Antiangiogenic and anticancer potential of unsaturated vitamin E (tocotrienol)

Journal of Nutritional Biochemistry

Volumn 20, Issue 2, 2009, Pages 79-86

  Miyazawa, Teruo ^a   Shibata, Akira ^a   Sookwong, Phumon ^a   Kawakami, Yuki ^a   Eitsuka, Takahiro ^a   Asai, Akira ^b   Oikawa, Shinichi ^b   Nakagawa, Kiyotaka ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

Antiangiogenesis; Endothelial cells; Tocotrienol; Tumor; Vitamin E

Indexed keywords

ALPHA TOCOTRIENOL; ANTINEOPLASTIC AGENT; GROWTH FACTOR;

ANTINEOPLASTIC ACTIVITY; BREAST CARCINOGENESIS; CANCER CHEMOTHERAPY; CANCER CLASSIFICATION; CANCER GROWTH; CANCER MORTALITY; CANCER PREVENTION; CANCER SURVIVAL; CELL PROLIFERATION; DIET THERAPY; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG STRUCTURE; ENDOTHELIUM CELL; HISTORY OF MEDICINE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NEOPLASM; NONHUMAN; NUTRITIONAL ASSESSMENT; REVIEW; SIGNAL TRANSDUCTION; VITAMIN SUPPLEMENTATION;

ANGIOGENESIS INHIBITORS; ANTICARCINOGENIC AGENTS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL DIVISION; HUMANS; NEOPLASMS; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; TOCOTRIENOLS;

EID: 58149107171     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2008.09.003     Document Type: Review

References (73)

