Na+-K+-ATPase inhibition and depolarization induce glutamate release via reverse Na+-dependent transport in spinal cord white matter

Neuroscience

Volumn 107, Issue 4, 2001, Pages 675-683

  Li, S ^a   Stys, P K ^a  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

Calcium; Excitotoxicity; L trans pyrrolidine 2,4 dicarboxylic acid; Myelin; Na+ Ca2+ exchange; amino 3 hydroxy 5 methyl isoxazole 4 propionate

Indexed keywords

1 (4 AMINOPHENYL) 4 METHYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; 2 [2 [4 (4 NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA METHANESULFONATE; 2,4 PYRROLIDINEDICARBOXYLIC ACID; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); AMPA RECEPTOR; AMPA RECEPTOR ANTAGONIST; CALCIUM ION; GLUTAMATE RECEPTOR ANTAGONIST; GLUTAMIC ACID; KYNURENIC ACID; OUABAIN; POTASSIUM ION; SODIUM ION;

ACTION POTENTIAL; AMINO ACID TRANSPORT; ANIMAL TISSUE; ARTICLE; CELL ENERGY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPOLARIZATION; ENZYME INHIBITION; IMMUNOHISTOCHEMISTRY; ION EXCHANGE; MALE; NERVE FIBER; NEUROPROTECTION; NEUROSECRETION; NEUROTRANSMITTER RELEASE; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; RAT; SODIUM TRANSPORT; SPINAL CORD INJURY; WHITE MATTER;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; ANTI-ANXIETY AGENTS; ANTI-ARRHYTHMIA AGENTS; BENZODIAZEPINES; CALCIUM; DICARBOXYLIC ACIDS; ENZYME INHIBITORS; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; KYNURENIC ACID; MALE; MEMBRANE POTENTIALS; NA(+)-K(+)-EXCHANGING ATPASE; NERVE FIBERS, MYELINATED; NEUROTRANSMITTER UPTAKE INHIBITORS; OUABAIN; POTASSIUM; PYRROLIDINES; RATS; RATS, LONG-EVANS; RECEPTORS, AMPA; SODIUM; SPINAL CORD; THIOUREA;

EID: 0035965699     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(01)00385-2     Document Type: Article

References (61)

1. 2+ exchanger
2. Role of NMDA and non-NMDA ionotropic glutamate receptors in traumatic spinal cord axonal injury
3. Nonvesicular release of neurotransmitter
4. Glutamate release through volume-activated channels during spreading depression
5. Axonal L-type Ca(2+) channels and anoxic injury in rat CNS white matter
6. Expression of high-affinity neuronal and glial glutamate transporters in the rat optic nerve
7. Glutamate uptake
8. AMPA receptor activation is rapidly toxic to cortical astrocytes when desensitization is blocked
9. Expression of glutamate transporters in the adult bovine corpus callosum
10. Cellular origin of ischemia-induced glutamate release from brain tissue in vivo and in vitro
11. Voltage-gated calcium channels in CNS white matter: Role in anoxic injury
12. Expression of kainate-selective glutamate receptor subunits in glial cells of the adult bovine white matter
13. Cellular distribution and kinetic properties of high-affinity glutamate transporters
14. Glutamate efflux via the reversal of the sodium-dependent glutamate transporter caused by glycolytic inhibition in rat cultured astrocytes
15. L-trans-pyrrolidine-2,4-dicarboxylate and cis-1-aminocyclobutane-1,3-dicarboxylate behave as transportable, competitive inhibitors of the high-affinity glutamate transporters
16. 2+-dependent injury of the dorsal columns
17. 2+ channels in anoxic injury of spinal cord white matter
18. Expression of glutamate receptor genes in white matter: Developing and adult rat optic nerve
19. Calcium-dependent glutamate release concomitant with massive potassium flux during cerebral ischemia in vivo
20. Calcium stores in neurons and glia
21. Calcium in ischemic cell death
22. Spinal cord sodium, potassium, calcium, and water concentration changes in rats after graded contusion injury
23. The sodium-potassium ATPase inhibitor ouabain is neurotoxic in the rat substantia nigra and striatum
24. +-dependent glutamate uptake
25. Mechanisms of ionotropic glutamate receptor-mediated excitotoxicity in isolated spinal cord white matter
26. +-dependent glutamate transport
27. Elemental composition and water content of rat optic nerve myelinated axons and glial cells: Effects of in vitro anoxia and reoxygenation
28. Experimental spinal cord injury: Spatiotemporal characterization of elemental concentrations and water contents in axons and neuroglia
29. Characteristics of acute and chronic kainate excitotoxic damage to the optic nerve
30. Glutamate receptor-mediated toxicity in optic nerve oligodendrocytes
31. Freeze-fracture and cytochemical evidence for structural and functional alteration in the axolemma and myelin sheath of adult guinea pig optic nerve fibers after stretch injury
32. Evidence that reversed glutamate uptake contributes significantly to glutamate release following experimental injury to the rat spinal cord
33. Oligodendrocytes from forebrain are highly vulnerable to AMPA/kainate receptor-mediated excitotoxicity
34. Mitochondria and neuronal survival
35. Is high extracellular glutamate the key to excitotoxicity in traumatic brain injury?
36. Ethidium bromide staining reveals rapid cell dispersion in the rat dentate gyrus following ouabain-induced injury
37. Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons
38. Glutamate excitotoxicity in a model of multiple sclerosis
39. 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline reduces glial loss and acute white matter pathology after experimental spinal cord contusion
40. Glutamate release in severe brain ischaemia is mainly by reversed uptake
41. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate
42. 3H]-D-aspartate from primary astrocyte cultures in response to raised external potassium
43. A putative mechanism of demyelination in multiple sclerosis by a proteolytic enzyme, calpain
44. 2+ exchanger in rat central and peripheral myelinated axons
45. News on glutamate receptors in glial cells
46. WaveTrak: A data acquisition system and waveform database for the Macintosh
47. Anoxic and ischemic injury of myelinated axons in CNS white matter: From mechanistic concepts to therapeutics
48. At physiological temperature, Na-Ca exchange plays an important role in mediating spinal cord white matter injury
49. 2+ exchanger
50. Triggering and execution of neuronal death in brain ischaemia: Two phases of glutamate release by different mechanisms
51. Non-vesicular release of glutamate from glial cells by reversed electrogenic glutamate uptake
52. The role of glutamate transporters in glutamate homeostasis in the brain
53. Local blockade of sodium channels by tetrodotoxin ameliorates tissue loss and long-term functional deficits resulting from experimental spinal cord injury
54. Cellular and subcellular distribution of 2′,3′-cyclic nucleotide 3′-phosphodiesterase and its mRNA in the rat central nervous system
55. Molecular pharmacology and physiology of glutamate transporters in the central nervous system
56. Neurotoxicity of acute glutamate transport blockade depends on coactivation of both NMDA and AMPA/kainate receptors in organotypic hippocampal cultures
57. 2+ following intense glutamate stimulation of cultured rat forebrain neurones
58. Dose-dependent reduction of tissue loss and functional impairment after spinal cord trauma with the AMPA/kainate antagonist NBQX
59. Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors mediate excitotoxicity in the oligodendroglial lineage
60. Pathophysiology of oligodendroglial excitotoxicity
61. Flux coupling in a neuronal glutamate transporter