A highly conserved glycine within linker I and the extreme C terminus of G protein α subunits interact cooperatively in switching G protein-coupled receptor-to-effector specificity

Journal of Pharmacology and Experimental Therapeutics

Volumn 313, Issue 1, 2005, Pages 78-87

  Kostenis, Evi ^a   Martini, Lene ^a,b   Ellis, James ^c   Waldhoer, Maria ^b   Heydorn, Arne ^d   Rosenkilde, Mette M ^d   Norregaard, Pia K ^a   Jorgensen, Rasmus ^a   Whistler, Jennifer L ^b   Milligan, Graeme ^c  

^a 7TM Pharma ^*  (Denmark)

^b UNIVERSITY OF CALIFORNIA SAN FRANCISCO   (United States)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; G PROTEIN COUPLED RECEPTOR; GLYCINE; GUANINE NUCLEOTIDE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; MUTANT PROTEIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; COMPARATIVE STUDY; CONTROLLED STUDY; GENETIC CONSERVATION; HUMAN; HUMAN CELL; MOLECULAR MODEL; MOLECULAR RECOGNITION; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; BLOTTING, WESTERN; CALCIUM; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; CONSERVED SEQUENCE; COS CELLS; DNA; ENZYME-LINKED IMMUNOSORBENT ASSAY; GLYCINE; GTP-BINDING PROTEIN ALPHA SUBUNITS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); INOSITOL PHOSPHATES; LIGANDS; MOLECULAR SEQUENCE DATA; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 20144371840     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.080424     Document Type: Article

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