The Dorsal-related immunity factor (Dif) can define the dorsal-ventral axis of polarity in the Drosophila embryo

Development

Volumn 125, Issue 11, 1998, Pages 2159-2169

  Stein, David ^a   Goltz, Jason S ^a   Jurcsak, Jennifer ^a   Stevens, Leslie ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

cactus; dorsal; Dorsal group genes; Drosophila; Embryonic polarity; NF( )B; Rel

Indexed keywords

HELIX LOOP HELIX PROTEIN; MEMBRANE PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DROSOPHILA; EMBRYO; EMBRYO PATTERN FORMATION; GENE ACTIVATION; GENE EXPRESSION; GENE REPRESSION; IMMUNE RESPONSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMALS; BODY PATTERNING; CELL COMPARTMENTATION; CELL MOVEMENT; CELL NUCLEUS; DNA-BINDING PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, INSECT; GENETIC COMPLEMENTATION TEST; HELIX-LOOP-HELIX MOTIFS; MORPHOGENESIS; NF-KAPPA B; NUCLEAR PROTEINS; PHOSPHOPROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-REL; TRANSCRIPTION FACTORS; TWIST TRANSCRIPTION FACTOR;

EID: 0031860827     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (101)

1. Alberga, A., Boulay, J.-L., Kempe, E., Dennefield, C. and Haenlin, M. (1991). The snail gene required for mesoderm formation in Drosophila is expressed dynamically in derivatives of all three germ layers. Development 111, 983-992.
2. Beg, A. A. and Baldwin, A. S., Jr. (1993). The IκB proteins: multifunctional regulators of Rel/NF-κB transcription factors. Genes Dev. 7, 2064-2070.
3. Beg, A. A., Ruben, S. M., Scheinman, R. I., Haskill, S., Rosen, C. A. and Baldwin, A. S., Jr. (1992). IκB interacts with nuclear localization sequences of the subunits of NF-κB: a mechanism for cytoplasmic retention. Genes Dev. 6, 1899-1913.
4. Belvin, M. P., Jin, Y. and Anderson, K. V. (1995). Cactus protein degradation mediates Drosophila dorsal-ventral signaling. Genes Dev. 9, 783-793.
5. Bergmann, A., Stein, D., Geisler, R., Hagenmaier, S., Schmid, B., Fernandez, N., Schnell, B. and Nüsslein-Volhard, C. (1996). A gradient of cytoplasmic Cactus degradation establishes the nuclear localization gradient of the dorsal morphogen in Drosophila. Mech. Dev. 60, 109-123.
6. Berleth, T., Burri, M., Thoma, G., Richstein, S., Frigerio, G., Noll, M. and Nüsslein-Volhard, C. (1988). The role of the localization of bicoid in organizing the anterior pattern of the Drosophila embryo. EMBO J. 7, 1749- 1756.
7. Bier, E., Jan, L. Y. and Jan, Y. N. (1990). rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster. Genes Dev. 4, 190-203.
8. Bouley, J. L., Dennefeld, C. and Alberga, A. (1987). The Drosophila developmental gene snail encodes a protein with nucleic acid binding fingers. Nature 330, 395-398.
9. Bours, V., Villalobos, J., Burd, P. R., Kelly, K. and Siebenlist, U. (1990). Cloning of a mitogen-inducible gene encoding a kappa B DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs. Nature 348, 76-80.
10. Brown, N. H. and Kafatos, F. C. (1988). Functional cDNA libraries from Drosophila embryos. J. Mol. Biol. 203, 425-437.
11. Campos-Ortega, J. A. and Hartenstein, V. (1985). The Embryonic Development of Drosophila melanogaster. Springer Verlag, Berlin.
12. Cao, Z., Henzel, W. J. and Gao, X. (1996). IRAK: a kinase associated with the interleukin-1 receptor. Science 271, 1128-31.
13. Colicelli, J., Birchmeier, C. Michaeli, T., O'Neill, K., Riggs, M. and Wigler, M. (1989). Isolation and characterization of a mammalian gene encoding a high-affinity cAMP phosphodiesterase. Proc. Nat. Acad. Sci. USA 86, 3599- 3603.
14. Crews S. T., Thomas, J. B. and Goodman, C. S. (1988). The Drosophila single-minded gene encodes a nuclear protein with sequence similarity to the per gene product. Cell 52, 143-151.
15. Doyle, H. J., Harding, K., Hoey, T. and Levine, M. (1986). Transcripts encoded by a homeo box are restricted to dorsal tissues of Drosophila embryos. Nature 323, 688-692.
