Autofluorescence characteristics of early, atrophic, and high-risk fellow eyes in age-related macular degeneration

Investigative Ophthalmology and Visual Science

Volumn 47, Issue 12, 2006, Pages 5495-5504

  Smith, R Theodore ^a,d   Chan, Jackie K ^a   Busuoic, Mihai ^a   Sivagnanave, Vasuki ^b   Bird, Alan C ^c   Chong, N Victor ^b,c  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d New York Presbyterian Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; AUTOFLUORESCENCE; AUTOMATION; DRUSEN; HIGH RISK POPULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RETINA MACULA AGE RELATED DEGENERATION; RETROSPECTIVE STUDY; SUBRETINAL NEOVASCULARIZATION; ATROPHY; DISEASE COURSE; FLUORESCENCE; PATHOLOGY; PHENOTYPE; RETINA; RETINA MACULA DEGENERATION; VISUAL SYSTEM EXAMINATION;

ATROPHY; CHOROIDAL NEOVASCULARIZATION; DIAGNOSTIC TECHNIQUES, OPHTHALMOLOGICAL; DISEASE PROGRESSION; FLUORESCENCE; HUMANS; MACULAR DEGENERATION; PHENOTYPE; RETINA; RETINAL DRUSEN; RETROSPECTIVE STUDIES;

EID: 34248155705     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.05-1318     Document Type: Article

References (39)

