메뉴 건너뛰기




Volumn 249, Issue 1, 2002, Pages 108-120

In vivo evidence that BMP signaling is necessary for apoptosis in the mouse limb

Author keywords

Apoptosis; BMP; FGF8; Hox; Keratin 14; Limb development; Msx; Noggin

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; CYCLIN D1; FIBROBLAST GROWTH FACTOR 8; HOX PROTEIN; HOXD10 PROTEIN; HOXD11 PROTEIN; HOXD12 PROTEIN; HOXD13 PROTEIN; KERATIN; NOGGIN; OSTEOGENIC PROTEIN 1; PROTEIN; SMAD PROTEIN; SMAD1 PROTEIN; SMAD5 PROTEIN; TRANSCRIPTION FACTOR MSX1; TRANSCRIPTION FACTOR MSX2; UNCLASSIFIED DRUG;

EID: 0036382871     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.2002.0752     Document Type: Article
Times cited : (130)

References (62)
  • 1
    • 0035204194 scopus 로고    scopus 로고
    • BMPR-IA signaling is required for the formation of the apical ectodermal ridge and dorsal-ventral patterning of the limb
    • Ahn, K., Mishina, Y., Hanks, M. C., Behringer, R. R., and Crenshaw, E. B., 3rd. (2001). BMPR-IA signaling is required for the formation of the apical ectodermal ridge and dorsal-ventral patterning of the limb. Development 128, 4449-4461.
    • (2001) Development , vol.128 , pp. 4449-4461
    • Ahn, K.1    Mishina, Y.2    Hanks, M.C.3    Behringer, R.R.4    Crenshaw E.B. III5
  • 2
    • 0030035153 scopus 로고    scopus 로고
    • Genomic structure of HOXD 13 gene: A nine polyalanine duplication causes synpolydactyly in two unrelated families
    • Akarsu, A. N., Stoilov, I., Yilmaz, E., Sayli, B., and Sarfarazi, M. (1996). Genomic structure of HOXD 13 gene: A nine polyalanine duplication causes synpolydactyly in two unrelated families. Hum. Mol. Genet. 5, 945-952.
    • (1996) Hum. Mol. Genet. , vol.5 , pp. 945-952
    • Akarsu, A.N.1    Stoilov, I.2    Yilmaz, E.3    Sayli, B.4    Sarfarazi, M.5
  • 3
    • 0033966734 scopus 로고    scopus 로고
    • Combinatorial signaling through BMP receptor IB and GDF5: Shaping of the distal mouse limb and the genetics of distal limb diversity
    • Baur, S. T., Mai, J. J., and Dymecki, S. M. (2000). Combinatorial signaling through BMP receptor IB and GDF5: Shaping of the distal mouse limb and the genetics of distal limb diversity. Development 127, 605-619.
    • (2000) Development , vol.127 , pp. 605-619
    • Baur, S.T.1    Mai, J.J.2    Dymecki, S.M.3
  • 4
    • 0032577276 scopus 로고    scopus 로고
    • Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton
    • Brunet, L. J., McMahon, J. A., McMahon, A. P., and Harland, R. M. (1998). Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton. Science 280, 1455-1457.
    • (1998) Science , vol.280 , pp. 1455-1457
    • Brunet, L.J.1    McMahon, J.A.2    McMahon, A.P.3    Harland, R.M.4
  • 5
    • 0027269672 scopus 로고
    • Probing keratinocyte and differentiation specificity of the human K5 promoter in vitro and in transgenic mice
    • Byrne, C., and Fuchs, E. (1993). Probing keratinocyte and differentiation specificity of the human K5 promoter in vitro and in transgenic mice. Mol. Cell. Biol. 13, 3176-3190.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 3176-3190
    • Byrne, C.1    Fuchs, E.2
  • 6
    • 0032524011 scopus 로고    scopus 로고
    • Endogenous and ectopic expression of noggin suggests a conserved mechanism for regulation of BMP function during limb and somite patterning
    • Capdevila, J., and Johnson, R. L. (1998). Endogenous and ectopic expression of noggin suggests a conserved mechanism for regulation of BMP function during limb and somite patterning. Dev. Biol. 197, 205-217.
