Does tetracycline bind helix 2 of prion? An integrated spectroscopical and computational study of the interaction between the antibiotic and α helix 2 human prion protein fragments

Proteins: Structure, Function and Genetics

Volumn 66, Issue 3, 2007, Pages 707-715

  Ronga, Luisa ^a,b   Langella, Emma ^a   Palladino, Pasquale ^a   Marasco, Daniela ^a   Tizzano, Barbara ^a,b   Saviano, Michele ^a   Pedone, Carlo ^a,b   Improta, Roberto ^a   Ruvo, Menotti ^a  

^a CNR   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

CD spectroscopy; Docking calculations; Fluorescence spectroscopy; Molecular dynamics; Prion peptides; Tetracycline

Indexed keywords

ANTIBIOTIC AGENT; PRION PROTEIN; SOLVENT; TETRACYCLINE; THREONINE;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ANTIBIOTIC THERAPY; BETA SHEET; CARBOXY TERMINAL SEQUENCE; CONFERENCE PAPER; DISSOCIATION CONSTANT; DRUG PROTEIN BINDING; FLUORESCENCE; HUMAN; MATHEMATICAL COMPUTING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN INTERACTION; SOLVENT EFFECT; SPECTROSCOPY;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; CIRCULAR DICHROISM; HUMANS; KINETICS; MOLECULAR SEQUENCE DATA; PEPTIDES; PRIONS; PROTEIN BINDING; PROTEIN CONFORMATION; SOLVENTS; SPECTROMETRY, FLUORESCENCE; TETRACYCLINE;

EID: 33846202560     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.21204     Document Type: Conference Paper

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