Synthesis, HIV-RT inhibitory activity and SAR of 1-benzyl-1H-1,2,3-triazole derivatives of carbohydrates

European Journal of Medicinal Chemistry

Volumn 44, Issue 1, 2009, Pages 373-383

  da Silva, Fernando de C ^a   de Souza, Maria Cecilia B V ^a   Frugulhetti, Izabel I P ^a   Castro, Helena C ^a   Souza, Silmara L de O ^a   de Souza, Thiago Moreno L ^a   Rodrigues, Diego Q ^a   Souza, Alessandra M T ^a   Abreu, Paula A ^a   Passamani, Fabiana ^b   Rodrigues, Carlos R ^b   Ferreira, Vitor F ^a  

^a FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

1,2,3 Triazole; Anti HIV; Antiviral; HIV RT

Indexed keywords

1 BENZYL 1H 1,2,3 TRIAZOLE DERIVATIVE; 1 BENZYL 5 METHYL 1H [1,2,3]TRIAZOL 4 CARBOXYLIC ACID 3 (1,2:5,6 DI O ISOPROPYLIDENE) ALPHA DEXTRO GLUCOFURANOSE; 1 BENZYL 5 METHYL 1H [1,2,3]TRIAZOL 4 CARBOXYLIC ACID 5 (1 METHOXY 2,3 O ISOPROPYLIDENE) BETA DEXTRO RIBOFURANOSE ESTER; 1 BENZYL 5 METHYL 1H [1,2,3]TRIAZOL 4 CARBOXYLIC ACID 5 (3 O BENZYL 1,2 O ISOPROPYLIDENE) ALPHA DEXTRO XYLOFURANOSE ESTER; 1,2,3 TRIAZOLE DERIVATIVE; CARBOHYDRATE DERIVATIVE; DIDANOSINE; LAMIVUDINE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG; ZALCITABINE; ZIDOVUDINE;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR MODEL; NONHUMAN; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; VERO CELL;

ANTI-HIV AGENTS; CARBOHYDRATES; HIV REVERSE TRANSCRIPTASE; HUMANS; HYDROPHOBICITY; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 57949104006     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.02.047     Document Type: Article

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