Distribution of tocotrienols in rats fed a rice bran tocotrienol concentrate

Bioscience, Biotechnology and Biochemistry

Volumn 71, Issue 2, 2007, Pages 464-471

  Kawakami, Yuki ^a   Tsuzuki, Tsuyoshi ^b   Nakagawa, Kiyotaka ^a   Miyazawa, Teruo ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b MIYAGI UNIVERSITY   (Japan)

Author keywords

Distribution; Rice bran; Tocopherol; Tocotrienol

Indexed keywords

DISTRIBUTION; ORAL INTUBATION; RICE BRAN; TOCOPHEROL; TOCOTRIENOL;

GROWTH KINETICS; METABOLISM; NUTRITION; TISSUE; VITAMINS;

LIVING SYSTEMS STUDIES;

ALPHA TOCOPHEROL; ALPHA TOCOTRIENOL; ANTIOXIDANT; CHROMAN DERIVATIVE; DRUG DERIVATIVE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHOLIPID; PLASTOCHROMANOL 8; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TOCOPHEROL; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; BLOOD; BODY WEIGHT; CHEMISTRY; DIET; DRUG EFFECT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIPID PEROXIDATION; MALE; METABOLISM; RAT; RICE; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION;

ANIMALS; ANTIOXIDANTS; BODY WEIGHT; CHROMANS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIET; LIPID PEROXIDATION; MALE; ORYZA SATIVA; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINES; PHOSPHOLIPIDS; RATS; RATS, SPRAGUE-DAWLEY; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TISSUE DISTRIBUTION; TOCOPHEROLS; TOCOTRIENOLS; VITAMIN E;

ANIMALIA; RATTUS; ZEA MAYS;

EID: 33847179423     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.60524     Document Type: Article

References (29)

