Membranes are more mosaic than fluid

Nature

Volumn 438, Issue 7068, 2005, Pages 578-580

  Engelman, Donald M ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUIDS; LIPIDS; PROTEINS;

COMPOSITION; ECTODOMAINS LIMIT; MOSAIC;

MEMBRANES;

MEMBRANE; PROTEIN;

BILAYER MEMBRANE; CHEMICAL COMPOSITION; LIPID BILAYER; LIPID MEMBRANE; MEMBRANE BINDING; MEMBRANE BIOLOGY; MEMBRANE FORMATION; MEMBRANE MODEL; MEMBRANE STRUCTURE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LIPID INTERACTION; PROTEIN STRUCTURE; REVIEW; STRUCTURE ANALYSIS;

EID: 28444437064     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature04394     Document Type: Review

References (34)

1. Singer, S. J. & Nicolson, G. L. The fluid mosaic model of the structure of cell membranes. Science 175, 720-731 (1972).
2. Liu, Y., Engelman, D. M. & Gerstein, M. Genomic analysis of membrane protein families: abundance and conserved motifs. Genome Biol. 3, 0054.1-0054.12 (2002).
3. Doura, A. K., Kobus, F. J., Dubrovsky, L., Hibbard, E. & Fleming, K. G. Sequence context modulates the stability of a GxxxG-mediated transmembrane helix-helix dimer. J. Mol. Biol. 341, 991-998 (2004).
4. Adams, P. D., Engelman, D. M. & Brunger, A. T. Improved prediction for the structure of the dimeric transmembrane domain of glycophorin A obtained through global searching. Proteins 26, 257-261 (1996).
5. Stenberg, F. et al. Protein complexes of the Escherichia coli cell envelope. J. Biol. Chem. 280, 34409-34419 (2005).
6. Wong, W., Scott, J. D. AKAP signalling complexes: focal points in space and time. Nature Rev. Mol. Cell Biol. 5, 959-970 (2004).
7. Grigorieff, N., Ceska, T. A., Downing, K. H., Baldwin, J. M. & Henderson, R. Electron-crystallographic refinement of the structure of bacteriorhodopsin. J. Mol. Biol. 259, 393-421 (1996).
8. Brown, D. A. & London, E. Functions of lipid rafts in biological membranes. Annu. Rev. Cell Dev. Biol. 14, 111-136 (1998).
9. Zaccai, G. How soft is a protein? A protein dynamics force constant measured by neutron scattering. Science 288, 1604-1607 (2000).
10. Petrache, H. I. et al. Hydrophobic matching mechanism investigated by molecular dynamics simulations. Langmuir 18, 1340-1351 (2002).
11. Mitra, K., Ubarretxena-Belandia, I., Taguchi, T., Warren, G. & Engelman, D. M. Modulation of the bilayer thickness of exocytic pathway membranes by membrane proteins rather than cholesterol. Proc. Natl Acad. Sci. USA 101, 4083-4088 (2004).
12. Williamson, I. M., Alvis, S. J., East, J. M. & Lee, A. G. Interactions of phospholipids with the potassium channel KcsA. Biophys. J. 83, 2026-2038 (2002).
13. Perozo, E., Kloda, A., Cortes, D. M. & Martina, B. Physical principles underlying the transduction of bilayer deformation forces during mechanosensitive channel gating. Nature Struct. Biol. 9, 636-637 (2002).
14. Abramson, J. et al. Structure and mechanism of the lactose permease of Escherichia coli. Science 301, 610-615 (2003).
15. Fu, D. et al. Structure of a glycerol-conducting channel and the basis for its selectivity. Science 290, 481-486 (2000).
16. Luecke, H., Schobert, B., Richter, H. T., Cartailler, J. P. & Lanyi, J. K. Structure of bacteriorhodopsin at 1.55 A resolution. J. Mol. Biol. 291, 899-911 (1999).
17. Zheng, L., Kostrewa, D., Berneche, S., Winkler, F. K. & Li, X. D. The mechanism of ammonia transport based on the crystal structure of AmtB of Escherichia coli. Proc. Natl Acad. Sci. USA 101, 17090-17095 (2004).
18. Abramson, J. et al. The structure of the ubiquinol oxidase from Escherichia coli and its ubiquinone binding site. Nature Struct. Biol. 7, 910-917 (2000).
19. Iverson, T. M., Luna-Chavez, C., Cecchini, G. & Rees, D. C. Structure of the Escherichia coli fumarate reductase respiratory complex. Science 284, 1961-1966 (1999).
20. + channel. Science 309, 897-903 (2005).
21. Kurisu, G., Zhang, H., Smith, J. L. & Cramer, W. A. Structure of the cytochrome b6f complex of oxygenic photosynthesis: tuning the cavity. Science 302, 1009-1014 (2003).
22. Miyazawa, A., Fujiyoshi, Y. & Unwin, N. (2003). Structure and gating mechanism of the acetylcholine receptor pore. Nature 423, 949-955.
23. Stock, D., Leslie, A. G. & Walker, J. E. Molecular architecture of the rotary motor in ATP synthase. Science 286, 1700-1705 (1999).
24. Stroebel, D., Choquet, Y., Popot, J. L. & Picot, D. An atypical haem in the cytochrome b(6)f complex. Nature 426, 413-418 (2003).
25. Xia, D. et al. Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria. Science 277, 60-66 (1997).
26. Zouni, A. et al. Crystal structure of photosystem II from Synechococcus elongatus at 3.8 Å resolution. Nature 409, 739-743 (2001).
27. Binda, C., Newton-Vinson, P., Hubalek, F., Edmondson, D. E. & Mattevi, A. Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders. Nature Struct. Biol. 9, 22-26 (2002).
28. Bracey, M. H., Hanson, M. A., Masuda, K. R., Stevens, R. C. & Cravatt, B. F. Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling. Science 298, 1793-1796 (2002).
29. Ferguson, K. M. et al. EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization. Mol. Cell 11, 507-517 (2003).
30. Newton, A. C. Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. Biochem. J. 370, 361-371 (2003).
31. Kusumi, A. et al. Paradigm shift of the plasma membrane concept from the two-dimensional continuum fluid to the partitioned fluid: high-speed single-molecule tracking of membrane molecules. Annu. Rev. Biophys. Biomol. Struct. 34, 351-378 (2005).
32. Saxton, M. J. & Jacobson, K. Single-particle tracking: applications to membrane dynamics. Annu. Rev. Biophys. Biomol. Struct. 26, 373-399 (1997).
33. Hessa, T. et al. Recognition of transmembrane helices by the endoplasmic reticulum translocon. Nature 433, 377-381 (2005).
34. Picot, D. Loll, P. J. & Garavito, R. M. The X-ray structure of the membrane protein prostaglandin H2 synthase-1. Nature 367, 243-249 (1994).