In vivo and in vitro characteristics for insulin-loaded PLA microparticles prepared by w/o/w solvent evaporation method with electrolytes in the continuous phase

Journal of Microencapsulation

Volumn 21, Issue 7, 2004, Pages 719-728

  Yeh, M K ^a   Chen, J L ^b   Chiang, C H ^b  

^a TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^b NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

Electrolytes; Insulin; Microparticles; Poly(lactide); Solvent evaporation method

Indexed keywords

CALCIUM CHLORIDE; ELECTROLYTE; GLUCOSE; INSULIN; POLYLACTIDE; SODIUM CHLORIDE; WATER OIL CREAM;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG RELEASE; EMULSION; EVAPORATION; GLUCOSE BLOOD LEVEL; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROENCAPSULATION; NONHUMAN; PARTICLE SIZE; PHASE TRANSITION; PHYSICAL CHEMISTRY; PROTEIN LOCALIZATION; PROTEIN SECRETION; RABBIT; SOLVENT EXTRACTION; STEADY STATE;

ANIMALS; BLOOD GLUCOSE; DELAYED-ACTION PREPARATIONS; DRUG COMPOUNDING; ELECTROLYTES; HYPOGLYCEMIC AGENTS; INSULIN; MALE; MICROSPHERES; POLYESTERS; RABBITS; RANDOM ALLOCATION;

EID: 11944260300     PISSN: 02652048     EISSN: None     Source Type: Journal    
DOI: 10.1080/02652040400008481     Document Type: Article

References (17)

1. Chen, J. L., Yeh, M. K. and Chiang, C. H., 2002, The mechanism of PLA microparticle formation by water-in-oil-in-water solvent evaporation method. Journal of Microencapsulation, 19, 333-346.
2. Chen, J. L., Yeh, M. K. and Chiang, C. H., 2003, The mechamism of surface-idented protein-loaded PLGA microparticle formulation: the effect of salt (NaCl) on the solidification process. Journal of Microencapsulation, in press.
3. Coombes, A. G. A., Yeh, M. K., Eavelle, E. C. and Davis, S. S., 1998, The control of protein release from poly(DL lactide co-glycolide) microparticles by variation of the external aqueous phase surfactant in the water-in oil-in water method. Journal of Controlled Release, 52, 311-320.
4. Crotts, G. and Park, T. G., 1997, Stability and release of bovine serum albumin encapsulated within poly(DL-lactide-co-glycolide) microparticles. Journal of Controlled Release, 44, 123-134.
5. Eavelle, E. C., Yeh, M. K., Coombes, A. G. A. and Davis, S. S., 1999, The stability and immunogenicity of a protein antigen encapsulated in biodegradable microparticles based on blends of lactide polymers and polyethylene glycol. Vaccine, 17, 512-529.
6. Gombotz, W. R. and Pettit, D. K., 1995, Biodegradable polymers for protein and peptide drug delivery. Bioconjugate Chemistry 6, 332-351.
7. Home, P., 1999, Insulin glargine: the first clinically useful extended acting insulin in half a century? Expert Opinions in Investigative Drugs, 8, 307-314.
8. Jenkins, P. G., Coombes, A. G. A., Yeh, M. K., Thomas, N. W. and Davis, S. S., 1995, Aspects of the design and delivery of microparticles for vaccine application. Journal of Drug Targeting, 3, 79-81.
9. Kim, H. K. and Park, T. G., 1999, Microencapsulation of human growth hormone within biodegradable polyester microspheres: protein aggregation, stability and incomplete release mechanism. Biotechnology and Bioengineering, 65, 659-667.
10. Uchida, T., Yoshida, K. and Goto, S., 1996, Preparation and characterization of polyactic acid microsphere containing water-soluble dyes using a novel w/o/w emulsion solvent evaporation method. Journal of Microencapsulation, 13, 219-228.
11. Weert, M., Hennink, W. E. and Jiskoot, W., 2000, Protein instability in poly(lactic-co-glycolic acid) microparticles. Pharmaceutical Research, 17, 1159-1167.
12. Yeh, M. K., 2000, The stability of insulin in biodegradable microparticles based on blends of lactide polymers and polyethylene glycol. Journal of Microencapsulation, 17, 743-756.
13. Yeh, M. K, Chen, J. L. and Chiang, C. H., 2002a, Vibrio cholerae-loaded poly(DL lactide co-glycolide) microparticles. Journal of Microencapsulation, 19, 203-212.
14. Yeh, M. K., Chen, J. L. and Chiang, C. H., 2002b, Oral immunogenicity of the inactived Vibrio cholerae whole-cell vaccine encapsulated in biodegradable microparticles. Journal of Controlled Release, 82, 237-247.
15. Yeh, M. K., Coombes, A. G. A., Chen, J. L. and Chiang, C. H., 2002c, Japanese encephalitis virus vaccine formulations using PLA lamellar and PLG microparticles adjuvant. Journal of Microencapsulation, 19, 671-682.
16. Yeh, M. K., Coombes, A. G. A., Jenkins, P. G. and Davis, S. S., 1995a, A novel emulsification-solvent extraction technique for production of protein loaded biodegradable microparticles for vaccine and drug delivery. Journal of Controlled Release, 33, 437-445.
17. Yeh, M. K., Jenkins, P. G., Davis, S. S. and Coombes, A. G. A., 1995b, Improving the delivery capacity of microparticle systems using blends of poly(DL lactide co-glycolide) and poly(ethylene glycol). Journal of Controlled Release, 37, 1-9.