1. Sundram, K., Thiagarajan, T., Gapor, A., and Basiron, Y., Palm tocotrienols: new antioxidants for the new millennium. Inform, 13, 634-640 (2002).
2. Serbinova, E., Kagan, V., Han, D., and Packer, L., Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol. Free Radic. Biol. Med., 10, 263-275 (1991).
3. Suzuki, Y. J., Tsuchiya, M., Wassall, S. R., Choo, Y. M., Govil, G., Kagan, V. E., and Packer, L., Structural and dynamic membrane properties of alpha-tocopherol and alpha-tocotrienol: implication to the molecular mechanism of their antioxidant potency. Biochemistry, 32, 10692-10699 (1993).
4. Parker, R. A., Pearce, B. C., Clark, R. W., Gordon, D. A., and Wright, J. J., Tocotrienols regulate cholesterol production in mammalian cells by post- transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J. Biol. Chem., 268, 11230-11238 (1993).
5. McIntyre, B. S., Briski, K. P., Gapor, A., and Sylvester, P. W., Antiproliferative and apoptotic effects of tocopherols and tocotrienols on preneoplastic and neoplastic mouse mammary epithelial cells. Proc. Soc. Exp. Biol. Med., 224, 292-301 (2000).
6. Sen, C. K., Khanna, S., Roy, S., and Packer, L., Molecular basis of vitamin E action. Tocotrienol potently inhibits glutamate-induced pp60c-src kinase activation and death of ht4 neuronal cells. J. Biol. Chem., 275, 13049-13055 (2000).
7. Khanna, S., Roy, S., Ryu, H., Bahadduri, P., Swaan, P. W., Ratan, R. R., and Sen, C. K., Molecular basis of vitamin E action. Tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration. J. Biol. Chem., 278, 43508-43515 (2003).
8. Inokuchi, H., Hirokane, H., Tsuzuki, T., Nakagawa, K., Igarashi, M., and Miyazawa, T., Anti-angiogenic activity of tocotrienol. Biosci. Biotechnol. Biochem., 67, 1623-1627 (2003).
9. Miyazawa, T., Tsuzuki, T., Nakagawa, K., and Igarashi, M., Antiangiogenic potency of vitamin E. Ann. NY Acad. Sci., 1031, 401-404 (2004).
10. Hayes, K. C., Pronczuk, A., and Liang, J. S., Differences in the plasma transport and tissue concentrations of tocopherols and tocotrienols: observations in humans and hamsters. Proc. Soc. Exp. Biol. Med., 202, 353-359 (1993).
11. Podda, M., Weber, C., Traber, M., and Packer, L., Simultaneous determination of tissue tocopherols, tocotrienols, ubiquinols, and ubiquinones. J. Lipid Res., 37, 893-901 (1996).
12. Ikeda, S., Toyoshima, K., and Yamashita, K., Dietary sesame seeds elevate α- and γ-tocotrienol concentrations in skin and adipose tissue of rats fed the tocotrienol-rich fraction extracted from palm oil. J. Nutr., 131, 2892-2897 (2001).
13. Qureshi, A. A., Sami, S. A., Salser, W. A., and Khan, F. A., Dose-dependent suppression of serum cholesterol by tocotrienol-rich fraction (TRF25) of rice bran in hypercholesterolemic humans. Atherosclerosis, 161, 199-207 (2002).
14. Iqbal, J., Minhajuddin, M., and Beg, Z. H., Suppression of diethylnitrosamine and 2-acetylaminofluorene-induced hepatocarcinogenesis in rats by tocotrienol-rich fraction isolated from rice bran oil. Eur. J. Cancer Prev., 13, 515-520 (2004).
15. Kanaya, Y., Doi, T., Sasaki, H., Fujita, A., Matsuno, S., Okamoto, K., Nakano, Y., Tsujiwaki, S., Furuta, H., Nishi, M., Tsuno, T., Taniguchi, H., and Nanjo, K., Rice bran extract prevents the elevation of plasma peroxylipid in KKAy diabetic mice. Diabetes Res. Clin. Pract., 66, S157-S160 (2004).
16. Minhajuddin, M., Beg, Z. H., and Iqbal, J., Hypolipidemic and antioxidant properties of tocotrienol rich fraction isolated from rice bran oil in experimentally induced hyperlipidemic rats. Food Chem. Toxicol., 43, 747-753 (2005).
17. Hathcock, J. N., Azzi, A., Blumberg, J., Bray, T., Dickinson, A., Frei, B., Jialal, I., Johnston, C. S., Kelly, F. J., Kraemer, K., Packer, L., Parthasarathy, S., Sies, H., and Traber, M. G., Vitamins E and C are safe across a broad range of intakes. Am. J. Clin. Nutr., 81, 736-745 (2005).
18. Kamal-Eldin, A., Görgen, S., Pettersson, J., and Lampi, A., Normal-phase high-performance liquid chromatography of tocopherols and tocotrienols. Comparison of different chromatographic columns. J. Chromatogr. A, 881, 217-227 (2000).
19. Tsuzuki, T., Igarashi, M., Komai, M., and Miyazawa, T., A metabolic conversion of 9,11,13-eleostearic acid (18:3) to 9,11-conjugated linoleic acid (18:2) in the rat. J. Nutr. Sci. Vitaminol., 49, 195-200 (2003).
20. Tsuzuki, T., Tokuyama, Y., Igarashi, M., and Miyazawa, T., Tumor growth suppression by α-eleostearic acid, a linolenic acid isomer with a conjugated triene system, via lipid peroxidation. Carcinogenesis, 25, 1417-1425 (2004).
21. Miyazawa, T., Determination of phospholipid hydroperoxides in human blood plasma by a chemiluminescence-HPLC assay. Free Radic. Biol. Med., 7, 209-217 (1989).
22. Ohkawa, H., Ohishi, N., and Yagi, K., Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem., 95, 351-358 (1979).
23. Yagi, K., A simple fluorometric assay for lipoperoxide in blood plasma. Biochem. Med., 15, 212-216 (1976).
24. Hosomi, A., Arita, M., Sato, Y., Kiyose, C., Ueda, T., Igarashi, O., Arai, H., and Inoue, K., Affinity for α-tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs. FEBS Lett., 409, 105-108 (1997).
25. Traber, M. G., Burton, G. W., Hughes, L., Ingold, K. U., Hidaka, H., Malloy, M., Kane, J., Hyams, J., and Kayden, H. J., Discrimination between forms of vitamin E by humans with and without genetic abnormalities of lipoprotein metabolism. J. Lipid Res., 33, 1171-1182 (1992).
26. Behrens, W. A., and Madere, R., Mechanisms of absorption, transport and tissue uptake of RRR-α-tocopherol and d-γ-Tocopherol in the white rat. J. Nutr., 117, 1562-1569 (1987).
27. Ikeda, S., Tohyama, T., Yoshimura, H., Hamamura, K., Abe, K., and Yamashita, K., Dietary α-tocopherol decreases α-tocotrienol but not γ-tocotrienol concentration in rats. J. Nutr., 133, 428-434 (2003).
28. Kalsotra, A., Anakk, S., Boehme, C. L., and Strobel, H. W., Sexual dimorphism and tissue specificity in the expression of CYP4F forms in Sprague Dawley rats. Drug Metab. Dispos., 30, 1022-1028 (2002).
29. Yoshinari, K., Sato, T., Okino, N., Sugatani, J., and Miwa, M., Expression and induction of cytochromes P450 in rat white adipose tissue. J. Pharmacol. Exp. Ther., 311, 147-154 (2004).