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Volumn 27, Issue 2, 2006, Pages 240-247

Aging and the brown norway rat leydig cell antioxidant defense system

Author keywords

Aging; Anti oxidants; Free radical aging; Pro oxidants; Testosterone

Indexed keywords

ANTIOXIDANT; COPPER ZINC SUPEROXIDE DISMUTASE; FREE RADICAL; GLUTATHIONE; GLUTATHIONE PEROXIDASE; LUTEINIZING HORMONE; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA; TESTOSTERONE;

EID: 33644534186     PISSN: 01963635     EISSN: None     Source Type: Journal    
DOI: 10.2164/jandrol.05075     Document Type: Article
Times cited : (103)

References (47)
  • 1
    • 0037369771 scopus 로고    scopus 로고
    • Isolation of Sertoli cells from adult rat testes: An approach to ex vivo studies of Sertoli cell function
    • Anway MD, Folmer J, Wright WW, Zirkin BR. Isolation of Sertoli cells from adult rat testes: an approach to ex vivo studies of Sertoli cell function. Biol Reprod. 2003;68:996-1002.
    • (2003) Biol Reprod , vol.68 , pp. 996-1002
    • Anway, M.D.1    Folmer, J.2    Wright, W.W.3    Zirkin, B.R.4
  • 2
    • 0029125737 scopus 로고
    • Alteration of the adrenal antioxidant defense system during aging in rats
    • Azhar S, Cao L, Reaven E. Alteration of the adrenal antioxidant defense system during aging in rats. J Clin Invest. 1995;96:1414-1424.
    • (1995) J Clin Invest , vol.96 , pp. 1414-1424
    • Azhar, S.1    Cao, L.2    Reaven, E.3
  • 4
    • 0018341648 scopus 로고
    • Age-related changes in reproductive hormones and in Leydig cell responsivity in the male Fischer 344 rat
    • Bethea CL, Walker RF. Age-related changes in reproductive hormones and in Leydig cell responsivity in the male Fischer 344 rat. J Gerontol. 1979;34:21-27.
    • (1979) J Gerontol , vol.34 , pp. 21-27
    • Bethea, C.L.1    Walker, R.F.2
  • 5
    • 0017659933 scopus 로고
    • Effects of single and multiple injections of synthetic GnRH on serum LH, FSH and testosterone in young and old male rats
    • Bruni JF, Huang HH, Marshall S, Meites J. Effects of single and multiple injections of synthetic GnRH on serum LH, FSH and testosterone in young and old male rats. Biol Reprod. 1977;17:309-312.
    • (1977) Biol Reprod , vol.17 , pp. 309-312
    • Bruni, J.F.1    Huang, H.H.2    Marshall, S.3    Meites, J.4
  • 6
    • 0033796250 scopus 로고    scopus 로고
    • Mitochondrial free radical generation, oxidative stress, and aging
    • Cadenas E, Davies KJ. Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med. 2000;29:222-230.
    • (2000) Free Radic Biol Med , vol.29 , pp. 222-230
    • Cadenas, E.1    Davies, K.J.2
  • 7
    • 1542329063 scopus 로고    scopus 로고
    • Aging alters the functional expression of enzymatic and non-enzymatic anti-oxidant defense systems in testicular rat Leydig cells
    • Cao LC, Leers-Sucheta S, Azhar S. Aging alters the functional expression of enzymatic and non-enzymatic anti-oxidant defense systems in testicular rat Leydig cells. J Steroid Biochem Molec Biol. 2004;88:61-67.
    • (2004) J Steroid Biochem Molec Biol , vol.88 , pp. 61-67
    • Cao, L.C.1    Leers-Sucheta, S.2    Azhar, S.3
  • 8
    • 0034899370 scopus 로고    scopus 로고
    • Age-related increase in mitochondrial superoxide generation in the testosterone-producing cells of Brown Norway rat testes: Relationship to reduced steroidogenic function?
    • Chen H, Cangello D, Benson S, Folmer J, Zhu H, Trush MA, Zirkin BR. Age-related increase in mitochondrial superoxide generation in the testosterone-producing cells of Brown Norway rat testes: relationship to reduced steroidogenic function? Exp Gerontol. 2001;36:1361-1373.
