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Volumn 25, Issue 12, 2008, Pages 1483-1497

Pathology dynamics predict spinal cord injury therapeutic success

Author keywords

Combination therapy; Neuroprotection; Secondary insult; Spinal cord injury; Therapeutic treatment window; Traumatic brain injury

Indexed keywords

ARTICLE; DISEASE COURSE; EVALUATION; EXPERIMENTAL STUDY; METHODOLOGY; NERVE CELL NECROSIS; PATHOLOGY; PREDICTION; QUANTITATIVE ANALYSIS; SPINAL CORD INJURY; TREATMENT OUTCOME;

EID: 59649093550     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.2008.0658     Document Type: Article
Times cited : (20)

References (84)
  • 2
    • 0031020308 scopus 로고    scopus 로고
    • Role of NMDA and non-NMDA ionotropic glutamate receptors in traumatic spinal cord axonal injury
    • Agrawal, S.K., and Fehlings, M.G. (1997). Role of NMDA and non-NMDA ionotropic glutamate receptors in traumatic spinal cord axonal injury. J. Neurosci. 17, 1055-1063.
    • (1997) J. Neurosci , vol.17 , pp. 1055-1063
    • Agrawal, S.K.1    Fehlings, M.G.2
  • 3
    • 0036931846 scopus 로고    scopus 로고
    • NMDA receptor activation contributes to a portion of the decreased mitochondrial membrane potential and elevated intracellular free calcium in strain-injured neurons
    • Ahmed, S.M., Weber, J.T., Liang, S., Willoughby, K.A., Sitterding, H.A., Rzigalinski, B.A., and Ellis, E.F. (2002). NMDA receptor activation contributes to a portion of the decreased mitochondrial membrane potential and elevated intracellular free calcium in strain-injured neurons. J. Neurotrauma 19, 1619-1629.
    • (2002) J. Neurotrauma , vol.19 , pp. 1619-1629
    • Ahmed, S.M.1    Weber, J.T.2    Liang, S.3    Willoughby, K.A.4    Sitterding, H.A.5    Rzigalinski, B.A.6    Ellis, E.F.7
  • 4
    • 0036488223 scopus 로고    scopus 로고
    • Mitochondrial permeability transition and calcium dynamics in striatal neurons upon intense NMDA receptor activation
    • Alano, C.C., Beutner, G., Dirksen, R.T., Gross, R.A., and Sheu, S.S. (2002). Mitochondrial permeability transition and calcium dynamics in striatal neurons upon intense NMDA receptor activation. J. Neurochem. 80, 531-538.
    • (2002) J. Neurochem , vol.80 , pp. 531-538
    • Alano, C.C.1    Beutner, G.2    Dirksen, R.T.3    Gross, R.A.4    Sheu, S.S.5
  • 5
    • 0018849188 scopus 로고
    • Spinal cord energy metabolism following compression trauma to the feline spinal cord
    • Anderson, D.K., Means, E.D., Waters, T.R., and Spears, C.J. (1980) Spinal cord energy metabolism following compression trauma to the feline spinal cord. J. Neurosurg. 53, 375-380.
    • (1980) J. Neurosurg , vol.53 , pp. 375-380
    • Anderson, D.K.1    Means, E.D.2    Waters, T.R.3    Spears, C.J.4
  • 6
    • 0028793257 scopus 로고
    • Glutamate-induced neuronal death - a succession of necrosis or apoptosis depending on mitochondrial-function
    • Ankarcrona, M., Dypbukt, J.M., Bonfoco, E., Zhivotovsky, B., Orrenius, S., Lipton, S.A., and Nicotera, P. (1995) Glutamate-induced neuronal death - a succession of necrosis or apoptosis depending on mitochondrial-function. Neuron 15, 961-973.
    • (1995) Neuron , vol.15 , pp. 961-973
    • Ankarcrona, M.1    Dypbukt, J.M.2    Bonfoco, E.3    Zhivotovsky, B.4    Orrenius, S.5    Lipton, S.A.6    Nicotera, P.7
  • 7
    • 34249069211 scopus 로고    scopus 로고
    • Comparative neuroprotective effect of sodium channel blockers after experimental spinal cord injury
    • Ates, O., Cayli, S.R., Gurses, I., Turkoz, Y., Tarim, O., Cakir, C.O., and Kocak, A. (2007). Comparative neuroprotective effect of sodium channel blockers after experimental spinal cord injury. J. Clin. Neurosci. 14, 658-665.
    • (2007) J. Clin. Neurosci , vol.14 , pp. 658-665
    • Ates, O.1    Cayli, S.R.2    Gurses, I.3    Turkoz, Y.4    Tarim, O.5    Cakir, C.O.6    Kocak, A.7
  • 8
    • 0030981722 scopus 로고    scopus 로고
    • Impaired mitochondrial function, oxidative stress and altered antioxidant enzyme activities following traumatic spinal cord injury
    • Azbill, R.D., Mu, X., Bruce-Keller, A.J., Mattson, M.P., and Springer, J.E. (1997). Impaired mitochondrial function, oxidative stress and altered antioxidant enzyme activities following traumatic spinal cord injury. Brain Res. 765, 283-290.
