Hepatocyte cytotoxicity induced by hydroperoxide (oxidative stress model) or glyoxal (carbonylation model): Prevention by bioactive nut extracts or catechins

Chemico-Biological Interactions

Volumn 178, Issue 1-3, 2009, Pages 324-331

  Banach, Monica S ^a   Dong, Qiang ^a,b   O'Brien, Peter J ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b NORTHWEST A F UNIVERSITY   (China)

Author keywords

Catechins; Cytotoxicity; Lipid peroxidation; Nut extracts; Oxidative stress; Protein carbonylation

Indexed keywords

ANTIOXIDANT; CATECHIN; EPICATECHIN; EPIGALLOCATECHIN GALLATE; GLYOXAL; HAZELNUT EXTRACT; HYDROPEROXIDE; PLANT EXTRACT; UNCLASSIFIED DRUG; WALNUT EXTRACT;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL ISOLATION; CELL PROTECTION; CONTROLLED STUDY; DRUG SCREENING; HAZELNUT; IN VITRO STUDY; LIPID PEROXIDATION; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN CARBONYLATION; RAT; WALNUT;

ANIMALS; CATECHIN; GLYOXAL; HEPATOCYTES; HYDROGEN PEROXIDE; LIPID PEROXIDATION; MALE; MICROSOMES, LIVER; NUTS; OXIDATIVE STRESS; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY;

CORYLUS; JUGLANS; RATTUS;

EID: 59049107185     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2008.10.003     Document Type: Article

References (65)

1. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 414 6865 (2001) 813-820
2. Sheetz M.J., and King G.L. Molecular understanding of hyperglycemia's adverse effects for diabetic complications. JAMA 288 20 (2002) 2579-2588
3. Beisswenger P.J., Howell S.K., Nelson R.G., Mauer M., and Szwergold B.S. Alpha-oxoaldehyde metabolism and diabetic complications. Biochem. Soc. Trans. 31 Pt 6 (2003) 1358-1363
4. Gugliucci A. Glycation as the glucose link to diabetic complications. J. Am. Osteopath. Assoc. 100 10 (2000) 621-634
5. O'Brien P.J., Siraki A.G., and Shangari N. Aldehyde sources, metabolism, molecular toxicity mechanisms, and possible effects on human health. Crit. Rev. Toxicol. 35 7 (2005) 609-662
6. Sullivan K.A., and Feldman E.L. New developments in diabetic neuropathy. Curr. Opin. Neurol. 18 5 (2005) 586-590
7. Rahbar S., and Figarola J.L. Novel inhibitors of advanced glycation endproducts. Arch. Biochem. Biophys. 419 1 (2003) 63-79
8. Thornalley P.J., Langborg A., and Minhas H.S. Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose. Biochem. J. 344 Pt 1 (1999) 109-116
9. Aldini G., Dalle-Donne I., Facino R.M., Milzani A., and Carini M. Intervention strategies to inhibit protein carbonylation by lipoxidation-derived reactive carbonyls. Med. Res. Rev. 27 6 (2007) 817-868
10. Vlassara H., and Palace M.R. Diabetes and advanced glycation endproducts. J. Intern. Med. 251 2 (2002) 87-101
11. Rosca M.G., Monnier V.M., Szweda L.I., and Weiss M.F. Alterations in renal mitochondrial respiration in response to the reactive oxoaldehyde methylglyoxal. Am. J. Physiol. Renal Physiol. 283 1 (2002) F52-F59
12. Han Y., Randell E., Vasdev S., Gill V., Gadag V., Newhook L.A., Grant M., and Hagerty D. Plasma methylglyoxal and glyoxal are elevated and related to early membrane alteration in young, complication-free patients with Type 1 diabetes. Mol. Cell Biochem. 305 1-2 (2007) 123-131
13. Beisswenger P.J., Howell S.K., Touchette A.D., Lal S., and Szwergold B.S. Metformin reduces systemic methylglyoxal levels in type 2 diabetes. Diabetes 48 1 (1999) 198-202
14. Lapolla A., Flamini R., Dalla, Vedova A., Senesi A., Reitano R., Fedele D., Basso E., Seraglia R., and Traldi P. Glyoxal and methylglyoxal levels in diabetic patients: quantitative determination by a new GC/MS method. Clin. Chem. Lab Med. 41 9 (2003) 1166-1173
15. Baynes J.W. Role of oxidative stress in development of complications in diabetes. Diabetes 40 4 (1991) 405-412
16. Baynes J.W., and Thorpe S.R. Role of oxidative stress in diabetic complications: a new perspective on an old paradigm. Diabetes 48 1 (1999) 1-9
17. Miyazaki Y., Kawano H., Yoshida T., Miyamoto S., Hokamaki J., Nagayoshi Y., Yamabe H., Nakamura H., Yodoi J., and Ogawa H. Pancreatic B-cell function is altered by oxidative stress induced by acute hyperglycaemia. Diabet. Med. 24 2 (2007) 154-160
18. Kesavulu M.M., Rao B.K., Giri R., Vijaya J., Subramanyam G., and Apparao C. Lipid peroxidation and antioxidant enzyme status in Type 2 diabetics with coronary heart disease. Diabetes Res. Clin. Pract. 53 1 (2001) 33-39
19. Pennathur S., and Heinecke J.W. Mechanisms of oxidative stress in diabetes: implications for the pathogenesis of vascular disease and antioxidant therapy. Front Biosci. 9 (2004) 565-574
20. Abou-Seif M.A., and Youssef A.A. Evaluation of some biochemical changes in diabetic patients. Clin. Chim. Acta 346 2 (2004) 161-170
21. Bolen S., Feldman L., Vassy J., Wilson L., Yeh H.C., Marinopoulos S., Wiley C., Selvin E., Wilson R., Bass E.B., and Brancati F.L. Systematic review: comparative effectiveness and safety of oral medications for type 2 diabetes mellitus. Ann. Intern. Med. 147 6 (2007) 386-399
22. Krentz A.J., and Bailey C.J. Oral antidiabetic agents: current role in type 2 diabetes mellitus. Drugs 65 3 (2005) 385-411
23. Franz M.J., Bantle J.P., Beebe C.A., Brunzell J.D., Chiasson J.L., Garg A., Holzmeister L.A., Hoogwerf B., Mayer-Davis E., Mooradian A.D., Purnell J.Q., and Wheeler M. Evidence-based nutrition principles and recommendations for the treatment and prevention of diabetes and related complications. Diabetes Care 25 1 (2002) 148-198