16. Doyle, H. J., Kraut, R. and Levine, M. (1989). Spatial regulation of zerknüllt: a dorsal-ventral patterning gene in Drosophila. Genes Dev. 3, 1518-1533.
17. Driever, W., Siegel, V. and Nüsslein-Volhard, C. (1990). Autonomous determination of anterior structures in the early Drosophila embryo by the bicoid morphogen. Development 109, 811-820.
18. Dubnicoff, T., Valentine, S. A., Chen, G., Shi, T., Lengyel, J. A., Paroush, Z. and Courey, A. J. (1997). Conversion of Dorsal from an activator to a repressor by the global corepressor Groucho. Genes Dev. 11, 2952-2957.
19. Engstrom, Y., Kadalayil, L., Sun, S.-C., Samakovlis, C., Hultmark, D. and Faye, I. (1993). κB-like motifs regulate the induction of immune genes in Drosophila. J. Mol. Biol. 232, 327-333.
20. Fields, S. and Song, O.-K. (1989). A novel genetic system to detect protein- protein interactions. Nature 340, 245-246.
21. Ganchi, P. A., Sun, S.-C., Greene, W. C. and Ballard, D. W. (1992). IκB/MAD-3 masks the nuclear localization signal of NFκB p65 and requires the transactivation domain to inhibit NFκB p65 DNA binding. Mol. Biol. Cell. 3, 1339-1352.
22. Gay, N. J. and Keith, F. J. (1991). Drosophila Toll and IL-1 receptor. Nature 351, 355-356.
23. Geisler, R., Bergmann, A., Hiromi, Y. and Nüsslein-Volhard, C. (1992). cactus, a gene involved in dorsoventral pattern formation in Drosophila, is related to the IκB gene family of vertebrates. Cell 71, 613-621.
24. Georgel, P., Kappler, C., Langley, E., Gross, I., Nicolas, E., Reichhart, J. M. and Hoffmann, J. A. (1995). Drosophila immunity. A sequence homologous to mammalian interferon consensus response element enhances the activity of the diptericin promoter. Nucleic Acids Res. 23, 1140-1145.
25. Ghosh, S., Gifford, A. M., Riviere, L. R., Tempst, P., Nolan, G. P. and Baltimore, D. (1990). Cloning of the p50 DNA binding subunit of NF-κB: homology to rel and dorsal. Cell 62, 1019-1029.
26. Gillespie, S. K. H. and Wasserman, S. A. (1994). Dorsal, a Drosophila Rellike protein, is phosphorylated upon activation of the transmembrane protein Toll. Mol. Cell. Biol. 14, 3559-3568.
27. Gonzalez-Crespo, S. and Levine, M. (1993). Interactions between dorsal and helix-loop-helix proteins initiate the differentiation of the embryonic mesoderm and neuroectoderm in Drosophila. Genes Dev. 7, 1703-1717.
28. Govind, S., Brennan, L. and Steward R. (1993). Homeostatic balance between Dorsal and Cactus proteins in the Drosophila embryo. Development 117, 135-148.
29. Gross, I., Georgel, P., Kappler, C., Reichart, J.-M. and Hoffman, J. A. (1996). Drosophila immunity: a comparative analysis of the Rel proteins Dorsal and Dif in the induction of the genes encoding diptericin and cecropin. Nucleic Acids Res. 24, 1238-1245.
30. Hashimoto, C., Hudson, K. L. and Anderson, K. V. (1988). The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein. Cell 52, 269-279.
31. Hemavathy, K., Meng, X. and Ip, Y. T. (1997), Differential regulation of gastrulation and neuroectodermal gene expression by Snail in the Drosophila embryo. Development 124, 3683-3691.
32. Henkel, T., Zabel, U., van Zee, K., Müller, J. M., Fanning, E. and Baeuerle, P. A. (1992). Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NFκB Subunit. Cell 68, 1121-1133.
33. Huang, J.-D., Dubnicoff, T., Liaw, G.-J., Bai, Y., Valentine, S., Shirokawa J. M., Lengyel, J. and Courey, A. J. (1995). Binding sites for transcription factor NTF-l/Elf-1 contribute to the ventral repression of decapentaplegic. Genes Dev. 9, 3177-3189.
34. Huang, J.-D., Schwyter, D. H., Shirokawa, J. M. and Courey, A. J. (1993). The interplay between multiple enhancer and silencer elements defines the pattern of decapentaplegic expression. Genes Dev. 7, 694-704.
35. Hultmark, D. (1993). Immune reactions in Drosophila and other insects: a model for innate immunity. Trends Genet. 9, 178-193.
