Evolutionary conserved functional mechanics across pepsin-like and retroviral aspartic proteases

Journal of the American Chemical Society

Volumn 127, Issue 11, 2005, Pages 3734-3742

  Cascella, Michele ^a,b   Micheletti, Cristian ^a   Rothlisberger, Ursula ^b   Carloni, Paolo ^a  

^a DEMOCRITOS NATIONAL SIMULATION CENTER   (Italy)

^b EPFL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; FREE ENERGY; MOLECULAR DYNAMICS; REACTION KINETICS; SUBSTRATES; TOPOLOGY;

ASPARTIC PROTEASE; CLASSICAL MOLECULAR DYNAMICS; SEQUENCE ALIGNMENT TECHNIQUES; STRUCTURAL FLUCTUATIONS;

PROTEINS;

ASPARTIC PROTEINASE; BETA SECRETASE; PEPSIN A; BACE1 PROTEIN, HUMAN; PROTEINASE; SECRETASE;

AMINO TERMINAL SEQUENCE; ARTICLE; BETA SHEET; CARBOXY TERMINAL SEQUENCE; CROSS LINKING; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME SUBSTRATE; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR DYNAMICS; PROTEIN FOLDING; PROTEIN LOCALIZATION; SEQUENCE ALIGNMENT; AMINO ACID SEQUENCE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; ENZYMOLOGY; GENETICS; HYDROGEN BOND; METABOLISM; MOLECULAR EVOLUTION; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROTEIN CONFORMATION; RETROVIRUS; THERMODYNAMICS;

AMINO ACID SEQUENCE; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; BINDING SITES; COMPUTER SIMULATION; CONSERVED SEQUENCE; ENDOPEPTIDASES; EVOLUTION, MOLECULAR; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPSIN A; PROTEIN CONFORMATION; RETROVIRIDAE; SEQUENCE ALIGNMENT; THERMODYNAMICS;

EID: 15744387343     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja044608+     Document Type: Article

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