    • (1998) Dev. Biol. , vol.197 , pp. 205-217
    • Capdevila, J.1    Johnson, R.L.2
  • 7
    • 0033231553 scopus 로고    scopus 로고
    • Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin
    • Capdevila, J., Tsukui, T., Rodriquez Esteban, C., Zappavigna, V., and Izpisua Belmonte, J. C. (1999). Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin. Mol. Cell 4, 839-849.
    • (1999) Mol. Cell , vol.4 , pp. 839-849
    • Capdevila, J.1    Tsukui, T.2    Rodriquez Esteban, C.3    Zappavigna, V.4    Izpisua Belmonte, J.C.5
  • 8
    • 0032544449 scopus 로고    scopus 로고
    • Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development
    • Cecconi, F., Alvarez-Bolado, G., Meyer, B. I., Roth, K. A., and Gruss, P. (1998). Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. Cell 94, 727-737.
    • (1998) Cell , vol.94 , pp. 727-737
    • Cecconi, F.1    Alvarez-Bolado, G.2    Meyer, B.I.3    Roth, K.A.4    Gruss, P.5
  • 9
    • 0032534752 scopus 로고    scopus 로고
    • Shaping limbs by apoptosis
    • Chen, Y., and Zhao, X. (1998). Shaping limbs by apoptosis. J. Exp. Zool. 282, 691-702.
    • (1998) J. Exp. Zool. , vol.282 , pp. 691-702
    • Chen, Y.1    Zhao, X.2
  • 10
    • 0026770257 scopus 로고
    • Cachexia and graft-vs.-host-disease-type skin changes in keratin promoter-driven TNF alpha transgenic mice
    • Cheng, J., Turksen, K., Yu, Q. C., Schreiber, H., Teng, M., and Fuchs, E. (1992). Cachexia and graft-vs.-host-disease-type skin changes in keratin promoter-driven TNF alpha transgenic mice. Genes Dev. 6, 1444-1456.
    • (1992) Genes Dev. , vol.6 , pp. 1444-1456
    • Cheng, J.1    Turksen, K.2    Yu, Q.C.3    Schreiber, H.4    Teng, M.5    Fuchs, E.6
  • 11
    • 0034698302 scopus 로고    scopus 로고
    • Interdigital regulation of digit identity and homeotic transformation by modulated BMP signaling
    • Dahn, R. D., and Fallon, J. F. (2000). Interdigital regulation of digit identity and homeotic transformation by modulated BMP signaling. Science 289, 438-441.
    • (2000) Science , vol.289 , pp. 438-441
    • Dahn, R.D.1    Fallon, J.F.2
  • 12
    • 0029963585 scopus 로고    scopus 로고
    • A mutational analysis of the 5′ HoxD genes: Dissection of genetic interactions during limb development in the mouse
    • Davis, A. P., and Capecchi, M. R. (1996). A mutational analysis of the 5′ HoxD genes: Dissection of genetic interactions during limb development in the mouse. Development 122, 1175-1185.
    • (1996) Development , vol.122 , pp. 1175-1185
    • Davis, A.P.1    Capecchi, M.R.2
  • 14
    • 0027358721 scopus 로고
    • Disruption of the HoxD13 gene induces localized heterochrony leading to mice with neotenic limbs
    • Dolle, P., Dierich, A., LeMeur, M., Schimmang, T., Schuhbaur, B., Chambon, P., and Duboule, D. (1993). Disruption of the HoxD13 gene induces localized heterochrony leading to mice with neotenic limbs. Cell 75, 431-441.
    • (1993) Cell , vol.75 , pp. 431-441
    • Dolle, P.1    Dierich, A.2    LeMeur, M.3    Schimmang, T.4    Schuhbaur, B.5    Chambon, P.6    Duboule, D.7
  • 15
    • 0033935424 scopus 로고    scopus 로고
    • Constructive antagonism in limb development
    • Dudley, A. T., and Tabin, C. J. (2000). Constructive antagonism in limb development. Curr. Opin. Genet. Dev. 10, 387-392.
