메뉴 건너뛰기




Volumn 24, Issue 2, 2009, Pages 265-271

Critical role of IκB kinase alpha in embryonic skin development and skin carcinogenesis

Author keywords

Embryonic skin development; I B kinase alpha (IKK ); Nuclear factorkappaB(NF B); Skin carcinogenesis

Indexed keywords

CARCINOGEN; I KAPPA B ALPHA; INTERFERON REGULATORY FACTOR 6; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

EID: 59149093518     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (19)

References (51)
  • 1
    • 0023925008 scopus 로고
    • Sequential development of aneuploidy, keratin modifications, and gamma-glutamyltransferase expression in mouse skin papillomas
    • Aldaz C.M., Conti C.J., Larcher F., Trono D., Roop D.R., Chesner J., Whitehead T. and Slaga T.J. (1988). Sequential development of aneuploidy, keratin modifications, and gamma-glutamyltransferase expression in mouse skin papillomas. Cancer Res. 48, 3253-3257.
    • (1988) Cancer Res , vol.48 , pp. 3253-3257
    • Aldaz, C.M.1    Conti, C.J.2    Larcher, F.3    Trono, D.4    Roop, D.R.5    Chesner, J.6    Whitehead, T.7    Slaga, T.J.8
  • 2
    • 0020586334 scopus 로고
    • Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene
    • Balmain A. and Pragnell I.B. (1983). Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene. Nature 303, 72-74.
    • (1983) Nature , vol.303 , pp. 72-74
    • Balmain, A.1    Pragnell, I.B.2
  • 3
    • 0033852872 scopus 로고    scopus 로고
    • Mutations of the human PTEN gene
    • Bonneau D. and Longy M. (2000). Mutations of the human PTEN gene. Hum. Mutat. 16, 109-122.
    • (2000) Hum. Mutat , vol.16 , pp. 109-122
    • Bonneau, D.1    Longy, M.2
  • 5
    • 0035861314 scopus 로고    scopus 로고
    • IKKα provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development
    • Cao Y., Bonizzi G., Seagroves T.N., Greten F.R., Johnson R., Schmidt E.V. and Karin M. (2001). IKKα provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cell 107, 763-775.
    • (2001) Cell , vol.107 , pp. 763-775
    • Cao, Y.1    Bonizzi, G.2    Seagroves, T.N.3    Greten, F.R.4    Johnson, R.5    Schmidt, E.V.6    Karin, M.7
  • 6
    • 0029554095 scopus 로고
    • CHUK, a new member of the helix-loop-helix and leucine zipper families of interacting proteins, contains a serine-threonine kinase catalytic domain
    • Connelly M.A. and Marcu K.B. (1995). CHUK, a new member of the helix-loop-helix and leucine zipper families of interacting proteins, contains a serine-threonine kinase catalytic domain. Cell. Mol. Biol. Res. 41, 537-549.
    • (1995) Cell. Mol. Biol. Res , vol.41 , pp. 537-549
    • Connelly, M.A.1    Marcu, K.B.2
  • 7
    • 0034729189 scopus 로고    scopus 로고
    • Downregulation of 14-3-3σ prevents clonal evolution and leads to immortalization of primary human keratinocytes
    • Dellambra E., Golisano O., Bondanza S., Siviero E., Lacal P., Molinari M., D'Atri S. and De Luca M. (2000). Downregulation of 14-3-3σ prevents clonal evolution and leads to immortalization of primary human keratinocytes. J. Cell Biol. 149, 1117-1130.
    • (2000) J. Cell Biol , vol.149 , pp. 1117-1130
    • Dellambra, E.1    Golisano, O.2    Bondanza, S.3    Siviero, E.4    Lacal, P.5    Molinari, M.6    D'Atri, S.7    De Luca, M.8
  • 8
    • 0030610362 scopus 로고    scopus 로고
    • A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
    • DiDonato J.A., Hayakawa M., Rothwarf D.M., Zandi E. and Karin M. (1997). A cytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature 388, 548-554.