    • (1997) Brain Res , vol.765 , pp. 283-290
    • Azbill, R.D.1    Mu, X.2    Bruce-Keller, A.J.3    Mattson, M.P.4    Springer, J.E.5
  • 9
    • 0030842973 scopus 로고    scopus 로고
    • Expression of pro-inflammatory cytokine and chemokine mRNA upon experimental spinal cord injury in mouse: An in situ hybridization study
    • Bartholdi, D., and Schwab, M.E. (1997). Expression of pro-inflammatory cytokine and chemokine mRNA upon experimental spinal cord injury in mouse: an in situ hybridization study. Eur. J. Neurosci. 9, 1422-1438.
    • (1997) Eur. J. Neurosci , vol.9 , pp. 1422-1438
    • Bartholdi, D.1    Schwab, M.E.2
  • 10
    • 23744457144 scopus 로고    scopus 로고
    • The neuroprotective effects of z-DEVD.fmk, a caspase-3 inhibitor, on traumatic spinal cord injury in rats
    • Barut, S., Unlu, Y.A., Karaoglan, A., Tuncdemir, M., Dagistanli, F.K., Ozturk, M., and Colak, A. (2005). The neuroprotective effects of z-DEVD.fmk, a caspase-3 inhibitor, on traumatic spinal cord injury in rats. Surg. Neurol. 64, 213-220.
    • (2005) Surg. Neurol , vol.64 , pp. 213-220
    • Barut, S.1    Unlu, Y.A.2    Karaoglan, A.3    Tuncdemir, M.4    Dagistanli, F.K.5    Ozturk, M.6    Colak, A.7
  • 11
    • 9644259008 scopus 로고    scopus 로고
    • Inflammation and apoptosis: Linked therapeutic targets in spinal cord injury
    • Beattie, M.S. (2004). Inflammation and apoptosis: linked therapeutic targets in spinal cord injury. Trends Mol. Med. 10, 580-583.
    • (2004) Trends Mol. Med , vol.10 , pp. 580-583
    • Beattie, M.S.1
  • 12
    • 0022252884 scopus 로고
    • Delayed demyelination and macrophage invasion: A candidate for secondary cell damage in spinal cord injury
    • Blight, A.R. (1985). Delayed demyelination and macrophage invasion: a candidate for secondary cell damage in spinal cord injury. Cent. Nerv. Syst. Trauma 2, 299-315.
    • (1985) Cent. Nerv. Syst. Trauma , vol.2 , pp. 299-315
    • Blight, A.R.1
  • 13
    • 33646574277 scopus 로고    scopus 로고
    • Clinical trials in spinal cord injury
    • Blight, A.R., and Tuszynski, M.H. (2006). Clinical trials in spinal cord injury. J. Neurotrauma 23, 586-593.
    • (2006) J. Neurotrauma , vol.23 , pp. 586-593
    • Blight, A.R.1    Tuszynski, M.H.2
  • 14
    • 0032079920 scopus 로고    scopus 로고
    • Acute inflammatory response in spinal cord following impact injury
    • Carlson, S.L., Parrish, M.E., Springer, J.E., Doty, K., and Dossett, L. (1998). Acute inflammatory response in spinal cord following impact injury. Exp. Neurol. 151, 77-88.
    • (1998) Exp. Neurol , vol.151 , pp. 77-88
    • Carlson, S.L.1    Parrish, M.E.2    Springer, J.E.3    Doty, K.4    Dossett, L.5
  • 16
    • 34047158711 scopus 로고    scopus 로고
    • Contusion, dislocation, and distraction: Primary hemorrhage and membrane permeability in distinct mechanisms of spinal cord injury
    • Choo, A.M., Liu, J., Lam, C.K., Dvorak, M., Tetzlaff, W., and Oxland, T.R. (2007). Contusion, dislocation, and distraction: primary hemorrhage and membrane permeability in distinct mechanisms of spinal cord injury. J. Neurosurg. Spine 6, 255-266.
    • (2007) J. Neurosurg. Spine , vol.6 , pp. 255-266
    • Choo, A.M.1    Liu, J.2    Lam, C.K.3    Dvorak, M.4    Tetzlaff, W.5    Oxland, T.R.6
  • 18
    • 0031015075 scopus 로고    scopus 로고
    • Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys
    • Crowe, M.J., Bresnahan, J.C., Shuman, S.L., Masters, J.N., and Beattie, M.S. (1997). Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys. Nat. Med. 3, 73-76.
    • (1997) Nat. Med , vol.3 , pp. 73-76
    • Crowe, M.J.1    Bresnahan, J.C.2    Shuman, S.L.3    Masters, J.N.4    Beattie, M.S.5
  • 19
    • 59649128703 scopus 로고    scopus 로고
    • Abstracts: The effects of shear versus compressive loading in 3-D neuronal-astrocytic co-cultures
    • Cullen, D.K., Vernekar, V., and LaPlaca, M.C. (2006a). Abstracts: The effects of shear versus compressive loading in 3-D neuronal-astrocytic co-cultures. J Neurotrauma 23, 986.