    • (2001) Exp Gerontol , vol.36 , pp. 1361-1373
    • Chen, H.1    Cangello, D.2    Benson, S.3    Folmer, J.4    Zhu, H.5    Trush, M.A.6    Zirkin, B.R.7
  • 9
    • 0028558510 scopus 로고
    • Age-related decreased Leydig cell testosterone production in the Brown Norway rat
    • Chen H, Hardy MP, Huhtaniemi I, Zirkin BR. Age-related decreased Leydig cell testosterone production in the Brown Norway rat. J Androl. 1994;15:551-557.
    • (1994) J Androl , vol.15 , pp. 551-557
    • Chen, H.1    Hardy, M.P.2    Huhtaniemi, I.3    Zirkin, B.R.4
  • 10
    • 0036227563 scopus 로고    scopus 로고
    • Age-related decreases in Leydig cell testosterone production are not restored by exposure to LH in vitro
    • Chen H, Hardy MP, Zirkin BR. Age-related decreases in Leydig cell testosterone production are not restored by exposure to LH in vitro. Endocrinology. 2002;143:1637-1642.
    • (2002) Endocrinology , vol.143 , pp. 1637-1642
    • Chen, H.1    Hardy, M.P.2    Zirkin, B.R.3
  • 11
    • 0029980067 scopus 로고    scopus 로고
    • Depletion and repopulation of Leydig cells in the testes of aging Brown Norway rats
    • Chen H, Huhtaniemi I, Zirkin BR. Depletion and repopulation of Leydig cells in the testes of aging Brown Norway rats. Endocrinology. 1996;137:3447-3452.
    • (1996) Endocrinology , vol.137 , pp. 3447-3452
    • Chen, H.1    Huhtaniemi, I.2    Zirkin, B.R.3
  • 12
    • 0347318172 scopus 로고    scopus 로고
    • Leydig cell gene expression: Effects of age and caloric restriction
    • Chen H, Irizarry RA, Luo L, Zirkin BR. Leydig cell gene expression: effects of age and caloric restriction. Exp Gerontol. 2004;39:31-43.
    • (2004) Exp Gerontol , vol.39 , pp. 31-43
    • Chen, H.1    Irizarry, R.A.2    Luo, L.3    Zirkin, B.R.4
  • 13
    • 0033055792 scopus 로고    scopus 로고
    • Expression of antioxidant protective proteins in the rat retina during prenatal and postnatal development
    • Chen W, Hunt DM, Lu H, Hunt RC. Expression of antioxidant protective proteins in the rat retina during prenatal and postnatal development. Invest Ophthalmol Vis Sci. 1999;40:744-751.
    • (1999) Invest Ophthalmol Vis Sci , vol.40 , pp. 744-751
    • Chen, W.1    Hunt, D.M.2    Lu, H.3    Hunt, R.C.4
  • 15
    • 0033805227 scopus 로고    scopus 로고
    • Effects of oxidative stress on the expression of antioxidative defense enzymes in spontaneously hypertensive rat hearts
    • Csonka C, Pataki T, Kovacs P, Muller SL, Schroeter ML, Tosaki A, Blasig IE. Effects of oxidative stress on the expression of antioxidative defense enzymes in spontaneously hypertensive rat hearts. Free Radic Biol Med. 2000;29:612-619.
    • (2000) Free Radic Biol Med , vol.29 , pp. 612-619
    • Csonka, C.1    Pataki, T.2    Kovacs, P.3    Muller, S.L.4    Schroeter, M.L.5    Tosaki, A.6    Blasig, I.E.7
  • 16
    • 0037661090 scopus 로고    scopus 로고
    • Reactive oxygen disrupts mitochondria in MA-10 tumor Leydig cells and inhibits steroidogenic acute regulatory (StAR) protein and steroidogenesis
    • Diemer T, Allen JA, Hales KH, Hales DB. Reactive oxygen disrupts mitochondria in MA-10 tumor Leydig cells and inhibits steroidogenic acute regulatory (StAR) protein and steroidogenesis. Endocrinology. 2003;144:2882-2891.
    • (2003) Endocrinology , vol.144 , pp. 2882-2891
    • Diemer, T.1    Allen, J.A.2    Hales, K.H.3    Hales, D.B.4
  • 17
    • 0026020970 scopus 로고
    • Antioxidant defense systems: The role of carotenoids, tocopherols, and thiols
    • Di Mascio P, Murphy ME, Sies H. Antioxidant defense systems: the role of carotenoids, tocopherols, and thiols. Am J Clin Nutr. 1991;53:194S-200S.
