Toll and Toll-like proteins: An ancient family of receptors signaling infection

Reviews in Immunogenetics

Volumn 2, Issue 3, 2000, Pages 294-304

  Imler, J L ^a   Hoffmann, J A ^a  

^a CNRS   (France)

Author keywords

Drosophila; Innate immunity; LPS; Pattern recognition receptors; TLR; Toll

Indexed keywords

INTERLEUKIN RECEPTOR; LIPOPOLYSACCHARIDE; TOLL LIKE RECEPTOR;

AUTOIMMUNITY; DROSOPHILA; IMMUNE RESPONSE; MAMMAL; NONHUMAN; PROTEIN ANALYSIS; PROTEIN FAMILY; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGENS, CD14; ANTIGENS, DIFFERENTIATION; AUTOANTIGENS; CELL ADHESION MOLECULES; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION; I-KAPPA B PROTEINS; IMMUNITY, NATURAL; INFECTION; INSECT PROTEINS; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; LARVA; LIPOPOLYSACCHARIDES; MAMMALS; MAP KINASE SIGNALING SYSTEM; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MULTIGENE FAMILY; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; PEPTIDOGLYCAN; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TEICHOIC ACIDS; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTOR 5; TOLL-LIKE RECEPTOR 6; TOLL-LIKE RECEPTOR 9; TOLL-LIKE RECEPTORS; UBIQUITINS;

EID: 0034526231     PISSN: 13981714     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (107)