    • (2000) Curr. Opin. Genet. Dev. , vol.10 , pp. 387-392
    • Dudley, A.T.1    Tabin, C.J.2
  • 16
    • 0033120650 scopus 로고    scopus 로고
    • Essential roles of retinoic acid signaling in interdigital apoptosis and control of BMP-7 expression in mouse autopods
    • Dupe, V., Ghyselinck, N. B., Thomazy, V., Nagy, L., Davies, P. J. A., Chambon, P., and Mark, M. (1999). Essential roles of retinoic acid signaling in interdigital apoptosis and control of BMP-7 expression in mouse autopods. Dev. Biol. 208, 30-43.
    • (1999) Dev. Biol. , vol.208 , pp. 30-43
    • Dupe, V.1    Ghyselinck, N.B.2    Thomazy, V.3    Nagy, L.4    Davies, P.J.A.5    Chambon, P.6    Mark, M.7
  • 17
    • 0030200262 scopus 로고    scopus 로고
    • Overexpression of BMP-2 and BMP-4 alters the size and shape of developing skeletal elements in the chick limb
    • Duprez, D., Bell, E. J., Richardson, M. K., Archer, C. W., Wolpert, L., Brickell, P. M., and Francis-West, P. H. (1996). Overexpression of BMP-2 and BMP-4 alters the size and shape of developing skeletal elements in the chick limb. Mech. Dev. 57, 145-157.
    • (1996) Mech. Dev. , vol.57 , pp. 145-157
    • Duprez, D.1    Bell, E.J.2    Richardson, M.K.3    Archer, C.W.4    Wolpert, L.5    Brickell, P.M.6    Francis-West, P.H.7
  • 18
    • 0032080590 scopus 로고    scopus 로고
    • Ectopic expression of Msx-2 in posterior limb bud mesoderm impairs limb morphogenesis while inducing BMP-4 expression, inhibiting cell proliferation, and promoting apoptosis
    • Ferrari, D., Lichtler, A. C., Pan, Z. Z., Dealy, C. N., Upholt, W. B., and Kosher, R. A. (1998). Ectopic expression of Msx-2 in posterior limb bud mesoderm impairs limb morphogenesis while inducing BMP-4 expression, inhibiting cell proliferation, and promoting apoptosis. Dev. Biol. 197, 12-24.
    • (1998) Dev. Biol. , vol.197 , pp. 12-24
    • Ferrari, D.1    Lichtler, A.C.2    Pan, Z.Z.3    Dealy, C.N.4    Upholt, W.B.5    Kosher, R.A.6
  • 19
    • 0032925596 scopus 로고    scopus 로고
    • BMP/GDF-signalling interactions during synovial joint development
    • Francis-West, P. H., Parish, J., Lee, K., and Archer, C. W. (1999). BMP/GDF-signalling interactions during synovial joint development. Cell Tissue Res. 296, 111-119.
    • (1999) Cell Tissue Res. , vol.296 , pp. 111-119
    • Francis-West, P.H.1    Parish, J.2    Lee, K.3    Archer, C.W.4
  • 20
    • 0032054908 scopus 로고    scopus 로고
    • Morphological diversity of the avian foot is related with the pattern of msx gene expression in the developing autopod
    • Ganan, Y., Macias, D., Basco, R. D., Merino, R., and Hurle, J. M. (1998). Morphological diversity of the avian foot is related with the pattern of msx gene expression in the developing autopod. Dev. Biol. 196, 33-41.
    • (1998) Dev. Biol. , vol.196 , pp. 33-41
    • Ganan, Y.1    Macias, D.2    Basco, R.D.3    Merino, R.4    Hurle, J.M.5
  • 21
    • 0035449522 scopus 로고    scopus 로고
    • Msx-2 and p21 mediate the pro-apoptotic but not the anti-proliferative effects of BMP4 on cultured sympathetic neuroblasts
    • Gomes, W. A., and Kessler, J. A. (2001). Msx-2 and p21 mediate the pro-apoptotic but not the anti-proliferative effects of BMP4 on cultured sympathetic neuroblasts. Dev. Biol. 237, 212-221.