    • (1991) Am J Clin Nutr , vol.53
    • Di Mascio, P.1    Murphy, M.E.2    Sies, H.3
  • 18
    • 0028194849 scopus 로고
    • The Brown Norway rat as a model of male reproductive aging: Evidence for both primary and secondary testicular failure
    • Gruenewald DA, Naai MA, Hess DL, Matsumoto AM. The Brown Norway rat as a model of male reproductive aging: evidence for both primary and secondary testicular failure. J Gerontol. 1994;49:B42-B50.
    • (1994) J Gerontol , vol.49
    • Gruenewald, D.A.1    Naai, M.A.2    Hess, D.L.3    Matsumoto, A.M.4
  • 19
    • 0031736458 scopus 로고    scopus 로고
    • Does age-associated reduced Leydig cell testosterone production in Brown Norway rats result from under-stimulation by luteinizing hormone?
    • Grzywacz FW, Chen H, Allegretti J, Zirkin BR. Does age-associated reduced Leydig cell testosterone production in Brown Norway rats result from under-stimulation by luteinizing hormone? J Androl. 1998;19:625-630.
    • (1998) J Androl , vol.19 , pp. 625-630
    • Grzywacz, F.W.1    Chen, H.2    Allegretti, J.3    Zirkin, B.R.4
  • 20
    • 0017064979 scopus 로고
    • A fluorometric method for determination of oxidized and reduced glutathione in tissues
    • Hissin PJ, Hilf R. A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal Biochem. 1976;74:214-226.
    • (1976) Anal Biochem , vol.74 , pp. 214-226
    • Hissin, P.J.1    Hilf, R.2
  • 21
    • 0017160247 scopus 로고
    • Current experience using the laboratory rat in aging studies
    • Hollander CE Current experience using the laboratory rat in aging studies. Lab Anim Sci. 1976;26:320-328.
    • (1976) Lab Anim Sci , vol.26 , pp. 320-328
    • Hollander, C.E.1
  • 22
    • 0020725727 scopus 로고
    • Enhanced daily sperm production in the remaining testis of aged rats following hemicastration
    • Johnson L, Neaves WB. Enhanced daily sperm production in the remaining testis of aged rats following hemicastration. J Androl. 1983;4:162-166.
    • (1983) J Androl , vol.4 , pp. 162-166
    • Johnson, L.1    Neaves, W.B.2
  • 23
    • 0021969986 scopus 로고
    • An analysis of the age-related decline in testicular steroidogenesis in the rat
    • Kinoshita Y, Higashi Y, Winters SJ, Oshima H, Troen P. An analysis of the age-related decline in testicular steroidogenesis in the rat. Biol Reprod. 1985;32:309-314.
    • (1985) Biol Reprod , vol.32 , pp. 309-314
    • Kinoshita, Y.1    Higashi, Y.2    Winters, S.J.3    Oshima, H.4    Troen, P.5
  • 24
    • 0023222052 scopus 로고
    • Effect of luteinizing hormone deprivation in situ on steroidogenesis of rat Leydig cells purified by a multistep procedure
    • Klinefelter GR, Hall PF, Ewing LL. Effect of luteinizing hormone deprivation in situ on steroidogenesis of rat Leydig cells purified by a multistep procedure. Biol Reprod. 1987;36:769-783.
    • (1987) Biol Reprod , vol.36 , pp. 769-783
    • Klinefelter, G.R.1    Hall, P.F.2    Ewing, L.L.3
  • 25
    • 0019208461 scopus 로고
    • The aging Leydig cell: 1. Testosterone and adenosine 3′,5′- monophosphate responses to gonadotropin stimulation in rats
    • Lin T, Murono E, Osterman J, Allen DO, Nankin HR. The aging Leydig cell: 1. Testosterone and adenosine 3′,5′-monophosphate responses to gonadotropin stimulation in rats. Steroids. 1980;35:653-663.
    • (1980) Steroids , vol.35 , pp. 653-663
    • Lin, T.1    Murono, E.2    Osterman, J.3    Allen, D.O.4    Nankin, H.R.5
  • 26
    • 0029827114 scopus 로고    scopus 로고
    • Are Leydig cell steroidogenic enzymes differentially regulated with aging?