24. Standards of medical care in diabetes-2008, Diabetes Care, 31 Suppl 1 (2008) S12-S54.
25. Lebovitz H.E. Differentiating members of the thiazolidinedione class: a focus on safety. Diabetes Metab. Res. Rev. 18 Suppl 2 (2002) S23-S29
26. Krentz A.J., Ferner R.E., and Bailey C.J. Comparative tolerability profiles of oral antidiabetic agents. Drug Saf. 11 4 (1994) 223-241
27. Halvorsen B.L., Holte K., Myhrstad M.C., Barikmo I., Hvattum E., Remberg S.F., Wold A.B., Haffner K., Baugerod H., Andersen L.F., Moskaug O., Jacobs Jr. D.R., and Blomhoff R. A systematic screening of total antioxidants in dietary plants. J. Nutr. 132 3 (2002) 461-471
28. Pellegrini N., Serafini M., Salvatore S., Del Rio D., Bianchi M., and Brighenti F. Total antioxidant capacity of spices, dried fruits, nuts, pulses, cereals and sweets consumed in Italy assessed by three different in vitro assays. Mol. Nutr. Food Res. 50 11 (2006) 1030-1038
29. Sabate J., Ros E., and Salas-Salvado J. Nuts: nutrition and health outcomes. Preface. Br. J. Nutr. 96 Suppl 2 (2006) S1-S2
30. Kris-Etherton P.M., Yu-Poth S., Sabate J., Ratcliffe H.E., Zhao G., and Etherton T.D. Nuts and their bioactive constituents: effects on serum lipids and other factors that affect disease risk. Am. J. Clin. Nutr. 70 3 Suppl (1999) 504S-511S
31. Jenkins D.J., Kendall C.W., Marchie A., Parker T.L., Connelly P.W., Qian W., Haight J.S., Faulkner D., Vidgen E., Lapsley K.G., and Spiller G.A. Dose response of almonds on coronary heart disease risk factors: blood lipids, oxidized low-density lipoproteins, lipoprotein(a), homocysteine, and pulmonary nitric oxide: a randomized, controlled, crossover trial. Circulation 106 11 (2002) 1327-1332
32. Durak I., Koksal I., Kacmaz M., Buyukkocak S., Cimen B.M., and Ozturk H.S. Hazelnut supplementation enhances plasma antioxidant potential and lowers plasma cholesterol levels. Clin. Chim. Acta 284 1 (1999) 113-115
33. Garg M.L., Blake R.J., and Wills R.B. Macadamia nut consumption lowers plasma total and LDL cholesterol levels in hypercholesterolemic men. J. Nutr. 133 4 (2003) 1060-1063
34. Morgan W.A., and Clayshulte B.J. Pecans lower low-density lipoprotein cholesterol in people with normal lipid levels. J. Am. Diet. Assoc. 100 3 (2000) 312-318
35. Hu F.B., and Stampfer M.J. Nut consumption and risk of coronary heart disease: a review of epidemiologic evidence. Curr. Atheroscler. Rep. 1 3 (1999) 204-209
36. Jiang R., Manson J.E., Stampfer M.J., Liu S., Willett W.C., and Hu F.B. Nut and peanut butter consumption and risk of type 2 diabetes in women. JAMA 288 20 (2002) 2554-2560
37. Chen C.Y., Milbury P.E., Lapsley K., and Blumberg J.B. Flavonoids from almond skins are bioavailable and act synergistically with vitamins C and E to enhance hamster and human LDL resistance to oxidation. J. Nutr. 135 6 (2005) 1366-1373
38. Shahidi F., Alasalvar C., and Liyana-Pathirana C.M. Antioxidant phytochemicals in hazelnut kernel (Corylus avellana L.) and hazelnut byproducts. J. Agric. Food Chem. 55 4 (2007) 1212-1220
39. Crews C., Hough P., Godward J., Brereton P., Lees M., Guiet S., and Winkelmann W. Study of the main constituents of some authentic walnut oils. J. Agric. Food Chem. 53 12 (2005) 4853-4860
40. Crews C., Hough P., Godward J., Brereton P., Lees M., Guiet S., and Winkelmann W. Study of the main constituents of some authentic hazelnut oils. J. Agric. Food Chem. 53 12 (2005) 4843-4852
41. Maguire L.S., O'Sullivan S.M., Galvin K., O'Connor T.P., and O'Brien N.M. Fatty acid profile, tocopherol, squalene and phytosterol content of walnuts, almonds, peanuts, hazelnuts and the macadamia nut. Int. J. Food Sci. Nutr. 55 3 (2004) 171-178
42. Li L., Tsao R., Yang R., Kramer J.K., and Hernandez M. Fatty acid profiles, tocopherol contents, and antioxidant activities of heartnut (Juglans ailanthifolia Var. cordiformis) and Persian walnut (Juglans regia L.). J. Agric. Food Chem. 55 4 (2007) 1164-1169