    • (2001) Dev. Biol. , vol.237 , pp. 212-221
    • Gomes, W.A.1    Kessler, J.A.2
  • 22
    • 0028598747 scopus 로고
    • The signaling molecule BMP4 mediates apoptosis in the rhombencephalic neural crest
    • Graham, A., Francis-West, P., Brickell, P. M., and Lumsden, A. (1994). The signaling molecule BMP4 mediates apoptosis in the rhombencephalic neural crest. Nature 372, 684-686.
    • (1994) Nature , vol.372 , pp. 684-686
    • Graham, A.1    Francis-West, P.2    Brickell, P.M.3    Lumsden, A.4
  • 23
    • 0030218004 scopus 로고    scopus 로고
    • Bone morphogenetic proteins in development
    • Hogan, B. L. (1996). Bone morphogenetic proteins in development. Curr. Opin. Genet. Dev. 6, 432-438.
    • (1996) Curr. Opin. Genet. Dev. , vol.6 , pp. 432-438
    • Hogan, B.L.1
  • 25
    • 0031883625 scopus 로고    scopus 로고
    • The life history of an embryonic signaling center: BMP-4 induces p21 and is associated with apoptosis in the mouse tooth enamel knot
    • Jernvall, J., Aberg, T., Kettunen, P., Keranen, S., and Thesleff, I. (1998). The life history of an embryonic signaling center: BMP-4 induces p21 and is associated with apoptosis in the mouse tooth enamel knot. Development 125, 161-169.
    • (1998) Development , vol.125 , pp. 161-169
    • Jernvall, J.1    Aberg, T.2    Kettunen, P.3    Keranen, S.4    Thesleff, I.5
  • 27
    • 0029835646 scopus 로고    scopus 로고
    • Function of posterior HoxD genes in the morphogenesis of the anal sphinctor
    • Kondo, T., Dolle, P., Zakany, J., and Duboule, D. (1996). Function of posterior HoxD genes in the morphogenesis of the anal sphinctor. Development 122, 2651-2659.
    • (1996) Development , vol.122 , pp. 2651-2659
    • Kondo, T.1    Dolle, P.2    Zakany, J.3    Duboule, D.4
  • 28
    • 0000368049 scopus 로고    scopus 로고
    • Control of colinearity in AbdB genes of the mouse HoxD complex
    • Kondo, T., Zakany, J., Innis, J. W., and Duboule, D. (1997). Control of colinearity in AbdB genes of the mouse HoxD complex. Mol. Cell 1, 289-300.
    • (1997) Mol. Cell , vol.1 , pp. 289-300
    • Kondo, T.1    Zakany, J.2    Innis, J.W.3    Duboule, D.4
  • 29
    • 0026616914 scopus 로고
    • Talpid2 limb bud mesoderm does not express Ghox-8 and has analteredexpression pattern of GHox-7
    • Krabbenhoft, K. M., and Fallon, J. (1992). Talpid2 limb bud mesoderm does not express Ghox-8 and has analteredexpression pattern of GHox-7. Dev. Dyn. 194, 52-62.
    • (1992) Dev. Dyn. , vol.194 , pp. 52-62
    • Krabbenhoft, K.M.1    Fallon, J.2
  • 30
    • 0028569704 scopus 로고
    • Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud
    • Laufer, E., Nelson, C. E., Johnson, R. L., Morgan, B. A., and Tabin, C. (1994). Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud. Cell 79, 993-1003.
    • (1994) Cell , vol.79 , pp. 993-1003
    • Laufer, E.1    Nelson, C.E.2    Johnson, R.L.3    Morgan, B.A.4    Tabin, C.5
  • 31
    • 0030779836 scopus 로고    scopus 로고
    • BMP expression in duck interdigital webbing: A reanalysis
    • Laufer, E., Pizette, S., Zou, H., Orozco, O. E., and Niswander, L. (1997). BMP expression in duck interdigital webbing: A reanalysis. Science 278, 305.
    • (1997) Science , vol.278 , pp. 305
    • Laufer, E.1    Pizette, S.2    Zou, H.3    Orozco, O.E.4    Niswander, L.5
  • 32
    • 0029162584 scopus 로고
    • Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm
    • Liem, K. F., Jr., Tremml, G., Roelink, H., and Jessell, T. M. (1995). Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm. Cell 82, 969-979.