1. Evans H.M., and Bishop K.S. On the existence of a hitherto unrecognized dietary factor essential for reproduction. Science 56 (1922) 650
2. Sure B. Dietary requirements for reproduction: II. The existence of a specific vitamin for reproduction. J Biol Chem 58 (1924) 693-709
3. Valentin H.E., and Qi Q. Biotechnological production and application of vitamin E: current state and prospects. Appl Microbiol Biotechnol 68 (2005) 436-444
4. Sundram K., Thiagarajan T., Gapor A., and Basiron Y. Palm tocotrienols: new antioxidants for the new millennium. Inform 13 (2002) 634-640
5. Sookwong P., Nakagawa K., Murata K., Kojima Y., and Miyazawa T. Quantitation of tocotrienol and tocopherol in various rice brains. J Agric Food Chem 55 (2007) 461-466
6. Serbinova E., Kagan V., Han D., and Packer L. Free radical recycling and intramembrane mobility in the antioxidant properties of α-tocopherol and α-tocotrienol. Free Radic Biol Med 10 (1991) 263-275
7. Schaffer S., Müller W.E., and Eckert G.P. Tocotrienols: constitutional effects in aging and disease. J Nutr 135 (2005) 151-154
8. Parker R.A., Pearce B.C., Clark R.W., Gordon D.A., and Wright J.J. Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J Biol Chem 268 (1993) 11230-11238
9. Khanna S., Roy S., Ryu H., Bahadduri P., Swaan P.W., Ratan R.R., et al. Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration. J Biol Chem 278 (2003) 43508-43515
10. Srivastava J.K., and Gupta S. Tocotrienol-rich fraction of palm oil induces cell cycle arrest and apoptosis selectively in human prostate cancer cells. Biochem Biophys Res Commun 346 (2006) 447-453
11. Agarwal M.K., Agarwal M.L., Athar M., and Gupta S. Tocotrienol-rich fraction of palm oil activates p53, modulates Bax/Bcl2 ratio and induces apoptosis independent of cell cycle association. Cell Cycle 3 (2004) 205-211
12. Shah S., and Sylvester P.W. Tocotrienol-induced caspase-8 activation is unrelated to death receptor apoptotic signaling in neoplastic mammary epithelial cells. Exp Biol Med 229 (2004) 745-755
13. Theriault A., Chao J.T., and Gapor A. Tocotrienol is the most effective vitamin E for reducing endothelial expression of adhesion molecules and adhesion to monocytes. Atherosclerosis 160 (2002) 21-30
14. Ahn K.S., Sethi G., Krishnan K., and Aggarwal B.B. γ-Tocotrienol inhibits nuclear factor-κB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis. J Biol Chem 282 (2007) 809-820
15. Eitsuka T., Nakagawa K., and Miyazawa T. Down-regulation of telomerase activity in DLD-1 human colorectal adenocarcinoma cells by tocotrienol. Biochem Biophys Res Commun 348 (2006) 170-175
16. Birringer M., Pfluger P., Kluth D., Landes N., and Brigelius-Flohe R. Identities and differences in the metabolism of tocotrienols and tocopherols in HepG2 cells. J Nutr 132 (2002) 3113-3118
17. Yap S.P., Yuen K.H., and Lim A.B. Influence of route of administration on the absorption and disposition of α-, γ- and δ-tocotrienols in rats. J Pharm Pharmacol 55 (2003) 53-58
18. Sen C.K., Khanna S., and Roy S. Tocotrienols: vitamin E beyond tocopherols. Life Sci 78 (2006) 2088-2098
19. Hosomi A., Arita M., Sato Y., Kiyose C., Ueda T., Igarashi O., et al. Affinity for α-tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs. FEBS Lett 409 (1997) 105-108
20. Fairus S., Nor R.M., Cheng H.M., and Sundram K. Postprandial metabolic fate of tocotrienol-rich vitamin E differs significantly from that of α-tocopherol. Am J Clin Nutr 84 (2006) 835-842
21. Komiyama K., Iizuka K., Yamaoka M., Wantanabe H., Tsuchiya N., and Umezawa I. Studies on the biological activity of tocotrienols. Chem Pharm Bull 37 (1989) 1369-1371
22. Gould M.N., Haag J.D., Kennan W.S., Tanner M.A., and Elson C.E. A comparison of tocopherol and tocotrienol for the chemoprevention of chemically induced rat mammary tumors. Am J Clin Nutr 53 (1991) 1068S-1070S
23. Yu W., Simmons-Menchaca M., Gapor A., Sanders B.G., and Kline K. Induction of apoptosis in human breast cancer cells by tocopherols and tocotrienols. Nutr Cancer 33 (1999) 26-32
24. He L., Mo H., Hadisusilo S., Qureshi A.A., and Elson C.E. Isoprenoids suppress the growth of murine B16 melanomas in vitro and in vivo. J Nutr 127 (1997) 668-674
25. Ngah W.Z., Jarien Z., San M.M., Marzuki A., Top G.M., Shamaan N.A., et al. Effect of tocotrienols on hepatocarcinogenesis induced by 2-acetylaminofluorene in rats. Am J Clin Nutr 53 (1991) 1076S-1081S
