Catechin is metabolized by both the small intestine and liver of rats

Journal of Nutrition

Volumn 131, Issue 6, 2001, Pages 1753-1757

  Donovan, J L ^a   Crespy, V ^a   Manach, C ^a   Morand, C ^a   Besson, C ^a   Scalbert, A ^a   Remesy C ^a  

^a CEMAGREF   (France)

Author keywords

Absorption; Catechin; Metabolism; Methylation; Rats

Indexed keywords

CATECHIN; FLAVAN DERIVATIVE; GLUCURONIDE; SULFATE;

ARTICLE; BILIARY EXCRETION; CONCENTRATION (PARAMETERS); GLUCURONIDATION; INTESTINE CELL; LIVER METABOLISM; MALE; MESENTERIC VEIN; METHYLATION; NONHUMAN; RAT; SMALL INTESTINE ABSORPTION; SULFATION;

EID: 0034994354     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/131.6.1753     Document Type: Article

References (51)

1. Green tea composition, consumption and polyphenol chemistry
2. Reversed-phase HPLC following thiolysis for quantitative estimation and characterization of the four main classes of phenolic compounds in different tissue zones of a French cider apple variety (Malus domestica Var. Kermerrien)
3. Identification of procyanidins in cocoa (Theobroma cacao) and chocolate using high-performance liquid chromatography mass spectrometry
4. A standard red wine: Monomeric phenolic analysis of commercial Cabernet Sauvignon wines
5. Proanthocyanidins and tannin-like compounds: Nature, occurrence, dietary intake and effects on nutrition and health
6. Dietary intake and bioavailability of polyphenols
7. Antioxidants in chocolate
8. Potent inhibitory action of red wine polyphenols on human breast cancer cells
9. Experimental studies of the inhibitory effects of green tea catechin on mice large intestinal cancers induced by 1,2-dimethylhydrazine
10. Growth inhibition and regression of human prostate and breast tumors in athymic mice by tea epigallocatechin gallate
11. Delayed tumor onset in transgenic mice fed an amino acid-based diet supplemented with red wine solids
12. Reduced progression of atherosclerosis in apolipoprotein E-deficient mice following consumption of red wine, or its polyphenols quercetin or catechin, is associated with reduced susceptibility of LDL to oxidation and aggregation
13. Effect of dietary catechin and vitamin E on aortic fatty streak development in hypercholesterolemic hamsters
14. Inhibition of smoking-induced platelet aggregation by aspirin and pycnogenol
15. Epicatechin in human plasma: In vivo determination and effect of chocolate consumption
16. Cocoa and wine polyphenols modulate platelet activation and function
17. 14C]cyanidol-3 in man following oral administration
18. Analysis of plasma and urinary tea polyphenols in human subjects
19. Catechin is present as metabolites in human plasma after consumption of red wine
20. Plasma kinetics in man of epicatechin from black chocolate
21. Heterogeneity of hepatic microsomal UDP-glucuronosyltransferase activities
22. UDP-glucuronosyltransferase activity in human liver and colon
23. Sulfation of the flavonoids quercetin and catechin by rat liver
24. Biochemistry and molecular biology of drug-metabolizing sulfotransferase
25. Catechol-O-methyltransferase
26. The detoxification enzyme systems
27. Intestinal uptake and biliary excretion of the isoflavone genistein in rats
28. Accumulation of (-)-epicatechin metabolites in rat plasma after oral administration and distribution of conjugation enzymes in rat tissues
29. Transport of the flavonoid chrysin and its conjugated metabolites by the human intestinal cell line Coco-2
30. The small intestine can both absorb and glucuronidate luminal flavonoids
31. Intestinal transport of quercetin glycosides in rats involves both deglycoslylation and interaction with the hexose transport pathway
32. Epicatechin and catechin are O-methylated and glucuronidated in the small intestine
33. Part of quercetin absorbed in the small intestine is conjugated and further secreted in the intestinal lumen
34. Analysis of (+)-catechin, (-)-epicatechin and their 3′- and 4′-O-methylated analogs. A comparison of sensitive methods
35. Intestinal fermentation lessens the inhibitory effects of phytic acid on mineral utilization in rats
36. Comparison of the bioavailability of quercetin and catechin in rats
37. 3′-O-Methyl-(+)-catechin glucuronide and 3′-O-methyl-(+)-catechin sulphate: New urinary metabolites of (+)-catechin in the rat and the marmoset
38. Identification of the major biliary metabolite of (+)-catechin in the rat
39. Gastroileal nitrogen and electrolyte movements after bovine milk ingestion in humans
40. A dose-response effect from chocolate consumption on plasma epicatechin and oxidative damage
41. Absorption, distribution, and excretion of toxicants
42. Transport of proanthocyanidin dimer, trimer and polymer across monolayers of human intestinal epithelial Caco-2 cells
43. Efflux of dietary flavonoid quercetin 4′-β-glucoside across human intestinal Caco-2 cell monolayers by apical multidrug resistance-associated protein-2
44. Extensive metabolism of the flavonoid chrysin by human Caco-2 and Hep G2 cells
45. Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver
46. β-Glucuronidase latency in isolated murine hematocytes
47. Identification of the major urinary metabolites of (+)-catechin and 3-O-methyl-(+)-catechin in man
48. In vitro biotransformation of flavonoids by rat liver microsomes
49. Sulfation
50. Assessment of rat liver slices as a suitable model system for studying the simultaneous sulphation and glucuronidation of phenolic xenobiotics