Mechanisms underlying saturable intestinal absorption of metformin

Drug Metabolism and Disposition

Volumn 36, Issue 8, 2008, Pages 1650-1658

  Proctor, William R ^a   Bourdet, David L ^b   Thakker, Dhiren R ^a  

^a University of North Carolina   (United States)

^b Roche Palo Alto ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; GLYCOPROTEIN P INHIBITOR; GW 918; MANNITOL; METFORMIN; N [4 [2 (1,2,3,4 TETRAHYDRO 6,7 DIMETHOXY 2 ISOQUINOLINYL)ETHYL]PHENYL] 9,10 DIHYDRO 5 METHOXY 9 OXO 4 ACRIDINE CARBOXAMIDE; ORGANIC CATION TRANSPORTER; QUINIDINE; TETRYLAMMONIUM BROMIDE;

APICAL MEMBRANE; ARTICLE; BASOLATERAL MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG MECHANISM; HUMAN; HUMAN CELL; IN VIVO STUDY; INHIBITION KINETICS; INTESTINE ABSORPTION; MATHEMATICAL MODEL; MEMBRANE TRANSPORT; PRIORITY JOURNAL; TRANSCYTOSIS; TRANSPORT KINETICS;

CACO-2 CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DNA, COMPLEMENTARY; HUMANS; HYPOGLYCEMIC AGENTS; INTESTINAL ABSORPTION; MASS SPECTROMETRY; METFORMIN; MICROSOMES, LIVER;

EID: 47949130628     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.107.020180     Document Type: Article

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