    • (1997) Nature , vol.388 , pp. 548-554
    • DiDonato, J.A.1    Hayakawa, M.2    Rothwarf, D.M.3    Zandi, E.4    Karin, M.5
  • 10
    • 0141929385 scopus 로고    scopus 로고
    • Binary switches and modification cassettes in histone biology and beyond
    • Fischle W., Wang Y. and Allis C.D. (2003). Binary switches and modification cassettes in histone biology and beyond. Nature 425, 475-479.
    • (2003) Nature , vol.425 , pp. 475-479
    • Fischle, W.1    Wang, Y.2    Allis, C.D.3
  • 11
    • 0028089871 scopus 로고
    • The epidermis: Rising to the surface
    • Fuchs E. and Byrne C. (1994). The epidermis: rising to the surface. Curr. Opin. Genet. Dev. 4, 725-736.
    • (1994) Curr. Opin. Genet. Dev , vol.4 , pp. 725-736
    • Fuchs, E.1    Byrne, C.2
  • 14
    • 0027496668 scopus 로고
    • FVB/N mice: An inbred strain sensitive to the chemical induction of squamous cell carcinomas in the skin
    • Hennings H., Glick A.B., Lowry D.T., Krsmanovic L.S., Sly L.M. and Yuspa S.H. (1993). FVB/N mice: an inbred strain sensitive to the chemical induction of squamous cell carcinomas in the skin. Carcinogenesis 14, 2353-2358.
    • (1993) Carcinogenesis , vol.14 , pp. 2353-2358
    • Hennings, H.1    Glick, A.B.2    Lowry, D.T.3    Krsmanovic, L.S.4    Sly, L.M.5    Yuspa, S.H.6
  • 16
    • 0033537767 scopus 로고    scopus 로고
    • Abnormal morphogenesis but intact IKK activation in mice lacking the IKKα subunit of IκB kinase
    • Hu Y., Baud V., Delhase M., Zhang P., Deerinck T., Ellisman M., Johnson R. and Karin M. (1999). Abnormal morphogenesis but intact IKK activation in mice lacking the IKKα subunit of IκB kinase. Science 284, 316-320.
    • (1999) Science , vol.284 , pp. 316-320
    • Hu, Y.1    Baud, V.2    Delhase, M.3    Zhang, P.4    Deerinck, T.5    Ellisman, M.6    Johnson, R.7    Karin, M.8
  • 17
    • 0035809983 scopus 로고    scopus 로고
    • IKKα controls formation of the epidermis independently of NF-κB
    • Hu Y., Baud V., Oga T., Kim K.I., Yoshida K. and Karin M. (2001). IKKα controls formation of the epidermis independently of NF-κB. Nature 410, 710-714.
    • (2001) Nature , vol.410 , pp. 710-714
    • Hu, Y.1    Baud, V.2    Oga, T.3    Kim, K.I.4    Yoshida, K.5    Karin, M.6
  • 20
    • 0037041422 scopus 로고    scopus 로고
    • Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase
    • Jackson J.P., Lindroth A.M., Cao X. and Jacobsen S.E. (2002). Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase. Nature 416, 556-560.
    • (2002) Nature , vol.416 , pp. 556-560
    • Jackson, J.P.1    Lindroth, A.M.2    Cao, X.3    Jacobsen, S.E.4
  • 21
    • 0027203921 scopus 로고
    • Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors
    • Kemp C.J., Donehower L.A., Bradley A. and Balmain A. (1993). Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors. Cell 74, 813-822.
    • (1993) Cell , vol.74 , pp. 813-822
    • Kemp, C.J.1    Donehower, L.A.2    Bradley, A.3    Balmain, A.4
  • 26
    • 0033537739 scopus 로고    scopus 로고
    • Severe liver degeneration in mice lacking the IkappaB kinase 2 gene
    • Li Q., Van Antwerp D., Mercurio F., Lee K.F. and Verma I.M. (1999b). Severe liver degeneration in mice lacking the IkappaB kinase 2 gene. Science 284, 321-325.
