Dendritic cells transduced with lentiviral-mediated RelB-specific ShRNAs inhibit the development of experimental autoimmune myasthenia gravis

Molecular Immunology

Volumn 46, Issue 4, 2009, Pages 657-667

  Zhang, Yong ^a   Yang, Huan ^a   Xiao, Bo ^a   Wu, Minghua ^b   Zhou, Wenbing ^a   Li, Jing ^a   Li, Guiyuan ^b   Christadoss, Premkumar ^c  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Dendritic cells; EAMG; Lentiviral vector; RelB; RNA interference

Indexed keywords

CHOLINERGIC RECEPTOR; GAMMA INTERFERON; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2B; INTERLEUKIN 10; INTERLEUKIN 4; LENTIVIRUS VECTOR; PEPTIDE DERIVATIVE; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR RELB;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; CELL BASED GENE THERAPY; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DISEASE SEVERITY; FEMALE; GENE; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IMMUNIZATION; IMMUNOGLOBULIN BLOOD LEVEL; INCIDENCE; LYMPHOCYTE PROLIFERATION; MOUSE; MYASTHENIA GRAVIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; RELB GENE; RNA INTERFERENCE; SPLEEN CELL; T LYMPHOCYTE; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; ANTIBODIES; DENDRITIC CELLS; FEMALE; IMMUNOTHERAPY, ADOPTIVE; LENTIVIRUS; MICE; MICE, INBRED C57BL; MYASTHENIA GRAVIS, AUTOIMMUNE, EXPERIMENTAL; NIH 3T3 CELLS; PEPTIDES; RECEPTORS, CHOLINERGIC; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSCRIPTION FACTOR RELB; TRANSDUCTION, GENETIC;

MUS;

EID: 58249106765     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2008.08.274     Document Type: Article

References (66)

