Can copper binding to the prion protein generate a misfolded form of the protein?

BioMetals

Volumn 22, Issue 1, 2009, Pages 159-175

  Pushie, M Jake ^a   Rauk, Arvi ^a   Jirik, Frank R ^b   Vogel, Hans J ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

Author keywords

cleavage; Copper binding; Density functional theory; Molecular dynamics; Oxidative damage; Prion protein; Protein misfolding

Indexed keywords

COPPER; GLYCINE; HISTIDINE; PRION PROTEIN; PROTEIN; TRYPTOPHAN;

CONFERENCE PAPER; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DENSITY FUNCTIONAL THEORY; ELECTRON TRANSPORT; METAL BINDING; MOLECULAR DYNAMICS; OXIDATION REDUCTION REACTION; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN FOLDING; PROTEIN LOCALIZATION; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; COMPUTER SIMULATION; COPPER; HUMANS; HYDROXYL RADICAL; INDOLES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; PRIONS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; THERMODYNAMICS; TRYPTOPHAN;

EID: 59449085625     PISSN: 09660844     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10534-008-9196-x     Document Type: Conference Paper

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