IL-12 is involved in the induction of experimental autoimmune myasthenia gravis, an antibody-mediated disease

European Journal of Immunology

Volumn 28, Issue 8, 1998, Pages 2487-2497

  Moiola, Lucia ^a   Galbiati, Francesca ^b   Martino, Gianvito ^a   Amadio, Stefano ^a   Brambilla, Elena ^a   Comi, Giancarlo ^a   Vincent, Angela ^c   Grimaldi, Luigi M E ^a   Adorini, Luciano ^b  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b ROCHE MILANO RICERCHE   (Italy)

^c JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

Experimental autoimmune myasthenia gravis; IgG2a; IL 12; Muscle nicotinic acetylcholine receptor; Th1

Indexed keywords

CHOLINERGIC RECEPTOR ANTIBODY; IMMUNOGLOBULIN E ANTIBODY; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; IMMUNOGLOBULIN RECEPTOR; INTERLEUKIN 12; NICOTINIC RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY BLOOD LEVEL; ARTICLE; CONTROLLED STUDY; FEMALE; MALE; MOUSE; MYASTHENIA GRAVIS; NEUROMUSCULAR TRANSMISSION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; DISEASE MODELS, ANIMAL; ELECTROMYOGRAPHY; FEMALE; HUMANS; IMMUNOGLOBULIN G; INTERFERON TYPE II; INTERLEUKIN-12; MALE; MICE; MICE, INBRED C57BL; MYASTHENIA GRAVIS; NEUROMUSCULAR JUNCTION; RECEPTORS, CHOLINERGIC; TH1 CELLS; TORPEDO;

EID: 0031902708     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199808)28:08<2487::AID-IMMU2487>3.0.CO;2-Y     Document Type: Article

References (55)

1. Drachman, D. B., Myasthenia gravis. N. Engl. J. Med. 1994. 330: 1797-1810.
2. Vincent, A., Immunology of acetylcholine receptors in relation in myasthenia gravis. Physiol. Rev. 1980. 60: 756-824.
3. Lindstrom, J. M., Seybold, M. E., Lennon, V. A., Whittingham, S. and Duane, D. D., Antibody to acetylcholine receptor in myasthenis gravis. Prevalence, clinical correlates, and diagnostic value. Neurology 1976. 26: 1054-1059.
4. Protti, M. P., Manfredi, A. A., Horton, R. M., Bellone, M. and Conti-Tronconi, B. M., Myasthenia gravis: recognition of a human autoantien at the molecular level. Immunol. Today 1993.14: 363-368.
5. Hawke, S., Matsuo, H., Nicolle, M., Malcharek, G., Melms, A. and Willcox, N., Autoimmune T cells in myasthenia gravis; heterogeneity and potential for specific immunotargeting. Immunol. Today 1996. 17: 307-311.
6. Engel, A. G. and Arahata, K., The membrane attack complex of complement at the endplate in myasthenia gravis. Ann. N.Y. Acad. Sci. 1987. 505: 326-332.
7. Drachman, D. B., Myasthenia gravis. N. Engl. J. Med. 1978. 298: 186-193.
8. Mosmann, T. R., Cherwinski, H., Bond, M. W., Giedlin, M. A. and Coffmann, R. L., Two types of murine helper T cell clone. I Definition according to profile of lymphokine activities and secreted proteins. J. Immunol. 1986. 136: 2348-2357.
9. Paul, W. E. and Seder, R. A., Lymphocyte responses and cytokines. Cell 1994. 76: 241-251.
10. Abbas, A. K., Murphy, K. M. and Sher, A., Functional diversity of helper T lymphocytes. Nature 1997. 383: 787-793.
11. + T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol. Today 1995. 16: 34-38.
12. Romagnani, S., Lymphokine production by human T cells in disease states. Annu. Rev. Immunol. 1994. 12: 227-257.
13. Trinchieri, G., Interleukin 12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 1995. 13: 251-276.
14. Wolf, S. F., Temple, P. A., Kobayashi, M., Young, D., Dicig, M., Lowe, L., Dzialo, R., Fitz, L., Ferenz, D., Hewick, R. M., Kelleher, H., Herrmann, S. H., Clark, S. C., Azzoni, L., Chan, S. H., Trinchieri, G. and Perussia, B., Cloning of cDNA for natural killer stimulatory factor, a heterodimeric cytokine with multiple biological effects on T and natural killer cells. J. Immunol. 1991. 146: 3074-3081.
15. Gubler, U., Chua, A. O., Schoenhaut, D. S., Dwyer, C. M., McComas, W., Motyka, R., Nabavi N., Wolitzky, A. G., Quinn, P. M., Familletti, P. C. and Gately, M. K., Coexpression of two distinct genes is required to generate secreted, bioactive cytotoxic lymphocyte maturation factor. Proc. Natl. Acad. Sci. USA 1991. 88: 4143-4147.
16. Cassatella, M. A., Meda, L., Gasperini, S., D'Andrea, A., Ma, X. and Trinchieri, G., Interleukin-12 production by human polymorphonuclear leukocytes. Eur. J. Immunol. 1995. 25: 1-5.
17. Trinchieri, G., Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood 1994. 84: 4008-4027.
18. Manetti, R., Parronchi, P., Giudizi, M. G., Piccinni, M.-P., Maggi, E., Trinchieri, G. and Romagnani, S., Natural killer cell stimulatory factor (interleukin 12, IL-12) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J. Exp. Med. 1993. 177: 1199-1204.
19. + T cells through IL-12 produced by Listeria-induced macrophages. Science 1993. 260: 547-549.
20. Afonso, L. C. C., Scharton, T. M., Vieira, L. Q., Wysocka, M., Trinchieri, G. and Scott, P., The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science 1994. 263: 235-237.
21. h2 cells. Eur. J. Immunol. 1993. 23: 1762-1770.
22. Trembleau, S., Germann, T., Gately, M. K. and Adorini, L., The role of IL-12 in the induction of organ-specific autoimmune diseases. Immunol. Today 1995. 16: 383-386.
23. Mclntyre, K. W., Shuster, D. J., Gillooly, K. M., Warrier, R. R., Connaughton, S. E., Hall, R. B., Arp, L. H., Gately, M. K. and Magram, J., Reduced incidence and severity of collagen-induced arthritis in interleukin-12-deficient mice. Eur. J. Immunol. 1996. 26: 2933-2938.
24. Del Prete, G., De Carli, M., Mastromauro, C., Biagiotti, R., Macchia, D., Falagiani, P., Ricci, M. and Romagnani, S., Purified protein derivative of mycobacterium tuberculosis and escretory-secretory antigen(s) of toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production. J. Clin. Invest. 1991. 88: 346-350.
25. Yi, Q., Ahlberg, R., Pirskanen, R. and Lefvert A. K., Acetilcholine receptor-reactive T cells in myasthenia gravis: evidence for the involvement of different subpopulations of T helper cells. J. Neuroimmunol. 1994. 50: 177-186.
26. Link, J., Soderstrom, M., Ljungdal, A., Hojeberg, B., Olsson, T., Xu, Z., Fredrikson, S., Wang, Z. Y. and Link, H., Organ-specific autoantigens induce interferongamma and interleukin-4 mRNA expression in mononuclear cells in multiple sclerosis and myasthenia gravis. Neurology 1994. 44: 728-734.
27. Vincent, A., Experimental autoimmune myasthenia gravis. In Cohen I. (Ed.), Autoimmune disease models: a guidebook, Academic Press 1994, p. 83-106.
28. Magram, J., Connaughton, S., Warrier, R., Carvajal, D., Wu, C., Ferrante, J., Stewart, C., Sarmiento, U., Faherty, D. and Gately, M. K., IL-12 deficient mice are defective in IFN-γ production and type 1 cytokine responses. Immunity 1996. 4: 471-482.
29. Leonard, J. P., Waldburger, K. E. and Goldman, S. J., Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin-12. J. Exp. Med. 1995. 181: 381-386.
30. Trembleau, S., Penna, G., Bosi, E., Mortara, A., Gately, M. K. and Adorini, L., IL-12 administration induces Th1 cells and accelerates autoimmune diabetes in NOD mice. J. Exp. Med. 1995. 181: 817-821.
