Degradation of fibrillar forms of Alzheimer's amyloid β-peptide by macrophages

Neurobiology of Aging

Volumn 29, Issue 5, 2008, Pages 707-715

  Majumdar, Amitabha ^a   Chung, Haeyong ^a,b   Dolios, Georgia ^c   Wang, Rong ^c   Asamoah, Nikiya ^a   Lobel, Peter ^d   Maxfield, Frederick R ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b Columbia University College of Physicians and Surgeons ^*  (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d RUTGERS UNIVERSITY   (United States)

Author keywords

A ; Alzheimer's disease; Clearance; Macrophages; Mass spectrometry

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; IODINE 125; LYSOSOME ENZYME; MANNOSE 6 PHOSPHATE;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL TYPE; CONTROLLED STUDY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MICROGLIA; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN DEGRADATION;

AMYLOID BETA-PROTEIN; CELLS, CULTURED; HUMANS; MACROPHAGES;

EID: 40849105303     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2006.12.001     Document Type: Article

References (35)

1. Akiyama H., Schwab C., Kondo H., Mori H., Kametani F., Ikeda K., and McGeer P.L. Granules in glial cells of patients with Alzheimer's disease are immunopositive for C-terminal sequences of beta-amyloid protein. Neurosci. Lett. 206 2-3 (1996) 169-172
2. Antzutkin O.N., Leapman R.D., Balbach J.J., and Tycko R. Supramolecular structural constraints on Alzheimer's beta-amyloid fibrils from electron microscopy and solid-state nuclear magnetic resonance. Biochemistry 41 51 (2002) 15436-15450
3. Bacskai B.J., Kajdasz S.T., Christie R.H., Carter C., Games D., Seubert P., Schenk D., and Hyman B.T. Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy. Nat. Med. 7 3 (2001) 369-372
4. Bard F., Cannon C., Barbour R., Burke R.L., Games D., Grajeda H., Guido T., Hu K., Huang J., Johnson-Wood K., Khan K., Kholodenko D., Lee M., Lieberburg I., Motter R., Nguyen M., Soriano F., Vasquez N., Weiss K., Welch B., Seubert P., Schenk D., and Yednock T. Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat. Med. 6 8 (2000) 916-919
5. Barton N.W., Furbish F.S., Murray G.J., Garfield M., and Brady R.O. Therapeutic response to intravenous infusions of glucocerebrosidase in a patient with Gaucher disease. Proc. Natl. Acad. Sci. U.S.A. 87 5 (1990) 1913-1916
6. Busciglio J., Gabuzda D.H., Matsudaira P., and Yankner B.A. Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells. Proc. Natl. Acad. Sci. U.S.A. 90 5 (1993) 2092-2096
7. Chung H., Brazil M.I., Soe T.T., and Maxfield F.R. Uptake, degradation, and release of fibrillar and soluble forms of Alzheimer's amyloid beta-peptide by microglial cells. J. Biol. Chem. 274 45 (1999) 32301-32308
8. Dahms N.M., Lobel P., and Kornfeld S. Mannose 6-phosphate receptors and lysosomal enzyme targeting. J. Biol. Chem. 264 21 (1989) 12115-12118
9. Davalos D., Grutzendler J., Yang G., Kim J.V., Zuo Y., Jung S., Littman D.R., Dustin M.L., and Gan W.B. ATP mediates rapid microglial response to local brain injury in vivo. Nat. Neurosci. 8 6 (2005) 752-758
10. Forman M.S., Trojanowski J.Q., and Lee V.M. Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs. Nat. Med. 10 10 (2004) 1055-1063
11. Frackowiak J., Wisniewski H.M., Wegiel J., Merz G.S., Iqbal K., and Wang K.C. Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce β-amyloid fibrils. Acta Neuropathol. (Berl.) 84 3 (1992) 225-233
12. Ghosh P., Dahms N.M., and Kornfeld S. Mannose 6-phosphate receptors: new twists in the tale. Nat. Rev. Mol. Cell. Biol. 4 3 (2003) 202-212
13. Kheterpal I., Williams A., Murphy C., Bledsoe B., and Wetzel R. Structural features of the Abeta amyloid fibril elucidated by limited proteolysis. Biochemistry 40 39 (2001) 11757-11767
14. Kyttala A., Heinonen O., Peltonen L., and Jalanko A. Expression and endocytosis of lysosomal aspartylglucosaminidase in mouse primary neurons. J. Neurosci. 18 19 (1998) 7750-7756
15. Lin L., and Lobel P. Production and characterization of recombinant human CLN2 protein for enzyme-replacement therapy in late infantile neuronal ceroid lipofuscinosis. Biochem. J. 357 Pt 1 (2001) 49-55
16. Nimmerjahn A., Kirchhoff F., and Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308 5726 (2005) 1314-1318
17. Paresce D.M., Chung H., and Maxfield F.R. Slow degradation of aggregates of the Alzheimer's disease amyloid β-protein by microglial cells. J. Biol. Chem. 272 46 (1997) 29390-29397
18. Paresce D.M., Ghosh R., and Maxfield F.R. Microglial cells internalize aggregates of the Alzheimer's disease amyloid β-protein via a scavenger receptor. Neuron 17 (1996) 553-565
19. Pessac B., Godin I., and Alliot F. Microglia: origin and development. Bull. Acad. Natl. Med. 185 2 (2001) 337-346 (discussion 46-47)
20. Petkova A.T., Buntkowsky G., Dyda F., Leapman R.D., Yau W.M., and Tycko R. Solid state NMR reveals a pH-dependent antiparallel beta-sheet registry in fibrils formed by a beta-amyloid peptide. J. Mol. Biol. 335 1 (2004) 247-260
21. Petkova A.T., Ishii Y., Balbach J.J., Antzutkin O.N., Leapman R.D., Delaglio F., and Tycko R. A structural model for Alzheimer's beta-amyloid fibrils based on experimental constraints from solid state NMR. Proc. Natl. Acad. Sci. U.S.A. 99 26 (2002) 16742-16747
22. Rogers J., and Lue L.F. Microglial chemotaxis, activation, and phagocytosis of amyloid beta-peptide as linked phenomena in Alzheimer's disease. Neurochem. Int. 39 5-6 (2001) 333-340
23. Saido T.C., Iwatsubo T., Mann D.M.A., Shimada H., Ihara Y., and Kawashima S. Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3 (pE), in senile plaques. Neuron 14 (1995) 457-466
24. Sakr S.W., Eddy R.J., Barth H., Wang F., Greenberg S., Maxfield F.R., and Tabas I. The uptake and degradation of matrix-bound lipoproteins by macrophages require an intact actin Cytoskeleton, Rho family GTPases, and myosin ATPase activity. J. Biol. Chem. 276 40 (2001) 37649-37658
25. Schenk D., Barbour R., Dunn W., Gordon G., Grajeda H., Guido T., Hu K., Huang J., Johnson-Wood K., Khan K., Kholodenko D., Lee M., Liao Z., Lieberburg I., Motter R., Mutter L., Soriano F., Shopp G., Vasquez N., Vandevert C., Walker S., Wogulls M., Yednock T., Games D., and Seubert P. Immunization with amyloid-β attenuates Alzheimer disease-like pathology in the PDAPP mouse. Nature 400 (1999) 173-177
26. Schiffmann R., Murray G.J., Treco D., Daniel P., Sellos-Moura M., Myers M., Quirk J.M., Zirzow G.C., Borowski M., Loveday K., Anderson T., Gillespie F., Oliver K.L., Jeffries N.O., Doo E., Liang T.J., Kreps C., Gunter K., Frei K., Crutchfield K., Selden R.F., and Brady R.O. Infusion of alpha-galactosidase A reduces tissue globotriaosylceramide storage in patients with Fabry disease. Proc. Natl. Acad. Sci. U.S.A. 97 1 (2000) 365-370
27. Shaffer L.M., Dority M.D., Gupta-Bansal R., Frederickson R.C.A., Younkin S.G., and Brunden K.R. Amyloid β protein (Aβ) removal by neuroglial cells in culture. Neurobiol. Aging 16 5 (1995) 737-745
28. Sleat D.E., Lackland H., Wang Y., Sohar I., Xiao G., Li H., and Lobel P. The human brain mannose 6-phosphate glycoproteome: a complex mixture composed of multiple isoforms of many soluble lysosomal proteins. Proteomics 5 6 (2005) 1520-1532
29. Steinberg D., Parthasarathy S., Carew T.E., Khoo J.C., and Witztum J.L. Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenicity. New Engl. J. Med. 320 14 (1989) 915-924
30. Wang R., Sweeney D., Gandy S.E., and Sisodia S.S. The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry. J. Biol. Chem. 271 50 (1996) 31894-31902
31. Wegiel J., Imaki H., Wang K.C., Wronska A., Osuchowski M., and Rubenstein R. Origin and turnover of microglial cells in fibrillar plaques of APPsw transgenic mice. Acta Neuropathol. (Berl.) 105 4 (2003) 393-402
32. Wegiel J., Wang K.C., Imaki H., Rubenstein R., Wronska A., Osuchowski M., Lipinski W.J., Walker L.C., and LeVine H. The role of microglial cells and astrocytes in fibrillar plaque evolution in transgenic APP (SW) mice. Neurobiol. Aging 22 1 (2001) 49-61
33. Wisniewski H.M., Wen G.Y., and Kim K.S. Comparison of four staining methods on the detection of neuritic plaques. Acta Neuropathol. (Berl.) 78 1 (1989) 22-27
34. Wisniewski T., Ghiso J., and Frangione B. Review: biology of Aβ amyloid in Alzheimer's disease. Neurobiol. Dis. 4 (1997) 313-328
35. Wright S.D., Weitz J.I., Huang A.J., Levin S.M., Silverstein S.C., and Loike J.D. Complement receptor type three (CD11b/CD18) of human polymorphonuclear leukocytes recognizes fibrinogen. Proc. Natl. Acad. Sci. U.S.A. 85 20 (1988) 7734-7738