    • (1995) Cell , vol.82 , pp. 969-979
    • Liem K.F., Jr.1    Tremml, G.2    Roelink, H.3    Jessell, T.M.4
  • 34
    • 0028882261 scopus 로고
    • BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning
    • Luo, G., Hofmann, C., Bronckers, A. L., Sohocki, M., Bradley, A., and Karsenty, G. (1995). BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes Dev. 9, 2808-2820.
    • (1995) Genes Dev. , vol.9 , pp. 2808-2820
    • Luo, G.1    Hofmann, C.2    Bronckers, A.L.3    Sohocki, M.4    Bradley, A.5    Karsenty, G.6
  • 35
    • 0027738612 scopus 로고
    • Interdigital soft tissue seperation induced by retinoic acid in mouse limbs cultured in vitro
    • Lussier, M., Canoun, C., Ma, C., Sank, A., and Shuler, C. (1993). Interdigital soft tissue seperation induced by retinoic acid in mouse limbs cultured in vitro. Int. J. Dev. Biol. 37, 555-564.
    • (1993) Int. J. Dev. Biol. , vol.37 , pp. 555-564
    • Lussier, M.1    Canoun, C.2    Ma, C.3    Sank, A.4    Shuler, C.5
  • 36
    • 0028960753 scopus 로고
    • Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development
    • Lyons, K. M., Hogan, B. L., and Robertson, E. J. (1995). Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development. Mech. Dev. 50, 71-83.
    • (1995) Mech. Dev. , vol.50 , pp. 71-83
    • Lyons, K.M.1    Hogan, B.L.2    Robertson, E.J.3
  • 37
    • 1842405367 scopus 로고    scopus 로고
    • Role of BMP-2 and OP-1 (BMP-7) in programmed cell death and skeletogenesis during chick limb development
    • Macias, D., Ganan, Y., Sampath, T. K., Piedra, M. E., Ros, M. A., and Hurle, J. M. (1997). Role of BMP-2 and OP-1 (BMP-7) in programmed cell death and skeletogenesis during chick limb development. Development 124, 1109-1117.
    • (1997) Development , vol.124 , pp. 1109-1117
    • Macias, D.1    Ganan, Y.2    Sampath, T.K.3    Piedra, M.E.4    Ros, M.A.5    Hurle, J.M.6
  • 38
    • 0030805626 scopus 로고    scopus 로고
    • Msx2 is a transcriptional regulator in the BMP4-mediated programmed cell death pathway
    • Marazzi, G., Wang, Y., and Sassoon, D. (1997). Msx2 is a transcriptional regulator in the BMP4-mediated programmed cell death pathway. Dev. Biol. 186, 127-138.
    • (1997) Dev. Biol. , vol.186 , pp. 127-138
    • Marazzi, G.1    Wang, Y.2    Sassoon, D.3
  • 39
    • 2642595047 scopus 로고    scopus 로고
    • The role of FGFs in the early development of vertebrate limbs
    • Martin, G. R. (1998). The role of FGFs in the early development of vertebrate limbs. Genes Dev. 12, 1571-1586.
    • (1998) Genes Dev. , vol.12 , pp. 1571-1586
    • Martin, G.R.1
  • 40
    • 0345266620 scopus 로고    scopus 로고
    • Morphogenesis of digits in the avian limb is controlled by FGFs, TGFbetas, and noggin through BMP signaling
    • Merino, R., Ganan, Y., Macias, D., Economides, A. N., Sampath, K. T., and Hurle, J. M. (1998). Morphogenesis of digits in the avian limb is controlled by FGFs, TGFbetas, and noggin through BMP signaling. Dev. Biol. 200, 35-45.
    • (1998) Dev. Biol. , vol.200 , pp. 35-45
    • Merino, R.1    Ganan, Y.2    Macias, D.3    Economides, A.N.4    Sampath, K.T.5    Hurle, J.M.6
  • 42
    • 0033402727 scopus 로고    scopus 로고
    • The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb
    • Merino, R., Rodriguez-Leon, J., Macias, D., Ganan, Y., Economides, A. N., and Hurle, J. M. (1999b). The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb. Development 126, 5515-5522.