    • Luo L, Chen H, Zirkin BR. Are Leydig cell steroidogenic enzymes differentially regulated with aging? J Androl. 1996;17:509-515.
    • (1996) J Androl , vol.17 , pp. 509-515
    • Luo, L.1    Chen, H.2    Zirkin, B.R.3
  • 27
    • 10844285662 scopus 로고    scopus 로고
    • Temporal relationships among testosterone production, steroidogenic acute regulatory protein (StAR), and P450 side-chain cleavage enzyme (P450scc) during Leydig cell aging
    • Luo L, Chen H, Zirkin BR. Temporal relationships among testosterone production, steroidogenic acute regulatory protein (StAR), and P450 side-chain cleavage enzyme (P450scc) during Leydig cell aging. J Androl. 2005;26:25-31.
    • (2005) J Androl , vol.26 , pp. 25-31
    • Luo, L.1    Chen, H.2    Zirkin, B.R.3
  • 29
    • 0020059070 scopus 로고
    • Changes in neuroendocrine control of anterior pituitary function during aging
    • Meites J. Changes in neuroendocrine control of anterior pituitary function during aging. Neuroendocrinology. 1982;34:151-156.
    • (1982) Neuroendocrinology , vol.34 , pp. 151-156
    • Meites, J.1
  • 30
    • 0034682963 scopus 로고    scopus 로고
    • Aging is associated with increased lipid peroxidation in human hearts, but not with mitochondrial respiratory chain enzyme defects
    • Miro O, Casademont J, Casals E, Perea M, Urbano-Marquez A, Rustin P, Cardellach F. Aging is associated with increased lipid peroxidation in human hearts, but not with mitochondrial respiratory chain enzyme defects. Cardiovasc Res. 2000;47:624-631.
    • (2000) Cardiovasc Res , vol.47 , pp. 624-631
    • Miro, O.1    Casademont, J.2    Casals, E.3    Perea, M.4    Urbano-Marquez, A.5    Rustin, P.6    Cardellach, F.7
  • 31
    • 0028140273 scopus 로고
    • Inhibition of protein synthesis and hormone-sensitive steroidogenesis in response to hydrogen peroxide in rat luteal cells
    • Musicki B, Aten RF, Behrman HR. Inhibition of protein synthesis and hormone-sensitive steroidogenesis in response to hydrogen peroxide in rat luteal cells. Endocrinology. 1994;134:588-595.
    • (1994) Endocrinology , vol.134 , pp. 588-595
    • Musicki, B.1    Aten, R.F.2    Behrman, H.R.3
  • 32
    • 0018129592 scopus 로고
    • In vitro and in vivo studies on Leydig cell function in old rats
    • Pirke KM, Vogt HJ, Geiss M. In vitro and in vivo studies on Leydig cell function in old rats. Acta Endocrinol Copenh. 1978;89:393-403.
    • (1978) Acta Endocrinol Copenh , vol.89 , pp. 393-403
    • Pirke, K.M.1    Vogt, H.J.2    Geiss, M.3
  • 34
    • 0031791849 scopus 로고    scopus 로고
    • GPx3: The plasma-type glutathione peroxidase is expressed under androgenic control in the mouse epididymis and vas deferens
    • Schwaab V, Faure J, Dufaure JP, Drevet JR. GPx3: the plasma-type glutathione peroxidase is expressed under androgenic control in the mouse epididymis and vas deferens. Mol Reprod Dev. 1998:51:362-372.
    • (1998) Mol Reprod Dev , vol.51 , pp. 362-372
    • Schwaab, V.1    Faure, J.2    Dufaure, J.P.3    Drevet, J.R.4
  • 35
    • 0024402834 scopus 로고
    • An assay for superoxide dismutase activity in mammalian tissue homogenates
    • Spitz DR, Oberley LW. An assay for superoxide dismutase activity in mammalian tissue homogenates. Anal Biochem. 1989;179:8-18.
    • (1989) Anal Biochem , vol.179 , pp. 8-18
    • Spitz, D.R.1    Oberley, L.W.2
  • 36
    • 0031727226 scopus 로고    scopus 로고
    • Only the glutathione dependent antioxidant enzymes are inhibited by haematotoxic hydroxylamines
    • Spooren AA, Evelo CT. Only the glutathione dependent antioxidant enzymes are inhibited by haematotoxic hydroxylamines. Hum Exp Toxicol. 1998;17:554-559.
