Dendritic cells transduced by multiply deleted HIV-1 vectors exhibit normal phenotypes and functions and elicit an HIV-specific cytotoxic T-lymphocyte response in vitro

Blood

Volumn 96, Issue 4, 2000, Pages 1327-1333

  Gruber, A ^a   Kan Mitchell, J ^a   Kuhen, K L ^a   Mukai, T ^a   Wong Staal, F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS VECTOR;

ACTIVE IMMUNIZATION; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; GENE DELETION; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNE RESPONSE; IMMUNOTHERAPY; LYMPHOCYTE PROLIFERATION; PHENOTYPE; PRIORITY JOURNAL;

EID: 0034663035     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.4.1327     Document Type: Article

References (37)

1. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome
2. Protective immunity against HIV infection: Has nature done the experiment for us?
3. Cytotoxic T lymphocytes in asymptomatic long-term nonprogressing HIV-1 infection: Breadth and specificity of the response and relation to in vivo viral quasi-species in a person with prolonged infection and low viral load
4. Efficient lysis of human immunodeficiency virus type 1-infected cells by cytotoxic T lymphocytes
5. Dendritic cells and the control of immunity
6. Dendritic cells: Unique leukocyte populations which control the primary immune response
7. Langerhans cells and HIV infection
8. Development of HIV vectors for anti-HIV gene therapy
9. Lentiviral vectors - The promise of gene therapy within reach?
10. Transduction of human macrophages using a stable HIV-1/HIV-2-derived gene delivery system
11. Identification of a human immunodeficiency virus type 2 (HIV-2) encapsidation determinant and transduction of nondividing human cells by HIV-2-based lentivirus vectors
12. Transduction of CD34+ cells by a vesicular stomach virus protein G (VSV-G) pseudotyped HIV-1 vector: Stable gene expression in progeny cells, including dendritic cells
13. Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood
14. Generation of mature dendritic cells from human blood: An improved method with special regard to clinical applicability
15. Phagocytosis: Flow cytometric quantitation with fluorescent microspheres
16. Identification of subdominant CTL epitopes of the GP100 melanoma-associated tumor antigen by primary in vitro immunization with peptide-pulsed dendritic cells
17. Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes
18. Molecular and functional characteristics of dendritic cells generated from highly purified CD14+ peripheral blood monocytes
19. The effect of in vitro human immunodeficiency virus infection on dendritic-cell differentiation and function
20. Productive infection of dendritic cells by HIV-1 and their ability to capture virus are mediated through separate pathways
21. Pseudotyping human immunodeficiency virus type 1 (HIV-1) by the glycoprotein of vesicular stomatitis virus targets HIV-1 entry to an endocytic pathway and suppresses both the requirement for Nef and the sensitivity to cyclosporin A
22. A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells
23. HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway
24. The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells
25. Minimal requirement for a lentivirus vector based on human Immunodeficiency virus type 1
26. Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo
27. Requirements for efficient production and transduction of human immunodeficiency virus type 1-based vectors
28. Generation of large numbers of fully mature and stable dendritic cells from leukapheresis products for clinical application
29. Induction of Epstein-Barr virus-specific cytotoxic T-lymphocyte responses using dendritic cells pulsed with EBNA-3A peptides or UV-inactivated, recombinant EBNA-3A vaccinia virus
30. The HIV-1 life cycle is blocked at two different points in mature dendritic cells
31. Live attenuated AIDS vaccines: Hazards and hopes
32. Live attenuated, multiply deleted simian immunodeficiency virus causes AIDS in infant and adult macaques
33. Temporal analyses of virus replication, immune responses, and efficacy in rhesus macaques immunized with a live, attenuated simian immunodeficiency virus vaccine
34. Efficient transduction of nondividing human cells by feline immunodeficiency virus lentiviral vectors
35. Cross-clade T cell recognition of HIV.1
36. Dendritic cells generated from blood monocytes of HIV-1 patients are not infected and act as competent antigen presenting cells eliciting potent T-cell responses
37. Circumvention of defective CD4 T helper cell function in HIV-infected individuals by stimulation with HLA alloantigens