메뉴 건너뛰기




Volumn 85, Issue SUPPL. 3, 2003, Pages 52-58

Structural basis of BMP signaling inhibition by Noggin, a novel twelve-membered cystine knot protein

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; CYSTINE; NOGGIN; OSTEOGENIC PROTEIN 1; PROTEIN INHIBITOR;

EID: 0041633631     PISSN: 00219355     EISSN: None     Source Type: Journal    
DOI: 10.2106/00004623-200300003-00010     Document Type: Conference Paper
Times cited : (78)

References (30)
  • 1
    • 34250019537 scopus 로고
    • Bone: Formation by autoinduction
    • Urist MR. Bone: formation by autoinduction. Science. 1965;150:893-9.
    • (1965) Science , vol.150 , pp. 893-899
    • Urist, M.R.1
  • 2
    • 0029737070 scopus 로고    scopus 로고
    • Bone morphogenetic proteins: Multifunctional regulators of vertebrate development
    • Hogan BL. Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev. 1996;10:1580-94.
    • (1996) Genes Dev , vol.10 , pp. 1580-1594
    • Hogan, B.L.1
  • 3
    • 0030218004 scopus 로고    scopus 로고
    • Bone morphogenetic proteins in development
    • Hogan BL. Bone morphogenetic proteins in development. Curr Opin Genet Dev. 1996;6:432-8.
    • (1996) Curr Opin Genet Dev , vol.6 , pp. 432-438
    • Hogan, B.L.1
  • 4
    • 0031685620 scopus 로고    scopus 로고
    • TGF-β signal transduction
    • Massague J. TGF-β signal transduction. Annu Rev Biochem. 1998;67:753-91.
    • (1998) Annu Rev Biochem , vol.67 , pp. 753-791
    • Massague, J.1
  • 5
    • 0026646326 scopus 로고
    • Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos
    • Smith WC, Harland RM. Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos. Cell 1992;70:829-40.
    • (1992) Cell , vol.70 , pp. 829-840
    • Smith, W.C.1    Harland, R.M.2
  • 6
    • 0032039482 scopus 로고    scopus 로고
    • The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities
    • Hsu DR, Economides AN, Wang X, Elmon PM, Harland RM. The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities. Mol Cell 1998;1:673-83.
    • (1998) Mol Cell , vol.1 , pp. 673-683
    • Hsu, D.R.1    Economides, A.N.2    Wang, X.3    Elmon, P.M.4    Harland, R.M.5
  • 7
    • 0030598867 scopus 로고    scopus 로고
    • Dorsoventral patterning in Xenopus: Inhibition of ventral signals by direct binding of chordin to BMP-4
    • Piccolo S, Sasal Y, Lu B, De Robertis EM. Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4. Cell. 1996;86:589-98.
    • (1996) Cell , vol.86 , pp. 589-598
    • Piccolo, S.1    Sasal, Y.2    Lu, B.3    De Robertis, E.M.4
  • 8
    • 0032577276 scopus 로고    scopus 로고
    • Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton
    • Brunet U, McMahon JA, McMahon AP, Harland RM. Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton. Science. 1998;280:1455-7.
    • (1998) Science , vol.280 , pp. 1455-1457
    • Brunet, U.1    McMahon, J.A.2    McMahon, A.P.3    Harland, R.M.4
  • 14
    • 0030042590 scopus 로고    scopus 로고
    • Three-dimensional structure of recombinant human osteogenic protein 1: Structural paradigm for the transforming growth factor beta superfamily
    • Griffith DL, Keck PC, Sampath TK, Rueger DC, Carlson WD. Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily. Proc Natl Acad Sci USA. 1996;93:878-83.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 878-883
    • Griffith, D.L.1    Keck, P.C.2    Sampath, T.K.3    Rueger, D.C.4    Carlson, W.D.5
  • 15
    • 0035010433 scopus 로고    scopus 로고
    • Evolution and classification of cystine knot-containing hormones and related extracellular signaling molecules
    • Vitt UA, Hsu SY, Hsueh AJ. Evolution and classification of cystine knot-containing hormones and related extracellular signaling molecules. Mol Endocrinol. 2001;15:681-94.
    • (2001) Mol Endocrinol , vol.15 , pp. 681-694
    • Vitt, U.A.1    Hsu, S.Y.2    Hsueh, A.J.3
  • 16
    • 0034043106 scopus 로고    scopus 로고
    • Crystal structure of the BMP-2-BRIA ectodomain complex
    • Kirsch T, Sebald W, Dreyer MK. Crystal structure of the BMP-2-BRIA ectodomain complex. Nat Struct Biol. 2000;7:492-6.
    • (2000) Nat Struct Biol , vol.7 , pp. 492-496
    • Kirsch, T.1    Sebald, W.2    Dreyer, M.K.3
  • 17
    • 0037351880 scopus 로고    scopus 로고
    • The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly
    • Greenwald J, Groppe J, Gray P, Wiater E, Kwiatkowski W, Vale W, Choe S. The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly. Mol Cell. 2003;11:605-17.
    • (2003) Mol Cell , vol.11 , pp. 605-617
    • Greenwald, J.1    Groppe, J.2    Gray, P.3    Wiater, E.4    Kwiatkowski, W.5    Vale, W.6    Choe, S.7
  • 18
    • 0037127221 scopus 로고    scopus 로고
    • Heparan sulfate proteoglycans retain Noggin at the cell surface: A potential mechanism for shaping bone morphogenetic protein gradients
    • Palne-Saunders S, Viviano BL, Economides AN, Saunders S. Heparan sulfate proteoglycans retain Noggin at the cell surface: a potential mechanism for shaping bone morphogenetic protein gradients. J Biol Chem. 2002;277:2089-96.
    • (2002) J Biol Chem , vol.277 , pp. 2089-2096
    • Palne-Saunders, S.1    Viviano, B.L.2    Economides, A.N.3    Saunders, S.4
  • 19
    • 0032582505 scopus 로고    scopus 로고
    • Biochemical and biophysical characterization of refolded Drosophila DPP, a homolog of bone morphogenetic proteins 2 and 4
    • Groppe J, Rumpel K, Economides AN, Stahl N, Sebald W, Affolter M. Biochemical and biophysical characterization of refolded Drosophila DPP, a homolog of bone morphogenetic proteins 2 and 4. J Biol Chem. 1998;273:29052-65.
    • (1998) J Biol Chem , vol.273 , pp. 29052-29065
    • Groppe, J.1    Rumpel, K.2    Economides, A.N.3    Stahl, N.4    Sebald, W.5    Affolter, M.6
  • 20
    • 0030598829 scopus 로고    scopus 로고
    • The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4
    • Zimmerman LB, De Jesus-Escobar JM, Harland RM. The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Cell. 1996;86:599-606.
    • (1996) Cell , vol.86 , pp. 599-606
    • Zimmerman, L.B.1    De Jesus-Escobar, J.M.2    Harland, R.M.3
  • 21
    • 0035746667 scopus 로고    scopus 로고
    • Identical mutations in NOG can cause either tarsal/carpal coalition syndrome or proximal symphalangism
    • Dixon ME, Armstrong P, Stevens DB, Bamshad M. Identical mutations in NOG can cause either tarsal/carpal coalition syndrome or proximal symphalangism. Genet Med. 2001;3:349-53.
    • (2001) Genet Med , vol.3 , pp. 349-353
    • Dixon, M.E.1    Armstrong, P.2    Stevens, D.B.3    Bamshad, M.4
  • 24
    • 0036514147 scopus 로고    scopus 로고
    • Identification of a novel NOG gene mutation (P35S) in an Italian family with symphalangism
    • Mangino M, Flex E, Digillo MC, Giannotti A, Dallapiccola S. Identification of a novel NOG gene mutation (P35S) in an Italian family with symphalangism. Hum Mutat. 2002;19:308.
    • (2002) Hum Mutat , vol.19 , pp. 308
    • Mangino, M.1    Flex, E.2    Digillo, M.C.3    Giannotti, A.4    Dallapiccola, S.5
  • 27
    • 85080852522 scopus 로고    scopus 로고
    • Significant difference of opinion regarding the role of noggin in fibrodysplasla ossificans progressiva
    • Warman ML. Significant difference of opinion regarding the role of noggin in fibrodysplasla ossificans progressiva. Am J Med Genet. 2002;109:162-4.
    • (2002) Am J Med Genet , vol.109 , pp. 162-164
    • Warman, M.L.1
  • 28
  • 29
    • 0042694249 scopus 로고    scopus 로고
    • Economides A, Stahl NE, Harland RM, inventors; Regeneron Pharmaceuticals, assignee. Modified noggin polypeptide and compositions. United States patent 6075007. 1997 July 17
    • Economides A, Stahl NE, Harland RM, inventors; Regeneron Pharmaceuticals, assignee. Modified noggin polypeptide and compositions. United States patent 6075007. 1997 July 17.
  • 30
    • 0043195386 scopus 로고    scopus 로고
    • In vivo somatic cell gene transfer of an engineered noggin mutein prevents BMP4-induced heterotopic ossification in the mouse: Implications for the treatment of disorders of heterotopic ossification
    • in press
    • Economides AN, Glaser DL, Wang L, Liu X, Kimble RD, Fandi JP, Wilson JP, Stahl N, Kaplan FS, Shore EM. In vivo somatic cell gene transfer of an engineered noggin mutein prevents BMP4-induced heterotopic ossification in the mouse: implications for the treatment of disorders of heterotopic ossification. J Bone Joint Surg Am, in press.
    • J Bone Joint Surg Am
    • Economides, A.N.1    Glaser, D.L.2    Wang, L.3    Liu, X.4    Kimble, R.D.5    Fandi, J.P.6    Wilson, J.P.7    Stahl, N.8    Kaplan, F.S.9    Shore, E.M.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.