1. Ardeshna K.M., Pizzey A.R., Devereux S., and Khwaja A. The PI3 kinase, p38 SAP kinase, and NF-kappaB signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte-derived dendritic cells. Blood 96 3 (2000) 1039-1046
2. Balasa B., Deng C., Lee J., Bradley L.M., Dalton D.K., Christadoss P., and Sarvetnick N. Interferonγ (IFN-γ) is necessary for the genesis of acetylcholine receptor-induced clinical experimental autoimmune myasthenia gravis in mice. J. Exp. Med. 186 (1997) 385-391
3. Bastos K.R., de Deus Vieira de Moraes L., Zago C.A., Marinho C.R., Russo M., Alvarez J.M., and D'Imperio Lima M.R. Analysis of the activation profile of dendritic cells derived from the bone marrow of interleukin-12/interleukin-23-deficient mice. Immunology 114 (2005) 499-506
4. Becher B., Blain M., Giacomini P.S., and Antel J.P. Inhibition of Th1 polarization by soluble TNF receptor is dependent on antigen-presenting cell derived IL-12. J. Immunol. 162 2 (1999) 684-688
5. Bonham C.A., Peng L., Liang X., Chen Z., Wang L., Ma L., Hackstein H., Robbins P.D., Thomson A.W., Fung J.J., Qian S., and Lu L. Marked prolongation of cardiac allograft survival by dendritic cells genetically engineered with NF-kappa B oligodeoxyribonucleotide decoys and adenoviral vectors encoding CTLA4-Ig. J. Immunol. 169 6 (2002) 3382-3391
6. Breckpot K., Dullaers M., Bonehill A., van Meirvenne S., Heirman C., de Greef C., van der Bruggen P., and Thielemans K. Lentivirally transduced dendritic cells as a tool for cancer immunotherapy. J. Genet. Med. 5 8 (2003) 654-667
7. Chang L.J., and Gay E.E. The molecular genetics of lentiviral vectors-current and future perspectives. Curr. Gene Ther. 1 3 (2001) 237-251
8. + regulatory T cells. J. Immunol. 177 6 (2006) 3806-3813
9. Chinnasamy N., Chinnasamy D., Toso J.F., Lapointe R., Candotti F., Morgan R.A., and Hwu P. Efficient gene transfer to human peripheral blood monocyte-derived dendritic cells using human immunodeficiency virus type 1-based lentiviral vectors. Hum. Gene Ther. 11 13 (2000) 1901-1909
10. Clark G.J., Gunningham S., Troy A., Vuckovic S., and Hart D.N. Expression of the RelB transcription factor correlates with the activation of human dendritic cells. Immunology 98 2 (1999) 189-196
11. Conti-Fine B.M., Milani M., and Kaminski H.J. Myasthenia gravis: past, present, and future. J. Clin. Invest. 116 11 (2006) 2843-2854 (review)
12. Cools N., Ponsaerts P., Van Tendeloo V.F., and Berneman Z.N. Balancing between immunity and tolerance: an interplay between dendritic cells, regulatory T cells, and effector T cells. J. Leukoc. Biol. 82 6 (2007) 1365-1374
13. Cristadoss P., Poussin M., and Deng C. Animal models of myasthenia gravis. Clin. Immunol. 94 2 (2000) 75-87
14. Dhodapkar M.V., Steinman R.M., Krasovsky J., Munz C., and Bhardwaj N. Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J. Exp. Med. 193 2 (2001) 233-238
15. Drachman D.B. Myasthenia gravis. N. Engl. J. Med. 330 (1994) 1797-1810
16. Esslinger C., Romero P., and MacDonald H.R. Efficient transduction of dendritic cells and induction of a T-cell response by third-generation lentivectors. Hum. Gene Ther. 13 9 (2002) 1091-1100
17. Fontenot J.D., Rasmussen J.P., Williams L.M., Dooley J.L., Farr A.G., and Rudensky A.Y. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 22 3 (2005) 329-341
18. Giannoukakis N., Bonham C.A., Qian S., Chen Z., Peng L., Harnaha J., Li W., Thomson A.W., Fung J.J., Robbins P.D., and Lu L. Prolongation of cardiac allograft survival using dendritic cells treated with NF-κB decoy oligodeoxyribonucleotides. Mol. Ther. 1 5 Pt 1 (2000) 430-437
19. Gruber A., Kan-Mitchell J., Kuhen K.L., Mukai T., and Wong-Staal F. Dendritic cells transduced by multiply deleted HIV-1 vectors exhibit normal phenotypes and functions and elicit an HIV specific cytotoxic T-lymphocyte response in vitro. Blood 96 4 (2000) 1327-1333
20. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389 6652 (1997) 737-742
21. Groux H., and Powrie F. Regulatory T cells and inflammatory bowel disease. Immunol. Today 20 (1999) 442-446
22. Hawiger D., Inaba K., Dorsett Y., Guo M., Mahnke K., Rivera M., Ravetch J.V., Steinman R.M., and Nussenzweig M.C. Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J. Exp. Med. 194 6 (2001) 769-779
23. Herrmann F. Cancer gene therapy: principles, problems, and perspectives. J. Mol. Med. 73 4 (1995) 157-163 Review
24. Ichim T.E., Li M., Qian H., Popov I.A., Rycerz K., Zheng X., White D., Zhong R., and Min W.P. RNA interference: a potent tool for gene-specific therapeutics. Am. J. Transplant. 4 8 (2004) 1227-1236 Review
25. Iruretagoyena M.I., Sepúlveda S.E., Lezana J.P., Hermoso M., Bronfman M., Gutiérrez M.A., Jacobelli S.H., and Kalergis A.M. Inhibition of nuclear factor-kappa B enhances the capacity of immature dendritic cells to induce antigen-specific tolerance in experimental autoimmune encephalomyelitis. J. Pharmacol. Exp. 318 1 (2006) 59-67
26. + epitope sequences of the acetylcholine receptor. J. Neuroimmunol. 95 1-2 (1999) 73-84
27. Karachunski P.I., Ostlie N.S., Okita D.K., and Conti-Fine B.M. Prevention of experimental myasthenia gravis by nasal administration of synthetic acetylcholine receptor T epitope sequences. J. Clin. Invest. 100 12 (1997) 3027-3035
28. Kim C.J., Prevette T., Cormier J., Overwijk W., Roden M., Restifo N.P., Rosenberg S.A., and Marincola F.M. Dendritic cells infected with poxviruses encoding MART-1/Melan A sensitize T lymphocytes in vitro. J. Immunother. 20 4 (1997) 276-286
29. Kondo E., Topp M.S., Kiem H.P., Obata Y., Morishima Y., Kuzushima K., Tanimoto M., Harada M., Takahashi T., and Akatsuka Y. Efficient generation of antigen-specific cytotoxic T cells using retrovirally transduced CD40-activated B cells. J. Immunol. 169 4 (2002) 2164-2171
30. Kordower J.H., Emborg M.E., Bloch J., Ma S.Y., Chu Y., Leventhal L., McBride J., Chen E.Y., Palfi S., Roitberg B.Z., Brown W.D., Holden J.E., Pyzalski R., Taylor M.D., Carvey P., Ling Z., Trono D., Hantraye P., Déglon N., and Aebischer P. Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science 290 5492 (2000) 767-773
31. Li L., Sun S., Cao X., Wang Y., Chang L., and Yin X. Experimental study on induction of tolerance to experimental myasthenia gravis by immature dendritic cells. J. Huazhong Univ. Sci. Technol. Med. Sci. 25 2 (2005) 215-218
32. Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25 4 (2001) 402-408
33. Lizee G., Gonzales M.I., and Topalian S.L. Lentivirus vector-mediated expression of tumor-associated epitopes by human antigen presenting cells. Hum. Gene. Ther. 15 4 (2004) 393-404
34. Martin E., O'Sullivan B., Low P., and Thomas R. Antigen-specific suppression of a primed immune response by dendritic cells mediated by regulatory T cells secreting interleukin-10. Immunity 18 1 (2003) 155-167
35. Min W.P., Gorczynski R., Huang X.Y., Kushida M., Kim P., Obataki M., Lei J., Suri R.M., and Cattral M.S. Dendritic cells genetically engineered to express Fas ligand induce donor-specific hyporesponsiveness and prolong allograft survival. J. Immunol. 164 1 (2000) 161-167
36. Moiola L., Galbiati F., Martino G., Amadio S., Brambilla E., Comi G., Vincent A., Grimaldi L.M., and Adorini L. IL-12 is involved in the induction of experimental autoimmune myasthenia gravis, an antibody mediated disease. Eur. J. Immunol. 28 8 (1998) 2487-2497
37. Nagane Y., Utsugisawa K., Obara D., Yamagata M., and Tohgi H. Dendritic cells in hyperplastic thymuses from patients with myasthenia gravis. Muscle Nerve 27 5 (2003) 582-589
38. Neumann M., Fries H., Scheicher C., Keikavoussi P., Kolb-Maurer A., Brocker E., Serfling E., and Kampgen E. Differential expression of Rel/NF-κB and octamer factors is a hallmark of the generation and maturation of dendritic cells. Blood 95 1 (2000) 277-285
39. O'Sullivan B.J., MacDonald K.P., Pettit A.R., and Thomas R. RelB nuclear translocation regulates B cell MHC molecule, CD40 expression, and antigen-presenting cell function. Proc. Natl. Acad. Sci. U.S.A. 97 21 (2000) 11421-11426
40. Pearson T.C., Trambley J., Odom K., Anderson D.C., Cowan S., Bray R., Lin A., Hollenbaugh D., Aruffo A., Siadak A.W., Strobert E., Hennigar R., and Larsen C.P. Anti-CD40 therapy extends renal allograft survival in rhesus macaques. Transplantation 74 7 (2002) 933-940
41. Pettit A.R., MacDonald K.P., O'Sullivan B., and Thomas R. Differentiated dendritic cells expressing nuclear RelB are predominantly located in rheumatoid synovial tissue perivascular mononuclear cell aggregates. Arthritis Rheum. 43 4 (2000) 791-800
