bellotti, C. V. Robinson, W. L. Hutchinson, P. E. Fraser, P. N. Hawkins, C. M. Dobson, S. E. Radford, C. C. F. Blake, and M. B. Pepys. 1997. Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis. Nature. 385: 787-793.
5. Bouchard, M., J. Zurdo, E. J. Nettleton, C. V. Robinson, and C. M. Dobson. submitted. Formation of insulin amyloid fibrils followed by FTIR simultaneously with CD and electron microscopy. Submitted.
6. Brange, J., L. Andersen, E. D. Laursen, G. Meyn, and E. Rasmussen. 1997a:Toward understanding insulin fibrillation. J. Pharm. Sci. 86: 517-25.