1. Dorsal-group genes of Drosophila
2. Female sterile mutations on the second chromosome of Drosophila melanogaster. I. Maternal effect mutations
3. The toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein
4. Drosophila toll and IL-1 receptor
5. The spaẗzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo
6. Proteolytic processing of the Drosophila Spatzle protein by easter generates a dimeric NGF-like molecule with ventralising activity
7. Signal transduction by a protease cascade
8. A conserved signaling pathway: The Drosophila toll-dorsal pathway
9. Control of development and immunity by rel transcription factors in Drosophila
10. Toll signaling pathways in the innate immune response
11. Immune reactions in Drosophila and other insects: A model for innate immunity
12. Drosophila immunity
13. Antimicrobial peptides in insects: Structure and function
14. Structure and expression of the attacin genes in Hyalophora cecropia
15. KB-like motifs regulate the induction of immune genes in Drosophila
16. Insect immunity. Two 17bp repeats nesting a kB-related sequence confer inducibility to the diptericin gene and bind a polypeptide in bacteria-challenged Drosophila
17. Insect immunity. A transgenic analysis in Drosophila defines several functional domains in the diptericin promoter
18. Serpent regulates Drosophila immunity genes in the larval fat body through an essential GATA motif
19. Dorsal, an embryonic polarity gene in Drosophila is homologous to the vertebrate proto-oncogene c-rel
20. Structure, regulation and function of NF-kB
21. Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins
22. Cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the IκB gene family of vertebrates
23. The dorsoventral regulatory gene cassette spätzle/toll/cactus controls the potent antifungal response in Drosophila adults
24. Evolution and revolution in immunology
25. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
26. A family of human receptors structurally related to Drosophila Toll
27. Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: Evidence for a multi-gene receptor family in humans
28. TLR6: A novel member of an expanding toll-like receptor family
29. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
30. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)
31. Constitutive activation of toll-mediated antifungal defense in serpin- deficient Drosophila
32. Clotting cascade in the immune response of the horseshoe crab
33. Purification and molecular cloning of an inducible gram-negative bacteria-binding protein from the silkworm, Bombyx mori
34. A peptidoglycan recognition protein in innate immunity conserved from insects to humans
35. A pattern recognition protein for peptidoglycan. Cloning the cDNA and the gene of the silkworm, Bombyx mori
36. A pattern-recognition protein for beta-1,3-glucan. The binding domain and the cDNA cloning of beta-1,3-glucan recognition protein from the silkworm, Bombyx mori
37. A beta1,3-glucan recognition protein from an insect, Manduca sexta, agglutinates microorganisms and activates the phenoloxidase cascade
38. Formation and biochemical characterization of tube/pelle death domain complexes: Critical regulators of postreceptor signaling by the Drosophila toll receptor
39. Oligomerisation of Tube and Pelle leads to nuclear localisation of dorsal
40. Three-dimensional structure of a complex between the death domains of Pelle and Tube
41. Phosphorylation modulates direct interactions between the Toll receptor, Pelle kinase and Tube
42. An activity-dependent network of interactions links the Re1 protein Dorsal with its cytoplasmic regulators
43. Relish, a central factor in the control of humoral but not cellular immunity in Drosophila
44. The Rel protein DIF mediates the Toll-dependent antifungal response in Drosophila
45. A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF
46. Toll receptor-mediated Drosophila immune response requires. Dif, an NF-kappaB factor
47. Drosophila cecropin as an antifungal agent
48. A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense
49. Regulated nuclear import of Rel proteins in the Drosophila immune response
50. The Drosophila IKKγ/NEMO homologue is involved in an innate immune response independent of the Toll pathway
51. Molecular and genetic analysis of the ird5 gene
52. Toll-related receptors and the control of antimicrobial peptide expression in Drosophila
53. The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense
54. Zygotic expression and activity of the Drosophila Toll gene, a gene required maternally for embryonic dorsal-ventral pattern formation
55. The Drosophila 18-wheeler is required for morphogenesis and has striking similarities to Toll
56. Expression of a novel Toll-like gene spans the parasegment boundary and contributes to hedgehog function in the adult eye of Drosophila
57. The Drosophila membrane receptor Toll can function to promote cellular adhesion
58. Molecular characterization and modular analysis of human MyD88
59. The cloning and characterization of human MyD88: A member of an IL-1 receptor related family
60. Plant disease resistance genes encode members of an ancient and diverse protein family within the nucleotide-binding superfamily
61. Independent evolution of Toll and related genes in insects and mammals
62. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling
63. Human Toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide
64. Signaling events induced by lipopolysaccharide-activated toll-like receptor 2
65. Peptidoglycan-and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2
66. Cutting edge: Recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2
67. The apoptotic signaling pathway activated by Toll-like receptor-2
68. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors
69. Cutting edge: Inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2
70. Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products
71. Human toll-like receptors mediate cellular activation by mycobacterium tuberculosis
72. The CD14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for Toll-like receptors
73. Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages
74. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
75. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction
76. Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
77. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
78. Cutting edge: Preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway
79. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
80. Toll, a new piece in the puzzle of innate immunity
81. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll- like receptor 4
82. Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide
83. Physical contact between lipopolysaccharide and Toll-like receptor 4 revealed by genetic complementation
84. The Toll-receptor family and control of innate immunity
85. Unresponsiveness of MyD88-deficient mice to endotoxin
86. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, LPS signaling
87. Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase
88. Defective interleukin (IL)-18-mediated natural killer and T helper cell type 1 responses in IL-1 receptor-associated kinase (IRAK)-deficient mice
89. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
90. IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family
91. The IKK complex: An integrator of all signals that activate NF-kappaB?
92. Phosphorylation meets ubiquitination: The control of NF-kappaB activity
93. The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis
94. Severe liver degeneration in mice lacking the IkappaB kinase 2 gene
95. Embryonic lethality, liver degeneration, impaired NF-kappa B activation in IKK-beta-deficient mice
96. Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice
97. MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1
98. JNK or IKK, AP-1 or NF-kappaB, which are the targets for MEK kinase 1 action?
99. The human toll signaling pathway: Divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)
100. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways
101. Lipopolysaccharide induces the rapid tyrosine phosphorylation of the mitogen-activated protein kinases erk-1 and p38 in cultured human vascular endothelial cells requiring the presence of soluble CD14
102. A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression
103. Sequence-specific transactivation of the Drosophila twist gene by the dorsal gene product
104. Molecular cloning and characterization of a second subunit of the interleukin-1 receptor complex
105. Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling
106. IL-1 receptor accessory protein is an essential component of the IL-1 receptor
107. The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation