Effects of isoflavone supplements vs. soy foods on blood concentrations of genistein and daidzein in adults

Journal of Nutritional Biochemistry

Volumn 20, Issue 3, 2009, Pages 227-234

  Gardner, Christopher D ^a   Chatterjee, Lorraine M ^a   Franke, Adrian A ^b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF HAWAII CANCER CENTER   (United States)

Author keywords

Humans; Isoflavones; Pharmacokinetics; Soy foods; Supplements

Indexed keywords

DAIDZEIN; GENISTEIN; ISOFLAVONE;

ADULT; AGED; ARTICLE; CALCULATION; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; SOYBEAN; SUPPLEMENTATION;

ADULT; AGED; BIOLOGICAL AVAILABILITY; BLOOD SPECIMEN COLLECTION; DIETARY SUPPLEMENTS; FEMALE; GENISTEIN; HUMANS; ISOFLAVONES; MIDDLE AGED; SOY FOODS;

EID: 58749092517     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2008.02.008     Document Type: Article

References (45)

1. Clarkson T.B. Soy, soy phytoestrogens and cardiovascular disease. J Nutr 132 3 (2002) 566S-569S
2. Messina M.J., Persky V., Setchell K.D., and Barnes S. Soy intake and cancer risk: a review of the in vitro and in vivo data. Nutr Cancer 21 2 (1994) 113-131
3. Messina M., and Hughes C. Efficacy of soyfoods and soybean isoflavone supplements for alleviating menopausal symptoms is positively related to initial hot flush frequency. J Med Food 6 1 (2003) 1-11
4. Messina M.J. Emerging evidence on the role of soy in reducing prostate cancer risk. Nutr Rev 61 4 (2003) 117-131
5. Nestel P. Isoflavones: their effects on cardiovascular risk and functions. Curr Opin Lipidol 14 1 (2003) 3-8
6. Setchell K.D., and Lydeking-Olsen E. Dietary phytoestrogens and their effect on bone: evidence from in vitro and in vivo, human observational, and dietary intervention studies. Am J Clin Nutr 78 3 Suppl (2003) 593S-609S
7. 41Ca. J Clin Endocrinol Metab 92 2 (2007) 577-582
8. Kreijkamp-Kaspers S., Kok L., Grobbee D.E., et al. Effect of soy protein containing isoflavones on cognitive function, bone mineral density, and plasma lipids in postmenopausal women: a randomized controlled trial. JAMA 292 1 (2004) 65-74
9. Sacks F.M., Lichtenstein A., Van Horn L., Harris W., Kris-Etherton P., and Winston M. Soy protein, isoflavones, and cardiovascular health: an American Heart Association Science Advisory for professionals from the Nutrition Committee. Circulation 113 7 (2006) 1034-1044
10. St Germain A., Peterson C.T., Robinson J.G., and Alekel D.L. Isoflavone-rich or isoflavone-poor soy protein does not reduce menopausal symptoms during 24 weeks of treatment. Menopause 8 1 (2001) 17-26
11. Chen X.W., Garner S.C., and Anderson J.J. Isoflavones regulate interleukin-6 and osteoprotegerin synthesis during osteoblast cell differentiation via an estrogen-receptor-dependent pathway. Biochem Biophys Res Commun 295 2 (2002) 417-422
12. Kostelac D., Rechkemmer G., and Briviba K. Phytoestrogens modulate binding response of estrogen receptors alpha and beta to the estrogen response element. J Agric Food Chem 51 26 (2003) 7632-7635
13. Mitropoulou T.N., Tzanakakis G.N., Nikitovic D., Tsatsakis A., and Karamanos N.K. In vitro effects of genistein on the synthesis and distribution of glycosaminoglycans/proteoglycans by estrogen receptor-positive and -negative human breast cancer epithelial cells. Anticancer Res 22 5 (2002) 2841-2846
14. Morito K., Hirose T., Kinjo J., et al. Interaction of phytoestrogens with estrogen receptors alpha and beta. Biol Pharm Bull 24 4 (2001) 351-356
15. Faughnan M.S., Hawdon A., Ah-Singh E., Brown J., Millward D.J., and Cassidy A. Urinary isoflavone kinetics: the effect of age, gender, food matrix and chemical composition. Br J Nutr 91 4 (2004) 567-574
16. King R.A., and Bursill D.B. Plasma and urinary kinetics of the isoflavones daidzein and genistein after a single soy meal in humans. Am J Clin Nutr 67 5 (1998) 867-872
17. 13C-labeled tracers in premenopausal women. Am J Clin Nutr 77 2 (2003) 411-419
18. Watanabe S., Yamaguchi M., Sobue T., et al. Pharmacokinetics of soybean isoflavones in plasma, urine and feces of men after ingestion of 60 g baked soybean powder (kinako). J Nutr 128 10 (1998) 1710-1715
19. Zubik L., and Meydani M. Bioavailability of soybean isoflavones from aglycone and glucoside forms in American women. Am J Clin Nutr 77 6 (2003) 1459-1465
20. Wiseman H., Casey K., Bowey E.A., et al. Influence of 10 wk of soy consumption on plasma concentrations and excretion of isoflavonoids and on gut microflora metabolism in healthy adults. Am J Clin Nutr 80 3 (2004) 692-699
21. Xu X., Wang H.J., Murphy P.A., Cook L., and Hendrich S. Daidzein is a more bioavailable soymilk isoflavone than is genistein in adult women. J Nutr 124 6 (1994) 825-832