36. Hultmark. D. (1994). Ancient relationships. Nature 367, 116-117
37. Ip, Y. T., Park, R. E., Kosman, D., Bier, E. and Levine, M. (1992a). The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo. Genes Dev 6, 1728- 1739.
38. Ip, Y. T., Park, R. E., Kosman, D., Yazdanbakhsh, K. and Levine, M. (1992b). dorsal-twist interactions establish snail expression in the presumptive mesoderm of the Drosophila embryo. Genes Dev. 6, 1518-1530.
39. Ip, Y. T., Reach, M., Engstrom, Y., Kadalayil, L., Cai, H., Gonzalez- Crespo, S., Tatei, K. and Levine, M. (1993). Dif, a dorsal-related gene that mediates an immune response in Drosophila. Cell 75, 753-763.
40. Ip, Y. T. (1995). Converting an activator into a repressor. Curr. Biol. 5, 1-3.
41. Ito, H., Fukuda, K., Murata, K., amd Kimura, A. (1983). Transformation of intact yeast cells treated with alkali cations. J. Bacterial. 153, 163-168.
42. Jiang, J., Cai, H., Zhou, Q. and Levine, M. (1993). Conversion of a dorsal- dependent silencer into an enhancer: evidence for dorsal corepressors. EMBO J. 12, 3201-3209.
43. Jiang, J., Kosman, D., Ip, Y. T. and Levine, M. (1991). The dorsal morphogen gradient regulates the mesoderm determinant twist in early Drosophila embryos. Genes Dev. 5, 1881-1891.
44. Jiang, J. and Levine, M. (1993). Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the Dorsal gradient morphogen. Cell 72, 741-752.
45. Jiang, J., Rushlow, C. A., Zhou, Q., Small., S. and Levine, M. (1992). Individual Dorsal morphogen binding sites mediate activation and repression in the Drosophila embryo. EMBO J. 11, 3147-3154.
46. Kalpana, G. V. and Goff, S. (1993). Analysis of homomeric interactions of human immune deficiency virus type 1 integrase using the yeast two-hybrid system. Proc. Nat. Acad. Sci. USA 90, 10593-10597.
47. Kasai, Y., Nambu, J. R., Lieberman, P. M. and Crews, S. T. (1992). Dorsalventral patterning in Drosophila: DNA binding of Snail protein to the single- minded gene. Proc. Nat. Acad. Sci. USA. 89, 3414-3418.
48. Kidd, S. (1992). Characterization of the Drosophila cactus locus and analysis of interactions between Cactus and Dorsal proteins. Cell 71, 623-635.
49. Kieran, M., Blank, V., Logeat, F., Vandekerckhove, J., Lottspeich, F., Le Bail, O., Urban, M. B., Kourilsky, P., Bauerle, P. A. and Israël, A. (1990). The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product. Cell 62, 1007-1018.
50. Kirov, N., Zhelnin, L., Shah, J. and Rushlow, C. A. (1993). Conversion of a silencer into an enhancer: evidence for a co-repressor in Dorsal-mediated repression in Drosophila. EMBO J. 12, 3193-3199.
51. Kosman, D., Ip, Y. T., Levine, M. and Arora, K. (1991). Establishment of the mesoderm-neuroectoderm boundary in the Drosophila embryo. Science 254, 118-122.
52. Lehming, N., McGuire, S., Brickman, J. M. and Ptashne, M. (1995). Interactions of a Rel protein with its inhibitor. Proc. Nat. Acad. Sci. USA 92, 10242-10246.
53. Lehming, N., Thanos, D., Brickman, J. M., Ma, J., Maniatis, T. and Ptashne, M. (1994). An HMG-like protein that can switch a transcriptional activator to a repressor. Nature 371, 175-179.
54. Lemaitre, B., Meister, M., Govind, S., Georgel, P., Steward, R., Reichhart, J. M. and Hoffmann, J. A. (1995). Functional analysis and regulation of nuclear import of Dorsal during the immune response in Drosophila. EMBO J. 14, 536-45
55. Lemaitre, B., Nicolas, E., Michaut, L, Reichhart, J.-M. and Hoffman, J. A. (1996). The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86, 973- 983.
56. Leptin, M. (1991). twist and snail as positive and negative regulators during Drusophila mesoderm development. Genes Dev. 5, 1568-1576.
57. Lindsley, D. L. and Zimm, G. (1992). The Genome of Drosophila melanogaster. Academic Press, Inc. San Diego.
58. Meister, M., Braun, A., Kappler, C., Reichhart, J. M. and Hoffmann, J. A. (1994). A transgenic analysis in Drosophila defines several functional domains in the diptericin promoter. EMBO J. 13, 5958-5966.