1. Smiddy WE, Fine SL. Prognosis of patients with bilateral macular drusen. Ophthalmology. 1984;91:271-277.
2. Bressler SB, Maguire MG, Bressler NM, Fine SL. Relationship of drusen and abnormalities of the retinal pigment epithelium to the prognosis of neovascular macular degeneration. The Macular Photocoagulation Study Group. Archives of Ophthalmology. 1990; 108:1442-1447.
3. Bressler NM, Bressler SB, Seddon JM, et al. Drusen characteristics in patients with exudative versus non-exudative age-related macular degeneration. Retina. 1998;8:109-114.
4. Holz FG, Wolfensberger TJ, Piguet B, et al. Bilateral macular drusen in age-related macular degeneration: prognosis and risk factors. Ophthalmology. 1994;101:1522-1528.
5. Abdelsalam A, Del Priore L, Zarbin MA. Drusen in age-related macular degeneration: pathogenesis, natural course, and laser photocoagulation-induced regression. Sum Ophthalmol. 1999,44:1-29.
6. Little HL, Showman JM, Brown BW. A pilot randomized controlled study on the effect of laser photocoagulation of confluent soft macular drusen [see comments]. Ophthalmology. 1997;104:623-631.
7. Frennesson IC, Nilsson SE. Effects of argon (green) laser treatment of soft drusen in early age-related maculopathy: a 6 month prospective study. Br J Ophthalmol. 1995;79:905-909.
8. Bressler NM, Munoz B, Maguire MG, et al. Five-year incidence and disappearance of drusen and retinal pigment epithelial abnormalities: Waterman study. Arch Ophthalmol. 1995;113:301-308.
9. Bressler SB, Bressler NM, Seddon JM, et al. Interobserver and intraobserver reliability in the clinical classification of drusen. Retina. 1988;8:102-108.
10. Klaver CC, Wolfs RC, Vingerling JR, et al. Age-specific prevalence and causes of blindness and visual impairment in an older population: the Rotterdam Study. Arch Ophthalmol. 1998;116: 653-658.
11. Smith RT, Chan JK, Nagasaki T, et al. A method of drusen measurement based on reconstruction of fundus reflectance. Br J Opthalmol. 2005;89:87-91.
12. Smith RT, Chan JK, Nagasaki T, et al. Automated detection of macular drusen using geometric background leveling and threshold selection. Arch Ophthalmol. 2005;123:200-207.
13. Smith RT, Nagasaki T, Sparrow JR, et al. A method of drusen measurement based on the geometry of fundus reflectance. BioMed Eng OnLine. 2003;2:10.
14. Delori FC, Dorey CK, Staurenghi G, et al. In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics. Invest Ophthalmol Vis Sci. 1995;36:718-729.
15. von Ruckmann A, Fitzke FW, Bird AC. In vivo fundus autofluorescence in macular dystrophies. Arch Ophthalmol. 1997;115:609-615.
16. Kitigawa K, Nishida S, Ogura Y. In vivo quantification of autofluorescence in human retinal pigment epithelium. Ophthalmologica. 1989;199:116-121.
17. Weiter JJ, Delori FC, Wing GL, Fitch KA. Retinal pigment epithelial lipofuscin and melanin and choroidal melanin in human eyes. Invest Ophthalmol Vis Sci. 1986;27:145-152.
18. Delori FC, Fleckner MR, Goger DG, et al. Autofluorescence distribution associated with drusen in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2000;41:496-504.
19. Dorey C, Wu G, Ebenstein D, et al. Cell loss in the ageing retina: relationship to lipofuscin accumulation and macular degeneration. Invest Ophthalmol Vis Sci. 1989;30:1691-1699.
20. von Ruckmann A, Fitzke FW, Bird AC. Distribution of fundus autofluorescence with a scanning laser ophthalmoscope [comment]. Br J Ophthalmol. 1995;79:407-412.
21. von Ruckmann A, Fitzke FW, Bird AC. Fundus autofluorescence in age-related macular disease imaged with a laser scanning ophthalmoscope. Invest Ophthalmol Vis Sci. 1997;38:478-486.
22. Feeney-Burns L, Hildebrand E, Eldridge S. Aging human RPE: Morphometry analysis of macular, equatorial, and peripheral cells. Invest Ophthalmol Vis Sci. 1984;25:195-200.
23. Feeney-Burns L, Berman E, Rothman H. Lipofuscin of the human retinal pigment epithelium. Am J Ophthalmol. 1980;90:783-791.
24. Wing G, Blanchard G, Weiter J. The topography and age relationship of lipofuscin concentrations in the RPE. Invest Ophthalmol Vis Sci. 1978;17:600-607.
25. Holz FG, Bellman C, Staudt S, et al. Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2001;42:1051-1056.
26. Lois N, Owens SL, Coco R, et al. Fundus autofluorescence in patients with age-related macular degeneration and high risk of visual loss. Am J Ophthalmol. 2002;133:341-349.
27. Arnold JJ, Sarks SH, Killingsworth MC, Sarks JP. Reticular pseudodrusen: a risk factor in age-related maculopathy. Retina. 1995;15:183-191.
28. Holz FG, Bellmann C, Margaritidis M, et al. Patterns of increased in vivo fundus autofluorescence in the junctional zone of geographic atrophy of the retinal pigment epithelium associated with age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol. 1999;237:145-152.
29. Smith RT, Koniarek JP, Chan JK, et al. Autofluorescence characteristics of normal foveas and reconstruction of foveal autofluorescence from limited data subsets. Invest Ophthalmol Vis Sci. 2005; 46:2940-2946.
30. Hwang JC, Chan J, Chang S, Smith RT. Predictive value of fundus autofluorescence for development of geographic atrophy in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2006; 47:2655-2661.
31. Bindewald A, Schmitz-Valckenberg S, Jorzik JJ, et al. Classification of abnormal fundus autofluorescence patterns in the junctional zone of geographic atrophy in patients with age related macular degeneration. Br J Ophthalmol. 2005;89:874-578.
32. Sarks JP, Sarks SH, Killingsworth MC. Evolution of soft drusen in age- related macular degeneration. Eye. 1994;8:269-283.
33. Hageman GS Luthert PJ, Victor Chong NH, Johnson LV, Anderson DH, Mullins RF. An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration. Prog Retin Eye Res. 2001;20:705-732.
34. Arnold JJ, Quaranta M, Soubrane G, Sarks SH, Coscas G. lndocyanine green angiography of drusen. Am J Ophthalmol. 1997;1997; 124:344-356.
35. Hageman GS Anderson DH, Johnson LV, et al. A common haplotype in the complement regulatory gene, factor H (HF1/CFH), predisposes individuals to age-related macular degeneration. Proc Nat Acad Sci. 2005;102:7227-7232.
36. Gold B, Merriam JE, Zernant J, et al. Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration. Nat Genet. 2006;38:458-462.
37. Arnold JJ, Sarks SH, Sarks J. Reticular pseudodrusen [letter]. Retina. 1996;16:168.
38. Sparrow JR, Parish CA, Nashimoto M, Nakanishi K. A2E, a lipofuscin fluorophore, in human retinal pigmented epithelial cells in culture. Invest Ophthalmol Vis Sci. 1999;40:2988-2995.
39. Marmorstein AD, Marmorstein LY, Sakaguchi H, Hollyfield JG. Spectral profiling of autofluorescence associated with lipofuscin, Bruch's membrane, and sub-RPE deposits in normal and AMD eyes. Invest Ophthalmol Vis Sci. 2002;43:2435-2441.