Raman optical activity and circular dichroism reveal dramatic differences in the influence of divalent copper and manganese ions on prion protein folding

Biochemistry

Volumn 47, Issue 8, 2008, Pages 2510-2517

  Zhu, Fujiang ^a   Davies, Paul ^b   Thompsett, Andrew R ^b   Kelly, Sharon M ^c   Tranter, George E ^d   Hecht, Lutz ^a   Isaacs, Neil W ^a   Brown, David R ^b   Barron, Laurence D ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b University of Bath   (United Kingdom)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINDING SITES; DICHROISM; MANGANESE COMPOUNDS;

COPPER BINDING; RAMAN OPTICAL ACTIVITY (ROA);

PROTEIN FOLDING;

COPPER; HISTIDINE; MANGANESE; PRION PROTEIN;

ALPHA HELIX; ARTICLE; CARBOXY TERMINAL SEQUENCE; CIRCULAR DICHROISM; GEOMETRY; OPTICAL ROTATION; PH; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN LOCALIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE;

ANIMALS; CATIONS, DIVALENT; CIRCULAR DICHROISM; COPPER; HEAVY IONS; MACROMOLECULAR SUBSTANCES; MANGANESE; MICE; MODELS, MOLECULAR; PRIONS; PROTEIN FOLDING; SPECTRUM ANALYSIS, RAMAN;

MURINAE;

EID: 39749155839     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi7022893     Document Type: Article

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