Design, synthesis and pharmacological profile of novel dopamine D2 receptor ligands

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 22, 2003, Pages 4807-4813

  Menegatti, Ricardo ^a   Cunha, Anna C ^b   Ferreira, Vítor F ^b   Perreira, Edna F R ^c   El Nabawi, Ahmed ^c   Eldefrawi, Amira T ^c   Albuquerque, Edson X ^a,c   Neves, Gilda ^d   Rates, Stela M K ^d   Fraga, Carlos A M ^a   Barreiro, Eliezer J ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

1 PHENYL 4 (1 PHENYL 1H [1,2,3]TRIAZOL 4 YLMETHYL)PIPERAZINE; 1 [1 (4 CHLOROPHENYL) 1H PYRAZOL 4 YLMETHYL] 4 PHENYLPIPERAZINE; 1 [1 (4 CHLOROPHENYL) 1H [1,2,3]TRIAZOL 4 YLMETHYL] 4 PHENYLPIPERAZINE; LASSBIO 579; LASSBIO 580; LASSBIO 581; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; BRAIN NERVE CELL; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; ELECTROPHYSIOLOGY; HIPPOCAMPUS POTENTIAL; MALE; NONHUMAN; RAT; RECEPTOR BINDING;

EID: 10744229749     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(03)00487-5     Document Type: Article

References (33)

1. Hiroeh U., Appleby L., Mortensen P.B., Dunn G. Lancet. 258:2001;2110.
2. Haukka J., Suvisaari J., Lonnqvist J. Am. J. Psychiatry. 148:2002;322.
3. Potkin S.G., Akva G., Fleming K., Anand R., Keator D., Carreon D., Doo M., Jin Y., Wu J.C., Fallon J.H. Am. J. Psychiatry. 159:2002;227.
4. McKenna P.J. Br. J. Psychiatry. 151:1987;288.
5. Davis K.L., Kahn R.S., Ko G., Davidson M. Am. J. Psychiatry. 148:1991;1474.
6. Fink-Jensen A. Dan. Med. Bull. 47:2000;151.
7. Emilien G., Maloteaux J.M., Geurts M., Hoogenberg K., Cragg S. Pharmacol. Ther. 84:1999;133.
8. Azorin, J. M. Int. Clin. Psychopharmacol. 15, S5.
9. Fitton A., Heel R. Drugs. 40:1990;722.
10. Rowley M., Bristow L.J., Hutson P.H. J. Med. Chem. 44:2001;477.
11. Liegeois J., Eyrolles L., Bruhwyler J., Delarge J. Curr. Med. Chem. 5:1998;77.
12. Kapur S., Seeman P. Am. J. Psychiatry. 158:2001;360.
13. Kulagowski J.J., Broughton H.B., Curtis N.R., Mawer I.A., Ridgill M.P., Baker R., Emms F., Freedman S.B., Marwood R., Patel S., Patel S., Ragan C.I., Leeson P.D. J. Med. Chem. 39:1996;1941.
14. Alkorta I., Elguero J. J. Chem. Soc., Perkin Trans. 2. 1998;2497.
15. Arnold Z., Saulióva J. Coll. Czech. Chem. Commun. 38:1973;2641.
16. L'abbé G.L., Bruynseels M., Delbeke P., Toppet S. J. Heterocyclic Chem. 27:1990;2021.
17. Finar I., Hurlock R. J. Chem. Soc. 1957;3024.
18. Robey R., Alt C., Van Meter E. J. Heterocylic. Chem. 34:1997;413.
19. Thurkauf A., Yuan J., Chen N., Wasley J.W.F., Meade R., Woodruff K.H., Huston K., Ross P.C. J. Med. Chem. 38:1995;4950.
20. Abdallah E.D., Jett D., Eldefrawi M., Eldefrawi A. J. Biochem. Toxicol. 7:1993;1.
21. Houghtling R.A., Davila-Garcia M.I., Kellar K.J. Mol. Pharmacol. 48:1995;280.
22. Levin E.D., Torry D., Christopher N., Yu X., Einstein G., Schwartz-Bloom R. Brain Res. Bull. 43:1997;295.
23. Niznik H.B., Grigoriadis D.E., Pri-Bar I., Buchman O., Seeman P. Naunyn-Schmiedeberg's Arch. Pharmacol. 329:1985;333.
24. El-Nabawi A.M., Eldefrawi M.E., Eldefrawi A.T. Toxicol. Sci. 54:2000;175.
25. Delbarre B., Delbarre G., Rochat C., Calinon F. Mol. Chem. Neuropathol. 26:1995;43.
26. Koga E., Momiyama T. J. Physiol. (Lond.). 523:2000;163.
27. Dewar M.J.S., Zoebisch E.G., Healy E.F., Stewart J.J.P. J. Am. Chem. Soc. 107:1985;3902.
28. Hessian matrix analyses were analyses were employed to unequivocally characterize them as true minima potential energy surface.
29. Wavefunction Inc.: Irvine, CA, 2000.
30. Neves G., Fenner R., Heckler A.P., Viana A.F., Tasso L., Menegatti R., Fraga C.A.M., Barreiro E.J., Dalla-Costa T., Rates S.M.K. Braz. J. Med. Biol. Res. 36:2003;625.
31. Pereira E.F.R., Reinhardt-Maelicke S., Schrattenholz A., Maelicke A., Albuquerque E.X. J. Pharmacol. Exp. Ther. 265:1993;1474.
32. Hamill O.P., Marty A., Neher E., Sakmann B., Sigworth F.J. Pflugers Arch. 391:1981;85.
33. Dempster, J. In The Computer Analysis of Electrophysiological Data; Frazer, P. J., Ed.; Oxford Irl: Oxford, 1989; p 51.