    • (1999) Science , vol.284 , pp. 321-325
    • Li, Q.1    Van Antwerp, D.2    Mercurio, F.3    Lee, K.F.4    Verma, I.M.5
  • 27
    • 27644525123 scopus 로고    scopus 로고
    • Identification of 14-3-3{sigma} mutation causing cutaneous abnormality in repeated-epilation mutant mouse
    • Li Q., Lu Q., Estepa G. and Verma I.M. (2005). Identification of 14-3-3{sigma} mutation causing cutaneous abnormality in repeated-epilation mutant mouse. Proc. Natl. Acad. Sci. USA 102, 15977-15982.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 15977-15982
    • Li, Q.1    Lu, Q.2    Estepa, G.3    Verma, I.M.4
  • 28
    • 0033532386 scopus 로고    scopus 로고
    • The IKKβ subunit of IκB kinase (IKK) is essential for nuclear factor kB activation and prevention of apoptosis
    • Li Z.W., Chu W., Hu Y., Delhase M., Deerinck T., Ellisman M., Johnson R. and Karin M. (1999). The IKKβ subunit of IκB kinase (IKK) is essential for nuclear factor kB activation and prevention of apoptosis. J. Exp. Med. 189, 1839-1845.
    • (1999) J. Exp. Med , vol.189 , pp. 1839-1845
    • Li, Z.W.1    Chu, W.2    Hu, Y.3    Delhase, M.4    Deerinck, T.5    Ellisman, M.6    Johnson, R.7    Karin, M.8
  • 29
    • 33751217161 scopus 로고    scopus 로고
    • A critical role for I{kappa}B kinase {alpha} in the development of human and mouse squamous cell carcinomas
    • Liu B., Park E., Zhu F., Bustos T., Liu J., Shen J., Fischer S.M. and Hu Y. (2006). A critical role for I{kappa}B kinase {alpha} in the development of human and mouse squamous cell carcinomas. Proc. Natl. Acad. Sci. USA 103, 17202-17207.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 17202-17207
    • Liu, B.1    Park, E.2    Zhu, F.3    Bustos, T.4    Liu, J.5    Shen, J.6    Fischer, S.M.7    Hu, Y.8
  • 30
    • 34548844747 scopus 로고    scopus 로고
    • Epigenetic inactivation of IkappaB Kinase-alpha in oral carcinomas and tumor progression
    • Maeda G., Chiba T., Kawashiri S., Satoh T. and Imai K. (2007). Epigenetic inactivation of IkappaB Kinase-alpha in oral carcinomas and tumor progression. Clin. Cancer Res. 13, 5041-5047.
    • (2007) Clin. Cancer Res , vol.13 , pp. 5041-5047
    • Maeda, G.1    Chiba, T.2    Kawashiri, S.3    Satoh, T.4    Imai, K.5
  • 31
    • 0033634663 scopus 로고    scopus 로고
    • Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti
    • Makris C., Godfrey V.L., Krahn-Senftleben G., Takahashi T., Roberts J.L., Schwarz T., Feng L., Johnson R.S. and Karin M. (2000). Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti. Mol. Cell 5, 969-979.
    • (2000) Mol. Cell , vol.5 , pp. 969-979
    • Makris, C.1    Godfrey, V.L.2    Krahn-Senftleben, G.3    Takahashi, T.4    Roberts, J.L.5    Schwarz, T.6    Feng, L.7    Johnson, R.S.8    Karin, M.9
  • 32
    • 3543056881 scopus 로고    scopus 로고
    • Mutually exclusive mutations of the Pten and ras pathways in skin tumor progression
    • Mao J.H., To M.D., Perez-Losada J., Wu D., Del Rosario R. and Balmain A. (2004). Mutually exclusive mutations of the Pten and ras pathways in skin tumor progression. Genes Dev. 18, 1800-1805.
    • (2004) Genes Dev , vol.18 , pp. 1800-1805
    • Mao, J.H.1    To, M.D.2    Perez-Losada, J.3    Wu, D.4    Del Rosario, R.5    Balmain, A.6
  • 33
    • 0034284715 scopus 로고    scopus 로고
    • Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex
    • May M.J., D'Acquisto F., Madge L.A., Glockner J., Pober J.S. and Ghosh S. (2000). Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex. Science 289, 1550-1554.
