Structural characterization of a neurotoxic threonine-rich peptide corresponding to the human prion protein α2-helical 180-195 segment and comparison with full-length α2-helix-derived peptides

Journal of Peptide Science

Volumn 14, Issue 10, 2008, Pages 1096-1102

  Ronga, Luisa ^a   Palladino, Pasquale ^a   Saviano, Gabriella ^b   Tancredi, Teodorico ^c   Benedetti, Ettore ^a   Ragone, Raffaele ^d   Rossi, Filomena ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF MOLISE   (Italy)

^c CNR   (Italy)

^d SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

2 helix; sheet; Amyloid; CD titration; Encephalopathies; NMR structure; Prion protein; Prion toxicity; Transmissible spongiform

Indexed keywords

DODECYL SULFATE; PRION PROTEIN; THREONINE;

ALPHA HELIX; ARTICLE; BETA SHEET; CARBOXY TERMINAL SEQUENCE; CIRCULAR DICHROISM; NUCLEAR MAGNETIC RESONANCE; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING; STRUCTURE ACTIVITY RELATION;

CIRCULAR DICHROISM; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; NEUROTOXINS; PEPTIDES; PRIONS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; THREONINE; TRIFLUOROETHANOL; WATER;

EID: 57849162808     PISSN: 10752617     EISSN: 10991387     Source Type: Journal    
DOI: 10.1002/psc.1046     Document Type: Article

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