Crystal structure of human ERK2 complexed with a pyrazolo[3,4-c]pyridazine derivative

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 1, 2006, Pages 55-58

  Kinoshita, Takayoshi ^a,b   Warizaya, Masaichi ^a   Ohori, Makoto ^a   Sato, Kentaro ^a   Neya, Masahiro ^a   Fujii, Takashi ^a  

^a ASTELLAS PHARMA INC   (Japan)

^b Osaka Prefecture University   (Japan)

Author keywords

ERK2; Structural change; X ray

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 1; PYRIDAZINE DERIVATIVE;

ARTICLE; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; HYDROPHILICITY; HYDROPHOBICITY; MOLECULAR RECOGNITION; X RAY ANALYSIS;

ADENOSINE TRIPHOSPHATE; BINDING, COMPETITIVE; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; GLUTAMIC ACID; GLYCINE; HUMANS; METHIONINE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PYRAZOLES; PYRIDINES;

EID: 27744461444     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.09.055     Document Type: Article

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