    • (2000) Science , vol.289 , pp. 1550-1554
    • May, M.J.1    D'Acquisto, F.2    Madge, L.A.3    Glockner, J.4    Pober, J.S.5    Ghosh, S.6
  • 35
    • 0029064179 scopus 로고
    • CHUK, a conserved helix-loop-helix ubiquitous kinase, maps to human chromosome 10 and mouse chromosome 19
    • Mock B.A., Connelly M.A., McBride O.W., Kozak C.A. and Marcu K.B. (1995). CHUK, a conserved helix-loop-helix ubiquitous kinase, maps to human chromosome 10 and mouse chromosome 19. Genomics 27, 348-351.
    • (1995) Genomics , vol.27 , pp. 348-351
    • Mock, B.A.1    Connelly, M.A.2    McBride, O.W.3    Kozak, C.A.4    Marcu, K.B.5
  • 37
    • 35148897233 scopus 로고    scopus 로고
    • Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas
    • Park E., Zhu F., Liu B., Xia X., Shen J., Bustos T., Fischer S.M. and Hu Y. (2007). Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas. Cancer Res. 67, 9158-9168.
    • (2007) Cancer Res , vol.67 , pp. 9158-9168
    • Park, E.1    Zhu, F.2    Liu, B.3    Xia, X.4    Shen, J.5    Bustos, T.6    Fischer, S.M.7    Hu, Y.8
  • 38
    • 0032581534 scopus 로고    scopus 로고
    • Distinct regions of allelic imbalance on chromosome 10q22-q26 in squamous cell carcinomas of the lung
    • Petersen S., Rudolf J., Bockmuhl U., Gellert K., Wolf G., Dietel M. and Petersen I. (1998). Distinct regions of allelic imbalance on chromosome 10q22-q26 in squamous cell carcinomas of the lung. Oncogene 17, 449-454.
    • (1998) Oncogene , vol.17 , pp. 449-454
    • Petersen, S.1    Rudolf, J.2    Bockmuhl, U.3    Gellert, K.4    Wolf, G.5    Dietel, M.6    Petersen, I.7
  • 40
    • 0032541657 scopus 로고    scopus 로고
    • IKK-gamma is an essential regulatory subunit of the IkB kinase complex
    • Rothwarf D.M., Zandi E., Natoli G. and Karin M. (1998). IKK-gamma is an essential regulatory subunit of the IkB kinase complex. Nature 395, 297-300.
    • (1998) Nature , vol.395 , pp. 297-300
    • Rothwarf, D.M.1    Zandi, E.2    Natoli, G.3    Karin, M.4
  • 41
    • 3142676732 scopus 로고    scopus 로고
    • Lupeol modulates NF-kappaB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice
    • Saleem M., Afaq F., Adhami V.M. and Mukhtar H. (2004). Lupeol modulates NF-kappaB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice. Oncogene 23, 5203-5214..
    • (2004) Oncogene , vol.23 , pp. 5203-5214
    • Saleem, M.1    Afaq, F.2    Adhami, V.M.3    Mukhtar, H.4
  • 42
    • 11144322225 scopus 로고    scopus 로고
    • Strong evidence of linkage disequilibrium between polymorphisms at the IRF6 locus and nonsyndromic cleft lip with or without cleft palate, in an Italian population
    • Scapoli L., Palmieri A., Martinelli M., Pezzetti F., Carinci P., Tognon M. and Carinci F. (2005). Strong evidence of linkage disequilibrium between polymorphisms at the IRF6 locus and nonsyndromic cleft lip with or without cleft palate, in an Italian population. Am. J. Hum. Genet. 76, 180-183.