26. Nesaretnam K., Khor H.T., Ganeson J., Chong Y.H., Sundram K., and Gapor A. The effect of vitamin E tocotrienols from palm oil on chemically induced mammary carcinogenesis in female rats. Nutr Res 12 (1992) 879-892
27. Iqbal J., Minhajuddin M., and Beg Z.H. Suppression of diethylnitrosamine and 2-acetylaminofluorene-induced hepatocarcinogenesis in rats by tocotrienol-rich fraction isolated from rice bran oil. Eur J Cancer Prev 13 (2004) 515-520
28. Folkman J., and Klagsbrun M. Angiogenic factors. Science 235 (1987) 442-447
29. Folkman J., and Shing Y. Angiogenesis. J Biol Chem 267 (1992) 10931-10934
30. Jensen R.L. Growth factor-mediated angiogenesis in the malignant progression of glial tumors: a review. Surg Neurol 49 (1998) 189-195
31. Kim K.J., Li B., Winer J., Armanini M., Gillett N., Philips H.S., et al. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 362 (1993) 841-844
32. Hanrahan E.O., and Heymach J.V. Vascular endothelial growth factor receptor tyrosine kinase inhibitors vandetanib (ZD6474) and AZD2171 in lung cancer. Clin Cancer Res 134 (2007) 4617S-4622S
33. Scott E.N., Meinhardt G., Jacques C., Laurent D., and Thomas A.L. Vatalanib: the clinical development of a tyrosine kinase inhibitor of angiogenesis in solid tumours. Expert Opin Invest Drugs 16 (2007) 367-379
34. Mantell D.J., Owens P.E., Bundred N.J., Mawer E.B., and Canfield A.E. 1α,25-Dihydroxyvitamin D3 inhibits angiogenesis in vitro and in vivo. Circ Res 87 (2000) 214-220
35. Min J.K., Han K.Y., Kim E.C., Kim Y.M., Lee S.W., Kim O.H., et al. Capsaicin inhibits in vitro and in vivo angiogenesis. Cancer Res 64 (2004) 644-651
36. Fassina G., Venè R., Morini M., Minghelli S., Benelli R., Noonan D.M., et al. Mechanisms of inhibition of tumor angiogenesis and vascular tumor growth by epigallocatechin-3-gallate. Clin Cancer Res 10 (2004) 4865-4873
37. Fang J., Zhou Q., Liu L.Z., Xia C., Hu X., Shi X., et al. Apigenin inhibits tumor angiogenesis through decreasing HIF-1α and VEGF expression. Carcinogenesis 28 (2007) 858-864
38. Tsuzuki T., Shibata A., Kawakami Y., Nakagawa K., and Miyazawa T. Conjugated eicosapentaenoic acid inhibits vascular endothelial growth factor-induced angiogenesis by suppressing the migration of human umbilical vein endothelial cells. J Nutr 137 (2007) 641-646
39. Tsuzuki T., Shibata A., Kawakami Y., Nakagaya K., and Miyazawa T. Anti-angiogenic effects of conjugated docosahexaenoic acid in vitro and in vivo. Biosci Biotechnol Biochem 71 (2007) 1902-1910
40. Inokuchi H., Hirokane H., Tsuzuki T., Nakagawa K., Igarashi M., and Miyazawa T. Anti-angiogenic activity of tocotrienol. Biosci Biotechnol Biochem 67 (2003) 1623-1627
41. Miyazawa T., Tsuzuki T., Nakagawa K., and Igarashi M. Antiangiogenic potency of vitamin E. Ann N Y Acad Sci 1031 (2004) 401-404
42. Nakagawa K., Eitsuka T., Inokuchi H., and Miyazawa T. DNA chip analysis of comprehensive food function: inhibition of angiogenesis and telomerase activity with unsaturated vitamin E, tocotrienol. Biofactors 21 (2004) 5-10
43. Nakagawa K., Shibata A., Yamashita S., Tsuzuki T., Kariya J., Oikawa S., et al. In vivo angiogenesis is suppressed by unsaturated vitamin E, tocotrienol. J Nutr 137 (2007) 1938-1943
44. Shibata A., Nakagawa K., Sookwong P., Tsuzuki T., Oikawa S., and Miyazawa T. Tumor anti-angiogenic effect and mechanism of action of δ-tocotrienol. Biochem Pharmacol 76 (2008) 330-339
45. Dietrich M., Traber M.G., Jacques P.F., Cross C.E., Hu Y., and Block G. Does γ-tocopherol play a role in the primary prevention of heart disease and cancer? A review. J Am Coll Nutr 25 (2006) 292-299
46. Nesaretnam K., Guthrie N., Chambers A.F., and Carroll K.K. Effect of tocotrienols on the growth of a human breast cancer cell line in culture. Lipids 30 (1995) 1139-1143
47. Nesaretnam K., Ambra R., Selvaduray K.R., Radhakrishnan A., Reimann K., Razak G., et al. Tocotrienol-rich fraction from palm oil affects gene expression in tumors resulting from MCF-7 cell inoculation in athymic mice. Lipids 39 (2004) 459-467
48. Iqbal J., Minhajuddin M., and Beg Z.H. Suppression of 7,12-dimethylbenz[α]anthracene-induced carcinogenesis and hypercholesterolaemia in rats by tocotrienol-rich fraction isolated from rice bran oil. Eur J Cancer Prev 12 (2003) 447-453