    • (1999) Development , vol.126 , pp. 5515-5522
    • Merino, R.1    Rodriguez-Leon, J.2    Macias, D.3    Ganan, Y.4    Economides, A.N.5    Hurle, J.M.6
  • 43
    • 6244256053 scopus 로고
    • Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis
    • Mishina, Y., Suzuki, A., Ueno, N., and Behringer, R. R. (1995). Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis. Genes Dev. 9, 3027-3037.
    • (1995) Genes Dev. , vol.9 , pp. 3027-3037
    • Mishina, Y.1    Suzuki, A.2    Ueno, N.3    Behringer, R.R.4
  • 44
    • 0033662330 scopus 로고    scopus 로고
    • Fgf8 is required for outgrowth and patterning of the limbs
    • Moon, A. M., and Capecchi, M. R. (2000). Fgf8 is required for outgrowth and patterning of the limbs. Nat. Genet. 26, 455-459.
    • (2000) Nat. Genet. , vol.26 , pp. 455-459
    • Moon, A.M.1    Capecchi, M.R.2
  • 45
    • 0029871929 scopus 로고    scopus 로고
    • Altered growth and branching patterns in synpolydactyly caused by mutations in HOXD13
    • Muragaki, Y., Mundlos, S., Upton, J., and Olsen, B. (1996). Altered growth and branching patterns in synpolydactyly caused by mutations in HOXD13. Science 272, 548-551.
    • (1996) Science , vol.272 , pp. 548-551
    • Muragaki, Y.1    Mundlos, S.2    Upton, J.3    Olsen, B.4
  • 46
    • 0028149891 scopus 로고
    • A positive feedback loop coordinates growth and patterning in the vertebrate limb
    • Niswander, L., Jefrey, S., Martin, G. R., and Tickle, C. (1994). A positive feedback loop coordinates growth and patterning in the vertebrate limb. Nature 371, 609-612.
    • (1994) Nature , vol.371 , pp. 609-612
    • Niswander, L.1    Jefrey, S.2    Martin, G.R.3    Tickle, C.4
  • 47
    • 0033135571 scopus 로고    scopus 로고
    • A mouse cerberus/Dan-related gene family
    • Pearce, J. J., Penny, G., and Rossant, J. (1999). A mouse cerberus/Dan-related gene family. Dev. Biol. 209, 98-110.
    • (1999) Dev. Biol. , vol.209 , pp. 98-110
    • Pearce, J.J.1    Penny, G.2    Rossant, J.3
  • 48
    • 0033042804 scopus 로고    scopus 로고
    • BMPs negatively regulate structure and function of the limb apical ectodermal ridge
    • Pizette, S., and Niswander, L. (1999). BMPs negatively regulate structure and function of the limb apical ectodermal ridge. Development 126, 883-894.
    • (1999) Development , vol.126 , pp. 883-894
    • Pizette, S.1    Niswander, L.2
  • 49
    • 0034643084 scopus 로고    scopus 로고
    • BMPs are required at two steps of limb chondrogenesis: Formation of prechondrogenic condensations and their differentiation into chondrocytes
    • Pizette, S., and Niswander, L. (2000). BMPs are required at two steps of limb chondrogenesis: Formation of prechondrogenic condensations and their differentiation into chondrocytes. Dev. Biol. 219, 237-249.
    • (2000) Dev. Biol. , vol.219 , pp. 237-249
    • Pizette, S.1    Niswander, L.2
  • 50
    • 0035228291 scopus 로고    scopus 로고
    • Early steps in limb patterning and chondrogenesis
    • Pizette, S., and Niswander, L. (2001). Early steps in limb patterning and chondrogenesis. Novartis Found. Symp. 232, 23-36.
    • (2001) Novartis Found. Symp. , vol.232 , pp. 23-36
    • Pizette, S.1    Niswander, L.2
  • 52
    • 0034141943 scopus 로고    scopus 로고
    • Bmp-4 requires the presence of the digits to initiate programmed cell death in limb interdigital tissues
    • Tang, M. K., Leung, A. K., Kwong, W. H., Chow, P. H., Chan, J. Y., Ngo-Muller, V., Li, M., and Lee, K. K. (2000). Bmp-4 requires the presence of the digits to initiate programmed cell death in limb interdigital tissues. Dev. Biol. 218, 89-98.