    • (2006) J Neurotrauma , vol.23 , pp. 986
    • Cullen, D.K.1    Vernekar, V.2    LaPlaca, M.C.3
  • 20
    • 33947667827 scopus 로고    scopus 로고
    • Neuronal response to high rate shear deformation depends on heterogeneity of the local strain field
    • Cullen, D.K., and LaPlaca, M.C. (2006b). Neuronal response to high rate shear deformation depends on heterogeneity of the local strain field. J. Neurotrauma 23, 1304-1319.
    • (2006) J. Neurotrauma , vol.23 , pp. 1304-1319
    • Cullen, D.K.1    LaPlaca, M.C.2
  • 21
    • 0028326548 scopus 로고
    • Secondary cell-death and the inflammatory reaction after dorsal hemisection of the rat spinal-cord
    • Dusart, I., and Schwab, M.E. (1994). Secondary cell-death and the inflammatory reaction after dorsal hemisection of the rat spinal-cord. Eur. J. Neurosci. 6, 712-724.
    • (1994) Eur. J. Neurosci , vol.6 , pp. 712-724
    • Dusart, I.1    Schwab, M.E.2
  • 22
    • 0023186384 scopus 로고
    • +-ATPase activity, and tissue water content of spinal cord following experimental traumatic injury
    • +-ATPase activity, and tissue water content of spinal cord following experimental traumatic injury. J. Neurochem. 48, 1809-1816.
    • (1987) J. Neurochem , vol.48 , pp. 1809-1816
    • Faden, A.I.1    Chan, P.H.2    Longar, S.3
  • 23
    • 34250305937 scopus 로고    scopus 로고
    • Neuroprotection: Challenges and opportunities
    • Faden, A.I., and Stoica, B. (2007). Neuroprotection: challenges and opportunities. Arch. Neurol. 64, 794-800.
    • (2007) Arch. Neurol , vol.64 , pp. 794-800
    • Faden, A.I.1    Stoica, B.2
  • 24
    • 33645220601 scopus 로고    scopus 로고
    • Mechanoporation induced by diffuse traumatic brain injury: An irreversible or reversible response to injury?
    • Farkas, O., Lifshitz, J., and Povlishock, J.T. (2006). Mechanoporation induced by diffuse traumatic brain injury: An irreversible or reversible response to injury? J. Neurosci. 26, 3130-3140.
    • (2006) J. Neurosci , vol.26 , pp. 3130-3140
    • Farkas, O.1    Lifshitz, J.2    Povlishock, J.T.3
  • 25
    • 0033180342 scopus 로고    scopus 로고
    • The glial scar and central nervous system repair
    • Fawcett, J.W., and Asher, R.A. (1999). The glial scar and central nervous system repair. Brain Res. Bull. 49, 377-391.
    • (1999) Brain Res. Bull , vol.49 , pp. 377-391
    • Fawcett, J.W.1    Asher, R.A.2
  • 26
    • 0028820408 scopus 로고
    • Role of sodium in the pathophysiology of secondary spinal cord injury
    • Fehlings, M.G., and Agrawal, S. (1995). Role of sodium in the pathophysiology of secondary spinal cord injury. Spine 20, 2187-2191.
    • (1995) Spine , vol.20 , pp. 2187-2191
    • Fehlings, M.G.1    Agrawal, S.2
  • 28
    • 23644454065 scopus 로고    scopus 로고
    • Geranylgeranylacetone limits secondary injury, neuronal death, and progressive necrosis and cavitation after spinal cord injury
    • Fujiki, M., Furukawa, Y., Kobayashi, H., Abe, T., Ishii, K., Uchida, S., and Kamida, T. (2005). Geranylgeranylacetone limits secondary injury, neuronal death, and progressive necrosis and cavitation after spinal cord injury. Brain Res. 1053, 175-184.
    • (2005) Brain Res , vol.1053 , pp. 175-184
    • Fujiki, M.1    Furukawa, Y.2    Kobayashi, H.3    Abe, T.4    Ishii, K.5    Uchida, S.6    Kamida, T.7
  • 29
    • 33744792355 scopus 로고    scopus 로고
    • Time course of acute phase in mouse spinal cord injury monitored by ex vivo quantitative MRI
    • Gaviria, M., Bonny, J.M., Haton, H., Jean, B., Teigell, M., Renou, J.P., and Privat, A. (2006). Time course of acute phase in mouse spinal cord injury monitored by ex vivo quantitative MRI. Neurobiol. Dis. 22, 694-701.