49. Shah S.J., and Sylvester P.W. γ-Tocotrienol inhibits neoplastic mammary epithelial cell proliferation by decreasing Akt and nuclear factor κB activity. Exp Biol Med 230 (2005) 235-241
50. Mizushina Y., Nakagawa K., Shibata A., Awata Y., Kuriyama I., Shimazaki N., et al. Inhibitory effect of tocotrienol on eukaryotic DNA polymerase 1 and angiogenesis. Biochem Biophys Res Commun 339 (2006) 949-955
51. Har C.H., and Keong C.K. Effects of tocotrienols on cell viability and apoptosis in normal murine liver cells (BNL CL.2) and liver cancer cells (BNL 1ME A.7R.1), in vitro. Asia Pac J Clin Nutr 14 (2005) 374-380
52. McIntyre B.S., Briski K.P., Gapor A., and Sylvester P.W. Antiproliferative and apoptotic effects of tocopherols and tocotrienols on preneoplastic and neoplastic mouse mammary epithelial cells. Proc Soc Exp Biol Med 224 (2000) 292-301
53. Sakai M., Okabe M., Tachibana H., and Yamada K. Apoptosis induction by γ-tocotrienol in human hepatoma Hep3B cells. J Nutr Biochem 17 (2006) 672-676
54. Sakai M., Okabe M., Yamasaki M., Tachibana H., and Yamada K. Induction of apoptosis by tocotrienol in rat hepatoma dRLh-84 cells. Anticancer Res 24 (2004) 1683-1688
55. Shah S., Gapor A., and Sylvester P.W. Role of caspase-8 activation in mediating vitamin E-induced apoptosis in murine mammary cancer cells. Nutr Cancer 45 (2003) 236-246
56. Sylvester P.W., and Shah S. Intracellular mechanisms mediating tocotrienol-induced apoptosis in neoplastic mammary epithelial cells. Asia Pac J Clin Nutr 14 (2005) 366-373
57. Shun M.C., Yu W., Gapor A., Parsons R., Atkinson J., Sanders B.G., et al. Pro-apoptotic mechanisms of action of a novel vitamin E analog (α-TEA) and a naturally occurring form of vitamin E (δ-tocotrienol) in MDA-MB-435 human breast cancer cells. Nutr Cancer 48 (2004) 95-105
58. Tonini T., Rossi F., and Claudio P.P. Molecular basis of angiogenesis and cancer. Oncogene 22 (2003) 6549-6556
59. Folkman J. Influence of geometry on growth of normal and malignant cells. Adv Pathobiol 4 (1976) 12-28
60. Traber M.G., and Packer L. Vitamin E: beyond antioxidant function. Am J Clin Nutr 62 (1995) 1501S-1509S
61. Chavakis E., and Dimmeler S. Regulation of endothelial cell survival and apoptosis during angiogenesis. Arterioscler Thromb Vasc Biol 22 (2002) 887-893
62. Nicholson K.M., and Anderson N.G. The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal 14 (2002) 381-395
63. Sun M., Wang G., Paciga J.E., Feldman R.I., Yuan Z.Q., Ma X.L., et al. AKT1/PKBα kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells. Am J Pathol 159 (2001) 431-437
64. Toker A. Protein kinases as mediators of phosphoinositide 3-kinase signaling. Mol Pharmacol 57 (2000) 652-658
65. Cross M.J., Dixelius J., Matsumoto T., and Claesson-Welsh L. VEGF-receptor signal transduction. Trends Biochem Sci 28 (2003) 488-494
66. Ferrara N., Gerber H.P., and LeCouter J. The biology of VEGF and its receptors. Nat Med 9 (2003) 669-676
67. Schlaeppi J.M., and Wood J.M. Targeting vascular endothelial growth factor (VEGF) for anti-tumor therapy, by anti-VEGF neutralizing monoclonal antibodies or by VEGF receptor tyrosine-kinase inhibitors. Cancer Metastasis Rev 18 (1999) 473-481
68. Staton C.A., Stribbling S.M., Tazzyman S., Hughes R., Brown N.J., and Lewis C.E. Current methods for assaying angiogenesis in vitro and in vivo. Int J Exp Pathol 85 (2004) 233-248
69. Yonekura K., Basaki Y., Chikahisa L., Okabe S., Miyadera K., and Yamada Y. UFT and its metabolites inhibit the angiogenesis induced by murine renal cell carcinoma, as determined by a dorsal air sac assay in mice. Clin Cancer Res 5 (1999) 2185-2191
70. Ribatti D., Vacca A., Roncali L., and Dammacco F. The chick embryo chorioallantoic membrane as a model for in vivo research on angiogenesis. Int J Dev Biol 40 (1996) 1189-1197
71. Kawakami Y., Tsuzuki T., Nakagawa K., and Miyazawa T. Distribution of tocotrienols in rats fed a rice bran tocotrienol concentrate. Biosci Biotechnol Biochem 71 (2007) 464-471
72. Scappaticci F.A. Mechanisms and future directions for angiogenesis-based cancer therapies. J Clin Oncol 20 (2002) 3906-3927
73. Marsh S.A., and Coombes J.S. Vitamin E and α-lipoic acid supplementation increase bleeding tendency via an intrinsic coagulation pathway. Clin Appl Thromb Hemost 12 (2006) 169-173