    • (2000) Dev. Biol. , vol.218 , pp. 89-98
    • Tang, M.K.1    Leung, A.K.2    Kwong, W.H.3    Chow, P.H.4    Chan, J.Y.5    Ngo-Muller, V.6    Li, M.7    Lee, K.K.8
  • 53
    • 0020560077 scopus 로고
    • The inhibitory effect of 5-bromodeoxyuridine on the programmed cell death in the chick limb
    • Tone, S., Kanaka, S., and Kato, Y. (1983). The inhibitory effect of 5-bromodeoxyuridine on the programmed cell death in the chick limb. Dev. Growth Differ. 25, 381-391.
    • (1983) Dev. Growth Differ. , vol.25 , pp. 381-391
    • Tone, S.1    Kanaka, S.2    Kato, Y.3
  • 54
    • 0025876488 scopus 로고
    • Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation
    • Vassar, R., and Fuchs, E. (1991). Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation. Genes Dev. 5, 714-727.
    • (1991) Genes Dev. , vol.5 , pp. 714-727
    • Vassar, R.1    Fuchs, E.2
  • 55
    • 0029149656 scopus 로고
    • Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse
    • Winnier, G., Blessing, M., Labosky, P. A., and Hogan, B. L. (1995). Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev. 9, 2105-2116.
    • (1995) Genes Dev. , vol.9 , pp. 2105-2116
    • Winnier, G.1    Blessing, M.2    Labosky, P.A.3    Hogan, B.L.4
  • 56
    • 0033960316 scopus 로고    scopus 로고
    • The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb
    • Yi, S. E., Daluiski, A., Pederson, R., Rosen, V., and Lyons, K. M. (2000). The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb. Development 127, 621-630.
    • (2000) Development , vol.127 , pp. 621-630
    • Yi, S.E.1    Daluiski, A.2    Pederson, R.3    Rosen, V.4    Lyons, K.M.5
  • 58
    • 0028040714 scopus 로고
    • Apoptotic cell death in the mouse limb and its suppression in the hammertoe mutant
    • Zakeri, Z., Quaglino, D., and Ahuja, H. S. (1994). Apoptotic cell death in the mouse limb and its suppression in the hammertoe mutant. Dev. Biol. 165, 294-297.
    • (1994) Dev. Biol. , vol.165 , pp. 294-297
    • Zakeri, Z.1    Quaglino, D.2    Ahuja, H.S.3
  • 59
    • 0029850112 scopus 로고    scopus 로고
    • Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development
    • Zhang, H., and Bradley, A. (1996). Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development. Development 122, 2977-2986.
    • (1996) Development , vol.122 , pp. 2977-2986
    • Zhang, H.1    Bradley, A.2
  • 60
    • 0029876835 scopus 로고    scopus 로고
    • Requirement for BMP signaling in interdigital apoptosis and scale formation
    • Zou, H., and Niswander, L. (1996). Requirement for BMP signaling in interdigital apoptosis and scale formation. Science 272, 738-741.
    • (1996) Science , vol.272 , pp. 738-741
    • Zou, H.1    Niswander, L.2
  • 61
    • 0030955344 scopus 로고    scopus 로고
    • Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage
    • Zou, H., Wieser, R., Massague, J., and Niswander, L. (1997). Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage. Genes Dev. 11, 2191-2203.
    • (1997) Genes Dev. , vol.11 , pp. 2191-2203
    • Zou, H.1    Wieser, R.2    Massague, J.3    Niswander, L.4
  • 62
    • 0041030051 scopus 로고    scopus 로고
    • Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds
    • Zuniga, A., Haramis, A. P., McMahon, A. P., and Zeller, R. (1999). Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds. Nature 401, 598-602.
    • (1999) Nature , vol.401 , pp. 598-602
    • Zuniga, A.1    Haramis, A.P.2    McMahon, A.P.3    Zeller, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.