42. Rescigno M., Martino M., Sutherland C.L., Gold M.R., and Ricciardi-Castagnoli P. Dendritic cell survival and maturation are regulated by different signaling pathways. J. Exp. Med. 188 11 (1998) 2175-2180
43. Scherr M., Morgan M.A., and Eder M. Gene silencing mediated by small interfering RNAs in mammalian cells. Curr. Med. Chem. 10 3 (2003) 245-256
44. Schroers R., Sinha I., Segall H., Schmidt-Wolf I.G., Rooney C.M., Brenner M.K., Sutton R.E., and Chen S.Y. Transduction of human PBMC derived dendritic cells and macrophages by an HIV-1-based lentiviral vector system. Mol. Ther. 1 2 (2000) 171-179
45. + regulatory T cells. J. Immunol. 177 8 (2006) 5296-5306
46. Sloan J.M., Kershaw M.H., Touloukian C.E., Lapointe R., Robbins P.F., Restifo N.P., and Hwu P. MHC class I and class II presentation of tumor antigen in retrovirally and adenovirally transduced dendritic cells. Cancer Gene. Ther. 9 11 (2002) 946-950
47. + regulatory T cells and infectious tolerance. Transplantation 77 1 Suppl (2004) S23-S25 (review)
48. Steinman R.M., Hawiger D., and Nussenzweig M.C. Tolerogenic dendritic cells. Annu. Rev. Immunol. 21 (2003) 685-711 (review)
49. Taylor P.C., Williams R.O., and Maini R.N. Anti-TNF alpha therapy in rheumatoid arthritis-current and future directions. Curr. Dir. Autoimmun. 2 (2000) 83-102 Review
50. + T cells. J. Immunol. 174 11 (2005) 7433-7439
51. Vincent A., Palace J., and Hilton-Jones D. Myasthenia gravis. Lancet 357 (2001) 2122-2128
52. Vlad G., Cortesini R., and Suciu-Foca N. License to heal: bidirectional interaction of antigen-specific regulatory T cells and tolerogenic APC. J. Immunol. 174 10 (2005) 5907-5914
53. Voisine C., Hubert F.X., Trinite B., Heslan M., and Josien R. Two phenotypically distinct subsets of spleen dendritic cells in rats exhibit different cytokine production and T cell stimulatory activity. J. Immunol. 169 5 (2002) 2284-2291
54. Wakkach A., Fournier N., Brun V., Breittmayer J.P., Cottrez F., and Groux H. Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo. Immunity 18 5 (2003) 605-617
55. Wang Q., Liu Y., Wang J., Ding G., Zhang W., Chen G., Zhang M., Zheng S., and Cao X. Induction of allospecific tolerance by immature dendritic cells genetically modified to express soluble TNF receptor. J. Immunol. 177 4 (2006) 2175-2185
56. + regulatory T cells in human thymus. Nature 436 7054 (2005) 1181-1185
57. Wu B., Goluszko E., and Christadoss P. Experimental autoimmune myasthenia gravis in the mouse. Curr. Protoc. Immunol. 15 (2001) (unit 15.8)
58. +dendritic cells. Immunity 9 6 (1998) 839-847
59. Xiao B.G., Duan R.S., Link H., and Huang Y.M. Induction of peripheral tolerance to experimental autoimmune myasthenia gravis by acetylcholine receptor-pulsed dendritic cells. Cell. Immunol. 223 1 (2003) 63-69
60. Yamamoto K., Yamaguchi M., Miyasaka N., and Miura O. SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12R β2 subunit. Biochem. Biophys. Res. Commun. 310 4 (2003) 1188-1193
61. Yang H., Goluszko E., David C., Okita D.K., Conti-Fine B., Chan T.S., Poussin M.A., and Christadoss P. Mapping myasthenia gravis-associated T cell epitopes on human acetylcholine receptors in HLA transgenic mice. J. Clin. Invest. 109 8 (2002) 1111-1120
62. Yang H., Kala M., Scott B.G., Goluszko E., Chapman H.A., and Christadoss P. Cathepsin S is required for murine autoimmune myasthenia gravis pathogenesis. J. Immunol. 174 3 (2005) 1729-1737
63. Yang H., Tüzün E., Alagappan D., Yu X., Scott B.G., Ischenko A., and Christadoss P. IL-1 receptor antagonist-mediated therapeutic effect in murine myasthenia gravis is associated with suppressed serum proinflammatory cytokines, C3, and anti-acetylcholine receptor IgG1. J. Immunol. 175 3 (2005) 2018-2025
64. Zhang G.X., Xiao B.G., Yu L.Y., van der Meide P.H., and Link H. Interleukin 10 aggravates experimental autoimmune myasthenia gravis through inducing Th2 and B cell responses to AChR. J. Neuroimmunol. 113 1 (2001) 10-18
65. Zhang G.X., Yu S., Gran B., Li J., Siglienti I., Chen X., Calida D., Ventura E., Kamoun M., and Rostami A. Role of IL-12 receptor beta 1 in regulation of T cell response by APC in experimental autoimmune encephalomyelitis. J. Immunol. 171 9 (2003) 4485-4492
66. Zhang M., Tang H., Guo Z., An H., Zhu X., Song W., Guo J., Huang X., Chen T., Wang J., and Cao X. Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells. Nat. Immunol. 5 11 (2004) 1124-1133