    • (2006) Neurobiol. Dis , vol.22 , pp. 694-701
    • Gaviria, M.1    Bonny, J.M.2    Haton, H.3    Jean, B.4    Teigell, M.5    Renou, J.P.6    Privat, A.7
  • 30
    • 0025058337 scopus 로고
    • Inhibition of mononuclear phagocytes reduces ischemic injury in the spinal cord
    • Giulian, D., and Robertson, C. (1990). Inhibition of mononuclear phagocytes reduces ischemic injury in the spinal cord. Ann. Neurol. 27, 33-42.
    • (1990) Ann. Neurol , vol.27 , pp. 33-42
    • Giulian, D.1    Robertson, C.2
  • 31
    • 3042776205 scopus 로고    scopus 로고
    • Mechanical injury modulates AMPA receptor kinetics via an NMDA receptor-dependent pathway
    • Goforth, P.B., Ellis, E.F., and Satin, L.S. (2004). Mechanical injury modulates AMPA receptor kinetics via an NMDA receptor-dependent pathway. J. Neurotrauma 21, 719-732.
    • (2004) J. Neurotrauma , vol.21 , pp. 719-732
    • Goforth, P.B.1    Ellis, E.F.2    Satin, L.S.3
  • 32
    • 8744287793 scopus 로고    scopus 로고
    • Astrocytosis, microglia activation, oligodendrocyte degeneration, and pyknosis following acute spinal cord injury
    • Gomes-Leal, W., Corkill, D.J., Freire, M.A., Picanco-Diniz, C.W., and Perry, V.H. (2004). Astrocytosis, microglia activation, oligodendrocyte degeneration, and pyknosis following acute spinal cord injury. Exp. Neurol. 190, 456-467.
    • (2004) Exp. Neurol , vol.190 , pp. 456-467
    • Gomes-Leal, W.1    Corkill, D.J.2    Freire, M.A.3    Picanco-Diniz, C.W.4    Perry, V.H.5
  • 33
    • 0032404536 scopus 로고    scopus 로고
    • The central executioners of apoptosis: Caspases or mitochondria?
    • Green, D., and Kroemer, G. (1998). The central executioners of apoptosis: caspases or mitochondria? Trends Cell Biol. 8, 267-271.
    • (1998) Trends Cell Biol , vol.8 , pp. 267-271
    • Green, D.1    Kroemer, G.2
  • 35
    • 17444392322 scopus 로고    scopus 로고
    • Neuroprotection and acute spinal cord injury: A reappraisal
    • Hall, E.D., and Springer, J.E. (2004). Neuroprotection and acute spinal cord injury: a reappraisal. NeuroRx 1, 80-100.
    • (2004) NeuroRx , vol.1 , pp. 80-100
    • Hall, E.D.1    Springer, J.E.2
  • 38
    • 0030974030 scopus 로고    scopus 로고
    • Cytokine-mediated neuronal apoptosis
    • Hu, S., Peterson, P.K., and Chao, C.C. (1997). Cytokine-mediated neuronal apoptosis. Neurochem. Int. 30, 427-431.
    • (1997) Neurochem. Int , vol.30 , pp. 427-431
    • Hu, S.1    Peterson, P.K.2    Chao, C.C.3
  • 39
    • 0036276141 scopus 로고    scopus 로고
    • Sodium accumulation during ischemia induces mitochondrial damage in perfused rat hearts
    • Iwai, T., Tanonaka, K., Inoue, R., Kasahara, S., Motegi, K., Nagaya, S., and Takeo, S. (2002). Sodium accumulation during ischemia induces mitochondrial damage in perfused rat hearts. Cardiovasc. Res. 55, 141-149.
    • (2002) Cardiovasc. Res , vol.55 , pp. 141-149
    • Iwai, T.1    Tanonaka, K.2    Inoue, R.3    Kasahara, S.4    Motegi, K.5    Nagaya, S.6    Takeo, S.7
  • 40
    • 0026653449 scopus 로고
    • Cell swelling, blebbing, and death are dependent on atp depletion and independent of calcium during chemical hypoxia in a glial-cell line (Roc-1)
    • Jurkowitzalexander, M.S., Altschuld, R.A., Hohl, C.M., Johnson, J.D., Mcdonald, J.S., Simmons, T.D., and Horrocks, L.A. (1992). Cell swelling, blebbing, and death are dependent on atp depletion and independent of calcium during chemical hypoxia in a glial-cell line (Roc-1). J. Neurochem. 59, 344-352.
    • (1992) J. Neurochem , vol.59 , pp. 344-352
    • Jurkowitzalexander, M.S.1    Altschuld, R.A.2    Hohl, C.M.3    Johnson, J.D.4    Mcdonald, J.S.5    Simmons, T.D.6    Horrocks, L.A.7
  • 42
    • 0030746939 scopus 로고    scopus 로고
    • Effects of pro-inflammatory cytokines in experimental spinal cord injury
    • Klusman, I., and Schwab, M.E. (1997). Effects of pro-inflammatory cytokines in experimental spinal cord injury. Brain Res. 762, 173-184.