    • (2005) Am. J. Hum. Genet , vol.76 , pp. 180-183
    • Scapoli, L.1    Palmieri, A.2    Martinelli, M.3    Pezzetti, F.4    Carinci, P.5    Tognon, M.6    Carinci, F.7
  • 43
    • 1942484963 scopus 로고    scopus 로고
    • IKKα acts in the epidermis to control skeletal and craniofacial morphogenesis
    • Sil A.K., Maeda S., Sano Y., Roop D.R. and Karin M. (2004). IKKα acts in the epidermis to control skeletal and craniofacial morphogenesis. Nature 428, 660-664.
    • (2004) Nature , vol.428 , pp. 660-664
    • Sil, A.K.1    Maeda, S.2    Sano, Y.3    Roop, D.R.4    Karin, M.5
  • 44
    • 15044350409 scopus 로고    scopus 로고
    • Relationship between histone H3 lysine 9 methylation, transcription repression, and heterochromatin protein 1 recruitment
    • Stewart M.D., Li J. and Wong J. (2005). Relationship between histone H3 lysine 9 methylation, transcription repression, and heterochromatin protein 1 recruitment. Mol. Cell. Biol. 25, 2525-2538.
    • (2005) Mol. Cell. Biol , vol.25 , pp. 2525-2538
    • Stewart, M.D.1    Li, J.2    Wong, J.3
  • 47
    • 34548848541 scopus 로고    scopus 로고
    • Inhibitor-kappaB kinase in tumor promotion and suppression during progression of squamous cell carcinoma
    • Van Waes C., Yu M., Nottingham L. and Karin M. (2007). Inhibitor-kappaB kinase in tumor promotion and suppression during progression of squamous cell carcinoma. Clin. Cancer Res. 13, 4956-4959.
    • (2007) Clin. Cancer Res , vol.13 , pp. 4956-4959
    • Van Waes, C.1    Yu, M.2    Nottingham, L.3    Karin, M.4
  • 48
    • 0032568792 scopus 로고    scopus 로고
    • Complementation cloning of NEMO, a component of the IkB kinase complex essential for NF-κB activation
    • Yamaoka S., Courtois G., Bessia C., Whiteside S.T., Weil R., Agou F., Kirk H.E., Kay R.J. and Israel A. (1998). Complementation cloning of NEMO, a component of the IkB kinase complex essential for NF-κB activation. Cell 93, 1231-1240.
    • (1998) Cell , vol.93 , pp. 1231-1240
    • Yamaoka, S.1    Courtois, G.2    Bessia, C.3    Whiteside, S.T.4    Weil, R.5    Agou, F.6    Kirk, H.E.7    Kay, R.J.8    Israel, A.9
  • 49
    • 0032575379 scopus 로고    scopus 로고
    • Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: Discrimination between free and NF-kappaB-bound substrate
    • Zandi E., Chen Y. and Karin M. (1998). Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate. Science 281, 1360-1363.
    • (1998) Science , vol.281 , pp. 1360-1363
    • Zandi, E.1    Chen, Y.2    Karin, M.3
  • 50
    • 0030613551 scopus 로고    scopus 로고
    • The IkB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IkB phosphorylation and NF-κB activation
    • Zandi E., Rothwarf D.M., Delhase M., Hayakawa M. and Karin M. (1997). The IkB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IkB phosphorylation and NF-κB activation. Cell 91, 243-252.
    • (1997) Cell , vol.91 , pp. 243-252
    • Zandi, E.1    Rothwarf, D.M.2    Delhase, M.3    Hayakawa, M.4    Karin, M.5
  • 51
    • 34447333358 scopus 로고    scopus 로고
    • IKKalpha shields 14-3-3sigma, a G(2)/M cell cycle checkpoint gene, from hypermethylation, preventing its silencing
    • Zhu F., Xia X., Liu B., Shen J., Hu Y., Person M. and Hu Y. (2007). IKKalpha shields 14-3-3sigma, a G(2)/M cell cycle checkpoint gene, from hypermethylation, preventing its silencing. Mol. Cell 27, 214-227.
    • (2007) Mol. Cell , vol.27 , pp. 214-227
    • Zhu, F.1    Xia, X.2    Liu, B.3    Shen, J.4    Hu, Y.5    Person, M.6    Hu, Y.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.