59. Miller, J .H. (1972). Experiments in Molecular Genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
60. Morisato, D. and Anderson, K. V. (1994). The spätzle gene encodes a component of the extracellular signaling pathway establishing the dorsalventral pattern of the Drosophila embryo. Cell 76, 677-688.
61. Morisato, D. and Anderson, K. V. (1995). Signaling pathways that establish the dorsal-ventral pattern of the Drosophila embryo. Ann. Rev. Genet. 29, 371-399.
62. Nolan, G. P., Ghosh, S., Liou, H.-C., Tempst, P. and Baltimore, D. (1991). DNA binding and 1κB inhibition of the cloned p65 subunit of NFκB, a Rel-related polypeptide. Cell 64, 961-969.
63. Norris, J. L. and Manley, J. L. (1992). Selective nuclear transport of the Drosophila morphogen dorsal can be established by a signaling pathway involving the transmembrane protein Toll and protein kinase A. Genes Dev. 6, 1654-1667.
64. Nüsslein-Volhard, C., Lohs-Schardin, M., Sander, K. and Cremer, C. (1980), A dorsoventral shift of embryonic primordia in a new maternal- effect mutant of Drosophila. Nature 283, 474-476.
65. Pan, D. and Courey, A. J. (1992). The same Dorsal binding site mediates both activation and repression in a context-dependent manner. EMBO J. 11, 1837-1842.
66. Pan, D., Huang J.-D. and Courey, A. J. (1991). Functional analysis of the Drosophila twist promoter reveals a Dorsal-binding ventral activator region. Genes Dev. 5, 1892-1901.
67. Petersen, U.-M., Björklund, G., Ip, Y. T. and Engstrom, Y. (1995). The dorsal-related immunity factor, Dif, is a sequence-specific trans-activator of Drosophila Cecropin gene expression. EMBO J. 14, 3146-3158.
68. Pirrotta, V. (1988). Vectors for P-element transformation in Drosophila. In Vectors. A Survey of Molecular Cloning Vectors and Their Uses (ed. R. L. Rodriguez and D. T. Denhardt), pp. 437-456. Butterworths, London.
69. Ray, R. P., Arora, K., Nusslein-Volhard, C. and Gelbart,W. M. (1991) The control of cell fate along the dorsal-ventral axis of the Drosophila embryo. Development 113, 35-54.
70. Reach, M., Galindo, R. L., Towb, P., Allen, J. L., Karin, M. and Wasserman, S. A. (1996). A gradient of Cactus protein degradation establishes dorsoventral polarity in the Drosophila embryo. Dev. Biol. 180, 353-364.
71. Reichhart, J. M., Meister, M., Dimarcq, J. L., Zachary, D., Hoffmann, D., Ruiz, C., Richards, G. and Hoffmann, J. A. (1992). Insect immunity: developmental and inducible activity of the Drosophila diptericin promoter. EMBO J. 11, 1469-1477.
72. Roberts, D. B. (1986). Basic Drosophila care and techniques. In Drosophila. A Practical Approach (ed. D. B. Roberts), pp. 1-38. IRL Press, Oxford.
73. Rose, M. D., Winston, F. and Mieter, P. (1990). Methods in Yeast Genetics: A Laboratory Course Manual. Cold Spring Harbor Laboratory Press. Cold Spring Harbor, NY.
74. Roth, S., Hiromi, Y., Godt, D. and Nusslein-Volhard, C. (1991). cactus, a maternal gene required for proper formation of the dorsoventral morphogen gradient in Drosophila embryos. Development 112, 371-388.
75. Ruben, S. M., Dillon, P. J., Schreck, R., Henkel, T., Chen, C.-H., Maher, M., Baeuerle, P. A. and Rosen, C. A. (1991). Isolation of a rel-related human cDNA that potentially encodes the 65-kd subunit of NF-κB. Science 251, 1490-1493.
76. Rusch, J. and Levine, M. (1996). Threshold responses to the dorsal regulatory gradient and the subdivision of primary territories in the Drosophila embryo. Curr. Opin. Genet. Dev. 6, 416-423.
77. Rushlow, C. and Arora, K. (1990). Dorsal ventral polarity and pattern formation in the Drosophila embryo. Sem. Cell Biol. 1, 137-149.
78. Rushlow, C., Frasch, M., Doyle, H. and Levine, M. (1987). Maternal regulation of zerknüllt: a homoeobox gene controlling differentiation of dorsal tissues in Drosophila. Nature 330, 583-586.
79. St Johnston, R. D. and Gelbart, W. M. (1987). Decapentaplegic transcripts are localized along the dorsal-ventral axis of the Drosophila embryo. EMBO J. 6, 2785-2791.