    • (1997) Brain Res , vol.762 , pp. 173-184
    • Klusman, I.1    Schwab, M.E.2
  • 44
    • 0032522795 scopus 로고    scopus 로고
    • Dynamic mechanical deformation of neurons triggers an acute calcium response and cell injury involving the N-methyl-D-aspartate glutamate receptor
    • LaPlaca, M.C., and Thibault, L.E. (1998). Dynamic mechanical deformation of neurons triggers an acute calcium response and cell injury involving the N-methyl-D-aspartate glutamate receptor. J. Neurosci. Res. 52, 220-229.
    • (1998) J. Neurosci. Res , vol.52 , pp. 220-229
    • LaPlaca, M.C.1    Thibault, L.E.2
  • 46
    • 0035965699 scopus 로고    scopus 로고
    • +-dependent transport in spinal cord white matter
    • +-dependent transport in spinal cord white matter. Neuroscience 107, 675-683.
    • (2001) Neuroscience , vol.107 , pp. 675-683
    • Li, S.1    Stys, P.K.2
  • 47
    • 0032791163 scopus 로고    scopus 로고
    • Neurotoxicity of glutamate at the concentration released upon spinal cord injury
    • Liu, D., Xu, G.Y., Pan, E., and McAdoo, D.J. (1999). Neurotoxicity of glutamate at the concentration released upon spinal cord injury. Neuroscience 93, 1383-1389.
    • (1999) Neuroscience , vol.93 , pp. 1383-1389
    • Liu, D.1    Xu, G.Y.2    Pan, E.3    McAdoo, D.J.4
  • 48
    • 34248570041 scopus 로고    scopus 로고
    • Neuroprotection from secondary injury by polyethylene glycol requires its internalization
    • Liu-Snyder, P., Logan, M.P., Shi, R., Smith, D.T., and Borgens, R.B. (2007). Neuroprotection from secondary injury by polyethylene glycol requires its internalization. J. Exp. Biol. 210, 1455-1462.
    • (2007) J. Exp. Biol , vol.210 , pp. 1455-1462
    • Liu-Snyder, P.1    Logan, M.P.2    Shi, R.3    Smith, D.T.4    Borgens, R.B.5
  • 49
    • 0027398906 scopus 로고
    • CNTF protection of oligodendrocytes against natural and tumor necrosis factor-induced death
    • Louis, J.C., Magal, E., Takayama, S., and Varon, S. (1993). CNTF protection of oligodendrocytes against natural and tumor necrosis factor-induced death. Science 259, 689-692.
    • (1993) Science , vol.259 , pp. 689-692
    • Louis, J.C.1    Magal, E.2    Takayama, S.3    Varon, S.4
  • 50
    • 0342288638 scopus 로고    scopus 로고
    • Axonal changes in chronic demyelinated cervical spinal cord plaques
    • Lovas, G., Szilagyi, N., Majtenyi, K., Palkovits, M., and Komoly, S. (2000). Axonal changes in chronic demyelinated cervical spinal cord plaques. Brain 123, 308-317.
    • (2000) Brain , vol.123 , pp. 308-317
    • Lovas, G.1    Szilagyi, N.2    Majtenyi, K.3    Palkovits, M.4    Komoly, S.5
  • 51
    • 0034662011 scopus 로고    scopus 로고
    • Advances in secondary spinal cord injury: Role of apoptosis
    • Lu, J., Ashwell, K.W., and Waite, P. (2000). Advances in secondary spinal cord injury: role of apoptosis. Spine 25, 1859-1866.
    • (2000) Spine , vol.25 , pp. 1859-1866
    • Lu, J.1    Ashwell, K.W.2    Waite, P.3
  • 52
    • 9644291425 scopus 로고    scopus 로고
    • Analysis of mitochondrial generation and release of reactive oxygen species
    • Mattiasson, G. (2004). Analysis of mitochondrial generation and release of reactive oxygen species. Cytometry A 62A, 89-96.
    • (2004) Cytometry A , vol.62 A , pp. 89-96
    • Mattiasson, G.1
  • 53
    • 0027161216 scopus 로고
    • Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide
    • Merrill, J.E., Ignarro, L.J., Sherman, M.P., Melinek, J., and Lane, T.E. (1993). Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide. J. Immunol. 151, 2132-2141.
    • (1993) J. Immunol , vol.151 , pp. 2132-2141
    • Merrill, J.E.1    Ignarro, L.J.2    Sherman, M.P.3    Melinek, J.4    Lane, T.E.5
  • 54
    • 36949025998 scopus 로고    scopus 로고
    • Mitchell, C.S., Feng, S.S., and Lee, R.H. (2007). An analysis of glutamate spillover on the N-methyl-D-aspartate receptors at the cerebellar glomerulus. J. Neural Eng. 4, 276-282.
    • Mitchell, C.S., Feng, S.S., and Lee, R.H. (2007). An analysis of glutamate spillover on the N-methyl-D-aspartate receptors at the cerebellar glomerulus. J. Neural Eng. 4, 276-282.
