Potential role of retinal pigment epithelial lipofuscin accumulation in age-related macular degeneration

Archives of Gerontology and Geriatrics

Volumn 34, Issue 3, 2002, Pages 359-370

  Katz, M L ^a  

^a University of Missouri   (United States)

Author keywords

Lipofuscin; Macular degeneration; Retina; Retinal pigment epithelium

Indexed keywords

LIPOFUSCIN; PROTEIN;

AGE; AUTOFLUORESCENCE; BIOACCUMULATION; CELL FUNCTION; CONFERENCE PAPER; CORRELATION ANALYSIS; GENE MUTATION; HUMAN; HYPOTHESIS; LYSOSOME STORAGE DISEASE; PHOTORECEPTOR; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA; RETINA MACULA AGE RELATED DEGENERATION; RETINA MACULA LUTEA; SENESCENCE; VISUAL IMPAIRMENT;

EID: 0036119813     PISSN: 01674943     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4943(02)00012-2     Document Type: Conference Paper

References (45)

1. Histopathology and immunocytochemistry of the neurosensory retina in fundus flavmaculatus
2. Lipofuscin is a photoinducible free radical generator
3. Aging of the human photoreceptor mosaic: evidence for selective vulnerability of rods in central retina
4. Photoreceptor loss in age-related macular degeneration
5. Lipofuscin-does it affect cellular performance?
6. The effect of lipofuscin on cellular function
7. In vivo measurement of lipofuscin in Stargardt's Disease-Fundus flavimaculatus
8. Autofluorescence distribution associated with drusen in age-related macular degeneration
9. Cell loss in the aging retina: relationship to lipofuscin accumulation and macular degeneration
10. Mechanisms of maculopathy
11. Lipofuscin fluorophore inhibits lysosomal protein degradation and may cause early stages of macular degeneration
12. Retinal age pigments generated by self-assembling lysosomotropic detergents
13. Aging human RPE: morphometric analysis of macular, equatorial, and peripheral cells
14. Aging of the human retina. Differential loss of neurons and retinal pigment epithelial cells
15. Histopathology of age-related macular degeneration
16. Retinal degeneration in monkeys induced by deficiencies of vitamin E or A
17. Age-related alterations in the retina
18. Retinal light damage reduces autofluorescent pigment deposition in the retinal pigment epithelium
19. Vitamin A incorporation into lipofuscin-like inclusions in the retinal pigment epithelium
20. Influence of dietary vitamin A on autofluorescence of leupeptin-induced inclusions in the retinal pigment epithelium
21. Age-related changes in the retinal pigment epithelium of pigmented rats
22. Senescence and the retinal pigment epithelium: alterations in basal plasma membrane morphology
23. Evidence of cell loss from the rat retina during senescence
24. Development of lipofuscin-like fluorescence in the retinal pigment epithelium in response to protease inhibitor treatment
25. Fluorescent pigment accumulation in retinal pigment epithelium of antioxidant deficient rats
26. Effects of antioxidant nutrient deficiency on the retina and retinal pigment epithelium of albino rats: a light and electron microscopic study
27. Influence of early photoreceptor degeneration on lipofuscin in the retinal pigment epithelium
28. Age-related alterations in vitamin A metabolism in the rat retina
29. Lipofuscin autofluorescence: evidence for vitamin A involvement in the retina
30. Factors influencing lipofuscin accumulation in the retinal pigment epithelium
31. Iron-induced fluorescence in the retina: dependence on vitamin A
32. Formation of lipofuscin-like fluorophores by reaction of retinal with photoreceptor outer segments and liposomes
33. Long-term variations in cyclic light intensity and dietary vitamin A intake modulate lipofuscin content of the retinal pigment epithelium
34. Some observations in the fine structure of age changes of the mouse retinal pigment epithelium
35. Inherited retinal dystrophy: primary defect in pigment epithelium determined with experimental rat chimeras
36. The relationships of age changes in retinal pigment epithelium and Bruch's membrane
37. Lipid pigments in relation to aging and dietary factors (lipofuscins)
38. Vitamin E deficiency and the retina: photoreceptor and pigment epithelial changes
39. Deficiencies of vitamins E and A in the rat: retinal damage and lipofuscin accumulation
40. Location, substructure, and composition of basal laminar drusen compared with drusen associated with aging and age-related macular degeneration
41. Aging and degeneration in the macular region: a clinico-pathological study
42. Histologic and morphmetric analysis of the choroid, Bruch's membrane, and retinal pigment epithelium in postmortem eyes wit age-related macular degeneration and histologic examination of surgically excised choroidal neovascular membranes
43. Lipofuscin accumulation in cultured retinal pigment epithelial cells reduces their phagocytic capacity
44. The topography and age relationship of lipofuscin concentration in the retinal pigment epithelium