22. Bloedon L.T., Jeffcoat A.R., Lopaczynski W., et al. Safety and pharmacokinetics of purified soy isoflavones: single-dose administration to postmenopausal women. Am J Clin Nutr 76 5 (2002) 1126-1137
23. Busby M.G., Jeffcoat A.R., Bloedon L.T., et al. Clinical characteristics and pharmacokinetics of purified soy isoflavones: single-dose administration to healthy men. Am J Clin Nutr 75 1 (2002) 126-136
24. Setchell K.D., Brown N.M., Desai P.B., et al. Bioavailability, disposition, and dose-response effects of soy isoflavones when consumed by healthy women at physiologically typical dietary intakes. J Nutr 133 4 (2003) 1027-1035
25. Hutchins A.M., Slavin J.L., and Lampe J.W. Urinary isoflavonoid phytoestrogen and lignan excretion after consumption of fermented and unfermented soy products. J Am Diet Assoc 95 5 (1995) 545-551
26. Izumi T., Piskula M.K., Osawa S., et al. Soy isoflavone aglycones are absorbed faster and in higher amounts than their glucosides in humans. J Nutr 130 7 (2000) 1695-1699
27. Richelle M., Pridmore-Merten S., Bodenstab S., Enslen M., and Offord E.A. Hydrolysis of isoflavone glycosides to aglycones by beta-glycosidase does not alter plasma and urine isoflavone pharmacokinetics in postmenopausal women. J Nutr 132 9 (2002) 2587-2592
28. Setchell K.D., Brown N.M., Desai P., et al. Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements. J Nutr 131 4 Suppl (2001) 1362S-1375S
29. Zheng Y., Sun-Ok L., Verbruggen M.A., Murphy P.A., and Hendrich S. The apparent absorptions of isoflavone glucosides and aglucons are similar in women and are increased by rapid gut transit time and low fecal isoflavone degradation. J Nutr 134 (2004) 2534-2539
30. Cassidy A., Brown J.E., Hawdon A., et al. Factors affecting the bioavailability of soy isoflavones in humans after ingestion of physiologically relevant levels from different soy foods. J Nutr 136 1 (2006) 45-51
31. Kano M., Takayanagi T., Harada K., Sawada S., and Ishikawa F. Bioavailability of isoflavones after ingestion of soy beverages in healthy adults. J Nutr 136 9 (2006) 2291-2296
32. Reinli K., and Block G. Phytoestrogen content of foods - a compendium of literature values. Nutr Cancer 26 2 (1996) 123-148
33. Franke A.A., Hankin J.H., Yu M.C., Maskarinec G., Low S.H., and Custer L.J. Isoflavone levels in soy foods consumed by multiethnic populations in Singapore and Hawaii. J Agric Food Chem 47 3 (1999) 977-986
34. Franke A.A., Custer L.J., Wilkens L.R., et al. Liquid chromatographic-photodiode array mass spectrometric analysis of dietary phytoestrogens from human urine and blood. J Chromatogr B Analyt Technol Biomed Life Sci 777 1-2 (2002) 45-59
35. Cline J.M., Franke A.A., Register T.C., Golden D.L., and Adams M.R. Effects of dietary isoflavone aglycones on the reproductive tract of male and female mice. Toxicol Pathol 32 1 (2004) 91-99
36. Blair R.M., Appt S.E., Franke A.A., and Clarkson T.B. Treatment with antibiotics reduces plasma equol concentration in cynomolgus monkeys (Macaca fascicularis). J Nutr 133 7 (2003) 2262-2267
37. Manach C., Williamson G., Morand C., Scalbert A., and Remesy C. Bioavailability and bioefficacy of polyphenols in humans: I. Review of 97 bioavailability studies. Am J Clin Nutr 81 1 Suppl (2005) 230S-242S
38. Frank R.A., and van der Klaauw N.J. The contribution of chemosensory factors to individual differences in reported food preferences. Appetite 22 2 (1994) 101-123
39. Franke A.A., Custer L.J., and Hundahl S.A. Determinants for urinary and plasma isoflavones in humans after soy intake. Nutr Cancer 50 2 (2004) 141-154
40. Lee S.J., Ahn J.K., Kim S.H., et al. Variation in isoflavone of soybean cultivars with location and storage duration. J Agric Food Chem 51 11 (2003) 3382-3389
41. Arai Y., Watanabe S., Kimira M., Shimoi K., Mochizuki R., and Kinae N. Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration. J Nutr 130 9 (2000) 2243-2250
42. Kelly G.E., Nelson C., Waring M.A., Joannou G.E., and Reeder A.Y. Metabolites of dietary (soya) isoflavones in human urine. Clin Chim Acta 223 1-2 (1993) 9-22
43. Kirkman L.M., Lampe J.W., Campbell D.R., Martini M.C., and Slavin J.L. Urinary lignan and isoflavonoid excretion in men and women consuming vegetable and soy diets. Nutr Cancer 24 1 (1995) 1-12
44. Lu L.J., and Anderson K.E. Sex and long-term soy diets affect the metabolism and excretion of soy isoflavones in humans. Am J Clin Nutr 68 6 Suppl (1998) 1500S-1504S
45. Setchell K.D., Borriello S.P., Hulme P., Kirk D.N., and Axelson M. Nonsteroidal estrogens of dietary origin: possible roles in hormone-dependent disease. Am J Clin Nutr 40 3 (1984) 569-578