  • 55
    • 36949035996 scopus 로고    scopus 로고
    • Mitchell, C.S., and Lee, R.H. (2007). Output-based comparison of alternative kinetic schemes for the NMDA receptor within a glutamate spillover model. J. Neural Eng. 4, 380-389.
    • Mitchell, C.S., and Lee, R.H. (2007). Output-based comparison of alternative kinetic schemes for the NMDA receptor within a glutamate spillover model. J. Neural Eng. 4, 380-389.
  • 56
    • 0033971898 scopus 로고    scopus 로고
    • Mitochondria and neuronal survival
    • Nicholls, D.G., and Budd, S.L. (2000). Mitochondria and neuronal survival. Physiol. Rev. 80, 315-360.
    • (2000) Physiol. Rev , vol.80 , pp. 315-360
    • Nicholls, D.G.1    Budd, S.L.2
  • 57
    • 0028007254 scopus 로고
    • Astrocyte response and transforming growth factor-beta localization in acute spinal cord injury
    • O'Brien, M.F., Lenke, L.G., Lou, J., Bridwell, K.H., and Joyce, M.E. (1994). Astrocyte response and transforming growth factor-beta localization in acute spinal cord injury. Spine 19, 2321-2329.
    • (1994) Spine , vol.19 , pp. 2321-2329
    • O'Brien, M.F.1    Lenke, L.G.2    Lou, J.3    Bridwell, K.H.4    Joyce, M.E.5
  • 58
    • 3042816808 scopus 로고    scopus 로고
    • The role of excitotoxicity in secondary mechanisms of spinal cord injury: A review with an emphasis on the implications for white matter degeneration
    • Park, E., Velumian, A.A., and Fehlings, M.G. (2004). The role of excitotoxicity in secondary mechanisms of spinal cord injury: a review with an emphasis on the implications for white matter degeneration. J. Neurotrauma 21, 754-774.
    • (2004) J. Neurotrauma , vol.21 , pp. 754-774
    • Park, E.1    Velumian, A.A.2    Fehlings, M.G.3
  • 59
    • 0029896102 scopus 로고    scopus 로고
    • Characterization of a distinct set of intra-axonal ultrastructural changes associated with traumatically induced alteration in axolemmal permeability
    • Pettus, E.H., and Povlishock, J.T. (1996). Characterization of a distinct set of intra-axonal ultrastructural changes associated with traumatically induced alteration in axolemmal permeability. Brain Res. 722, 1-11.
    • (1996) Brain Res , vol.722 , pp. 1-11
    • Pettus, E.H.1    Povlishock, J.T.2
  • 60
    • 33845568271 scopus 로고    scopus 로고
    • Proinflammatory cytokine synthesis in the injured mouse spinal cord: Multiphasic expression pattern and identification of the cell types involved
    • Pineau, I., and Lacroix, S. (2007). Proinflammatory cytokine synthesis in the injured mouse spinal cord: multiphasic expression pattern and identification of the cell types involved. J. Comp. Neurol. 500, 267-285.
    • (2007) J. Comp. Neurol , vol.500 , pp. 267-285
    • Pineau, I.1    Lacroix, S.2
  • 61
    • 0036295056 scopus 로고    scopus 로고
    • The neuropathological and behavioral consequences of intraspinal microglial/macrophage activation
    • Popovich, P.G., Guan, Z., McGaughy, V., Fisher, L., Hickey, W.F., Basso, D.M. (2002). The neuropathological and behavioral consequences of intraspinal microglial/macrophage activation. J Neuropathol Exp Neurol 61, 623-633.
    • (2002) J Neuropathol Exp Neurol , vol.61 , pp. 623-633
    • Popovich, P.G.1    Guan, Z.2    McGaughy, V.3    Fisher, L.4    Hickey, W.F.5    Basso, D.M.6
  • 62
    • 0031024876 scopus 로고    scopus 로고
    • Non-NMDA and NMDA receptor-mediated excitotoxic neuronal deaths in adult brain are morphologically distinct: Further evidence for an apoptosis-necrosis continuum
    • PorteraCailliau, C., Price, D.L., and Martin, L.J. (1997). Non-NMDA and NMDA receptor-mediated excitotoxic neuronal deaths in adult brain are morphologically distinct: further evidence for an apoptosis-necrosis continuum. J. Comp. Neurol. 378, 88-104.
    • (1997) J. Comp. Neurol , vol.378 , pp. 88-104
    • PorteraCailliau, C.1    Price, D.L.2    Martin, L.J.3
  • 63
    • 15244346246 scopus 로고    scopus 로고
    • Modeling of slow glutamate diffusion and AMPA receptor activation in the cerebellar glomerulus
    • Saftenku, E.E. (2005). Modeling of slow glutamate diffusion and AMPA receptor activation in the cerebellar glomerulus. J. Theoret. Biol. 234, 363-382.
