Practical synthesis of the anti-HIV drug, PMPA

Tetrahedron Letters

Volumn 39, Issue 14, 1998, Pages 1853-1856

  Schultze, Lisa M ^a   Chapman, Harlan H ^a   Dubree, Nathan J P ^a   Jones, Robert J ^a   Kent, Kenneth M ^a   Lee, Thomas T ^b   Louie, Michael S ^a   Postich, Michael J ^a   Prisbe, Ernest J ^a   Rohloff, John C ^a   Yu, Richard H ^a  

^a Process Chemistry   (United States)

^b Analytical Chemistry   (United States)

Author keywords

HIV; Nucleotide; Phosphonate; PMEA; PMPA

Indexed keywords

ADENOSINE DERIVATIVE; ANTIRETROVIRUS AGENT; ANTIVIRUS AGENT; NUCLEOTIDE DERIVATIVE; TENOFOVIR; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTIVIRAL ACTIVITY; ARTICLE; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; RETROVIRUS;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; UNIDENTIFIED RETROVIRUS;

EID: 0032473894     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)00131-2     Document Type: Article

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19. 4OAc in 5% MeOH in water, Mobile Phase B = MeOH; linear ramp over 20 min. from 0% B to 60% B. Column conditions: Hypersil ODS (C18), 5 μm, 4.6 × 150 mm, (Alltech Assoc., 2051 Waubegan Road, Deerfield, IL, 60015); 10 μL injection; flow rate 1 mL/min.; detection @ 262 nm by absorbance; ambient temperature.
20. 4 in a 3.8% [v/v] solution of acetonitrile in water). Column conditions: Hypersil ODS (C18), 5 μm, 4.6 × 250 mm, (Alltech Assoc., 2051 Waukegan Road, Deerfield, IL, 60015); 10 μL injection; flow rate 0.6 mL/min. (isocratic); detection @ 274 nm by absorbance; ambient temperature; RT(ent-2) = 10.5 to 12.5 min; RT(R-2) = 12.5 to 14.5 min.