Conformational diseases and structure-toxicity relationships: Lessons from prion-derived peptides

Current Protein and Peptide Science

Volumn 8, Issue 1, 2007, Pages 83-90

  Ronga, Luisa ^a   Palladino, Pasquale ^a   Costantini, Susan ^b,c   Facchiano, Angelo ^c   Ruvo, Menotti ^a   Benedetti, Ettore ^a   Ragone, Raffaele ^b   Rossi, Filomena ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

^c CNR   (Italy)

Author keywords

Amyloid; Copper binding protein; N linked glycoprotein; Prion structure; Prion toxicity; Transmissible spongiform encephalopathies

Indexed keywords

AMYLOID PROTEIN; ANTIBIOTIC AGENT; COPPER; METAL ION; POLYAMINE DERIVATIVE; POLYANION; POLYENE ANTIBIOTIC AGENT; POLYPEPTIDE; PRION PROTEIN; PROTEINASE; TETRACYCLINE; TETRAPYRROLE DERIVATIVE;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; BETA SHEET; CARBOXY TERMINAL SEQUENCE; CELL FUNCTION; CENTRAL NERVOUS SYSTEM DISEASE; CONFORMATIONAL TRANSITION; COPPER METABOLISM; DRUG PROTEIN BINDING; ENZYME INHIBITION; HUMAN; MAMMAL CELL; METAL BINDING; NEUROPATHOLOGY; NONHUMAN; OXIDATIVE STRESS; PRION DISEASE; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN SECONDARY STRUCTURE; REVIEW; SCRAPIE; SPECIES CONSERVATION; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; HUMANS; METALS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NERVE DEGENERATION; PRION DISEASES; PRIONS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; THERMODYNAMICS;

MAMMALIA;

EID: 33847296574     PISSN: 13892037     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920307779941505     Document Type: Review

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