Structure/function relationships responsible for coenzyme specificity and the isomerase activity of human type 1 3β-hydroxysteroid dehydrogenase/isomerase

Journal of Biological Chemistry

Volumn 278, Issue 37, 2003, Pages 35483-35490

  Thomas, James L ^a   Duax, William L ^b,c   Addlagatta, Anthony ^b,d   Brandt, Stacey ^a   Fuller, Robert R ^a   Norris, Wendy ^a  

^a MERCER UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HAUPTMAN WOODWARD MEDICAL RESEARCH INSTITUTE   (United States)

^c UNIVERSITY AT BUFFALO   (United States)

^d UNIVERSITY OF OREGON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CONFORMATIONS; MUTAGENESIS; TUMORS;

ENZYME REACTIONS;

COENZYMES;

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; 3(OR 17)BETA HYDROXYSTEROID ISOMERASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE GLUCOSE 4 EPIMERASE;

AMINO TERMINAL SEQUENCE; ARTICLE; BREAST TUMOR; ENZYME ACTIVITY; ENZYME BINDING; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME STRUCTURE; HUMAN; ISOMERISM; MOLECULAR MODEL; PH MEASUREMENT; PLACENTA; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REACTION ANALYSIS; SEQUENCE HOMOLOGY; STEROID METABOLISM; TUMOR GROWTH;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARGININE; ASPARTIC ACID; COENZYMES; FEMALE; HUMANS; KINETICS; MALE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; MUTAGENESIS, SITE-DIRECTED; NAD; PLACENTA; PREGNANCY; PROGESTERONE REDUCTASE; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; STEROID ISOMERASES; SUBSTRATE SPECIFICITY; TUMOR CELLS, CULTURED;

EID: 0041816090     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M304752200     Document Type: Article

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