    • (2005) J. Theoret. Biol , vol.234 , pp. 363-382
    • Saftenku, E.E.1
  • 64
    • 0032821690 scopus 로고    scopus 로고
    • Acute inflammatory responses to mechanical lesions in the CNS: Differences between brain and spinal cord
    • Schnell, L., Fearn, S., Klassen, H., Schwab, M.E., and Perry, V.H. (1999). Acute inflammatory responses to mechanical lesions in the CNS: differences between brain and spinal cord. Eur. J. Neurosci. 11, 3648-3658.
    • (1999) Eur. J. Neurosci , vol.11 , pp. 3648-3658
    • Schnell, L.1    Fearn, S.2    Klassen, H.3    Schwab, M.E.4    Perry, V.H.5
  • 65
    • 0029900303 scopus 로고    scopus 로고
    • Degeneration and regeneration of axons in the lesioned spinal cord
    • Schwab, M.E., and Bartholdi, D. (1996). Degeneration and regeneration of axons in the lesioned spinal cord. Physiol. Rev. 76, 319-370.
    • (1996) Physiol. Rev , vol.76 , pp. 319-370
    • Schwab, M.E.1    Bartholdi, D.2
  • 66
    • 0034867539 scopus 로고    scopus 로고
    • Evaluation of the neuroprotective effects of sodium channel blockers after spinal cord injury: Improved behavioral and neuroanatomical recovery with riluzole
    • Schwartz, G., and Fehlings, M.G. (2001). Evaluation of the neuroprotective effects of sodium channel blockers after spinal cord injury: improved behavioral and neuroanatomical recovery with riluzole. J. Neurosurg. 94, 245-256.
    • (2001) J. Neurosurg , vol.94 , pp. 245-256
    • Schwartz, G.1    Fehlings, M.G.2
  • 67
    • 33744933675 scopus 로고    scopus 로고
    • Conduction deficits and membrane disruption of spinal cord axons as a function of magnitude and rate of strain
    • Shi, R., and Whitebone, J. (2006). Conduction deficits and membrane disruption of spinal cord axons as a function of magnitude and rate of strain. J. Neurophysiol. 95, 3384-3390.
    • (2006) J. Neurophysiol , vol.95 , pp. 3384-3390
    • Shi, R.1    Whitebone, J.2
  • 68
    • 0032790541 scopus 로고    scopus 로고
    • Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury
    • Springer, J.E., Azbill, R.D., and Knapp, P.E. (1999). Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury. Nat. Med. 5, 943-946.
    • (1999) Nat. Med , vol.5 , pp. 943-946
    • Springer, J.E.1    Azbill, R.D.2    Knapp, P.E.3
  • 70
    • 0002625836 scopus 로고    scopus 로고
    • Review of clinical trials of neuroprotection in acute spinal cord injury
    • Tator, C.H., and Fehlings, M.G. (1999). Review of clinical trials of neuroprotection in acute spinal cord injury. Neurosurg. Focus 6, e8.
    • (1999) Neurosurg. Focus , vol.6
    • Tator, C.H.1    Fehlings, M.G.2
  • 71
    • 33749462602 scopus 로고    scopus 로고
    • Suppression of astroglial scar formation and enhanced axonal regeneration associated with functional recovery in a spinal cord injury rat model by the cell cycle inhibitor olomoucine
    • Tian, D.S., Yu, Z.Y., Xie, M.J., Bu, B.T., Witte, O.W., and Wang, W. (2006). Suppression of astroglial scar formation and enhanced axonal regeneration associated with functional recovery in a spinal cord injury rat model by the cell cycle inhibitor olomoucine. J. Neurosci. Res. 84, 1053-1063.
    • (2006) J. Neurosci. Res , vol.84 , pp. 1053-1063
    • Tian, D.S.1    Yu, Z.Y.2    Xie, M.J.3    Bu, B.T.4    Witte, O.W.5    Wang, W.6
  • 72
    • 33846590145 scopus 로고    scopus 로고
    • Cell cycle inhibition attenuates microglia induced inflammatory response and alleviates neuronal cell death after spinal cord injury in rats
    • Tian, D.S., Xie, M.J., Yu, Z.Y., Zhang, Q., Wang, Y.H., Chen, B., Chen, C., and Wang, W. (2007). Cell cycle inhibition attenuates microglia induced inflammatory response and alleviates neuronal cell death after spinal cord injury in rats. Brain Res. 1135, 177-185.
    • (2007) Brain Res , vol.1135 , pp. 177-185
    • Tian, D.S.1    Xie, M.J.2    Yu, Z.Y.3    Zhang, Q.4    Wang, Y.H.5    Chen, B.6    Chen, C.7    Wang, W.8
  • 73
    • 5444245546 scopus 로고    scopus 로고
    • Critical appraisal of neuroprotection trials in head injury: What have we learned?
    • Tolias, C.M., and Bullock, M.R. (2004). Critical appraisal of neuroprotection trials in head injury: what have we learned? NeuroRx 1, 71-79.
