Recognition and transport characteristics of nonpeptidic compounds by basolateral peptide transporter in Caco-2 cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 298, Issue 2, 2001, Pages 711-717

  Irie, Megumi ^a   Terada, Tomohiro ^a   Sawada, Kyoko ^a   Saito, Hideyuki ^a   Inui, Ken Ichi ^a  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOLEVULINIC ACID; CARRIER PROTEIN; GLIBENCLAMIDE; GLYCINE; GLYCYLSARCOSINE; NATEGLINIDE; PEPTIDE; PEPTIDE TRANSPORTER 1; PEPTIDE TRANSPORTER 2; UNCLASSIFIED DRUG; VALACICLOVIR; VALINE;

ARTICLE; BASOLATERAL MEMBRANE; BRUSH BORDER; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG ABSORPTION; DRUG TRANSPORT; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; PRIORITY JOURNAL;

ACYCLOVIR; AMINOLEVULINIC ACID; ANTIVIRAL AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; CACO-2 CELLS; CARRIER PROTEINS; DIETHYL PYROCARBONATE; DIPEPTIDES; HUMANS; PHOTOSENSITIZING AGENTS; SYMPORTERS; VALINE;

EID: 0034918742     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. +-peptide transporter PepT1
2. 50) of an enzymatic reaction
3. Pharmacokinetics of aminolevulinic acid after oral and intravenous administration in dogs
4. Delta-aminolevulinic acid transport by intestinal and renal peptide transporters and its physiological and clinical implications
5. Minimal molecular determinants of substrates for recognition by the intestinal peptide transporter
6. Feasibility of photodynamic therapy using endogenous photosensitization for colon cancer
7. Differential recognition of β-lactam antibiotics by intestinal and renal peptide transporters, PEPT1 and PEPT2
8. 5′-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter
9. Cellular uptake mechanism of amino acid ester prodrugs in Caco-2/hPEPT1 cells overexpressing a human peptide transporter
10. Dipeptide transporters
11. Transepithelial transport of oral cephalosporins by monolayers of intestinal epithelial cell line Caco-2: Specific transport systems in apical and basolateral membranes
12. Active and higher intracellular uptake of 5-aminolevulinic acid in tumors may be inhibited by glycine
13. Peptide transporters in the intestine and the kidney
14. Oral versus intravenous administration of 5-aminolevulinic acid for photodynamic therapy
15. 5-Aminolevulinic acid-based photodynamic therapy. Clinical research and future challenges
16. 5-Aminolevulinic acid, but not 5-aminolevulinic acid esters, is transported into adenocarcinoma cells by system BETA transporters
17. Dipeptide transporters in apical and basolateral membranes of the human intestinal cell line Caco-2
18. +/peptide cotransporter mediating absorption of β-lactam antibiotics in the intestine and kidney
19. Effects of glibenclamide on glycylsarcosine transport by the rat peptide transporters PEPT1 and PEPT2
20. Recognition of L-amino acid ester compounds by rat peptide transporters PEPT1 and PEPT2
21. +/peptide cotransporters, PEPT1 and PEPT2
22. 1 cells
23. Functional characteristics of basolateral peptide transporter in the human intestinal cell line Caco-2
24. Inhibitory effect of novel oral hypoglycemic agent nateglinide (AY4166) on peptide transporters PEPT1 and PEPT2
25. Accumulation of 5-aminolevulinic acid-induced protoporphyrin IX in normal and neoplastic human endometrial epithelial cells