    • (1998) Hum Exp Toxicol , vol.17 , pp. 554-559
    • Spooren, A.A.1    Evelo, C.T.2
  • 37
    • 0035039021 scopus 로고    scopus 로고
    • Protein oxidation in aging and age-related diseases
    • Stadtman ER. Protein oxidation in aging and age-related diseases. Ann N Y Acad Sci. 2001;928:22-38.
    • (2001) Ann N Y Acad Sci , vol.928 , pp. 22-38
    • Stadtman, E.R.1
  • 39
    • 0021624529 scopus 로고
    • Reduced pulsatile luteinizing hormone and testosterone secretion with aging in the male rat
    • Steiner RA, Bremner WJ, Clifton DK, Dorsa DM. Reduced pulsatile luteinizing hormone and testosterone secretion with aging in the male rat. Biol Reprod. 1984;31:251-258.
    • (1984) Biol Reprod , vol.31 , pp. 251-258
    • Steiner, R.A.1    Bremner, W.J.2    Clifton, D.K.3    Dorsa, D.M.4
  • 40
    • 0027132475 scopus 로고
    • The effects of hydrogen peroxide on steroidogenesis in mouse Leydig tumor cells
    • Stocco DM, Wells J, Clark BJ. The effects of hydrogen peroxide on steroidogenesis in mouse Leydig tumor cells. Endocrinology. 1993;133:2827-2832.
    • (1993) Endocrinology , vol.133 , pp. 2827-2832
    • Stocco, D.M.1    Wells, J.2    Clark, B.J.3
  • 41
    • 0025312043 scopus 로고
    • Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 antigens
    • Suthanthiran M, Anderson ME, Sharma VK, Meister A. Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 antigens. Proc Natl Acad Sci USA. 1990;87:3343-3347.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 3343-3347
    • Suthanthiran, M.1    Anderson, M.E.2    Sharma, V.K.3    Meister, A.4
  • 42
  • 43
    • 0027197451 scopus 로고
    • Androgens and aging in men
    • Swerdloff RS, Wang C. Androgens and aging in men. Exp Gerontol. 1993;28:435-446.
    • (1993) Exp Gerontol , vol.28 , pp. 435-446
    • Swerdloff, R.S.1    Wang, C.2
  • 44
    • 0035210684 scopus 로고    scopus 로고
    • Gene expression in Brown Norway rat Leydig cells: Effects of age and of age-related germ cell loss
    • Syntin P, Chen H, Zirkin BR, Robaire B. Gene expression in Brown Norway rat Leydig cells: effects of age and of age-related germ cell loss. Endocrinology. 2001;142:5277-5285.
    • (2001) Endocrinology , vol.142 , pp. 5277-5285
    • Syntin, P.1    Chen, H.2    Zirkin, B.R.3    Robaire, B.4
  • 45
    • 0027160663 scopus 로고
    • Relationship between the critical level of oxidative stresses and the glutathione peroxidase activity
    • Toussaint O, Houbion A, Remacle J. Relationship between the critical level of oxidative stresses and the glutathione peroxidase activity. Toxicology. 1993;81:89-101.
    • (1993) Toxicology , vol.81 , pp. 89-101
    • Toussaint, O.1    Houbion, A.2    Remacle, J.3
  • 46
    • 0027146119 scopus 로고
    • Reproductive aging in the male Brown-Norway rat: A model for the human
    • Wang C, Leung A, Sinha-Hikim AP. Reproductive aging in the male Brown-Norway rat: a model for the human. Endocrinology. 1993;133:2773-2781.
    • (1993) Endocrinology , vol.133 , pp. 2773-2781
    • Wang, C.1    Leung, A.2    Sinha-Hikim, A.P.3
  • 47
    • 0033796721 scopus 로고    scopus 로고
    • Regulation of Leydig cell steroidogenic function during aging
    • Zirkin BR, Chen H. Regulation of Leydig cell steroidogenic function during aging. Biol Reprod. 2000;63:977-981.
    • (2000) Biol Reprod , vol.63 , pp. 977-981
    • Zirkin, B.R.1    Chen, H.2


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