43. Alasalvar C., Shahidi F., Liyanapathirana C.M., and Ohshima T. Turkish Tombul hazelnut (Corylus avellana L.). 1. Compositional characteristics. J. Agric. Food Chem. 51 13 (2003) 3790-3796
44. Wu X., Beecher G.R., Holden J.M., Haytowitz D.B., Gebhardt S.E., and Prior R.L. Lipophilic and hydrophilic antioxidant capacities of common foods in the United States. J. Agric. Food Chem. 52 12 (2004) 4026-4037
45. Blomhoff R., Carlsen M.H., Andersen L.F., and Jacobs Jr. D.R. Health benefits of nuts: potential role of antioxidants. Br. J. Nutr. 96 Suppl 2 (2006) S52-S60
46. Chen C.Y., and Blumberg J.B. In vitro activity of almond skin polyphenols for scavenging free radicals and inducing quinone reductase. J. Agric. Food Chem. 56 12 (2008) 4427-4434
47. Wijeratne S.S., Abou-Zaid M.M., and Shahidi F. Antioxidant polyphenols in almond and its coproducts. J. Agric. Food Chem. 54 2 (2006) 312-318
48. Shangari N., and O'Brien P.J. The cytotoxic mechanism of glyoxal involves oxidative stress. Biochem. Pharmacol. 68 7 (2004) 1433-1442
49. Mehta R., Shangari N., and O'Brien P.J. Preventing cell death induced by carbonyl stress, oxidative stress or mitochondrial toxins with vitamin B anti-AGE agents. Mol. Nutr. Food Res. 52 3 (2008) 379-385
50. Moldeus P., Hogberg J., and Orrenius S. Isolation and use of liver cells. Methods Enzymol. 52 (1978) 60-71
51. Smith M.T., Thor H., Hartizell P., and Orrenius S. The measurement of lipid peroxidation in isolated hepatocytes. Biochem. Pharmacol. 31 1 (1982) 19-26
52. Dallner G. Isolation of microsomal subfractions by use of density gradients. Methods Enzymol. 52 (1978) 71-82
53. Stoscheck C.M. Quantitation of protein. Methods Enzymol. 182 (1990) 50-68
54. Hartley D.P., Kroll D.J., and Petersen D.R. Prooxidant-initiated lipid peroxidation in isolated rat hepatocytes: detection of 4-hydroxynonenal- and malondialdehyde-protein adducts. Chem. Res. Toxicol. 10 8 (1997) 895-905
55. Gentile C., Tesoriere L., Butera D., Fazzari M., Monastero M., Allegra M., and Livrea M.A. Antioxidant activity of Sicilian pistachio (Pistacia vera L. var. Bronte) nut extract and its bioactive components. J. Agric. Food Chem. 55 3 (2007) 643-648
56. Donovan J.L., Crespy V., Manach C., Morand C., Besson C., Scalbert A., and Remesy C. Catechin is metabolized by both the small intestine and liver of rats. J. Nutr. 131 6 (2001) 1753-1757
57. Yen G.C. Scavenging effect of methanolic extracts of peanut hulls on free-radical and active-oxygen species. J. Agric. Food Chem. 42 (2008) 629-632
58. Totlani V.M., and Peterson D.G. Epicatechin carbonyl-trapping reactions in aqueous Maillard systems: identification and structural elucidation. J. Agric. Food Chem. 54 19 (2006) 7311-7318
59. Sang S., Shao X., Bai N., Lo C.Y., Yang C.S., and Ho C.T. Tea polyphenol (-)-epigallocatechin-3-gallate: a new trapping agent of reactive dicarbonyl species. Chem. Res. Toxicol. 20 12 (2007) 1862-1870
60. Shangari N., Chan T.S., Popovic M., and O'Brien P.J. Glyoxal markedly compromises hepatocyte resistance to hydrogen peroxide. Biochem. Pharmacol. 71 11 (2006) 1610-1618
61. R. Mehta, L. Wong, P.J. O'Brien. Cytoprotective mechanisms of carbonyl scavenging drugs in isolated rat hepatocytes, Chem. Biol. Interac. (2008) (in press).
62. Papoutsi Z., Kassi E., Chinou I., Halabalaki M., Skaltsounis L.A., and Moutsatsou P. Walnut extract (Juglans regia L.) and its component ellagic acid exhibit anti-inflammatory activity in human aorta endothelial cells and osteoblastic activity in the cell line KS483. Br. J. Nutr. 99 4 (2008) 715-722
63. Milbury P.E., Chen C.Y., Dolnikowski G.G., and Blumberg J.B. Determination of flavonoids and phenolics and their distribution in almonds. J. Agric. Food Chem. 54 14 (2006) 5027-5033
64. Pedrielli P., and Skibsted L.H. Antioxidant synergy and regeneration effect of quercetin, (-)-epicatechin, and (+)-catechin on alpha-tocopherol in homogeneous solutions of peroxidating methyl linoleate. J. Agric. Food Chem. 50 24 (2002) 7138-7144
65. Siriwardhana S.S.K.W., and Shahidi F. Antiradical activity of extracts of almond and its by-products. J. Am. Oil. Chem. Soc. 79 9 (2002) 903-908