80. Schneider, D. S., Hudson, K. L., Lin, T.-Y. and Anderson, K. V. (1991). Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo. Genes Dev. 5, 797-807.
81. Schneider, D. S., Jin, Y., Morisato, D. and Anderson, K. V. (1994). A processed form of the Spätzle protein defines dorsal-ventral polarity in the Drosophila embryo. Development 120, 1243-50.
82. Shell on, C. A. and Wasserman, S. A. (1993). pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo. Cell 72, 515-525.
83. Shirokawa, J. and Courey, A. J. (1997). A Direct contact between the Dorsal rel homology domain and Twist may mediate transcriptional synergy. Mol. Cell. Biol. 17, 3345-3355.
84. Spradling, A. P. (1986). P-element mediated transformation. In Drosophila. A Practical Approach (ed. D. B. Roberts), pp. 175-197. IRL Press, Oxford.
85. Stein, D., Roth, S., Vogelsang, E. and Nüsslein-Volhard, C. (1991). The polarity of the dorsoventral axis in the Drosophila embryo is defined by an extracellular signal. Cell 65, 725-735.
86. Stephens, R. M., Rice, N. R., Hiebsch, R. R., Bose, H. R., Jr. and Gilden, R. V. (1983). Nucleotide sequence of v-rel: the oncogene of reticuloendotheliosis virus. Proc. Nat. Acad. Sci. USA 80, 6229-33
87. Steward, R. (1987). Dorsal, an embryonic polarity gene in Drosophila, is homologous to the vertebrate proto-oncogene, c-rel. Science 238, 692-694.
88. Szymanski, P. and Levine, M. (1995). Multiple modes of Dorsal-bHLH transcriptional synergy in the Drosophila embryo. EMBO J. 14, 2229-2238.
89. Tatei, K. and Levine, M. (1995). Specificity of Rel-inhibitor interactions in Drosophila embryos. Mol. Cell. Biol. 15, 3627-3634.
90. Tautz, D. and Pfeifle, C. (1989). A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. Chromosoma 98, 81-85.
91. Thisse, B., Stoetzal, C., El Messal, M. and Perrin-Schmitt, F. (1987). Genes of the Drosophila maternal dorsal group control the specific expression of the zygotic gene twist in presumptive mesodermal cells. Genes Dev. 1, 709-715.
92. Thisse, B., Stoetzal, C., Gorostiza-Thisse, C. and Perrin-Schmitt, F. (1988). Sequence of the twist gene and nuclear localization of its protein in endomesodermal cells of early Drosophila embryos. EMBO J. 7, 2175-2183.
93. Thisse, C., Perrin-Schmitt, F., Stoetzal, C. and Thisse, B. (1991). Sequence- specific transactivation of the Drosophila twist gene by the dorsal gene product. Cell 65, 1191-1201.
94. Thomas, J. B., Crews, S. T. and Goodman, C. S. (1988). Molecular genetics of the single-minded locus: a gene involved in the development of the Drosophila nervous system. Cell 52, 133-141.
95. van der Meer, J. M. (1977). Optical clean and permanent whole mount preparations for phase-contrast microscopy of cuticular structures of insect larvae. Dros. Inf. Serv. 52, 160.
96. Verma, I. M., Stevenson, J. K., Schwartz, E. M., Van Antwerp, D. and Miyamoto, S. (1995). Rel/NF-κB/IκB family: intimate tales of association and dissociation. Genes Dev. 9, 2723-2735.
97. Wasserman, S. A. (1992). A conserved signal transduction pathway regulating the activity of the rel-like proteins Dorsal and NF-κB. Mol. Biol. Cell 4, 767-771.
98. Whalen, A.M. and Steward, R. (1993). Dissociation of the dorsal-cactus complex and phsophorylation of the dorsal protein correlate with the nuclear localization of dorsal. J. Cell Biol. 123, 523-534.
99. Wieschaus, E. and Nüsslein-Volhard, C. (1986). Looking at embryos. In Drosophila. A Practical Approach (ed. D. B. Roberts), pp. 199-228. IRL Press, Oxford.
100. Wilhelmsen, K. C., Eggleton, K. and Temin, H. M. (1984). Nucleic acid sequences of the oncogene v-rel in reticuloendotheliosis virus strain T and its cellular homolog, the proto-oncogene c-rel. J. Virol. 52, 172-82
101. Wilhelmsen, K. C. and Temin, H. M. (1984). Structure and dimorphism of c-rel (turkey), the cellular homolog to the oncogene of reticuloendotheliosis virus strain T. J. Virol. 49, 521-9.