31. Germann, T., Szeliga, J., Hess, H., Stoerkel, S., Podlaski, F. J., Gately, M. K., Schmitt, E. and Ruede, E., Administration of IL-12 in combination with type II collagen induces severe arthritis in DBA/1 mice. Proc. Natl. Acad. Sci. USA 1995. 92: 4823-4827.
32. Neurath, M. F., Fuss, I., Kelsall, B. L., Stueber, E. and Strober, W., Antibodies to interleukin 12 abrogate established experimental colitis in mice. J. Exp. Med. 1995. 182: 1281-1290.
33. Yokoi, H., Kato, K., Kezuka, T., Sakai, J., Usui, M., Yagita, H. and Okumura, K., Prevention of experimental autoimmune uvoretinitis by monoclonal antibody to interleukin-12 . Eur. J. Immunol. 1997. 27: 641-646.
34. Nakajima, A., Hirose, S., Yagita, H. and Okumura, K., Roles of IL-4 and IL-12 in the development of lupus in NZB/W F1 mice. J. Immunol. 1997. 158: 1466-1472.
35. Huang, F.-P., Feng, G.-J., Lindop, G., Stott, D. I. and Liew, F. Y., The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL/MP-lpr/lpr mice. J. Exp. Med. 1996. 183: 1447-1459.
36. Balasa, B., Deng, C., Lee, J., Bradley, L. M., Dalton, D. K., Christadoss, P. and Sarvetnick, N., Interferon γ (IFN-γ) is necessary for the genesis of acetylcholine receptor-induced clinical experimental autoimmune myasthenia gravis in mice. J. Exp. Med. 1997. 186: 385-391.
37. Gu, D., Wogesen, L., Calcutt, N. A., Xia, C., Zhu, S., Merlie, J. P., Fox. H. S., Lindstrom, J., Powell, H. C. and Sarvetnick, N., Myasthenia gravis-like syndrome induced by expression of IFN-γ in the neuromuscular junction. J. Exp. Med. 1995. 181: 547-557.
38. Germann, T., Bongartz, M., Dlugonska, H., Hess, H., Schmitt, E., Kolbe, L., Koelsch, E., Podlaski, F. J., Gately, M. K. and Ruede, E., Interleukin-12 profoundly up-regulates the synthesis of antigen-specific complement-fixing IgG2a, IgG2b and IgG3 antibody subclasses in vivo. Eur. J. Immunol. 1995. 25: 823-829.
39. Whittling, P. J., Vincent, A., Schluep, M. and Newsom-Davis, J., Monoclonal antibodies that distinguish between normal and denervated human acetylcholine receptor. J. Neuroimmunol. 1986. 11: 223-235.
40. Tsartos, S., Hochschwender, S., Vasquez, P. and Lindstrom, J., Passive transfer of experimental autoimmune myasthenia gravis by monoclonal antibodies to the main immunogenic region of the acetylcholine receptor. J. Neuroimmunol. 1987. 15: 185-194.
41. Zhang, Y. and Tzartos, S., B-T lymphocyte interactions in experimental autoimmune myasthenia gravis: autoantibody mediated upregulation of the response of acetylcholine receptor specific T cells. Immunology 1992. 77: 571-576.
42. Jermy, A., Beeson, D. and Vincent, A., Pathogenic autoimmunity to affinity purified mouse acetylcholine receptor induced without adjuvant in BALB/c mice. Eur. J. Immunol. 1993. 23: 973-976.
43. Bond, A., Corlett, L., Nagvekar, N., Jacobson, L., Pantic, N., Beeson, D., Nicolle, M., Vincent, A., Newsom-Davis, J., Spack, E. and Willcox, N., Heterogeneity and immunotherapy of specific T cells in myasthenia gravis. Biochem. Soc. Trans. 1997. 25: 665-670.
44. Vincent, A. and Newsom-Davis, J., Acetylcholine receptor antibody characteristics in myasthenia gravis. I. Patients with generalized myasthenia or disease restricted to ocular muscles. Clin. Exp. Immunol 1982. 49: 257-265.
45. Rodgaard, A., Nielsen, F. C., Djurup, R., Somnier, F. and Gammeltoft, S., Acetylcholine receptor antibody and myasthenia gravis: predominance of subclasses 1 and 3. Clin. Exp. Immunol. 1987. 67: 82-88.
46. + T cells are essential to induce experimental autoimmune myasthenia gravis. J. Exp. Med. 1996. 184: 349-356.
47. Ma, C.-G., Zhang, G.-X., Xiao, B.-G., Wang, Z.-Y., Link, J., Olsson, T. and Link, H., Mucosal tolerance to experimental autoimmune myasthenia gravis is associated with down-regulation of AChR-specific IFN-γ expressing Th1-like cells and up-regulation of TGF-β mRNA in mononuclear cells. Ann. N. Y. Acad. Sci. 1996. 778: 273-287.
48. Okamura, H., Tsutsui, H., Komatsu, T., Yutsudo, M., Hakura, A., Tanimoto, T., Torigoe, K., Okura, T., Nukada, Y., Hattori, K., Akita, K., Namba, M., Tanabe, F., Konishi, K., Fukuda, S. and Kurimoto, M., Cloning of a new cytokine that induces IFN-γ production by T cells. Nature 1995. 378: 88-91.
49. Adorini, L., Aloisi, F., Galbiati, F., Gately, M. K., Gregori, S., Penna, G., Ria, F., Smiroldo, S. and Trembleau, S., Targeting IL-12, the key cytokine driving Th1-mediated autoimmune diseases. Chem. Immunol. 1997. 68: 175-197.
50. Klimkowsky, M. W., Heuser, J. E. and Stroud, R. M., Protease effects on the structure of acetylcholine receptor membranes from Torpedo californica. J. Cell Biol. 1980. 85: 823-838.
51. Gately, M. K., Warrier, R. R., Honasoge, S., Carvajal, D. M., Faherty, D. A., Connaughton, S. E., Anderson, T. D., Sarmiento, U., Hubbard, B. R. and Murphy, M., Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-γ in vivo. Int. Immunol. 1994. 6: 157-167.
52. Prat, M., Ghbaudo, G., Comoglio, P. M., Cavallo, G. and Landolfo, S., Monoclonal antibodies against murine γ interferon. Proc. Natl. Acad. Sci. USA 1984. 81: 4515-4519.
53. Cherwinski, H., Shumacher, J., Brown, K. and Mosmann, T., Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies. J. Exp. Med. 1987. 166: 1229-1244.
54. Openshaw, P., Murphy, E. E., Hosken, N. A., Maino, Y., Davis, K., Murphy, K. and O'Garra, A., Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations. J. Exp. Med. 1995. 182: 1357-1367.
55. Whiting, P. J. and Lindstrom, J. M., Purification and characterization of a nicotinic acetylcholine receptor from chick brain. Biochemistry 1986. 25: 2082-2093.