    • (2004) NeuroRx , vol.1 , pp. 71-79
    • Tolias, C.M.1    Bullock, M.R.2
  • 74
    • 18044391661 scopus 로고    scopus 로고
    • Spinal cord injury is accompanied by chronic progressive demyelination
    • Totoiu, M.O., and Keirstead, H.S. (2005). Spinal cord injury is accompanied by chronic progressive demyelination. J. Comp. Neurol. 486, 373-383.
    • (2005) J. Comp. Neurol , vol.486 , pp. 373-383
    • Totoiu, M.O.1    Keirstead, H.S.2
  • 75
    • 0036858432 scopus 로고    scopus 로고
    • Time course of proliferation and, elimination of microglia/macrophages in different neurodegenerative conditions
    • Vela, J.M., Yanez, A., Gonzalez, B., and Castellano, B. (2002). Time course of proliferation and, elimination of microglia/macrophages in different neurodegenerative conditions. J. Neurotrauma 19, 1503-1520.
    • (2002) J. Neurotrauma , vol.19 , pp. 1503-1520
    • Vela, J.M.1    Yanez, A.2    Gonzalez, B.3    Castellano, B.4
  • 76
    • 0028208495 scopus 로고
    • Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes
    • Volterra, A., Trotti, D., Tromba, C., Floridi, S., and Racagni, G. (1994). Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes. J. Neurosci. 14, 2924-2932.
    • (1994) J. Neurosci , vol.14 , pp. 2924-2932
    • Volterra, A.1    Trotti, D.2    Tromba, C.3    Floridi, S.4    Racagni, G.5
  • 77
    • 0029788243 scopus 로고    scopus 로고
    • Mitochondrial depolarization in glutamate-stimulated neurons: An early signal specific to excitotoxin exposure
    • White, R.J., and Reynolds, I.J. (1996). Mitochondrial depolarization in glutamate-stimulated neurons: an early signal specific to excitotoxin exposure. J. Neurosci. 16, 5688-5697.
    • (1996) J. Neurosci , vol.16 , pp. 5688-5697
    • White, R.J.1    Reynolds, I.J.2
  • 78
    • 0037716293 scopus 로고    scopus 로고
    • Early induction of secondary injury factors causing activation of calpain and mitochondria-mediated neuronal apoptosis following spinal cord injury in rats
    • Wingrave, J.M., Schaecher, K.E., Sribnick, E.A., Wilford, G.G., Ray, S.K., Hazen-Martin, D.J., Hogan, E.L., and Banik, N.L. (2003). Early induction of secondary injury factors causing activation of calpain and mitochondria-mediated neuronal apoptosis following spinal cord injury in rats. J. Neurosci. Res. 73, 95-104.
    • (2003) J. Neurosci. Res , vol.73 , pp. 95-104
    • Wingrave, J.M.1    Schaecher, K.E.2    Sribnick, E.A.3    Wilford, G.G.4    Ray, S.K.5    Hazen-Martin, D.J.6    Hogan, E.L.7    Banik, N.L.8
  • 79
    • 33846196606 scopus 로고    scopus 로고
    • Role of peroxynitrite in secondary oxidative damage after spinal cord injury
    • Xiong, Y., Rabchevsky, A.G., and Hall, E.D. (2007). Role of peroxynitrite in secondary oxidative damage after spinal cord injury. J. Neurochem. 100, 639-649.
    • (2007) J. Neurochem , vol.100 , pp. 639-649
    • Xiong, Y.1    Rabchevsky, A.G.2    Hall, E.D.3
  • 80
    • 2342550091 scopus 로고    scopus 로고
    • Concentrations of glutamate released following spinal cord injury kill oligodendrocytes in the spinal cord
    • Xu, G.Y., Hughes, M.G., Ye, Z., Hulsebosch, C.E., and McAdoo, D.J. (2004). Concentrations of glutamate released following spinal cord injury kill oligodendrocytes in the spinal cord. Exp. Neurol. 187, 329-336.
    • (2004) Exp. Neurol , vol.187 , pp. 329-336
    • Xu, G.Y.1    Hughes, M.G.2    Ye, Z.3    Hulsebosch, C.E.4    McAdoo, D.J.5
  • 81
    • 0028785511 scopus 로고
    • Role of N-methyl-D-aspartate receptor in acute spinal-cord injury
    • Yanase, M., Sakou, T., and Fukuda, T. (1995). Role of N-methyl-D-aspartate receptor in acute spinal-cord injury. J. Neurosurg. 83, 884-888.
    • (1995) J. Neurosurg , vol.83 , pp. 884-888
    • Yanase, M.1    Sakou, T.2    Fukuda, T.3
  • 82
    • 0029851067 scopus 로고    scopus 로고
    • Pathophysiology of oligodendroglial excitotoxicity
    • Yoshioka, A., Bacskai, B., and Pleasure, D. (1996). Pathophysiology of oligodendroglial excitotoxicity. J. Neurosci. Res. 46, 427-437.
    • (1996) J. Neurosci. Res , vol.46 , pp. 427-437
    • Yoshioka, A.1    Bacskai, B.2    Pleasure, D.3


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