Pepsinogen-like activation intermediate of plasmepsin II revealed by molecular dynamics analysis

Proteins: Structure, Function and Genetics

Volumn 73, Issue 4, 2008, Pages 814-827

  Friedman, Ran ^a   Caflisch, Amedeo ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Essential dynamics sampling; Malaria; Molecular dynamics simulation; Plasmepsin; Plasmodium; Proplasmepsin; Protease inhibitor design

Indexed keywords

ASPARTIC ACID; ASPARTIC PROTEINASE; ENZYME PRECURSOR; HEMOGLOBIN; HYDROXYL GROUP; LYSINE; PEPSINOGEN; PLASMEPSIN II; PROTEINASE INHIBITOR; SERINE; TYROSINE; WATER;

AMINO TERMINAL SEQUENCE; ARTICLE; CONFORMATIONAL TRANSITION; ELECTRICITY; ENZYME ACTIVATION; ENZYME STRUCTURE; HYDROGEN BOND; MOLECULAR DYNAMICS; MOLECULAR LIBRARY; NONHUMAN; PLASMODIUM; PRIORITY JOURNAL; SIMULATION; X RAY; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; ENZYME ACTIVE SITE; METABOLISM; PLIABILITY; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; THERMODYNAMICS;

ASPARTIC ENDOPEPTIDASES; CATALYSIS; CATALYTIC DOMAIN; COMPUTER SIMULATION; ENZYME ACTIVATION; ENZYME PRECURSORS; HYDROGEN BONDING; MODELS, MOLECULAR; PEPSINOGENS; PLIABILITY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; THERMODYNAMICS;

EID: 58149288621     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.22105     Document Type: Article

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